BACKGROUND As a serious global problem,knee osteoarthritis(KOA)often leads to pain and disability.Manual therapy is widely used as a kind of physical treatment for KOA.AIM To explore further the efficacy of Maitland a...BACKGROUND As a serious global problem,knee osteoarthritis(KOA)often leads to pain and disability.Manual therapy is widely used as a kind of physical treatment for KOA.AIM To explore further the efficacy of Maitland and Mulligan mobilization methods for adults with KOA.METHODS We searched PubMed,the Cochrane Library,EMbase,Web of Science and Google Scholar from inception to September 20,2020 to collect studies comparing Maitland and Mulligan mobilization methods in adults with KOA.The quality of the studies was assessed using the Physiotherapy Evidence Database Scale for randomized controlled trials.Data analyses were performed using Review Manager 5.0 software.RESULTS A total of 341 articles were screened from five electronic databases(PubMed,the Cochrane Library,EMbase,Web of Science and Google Scholar)after excluding duplicates.Ultimately,eight trials involving 471 subjects were included in present systematic review and meta-analysis.The mean PEDro scale score was 6.6.Mulligan mobilization was more effective in alleviating pain[standardized mean difference(SMD)=0.60;95%confidence interval(CI):0.17 to 1.03,P=0.007;I2=60%,P=0.020]and improving Western Ontario and McMaster Universities function score(SMD=7.41;95%CI:2.36 to 12.47,P=0.004;I2=92%,P=0.000).There was no difference in the effect of the two kinds of mobilization on improving the range of motion(SMD=9.63;95%CI:-1.23 to 20.48,P=0.080;I2=97%,P=0.000).CONCLUSION Mulligan mobilization technique is a promising intervention in alleviating pain and improving function score in KOA patients.展开更多
For a nonlinear limit state function, the first-order reliability method(FORM) may cause large errors in the computation of not only the reliability index or failure probability but also the reliability sensitivity. I...For a nonlinear limit state function, the first-order reliability method(FORM) may cause large errors in the computation of not only the reliability index or failure probability but also the reliability sensitivity. In order to obtain more the accurate results of the reliability sensitivity analysis, a number of hyperplanes are built near the design point by first-order Tayler series expansion, which replace the known nonlinear limit state hypersurface, and an equivalent computational method is utilized to construct an equivalent hyperplane of the obtained hyperplanes. And the reliability sensitivities can be estimated more accurately by the derived equations based on the equivalent hyperplane. An example shows that the method is effective and feasible.展开更多
Isothermal sections of the Co−Al−Re ternary system at 1100 and 1300℃ were determined experimentally by electron probe microanalysis and X-ray diffraction.The results show that there are seven three-phase regions in t...Isothermal sections of the Co−Al−Re ternary system at 1100 and 1300℃ were determined experimentally by electron probe microanalysis and X-ray diffraction.The results show that there are seven three-phase regions in the 1100℃ isothermal section and five three-phase regions in the 1300℃ isothermal section.The solid solubilities ofαCo,εRe and CoAl increase a little with temperature increasing from 1100 to 1300℃.The solubility of Co in compounds AlRe2,Al11Re4 and Al4Re is negligible,<1.5 at.%.And no ternary compounds are found.展开更多
To address the restriction of fiber-optic surface plasmon resonance(SPR) sensors in the field of multi-sample detection, a novel dual-channel fiber-optic SPR sensor based on the cascade of coaxial dual-waveguide D-typ...To address the restriction of fiber-optic surface plasmon resonance(SPR) sensors in the field of multi-sample detection, a novel dual-channel fiber-optic SPR sensor based on the cascade of coaxial dual-waveguide D-type structure and microsphere structure is proposed in this paper. The fiber sidepolishing technique converts the coaxial dual-waveguide fiber into a D-type one, and the evanescent wave in the ring core leaks, generating a D-type sensing region;the fiber optic fused ball push technology converts the coaxial dual waveguides into microspheres, and the stimulated cladding mode evanescent wave leaks, producing the microsphere sensing region. By injecting light into the coaxial dual-waveguide middle core alone, the sensor can realize single-stage sensing in the microsphere sensing area;it can also realize dual-channel sensing in the D-type sensing area and microsphere sensing area by injecting light into the ring core. The refractive index measurement ranges for the two channels are 1.333–1.365 and 1.375–1.405, respectively, with detection sensitivities of 981.56 nm/RIU and 4138 nm/RIU. The sensor combines wavelength division multiplexing and space division multiplexing technologies, presenting a novel research concept for multi-channel fiber SPR sensors.展开更多
BACKGROUND The therapeutic effects of a combination of Chinese medicines called Biyu decoction have been clinically verified,although its molecular targets in psoriasis remain unknown.AIM To explore the molecular mech...BACKGROUND The therapeutic effects of a combination of Chinese medicines called Biyu decoction have been clinically verified,although its molecular targets in psoriasis remain unknown.AIM To explore the molecular mechanisms of Biyu decoction for psoriasis treatment.METHODS In this network pharmacology and molecular docking study,the Traditional Chinese Medicine Systems Pharmacology database was searched for Biyu decoction active ingredients.GeneCards,Online Mendelian Inheritance in Man,PharmGkb,Therapeutic Target Database,and DrugBank databases were searched for psoriasis-related genes.The genes targeted by the decoction’s active ingredient and disease genes were intersected to obtain predictive targets of the drug during psoriasis treatment.Cytoscape 3.8.0 was used to construct a drug component/target disease network.The The functional protein association networks database and Cytoscape were used to construct a protein-protein interaction network and streamline the core network.The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used for pathway enrichment analysis.Molecular docking technology was used to verify the drug component/target disease network.RESULTS We screened 117 major active ingredients,including quercetin,kaempferol,naringenin,and acetyl-shikonin,and identified 213 gene targets,such as MAPK3,JUN,FOS,MYC,MAPK8,STAT3,and NFKBIA.Using a molecular docking analysis,the main active ingredients demonstrated good binding to the core targets.The Gene Ontology analysis showed that these ingredients were significantly associated with biological activities,such as transcription factor DNA binding,RNA polymerase II-specific DNA binding of transcription factors,and cytokine receptor binding;responses to lipopolysaccharides,molecules of bacterial origin,and oxidative stress;and were mainly distributed in membrane rafts,microdomains,and regions.The Kyoto Encyclopedia of Genes and Genomes analysis showed that decoction ingredients act on Th17 cell differentiation,tumor necrosis factor and mitogen-activated protein signaling pathways,the interleukin-17 signaling pathway,and the PI3K-Akt signaling pathway.CONCLUSION Biyu decoction may be effective against psoriasis through multi-component,multi-target,and multi-channel synergy.展开更多
The complexity of the loads acting on the offshore wind turbines （OWl＇s） structures and the significance of investigation on structure dynamics are explained. Test results obtained from a scaled wind turbine model ...The complexity of the loads acting on the offshore wind turbines （OWl＇s） structures and the significance of investigation on structure dynamics are explained. Test results obtained from a scaled wind turbine model are also summarized. The model is supported on monopile, subjected to different types of dynamic loading using an innovative out of balance mass system to apply cyclic/dynamic loads. The test results show the natural frequency of the wind turbine structure increases with the number of cycles, but with a reduced rate of increase with the accumulation of soil strain level. The change is found to be dependent on the shear strain level in the soil next to the pile which matches with the expectations from the element tests of the soil. The test results were plotted in a non-dimensional manner in order to be scaled to predict the orototvoe conseouences usin~ element tests of a soil usin~ resonant column aoDararus.展开更多
Objective:To investigate the self-efficacy and mental health of elderly patients with coronary heart disease(CHD)in rural Hebei Province as well as to analyze the relationship between them.Methods:From June 2021 to De...Objective:To investigate the self-efficacy and mental health of elderly patients with coronary heart disease(CHD)in rural Hebei Province as well as to analyze the relationship between them.Methods:From June 2021 to December 2021,480 elderly patients with CHD from rural areas,who had been discharged by the Department of Cardiology from three tertiary hospitals in three cities with different economic levels in Hebei Province for more than a year,were selected as the research subjects.The general self-efficacy scale(GSES)and symptom self-rating scale(SCL-90)were used to investigate the self-efficacy and mental health of these patients.SPSS 25.0 was used for data analysis.Results:The total mean self-efficacy score of elderly patients with CHD in rural Hebei Province was 17.18±4.68,which is lower than the international norm(t=-32.067,P=0.000)and the national norm(t=-28.783,P=0.000);the total average SCL-90 score was 148.64±55.13,which is higher than the national norm for adults and the reference norm for ordinary elderly people;except for hostility and psychosis,the other dimensions were significantly higher than the national norm for adults(P<0.05);except for psychosis,the other dimensions were significantly higher than the reference norm for ordinary elderly people(P<0.05);the self-efficacy score was found to be negatively correlated with the total SCL-90 score and the score for each dimension(P<0.05).Conclusion:Elderly CHD patients with higher self-efficacy in rural Hebei Province have higher mental health level.It is suggested that the mental health of elderly patients with CHD in rural areas can be improved by improving their self-efficacy.展开更多
BACKGROUND Dystrophic epidermolysis bullosa pruriginosa(DEB-Pr)is a rare subtype of DEB,characterized by recurrent pruritus of the extremities,pruritus papules,nodules,and mossy-like plaques.To date,fewer than 100 cas...BACKGROUND Dystrophic epidermolysis bullosa pruriginosa(DEB-Pr)is a rare subtype of DEB,characterized by recurrent pruritus of the extremities,pruritus papules,nodules,and mossy-like plaques.To date,fewer than 100 cases have been reported.We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment,thereby serving as a guide to correct diagnosis and treatment.CASE SUMMARY A 30-year-old man presented with recurrent itching plaques of 1-year duration in the left tibia that aggravated and involved both legs and the back.Examination revealed multiple symmetrical,purple,and hyperpigmented papules and nodules with surface exfoliation involving the tibia and dorsum of the neck with negative Nissl's sign,no abnormalities in the skin,mucosa,hair,or fingernail,and no local lymph node enlargement.Blisters were never reported prior to presentation.Serum immunoglobulin E level was 636 IU/mL.Clinical manifestations suggested DEB-Pr.Histological examination showed subepidermal fissure,scar tissue,and milia.Direct immunofluorescence showed no obvious abnormalities.However,we were unable to perform electron microscopy or genetic research following his choice.We treated him with topical tacrolimus.After 2 wk,the itching alleviated,and the skin lesions began to subside.No adverse reactions were observed during treatment.CONCLUSION Topical tacrolimus is a safe treatment option for patients with DEB-Pr and can achieve continuous relief of severe itching.展开更多
Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resi...Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resistance mutations in advanced non-small cell lung cancer(NSCLC).[1−3]With its widespread use,the cardiotoxicity of osimertinib has been of great concern.According to the U.S.Food and Drug Administration Adverse Events Reporting System(FAERS),the main cardiac-related adverse events with EGFR-TKIs are heart failure,QT prolongation,atrial fibrillation,acute myocardial infarction and pericardial effusion,and osimertinib has a higher incidence of QT prolongation,heart failure and atrial fibrillation than other EGFR-TKIs.展开更多
Mesenchymal stem cells(MSCs)are gaining the spotlight in research due to their abundant sources,immune privileges,and ability to proliferate and differentiate.These cells provide invaluable resources for stem cell-bas...Mesenchymal stem cells(MSCs)are gaining the spotlight in research due to their abundant sources,immune privileges,and ability to proliferate and differentiate.These cells provide invaluable resources for stem cell-based therapy and present therapeutic opportunities in cell/tissue regeneration medicine.A growing evidence suggests that,mitochondria transfer from MSCs could rescue tissue degeneration caused by mitochondria damage.Although this emerging tissue regeneration treatment method brings hope for the treatment of mitochondria dysfunction related diseases,the necessary conditions and underlying mechanisms for mitochondrial transfer remain poorly understood.In this review,a large number of mitochondrial transfer phenomena between MSCs and recipient cells are summarized,with particular emphasis on the conditions and potential mechanisms of mitochondrial transfer from MSCs,so as to provide reference for the clinical application of MSCs transformation in the future.展开更多
The study was conducted to understand the cognitive status of medical staff and patients on the status of periodontal disease and oral health care in patients with diabetes,and to provide reference for the implementat...The study was conducted to understand the cognitive status of medical staff and patients on the status of periodontal disease and oral health care in patients with diabetes,and to provide reference for the implementation and improvement of diabetes management and health education.Using the Diabetes Periodontal Status and Oral Health Knowledge Questionnaire,108 doctors,190 nurses,and 212 inpatients were investigated.This study demonstrated that,the total scores of doctors,nurses,and patients with diabetes periodontal status and oral health knowledge were(31.18±5.14),(28.58±4.09)and(18.67±3.45)points,respectively.The results of regression analysis showed that education level,department,and related training experience(p<0.05,p<0.01)were the influencing factors of the diabetic periodontal status and oral health knowledge level of the medical staff,meanwhile the monthly income,department,and relevant training experience(p<0.05,p<0.01)were the factors influencing the diabetic periodontal status and oral health care knowledge level of the patients.In summary,the cognitive level of diabetic periodontal status and oral health care knowledge of the medical staff and patients’needs to be improved.Medical staff should pay attention to the study of diabetic periodontal status and oral health care knowledge,further perform a good job in the relevant health education of patients,which is helpful to maintain good oral hygiene.展开更多
A novel coumarin-based "turn-on" fluorescent probe SS-1 was developed for selective detection of SO_2 derivatives in 100% water solution among reactive sulfur species(RSS). The detection limit of the method ...A novel coumarin-based "turn-on" fluorescent probe SS-1 was developed for selective detection of SO_2 derivatives in 100% water solution among reactive sulfur species(RSS). The detection limit of the method was 91.7 nM. Moreover, the probe exhibited low cytotoxicity and was successfully applied in the imaging of endogenously generated SO_2 in HeLa cells.展开更多
Background and aims:Mucosal healing is regarded as a clinical endpoint of Crohn’s disease(CD),and transmural healing is correlated to the concept of deep remission.Current therapies to induce mucosal and transmural h...Background and aims:Mucosal healing is regarded as a clinical endpoint of Crohn’s disease(CD),and transmural healing is correlated to the concept of deep remission.Current therapies to induce mucosal and transmural healing in CD are not satisfactory.Exclusive enteral nutrition(EEN)is underestimated therapy and its value has not been fully evaluated.Our aim was to investigate the efficacy of oral EEN for inducing mucosal and transmural healing in CD patients.Methods:This was a prospective,single-center,open-label study including diagnosed CD children and adults conducted between January 2015 and December 2016 in the Sixth Affiliated Hospital of Sun Yat-sen University.All patients were treated with oral EEN and underwent paired assessment at baseline and completion using C-reaction protein,erythrocyte sedimentation rate,platelets,hemoglobin,body mass index,CD activity index,simple endoscopic score for CD and bowel sonography.Azathioprine was combined to prevent relapse.Results:In this prospective observational study,29 CD patients with an average age of 28.9 years were identified.After oral EEN treatment,23 patients(79%)achieved complete mucosal healing,and the mean time to reach mucosal healing was 123 days(ranged from 50 to 212 days).Although only five patients(17%)achieved transmural healing,a significant reduction was observed in bowel-wall thickness(9.4163.06 vs 4.9761.76mm,P<0.001)and a significant improvement was observed in complications(including fistulas,abscess,ascites,stricture)assessed by bowel sonography(all P<0.05).Conclusions:Oral EEN therapy is highly effective for inducing mucosal healing in CD patients.Both CD patients at active stage and those at clinical remission show excellent clinical response to oral EEN.展开更多
Objective:The objective was to study the effect of total flavonoids of Herba Taxilli(TFHT)on osteoporotic(OP)rats induced by retinoic acid(RA)and explore its mechanism.Methods:Three-month-old female Sprague Dawley rat...Objective:The objective was to study the effect of total flavonoids of Herba Taxilli(TFHT)on osteoporotic(OP)rats induced by retinoic acid(RA)and explore its mechanism.Methods:Three-month-old female Sprague Dawley rats were randomly divided into six groups,each with ten rats,i.e.normal control group,model group,and positive control group and three TFHT groups(at high-,middle-,and low-doses).Except the normal control group,rats of all the other groups were administered RA by gavage(70 mg/kg/day)every morning for 14 days to establish an OP model;at the same time,all the rats were given Corresponding therapeutic drug by gavage for 28 days:rats in the three TFHT groups were given TFHT(400,200,and 100 mg/kg/day,respectively)and rats in the positive control group were given Long mu Zhuang gu Granule 300 mg/kg/day.Rats in the model group and normal group were given an equal volume of 1%sodium carboxymethyl cellulose sodium suspension.After the experiment,blood was taken to measure the levels of serum calcium(Ca^(2+)),alkaline phosphatase(ALP),and tartrate-resistant acid phosphatase(TRAP);the spleen,uterus,and ovary were dissected to determine the organ coefficient;the left hind limb femur was dissected to determine bone mineral density(BMD),bone dry weight(BDW),bone wet weight(BWW),bone diameter(BD),bone length(BL),bone dry weight/rat weight(BDW/W),bone wet weight/rat weight(BWW/W),bone dry weight/bone wet weight(BDW/BWW),bone dry weight/bone length(BDW/L),and bone wet weight/bone diameter(BWW/D);and the right hind limb femur was dissected to observe the bone path morphological changes.Results:Compared with the model group,the serum Ca^(2+)content,uterus plus ovary coefficient,BMD,BDW,BDW/W,BWW/W,BDW/BWW,BDW/L,and BWW/D in the TFHT groups increased,whereas the spleen coefficient,ALP,and TRAP decreased in the TFHT groups,and the differences were statistically significant(P<0.05 or P<0.01).Conclusion:TFHT was found effective in treating OP in rats induced by RA;the main mechanisms were increasing the serum Ca^(2+)content and reducing the level of ALP and TRAP.展开更多
The phase equilibria in the Co-Ti-Re ternary system at 800,1000,1100 and 12000C were studied combined with electron probe microanalyzer(EPMA),X-ray diffraction(XRD),scanning electron microscope(SEM)and transmission el...The phase equilibria in the Co-Ti-Re ternary system at 800,1000,1100 and 12000C were studied combined with electron probe microanalyzer(EPMA),X-ray diffraction(XRD),scanning electron microscope(SEM)and transmission electron microscope(TEM).The new phaseτwith a large solubility was discovered at all four isothermal sections,and its structure still needs a further study.A large solubility of Re in the CoTi phase was observed.The solubility of Re in the Co_(3)Ti phase is6.1%at 800℃,8.7%at 1000℃and 7.7%at 1100℃.The present work could be significant for alloy design of Co-based alloys and thermodynamic analysis of the Co-TiRe ternary system.展开更多
Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific research.Herein,cobalt phthalocyanine...Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific research.Herein,cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4)(CoPc/OCN) S-scheme heterojunction photocatalyst was designed by coupling multi-step calcination with solvothermal method for enhanced photothermal-assisted photocatalytic H_(2) evolution.The multistep calcined g-C_(3)N_(4) is easier for O-doping formation,and the ethanol solvothermal strategy is utilized to enhance the dispersion of CoPc on OCN nano sheet surface and forms sufficient S-scheme heterojunction through H-bonds.In addition,the active sites and excellent photothermal properties of CoPc itself further improve the integrated photocatalytic activity of CoPc/OCN S-scheme heterojunction.The optimal photocatalytic hydrogen evolution rate of CoPc/OCN S-scheme heterojunction photocatalyst reached 9.56 mmol·g^(-1)·h^(-1),which is 2.69 and 1.23 times higher than that of CN and OCN,respectively.This work provides a valuable design idea and scheme for enhancing the multi-factor co-assisted photocatalytic H_(2) evolution performance.展开更多
Pyridine-Si-xanthene,a novel near-infrared fluorescent dye,dispalys better photophysical properties compared with Si-rhodamines including improved modifiability and red-shifted emission wavelength.The application is e...Pyridine-Si-xanthene,a novel near-infrared fluorescent dye,dispalys better photophysical properties compared with Si-rhodamines including improved modifiability and red-shifted emission wavelength.The application is exemplified through the development of a lysosomes-targeting probe capable of imaging cysteine in cells and in vivo.展开更多
Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with c...Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with chronic obstructive pulmonary disease(COPD) by means of the "syndrome?efficacy?biological sample analysis" method and then to explore its meridian tropism. Methods: Wistar rats were given nasal drops of 200-μL lipopolysaccharide and smoke 30 min two times a day, then put the appropriate dose of ice water, and freeze for an hour to build model rats. On the 16 th day, the drug group was orally administered of DG(500 mg/mL) until the 30 th day. Blood samples and biological tissues were collected from the orbital venous plexus into heparinized hemostasis tubes at 5, 10, 15, 30, 45, 60, 90, 120, 180, 240, and 360 min after the last administration. Using ultraviolet-high-performance liquid chromatography(Waters, USA) method, the effective components were tested, and DAS 3.0 software(Mathematical Pharmacology Professional Committee of China, Shanghai, China) was used to analyze the results. Results: The compounds of DG entering into blood were 6-gingerol, 6-shogaol, and 8-gingerol. Tissue distribution analysis indicates that three active ingredients are widely present in the lung, spleen, kidney, liver, heart, large intestine, stomach, small intestine, and other organs of rats with COPD. Conclusions: 6?gingerol, 6?shogaol, and 8?gingerol belong to effective components of DG in curing the syndrome of cold fluid retained in lung of rats with COPD and mainly distributed in organs including the spleen, stomach, lung, kidney, liver, and heart.展开更多
基金Supported by the National Key Research and Development Program of China,No.2018YFF0301104.
文摘BACKGROUND As a serious global problem,knee osteoarthritis(KOA)often leads to pain and disability.Manual therapy is widely used as a kind of physical treatment for KOA.AIM To explore further the efficacy of Maitland and Mulligan mobilization methods for adults with KOA.METHODS We searched PubMed,the Cochrane Library,EMbase,Web of Science and Google Scholar from inception to September 20,2020 to collect studies comparing Maitland and Mulligan mobilization methods in adults with KOA.The quality of the studies was assessed using the Physiotherapy Evidence Database Scale for randomized controlled trials.Data analyses were performed using Review Manager 5.0 software.RESULTS A total of 341 articles were screened from five electronic databases(PubMed,the Cochrane Library,EMbase,Web of Science and Google Scholar)after excluding duplicates.Ultimately,eight trials involving 471 subjects were included in present systematic review and meta-analysis.The mean PEDro scale score was 6.6.Mulligan mobilization was more effective in alleviating pain[standardized mean difference(SMD)=0.60;95%confidence interval(CI):0.17 to 1.03,P=0.007;I2=60%,P=0.020]and improving Western Ontario and McMaster Universities function score(SMD=7.41;95%CI:2.36 to 12.47,P=0.004;I2=92%,P=0.000).There was no difference in the effect of the two kinds of mobilization on improving the range of motion(SMD=9.63;95%CI:-1.23 to 20.48,P=0.080;I2=97%,P=0.000).CONCLUSION Mulligan mobilization technique is a promising intervention in alleviating pain and improving function score in KOA patients.
文摘For a nonlinear limit state function, the first-order reliability method(FORM) may cause large errors in the computation of not only the reliability index or failure probability but also the reliability sensitivity. In order to obtain more the accurate results of the reliability sensitivity analysis, a number of hyperplanes are built near the design point by first-order Tayler series expansion, which replace the known nonlinear limit state hypersurface, and an equivalent computational method is utilized to construct an equivalent hyperplane of the obtained hyperplanes. And the reliability sensitivities can be estimated more accurately by the derived equations based on the equivalent hyperplane. An example shows that the method is effective and feasible.
基金financial supports from the National Natural Science Foundation of China(No.51831007)the National Key Research&Development Program of China(No.2017YFB0702901)。
文摘Isothermal sections of the Co−Al−Re ternary system at 1100 and 1300℃ were determined experimentally by electron probe microanalysis and X-ray diffraction.The results show that there are seven three-phase regions in the 1100℃ isothermal section and five three-phase regions in the 1300℃ isothermal section.The solid solubilities ofαCo,εRe and CoAl increase a little with temperature increasing from 1100 to 1300℃.The solubility of Co in compounds AlRe2,Al11Re4 and Al4Re is negligible,<1.5 at.%.And no ternary compounds are found.
基金supported by the National Natural Science Foundation of China (Grant No. 61705025)the Natural Science Foundation of Chongqing (Grant Nos. cstc2019jcyjmsxm X043 and cstc2018jcyj AX0817)+2 种基金the Fund from the Science and Technology Project Affiliated to the Education Department of Chongqing Municipality (Grant Nos. KJQN201801217, KJQN202001214, KJQN201901226, and KJ1710247)the Fund from Chongqing Key Laboratory of Geological Environment Monitoring and Disaster Early-Warning in Three Gorges Reservoir Area (Grant Nos. ZD2020A0103 and ZD2020A0102)the Fundamental Research Funds for Chongqing Three Gorges University of China (Grant No. 19ZDPY08)。
文摘To address the restriction of fiber-optic surface plasmon resonance(SPR) sensors in the field of multi-sample detection, a novel dual-channel fiber-optic SPR sensor based on the cascade of coaxial dual-waveguide D-type structure and microsphere structure is proposed in this paper. The fiber sidepolishing technique converts the coaxial dual-waveguide fiber into a D-type one, and the evanescent wave in the ring core leaks, generating a D-type sensing region;the fiber optic fused ball push technology converts the coaxial dual waveguides into microspheres, and the stimulated cladding mode evanescent wave leaks, producing the microsphere sensing region. By injecting light into the coaxial dual-waveguide middle core alone, the sensor can realize single-stage sensing in the microsphere sensing area;it can also realize dual-channel sensing in the D-type sensing area and microsphere sensing area by injecting light into the ring core. The refractive index measurement ranges for the two channels are 1.333–1.365 and 1.375–1.405, respectively, with detection sensitivities of 981.56 nm/RIU and 4138 nm/RIU. The sensor combines wavelength division multiplexing and space division multiplexing technologies, presenting a novel research concept for multi-channel fiber SPR sensors.
基金Supported by the National Natural Science Foundation of China(NSFC),No.81874393.
文摘BACKGROUND The therapeutic effects of a combination of Chinese medicines called Biyu decoction have been clinically verified,although its molecular targets in psoriasis remain unknown.AIM To explore the molecular mechanisms of Biyu decoction for psoriasis treatment.METHODS In this network pharmacology and molecular docking study,the Traditional Chinese Medicine Systems Pharmacology database was searched for Biyu decoction active ingredients.GeneCards,Online Mendelian Inheritance in Man,PharmGkb,Therapeutic Target Database,and DrugBank databases were searched for psoriasis-related genes.The genes targeted by the decoction’s active ingredient and disease genes were intersected to obtain predictive targets of the drug during psoriasis treatment.Cytoscape 3.8.0 was used to construct a drug component/target disease network.The The functional protein association networks database and Cytoscape were used to construct a protein-protein interaction network and streamline the core network.The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were used for pathway enrichment analysis.Molecular docking technology was used to verify the drug component/target disease network.RESULTS We screened 117 major active ingredients,including quercetin,kaempferol,naringenin,and acetyl-shikonin,and identified 213 gene targets,such as MAPK3,JUN,FOS,MYC,MAPK8,STAT3,and NFKBIA.Using a molecular docking analysis,the main active ingredients demonstrated good binding to the core targets.The Gene Ontology analysis showed that these ingredients were significantly associated with biological activities,such as transcription factor DNA binding,RNA polymerase II-specific DNA binding of transcription factors,and cytokine receptor binding;responses to lipopolysaccharides,molecules of bacterial origin,and oxidative stress;and were mainly distributed in membrane rafts,microdomains,and regions.The Kyoto Encyclopedia of Genes and Genomes analysis showed that decoction ingredients act on Th17 cell differentiation,tumor necrosis factor and mitogen-activated protein signaling pathways,the interleukin-17 signaling pathway,and the PI3K-Akt signaling pathway.CONCLUSION Biyu decoction may be effective against psoriasis through multi-component,multi-target,and multi-channel synergy.
基金supported by the National Natural Science Foundation of China(51109184,51209183,and 51325901)
文摘The complexity of the loads acting on the offshore wind turbines （OWl＇s） structures and the significance of investigation on structure dynamics are explained. Test results obtained from a scaled wind turbine model are also summarized. The model is supported on monopile, subjected to different types of dynamic loading using an innovative out of balance mass system to apply cyclic/dynamic loads. The test results show the natural frequency of the wind turbine structure increases with the number of cycles, but with a reduced rate of increase with the accumulation of soil strain level. The change is found to be dependent on the shear strain level in the soil next to the pile which matches with the expectations from the element tests of the soil. The test results were plotted in a non-dimensional manner in order to be scaled to predict the orototvoe conseouences usin~ element tests of a soil usin~ resonant column aoDararus.
文摘Objective:To investigate the self-efficacy and mental health of elderly patients with coronary heart disease(CHD)in rural Hebei Province as well as to analyze the relationship between them.Methods:From June 2021 to December 2021,480 elderly patients with CHD from rural areas,who had been discharged by the Department of Cardiology from three tertiary hospitals in three cities with different economic levels in Hebei Province for more than a year,were selected as the research subjects.The general self-efficacy scale(GSES)and symptom self-rating scale(SCL-90)were used to investigate the self-efficacy and mental health of these patients.SPSS 25.0 was used for data analysis.Results:The total mean self-efficacy score of elderly patients with CHD in rural Hebei Province was 17.18±4.68,which is lower than the international norm(t=-32.067,P=0.000)and the national norm(t=-28.783,P=0.000);the total average SCL-90 score was 148.64±55.13,which is higher than the national norm for adults and the reference norm for ordinary elderly people;except for hostility and psychosis,the other dimensions were significantly higher than the national norm for adults(P<0.05);except for psychosis,the other dimensions were significantly higher than the reference norm for ordinary elderly people(P<0.05);the self-efficacy score was found to be negatively correlated with the total SCL-90 score and the score for each dimension(P<0.05).Conclusion:Elderly CHD patients with higher self-efficacy in rural Hebei Province have higher mental health level.It is suggested that the mental health of elderly patients with CHD in rural areas can be improved by improving their self-efficacy.
基金National Natural Science Foundation of China,No.81874393.
文摘BACKGROUND Dystrophic epidermolysis bullosa pruriginosa(DEB-Pr)is a rare subtype of DEB,characterized by recurrent pruritus of the extremities,pruritus papules,nodules,and mossy-like plaques.To date,fewer than 100 cases have been reported.We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment,thereby serving as a guide to correct diagnosis and treatment.CASE SUMMARY A 30-year-old man presented with recurrent itching plaques of 1-year duration in the left tibia that aggravated and involved both legs and the back.Examination revealed multiple symmetrical,purple,and hyperpigmented papules and nodules with surface exfoliation involving the tibia and dorsum of the neck with negative Nissl's sign,no abnormalities in the skin,mucosa,hair,or fingernail,and no local lymph node enlargement.Blisters were never reported prior to presentation.Serum immunoglobulin E level was 636 IU/mL.Clinical manifestations suggested DEB-Pr.Histological examination showed subepidermal fissure,scar tissue,and milia.Direct immunofluorescence showed no obvious abnormalities.However,we were unable to perform electron microscopy or genetic research following his choice.We treated him with topical tacrolimus.After 2 wk,the itching alleviated,and the skin lesions began to subside.No adverse reactions were observed during treatment.CONCLUSION Topical tacrolimus is a safe treatment option for patients with DEB-Pr and can achieve continuous relief of severe itching.
文摘Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resistance mutations in advanced non-small cell lung cancer(NSCLC).[1−3]With its widespread use,the cardiotoxicity of osimertinib has been of great concern.According to the U.S.Food and Drug Administration Adverse Events Reporting System(FAERS),the main cardiac-related adverse events with EGFR-TKIs are heart failure,QT prolongation,atrial fibrillation,acute myocardial infarction and pericardial effusion,and osimertinib has a higher incidence of QT prolongation,heart failure and atrial fibrillation than other EGFR-TKIs.
基金supported by the Scientific Research Project of Tianjin Education Commission(2017KJ162).
文摘Mesenchymal stem cells(MSCs)are gaining the spotlight in research due to their abundant sources,immune privileges,and ability to proliferate and differentiate.These cells provide invaluable resources for stem cell-based therapy and present therapeutic opportunities in cell/tissue regeneration medicine.A growing evidence suggests that,mitochondria transfer from MSCs could rescue tissue degeneration caused by mitochondria damage.Although this emerging tissue regeneration treatment method brings hope for the treatment of mitochondria dysfunction related diseases,the necessary conditions and underlying mechanisms for mitochondrial transfer remain poorly understood.In this review,a large number of mitochondrial transfer phenomena between MSCs and recipient cells are summarized,with particular emphasis on the conditions and potential mechanisms of mitochondrial transfer from MSCs,so as to provide reference for the clinical application of MSCs transformation in the future.
基金The Research Project of Traditional Chinese Medicine in Bureau of Hebei Provincial Traditional Chinese Medicine Administration in 2019(Project Number:2019178)。
文摘The study was conducted to understand the cognitive status of medical staff and patients on the status of periodontal disease and oral health care in patients with diabetes,and to provide reference for the implementation and improvement of diabetes management and health education.Using the Diabetes Periodontal Status and Oral Health Knowledge Questionnaire,108 doctors,190 nurses,and 212 inpatients were investigated.This study demonstrated that,the total scores of doctors,nurses,and patients with diabetes periodontal status and oral health knowledge were(31.18±5.14),(28.58±4.09)and(18.67±3.45)points,respectively.The results of regression analysis showed that education level,department,and related training experience(p<0.05,p<0.01)were the influencing factors of the diabetic periodontal status and oral health knowledge level of the medical staff,meanwhile the monthly income,department,and relevant training experience(p<0.05,p<0.01)were the factors influencing the diabetic periodontal status and oral health care knowledge level of the patients.In summary,the cognitive level of diabetic periodontal status and oral health care knowledge of the medical staff and patients’needs to be improved.Medical staff should pay attention to the study of diabetic periodontal status and oral health care knowledge,further perform a good job in the relevant health education of patients,which is helpful to maintain good oral hygiene.
基金supported by the National Program on Key Basic Research Project of China (2012CB720603)the National Natural Science Foundation of China (21232005, 21572147, J1103315)
文摘A novel coumarin-based "turn-on" fluorescent probe SS-1 was developed for selective detection of SO_2 derivatives in 100% water solution among reactive sulfur species(RSS). The detection limit of the method was 91.7 nM. Moreover, the probe exhibited low cytotoxicity and was successfully applied in the imaging of endogenously generated SO_2 in HeLa cells.
基金supported by the National Natural Science Foundation of China(81470795)the Science and Technology Planning Project of Guangdong Province,China(2013B022000035).
文摘Background and aims:Mucosal healing is regarded as a clinical endpoint of Crohn’s disease(CD),and transmural healing is correlated to the concept of deep remission.Current therapies to induce mucosal and transmural healing in CD are not satisfactory.Exclusive enteral nutrition(EEN)is underestimated therapy and its value has not been fully evaluated.Our aim was to investigate the efficacy of oral EEN for inducing mucosal and transmural healing in CD patients.Methods:This was a prospective,single-center,open-label study including diagnosed CD children and adults conducted between January 2015 and December 2016 in the Sixth Affiliated Hospital of Sun Yat-sen University.All patients were treated with oral EEN and underwent paired assessment at baseline and completion using C-reaction protein,erythrocyte sedimentation rate,platelets,hemoglobin,body mass index,CD activity index,simple endoscopic score for CD and bowel sonography.Azathioprine was combined to prevent relapse.Results:In this prospective observational study,29 CD patients with an average age of 28.9 years were identified.After oral EEN treatment,23 patients(79%)achieved complete mucosal healing,and the mean time to reach mucosal healing was 123 days(ranged from 50 to 212 days).Although only five patients(17%)achieved transmural healing,a significant reduction was observed in bowel-wall thickness(9.4163.06 vs 4.9761.76mm,P<0.001)and a significant improvement was observed in complications(including fistulas,abscess,ascites,stricture)assessed by bowel sonography(all P<0.05).Conclusions:Oral EEN therapy is highly effective for inducing mucosal healing in CD patients.Both CD patients at active stage and those at clinical remission show excellent clinical response to oral EEN.
文摘Objective:The objective was to study the effect of total flavonoids of Herba Taxilli(TFHT)on osteoporotic(OP)rats induced by retinoic acid(RA)and explore its mechanism.Methods:Three-month-old female Sprague Dawley rats were randomly divided into six groups,each with ten rats,i.e.normal control group,model group,and positive control group and three TFHT groups(at high-,middle-,and low-doses).Except the normal control group,rats of all the other groups were administered RA by gavage(70 mg/kg/day)every morning for 14 days to establish an OP model;at the same time,all the rats were given Corresponding therapeutic drug by gavage for 28 days:rats in the three TFHT groups were given TFHT(400,200,and 100 mg/kg/day,respectively)and rats in the positive control group were given Long mu Zhuang gu Granule 300 mg/kg/day.Rats in the model group and normal group were given an equal volume of 1%sodium carboxymethyl cellulose sodium suspension.After the experiment,blood was taken to measure the levels of serum calcium(Ca^(2+)),alkaline phosphatase(ALP),and tartrate-resistant acid phosphatase(TRAP);the spleen,uterus,and ovary were dissected to determine the organ coefficient;the left hind limb femur was dissected to determine bone mineral density(BMD),bone dry weight(BDW),bone wet weight(BWW),bone diameter(BD),bone length(BL),bone dry weight/rat weight(BDW/W),bone wet weight/rat weight(BWW/W),bone dry weight/bone wet weight(BDW/BWW),bone dry weight/bone length(BDW/L),and bone wet weight/bone diameter(BWW/D);and the right hind limb femur was dissected to observe the bone path morphological changes.Results:Compared with the model group,the serum Ca^(2+)content,uterus plus ovary coefficient,BMD,BDW,BDW/W,BWW/W,BDW/BWW,BDW/L,and BWW/D in the TFHT groups increased,whereas the spleen coefficient,ALP,and TRAP decreased in the TFHT groups,and the differences were statistically significant(P<0.05 or P<0.01).Conclusion:TFHT was found effective in treating OP in rats induced by RA;the main mechanisms were increasing the serum Ca^(2+)content and reducing the level of ALP and TRAP.
基金financially supported by the National Natural Science Foundation of China(No.51831007)the Key-area Research and Development Program of Guangdong Province(No.2019B010943001)。
文摘The phase equilibria in the Co-Ti-Re ternary system at 800,1000,1100 and 12000C were studied combined with electron probe microanalyzer(EPMA),X-ray diffraction(XRD),scanning electron microscope(SEM)and transmission electron microscope(TEM).The new phaseτwith a large solubility was discovered at all four isothermal sections,and its structure still needs a further study.A large solubility of Re in the CoTi phase was observed.The solubility of Re in the Co_(3)Ti phase is6.1%at 800℃,8.7%at 1000℃and 7.7%at 1100℃.The present work could be significant for alloy design of Co-based alloys and thermodynamic analysis of the Co-TiRe ternary system.
基金financially supported by the National Natural Science Foundation of China (Nos.21906072, 21906039, 21908115 and 22006057)Hebei Province 333 Talents Project (No.A202101020)+3 种基金the Science and Technology Project of Hebei Education Department (No.BJ2021010)the Graduate Student Innovation Ability Training Funding Project of Hebei Province (No.CXZZSS2023129)the Open Fund for Hebei Province Key Laboratory of Sustained Utilization & Development of Water Recourse (No.HSZYL2022002)Instrumental Analysis Center, Jiangsu University of Science and Technology。
文摘Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific research.Herein,cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4)(CoPc/OCN) S-scheme heterojunction photocatalyst was designed by coupling multi-step calcination with solvothermal method for enhanced photothermal-assisted photocatalytic H_(2) evolution.The multistep calcined g-C_(3)N_(4) is easier for O-doping formation,and the ethanol solvothermal strategy is utilized to enhance the dispersion of CoPc on OCN nano sheet surface and forms sufficient S-scheme heterojunction through H-bonds.In addition,the active sites and excellent photothermal properties of CoPc itself further improve the integrated photocatalytic activity of CoPc/OCN S-scheme heterojunction.The optimal photocatalytic hydrogen evolution rate of CoPc/OCN S-scheme heterojunction photocatalyst reached 9.56 mmol·g^(-1)·h^(-1),which is 2.69 and 1.23 times higher than that of CN and OCN,respectively.This work provides a valuable design idea and scheme for enhancing the multi-factor co-assisted photocatalytic H_(2) evolution performance.
基金financially supported by the National Natural Science Foundation of China(Nos.21572147 and 21877082)
文摘Pyridine-Si-xanthene,a novel near-infrared fluorescent dye,dispalys better photophysical properties compared with Si-rhodamines including improved modifiability and red-shifted emission wavelength.The application is exemplified through the development of a lysosomes-targeting probe capable of imaging cysteine in cells and in vivo.
文摘Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with chronic obstructive pulmonary disease(COPD) by means of the "syndrome?efficacy?biological sample analysis" method and then to explore its meridian tropism. Methods: Wistar rats were given nasal drops of 200-μL lipopolysaccharide and smoke 30 min two times a day, then put the appropriate dose of ice water, and freeze for an hour to build model rats. On the 16 th day, the drug group was orally administered of DG(500 mg/mL) until the 30 th day. Blood samples and biological tissues were collected from the orbital venous plexus into heparinized hemostasis tubes at 5, 10, 15, 30, 45, 60, 90, 120, 180, 240, and 360 min after the last administration. Using ultraviolet-high-performance liquid chromatography(Waters, USA) method, the effective components were tested, and DAS 3.0 software(Mathematical Pharmacology Professional Committee of China, Shanghai, China) was used to analyze the results. Results: The compounds of DG entering into blood were 6-gingerol, 6-shogaol, and 8-gingerol. Tissue distribution analysis indicates that three active ingredients are widely present in the lung, spleen, kidney, liver, heart, large intestine, stomach, small intestine, and other organs of rats with COPD. Conclusions: 6?gingerol, 6?shogaol, and 8?gingerol belong to effective components of DG in curing the syndrome of cold fluid retained in lung of rats with COPD and mainly distributed in organs including the spleen, stomach, lung, kidney, liver, and heart.
