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生物膜休眠菌及其靶向治疗研究进展
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作者 李明基 朱禹璇 +5 位作者 刘鈊逸 罗颀颢 杨浩宇 刘铁鑫 林俊卿 郑宪友 《国际骨科学杂志》 2024年第2期123-126,共4页
随着抗生素的广泛使用,细菌耐药性问题日益突出。生物膜形成是导致耐药菌不断增加的重要因素,休眠菌是生物膜中一种具有特殊表型的细菌,可导致慢性和复发性感染,由于其来源多样、耐药机制复杂,目前尚无有效治疗措施,探索休眠菌靶向疗法... 随着抗生素的广泛使用,细菌耐药性问题日益突出。生物膜形成是导致耐药菌不断增加的重要因素,休眠菌是生物膜中一种具有特殊表型的细菌,可导致慢性和复发性感染,由于其来源多样、耐药机制复杂,目前尚无有效治疗措施,探索休眠菌靶向疗法具有重要临床价值。该文就生物膜休眠菌及其靶向治疗研究进展进行综述。 展开更多
关键词 生物膜 休眠菌 靶向治疗 耐药性
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Effects of Diet on the Volatile Flavor and Nutritional Ingredients of Common Octopus(Octopus vulgaris) 被引量:1
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作者 luo qihao WANG Weijun +5 位作者 LI Zan ZHU Xinghua WANG Xue ZHANG Tonghua XU He YANG Jianmin 《Journal of Ocean University of China》 SCIE CAS CSCD 2021年第2期393-401,共9页
Cephalopods are important economic shellfish that have been developed extensively in the coastal water of various countries. Octopus vulgaris is a large-scaled economic cephalopod that is mainly cultured in South Chin... Cephalopods are important economic shellfish that have been developed extensively in the coastal water of various countries. Octopus vulgaris is a large-scaled economic cephalopod that is mainly cultured in South China. This study explored the effect of different diets on the volatile flavor and nutritional ingredients of O. vulgaris. Four diets were tested in four groups: Group A(fish(Scomberomorus niphonius)), Group B(crab(Helice tridens tientsinensis Rathbun)), Group C(clam(Mactra veneriformis)), and Group D(squid(Loligo japonica)). Octopus muscles were sampled after 36 days of feeding, and volatile flavor substances(VFSs), fatty acids(FAs), and amino acids(AAs) were detected. Results showed that the VFSs, FAs, and AAs of octopus in the four groups were obviously different. The sum of volatile ketones and aldehydes was higher in Group B than in the other groups, which could present much more flavors. All groups were abundant in unsaturated FAs, including eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA). In terms of content and variety, the FAs in Group B were more beneficial to human health than those in the other groups. The content of each AA in Group B was basically higher than those in the other groups and was significantly higher than that in Group D(P < 0.05). Comparing the VFSs, FAs, and AAs in samples fed with four kinds of diets, the results indicate that using crab to feed O. vulgaris can achieve better effects on volatile flavor and nutritional ingredients. 展开更多
关键词 Octopus vulgaris volatile flavor substances fatty acids amino acids diet effect
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