Zircon U-Pb dating, whole-rock geochemical analyses and Hf isotope are undertaken for the monzogranite in Niubiziliang area with the aim of constraining its formation time,petrogenesis and the regional tectonic settin...Zircon U-Pb dating, whole-rock geochemical analyses and Hf isotope are undertaken for the monzogranite in Niubiziliang area with the aim of constraining its formation time,petrogenesis and the regional tectonic setting. The zircons from monzogranite are euhedral-subhedral in shape,and display rhythm growth zoning,indicating a magmatic origin. LA-ICP-MS zircon U-Pb dating indicates the monzogranite formed most probably in the Late Devonian( 359. 0 ± 2. 6 Ma). The monzogranite has Si O2= 74. 69%--76. 11%,Al2O3=12. 07%--12. 81%,Na2 O + K2 O = 8. 24%--8. 70%,Na2 O / K2 O = 0. 60--0. 68,A / CNK > 1,which shows that it belongs to high-Si and high-K weakly peraluminous calc-alkaline series. The monzogranite is enriched in K,Rb,Th( LILEs) and La,Ce,Sm,Nd( LREEs); and depleted in Ba,U( HREEs) and Ta,Nb( HFSEs).Their zircon εHf( t) values range from 1. 21 to 3. 46,in response to their two-stage Hf model ages( TDM2) ranging from 1 034 Ma to 1 159 Ma,respectively,indicating that the primary magma was derived from the young crust in Meso-Neoproterozoic. Combined with the regional geological evolution background,it is considered that the Niubiziliang monzogranite formed the closure of North Qaidam ocean,which was the stretching stage product after the collision between Qaidam block and Qilian block.展开更多
The study presents the results of U-Pb dating of zircons and whole-rock geochemical analyses of a syenogranite located in the western Niubiziliang area,China with the aim of determining its formation time,petrogenesis...The study presents the results of U-Pb dating of zircons and whole-rock geochemical analyses of a syenogranite located in the western Niubiziliang area,China with the aim of determining its formation time,petrogenesis and the regional tectonic setting. Zircons within the syenogranite are euhedral-subhedral and display rhythmic growth zoning,indicating a magmatic origin. Zircon U-Pb data obtained by LA-ICP-MS indicate the syenogranite formed in the Late Permian (260.7±1.5 Ma). The w(SiO_2) of syenogranites is 70.82%--73.59%,w(Al_2O_3) is 13.49%--14.82%,and w(Na_2O + K_2O) is 7.85%--8.52%,and yield K_2O/Na_2O ratios of 1.06--1.26. Therefore,the syenogranites belong to the high-K calc-alkaline and metaluminous (A/CNK< 1,A/NK > 1) series which display I-type granites similarly. The syenogranites also show the geochemical characteristics of volcanic arc rocks,being enriched in large-ion lithophile elements (LILEs; K,Rb) and light rare-earth elements (LREEs; La,Ce,Sm,Nd),but depleted in high field strength elements( HFSEs; Ta,Nb,P,Ti). On the whole,trace element ratios are close to the mean of the Earth's crust,indicating a lowercrust magma source. The low Sr (161--214) ×10^(-6) and Yb (1.08--1.80)×10^(-6) concentrations indicate that plagioclase and hornblende are residual mineral phases in the source. The regional geology and whole-rock geochemistry suggest that the formation of the syenogranites was related to subduction of the Zongwulong Ocean crust,and the north margin of Qaidam Block during the Late Permian was in an active continental margin tectonic setting.展开更多
Objective:To provide real-world evidence for the application of first-line dacomitinib treatment for epidermal growth factor receptor(EGFR)21L858R mutant non-small cell lung cancer(NSCLC)patients in China and to explo...Objective:To provide real-world evidence for the application of first-line dacomitinib treatment for epidermal growth factor receptor(EGFR)21L858R mutant non-small cell lung cancer(NSCLC)patients in China and to explore the factors influencing the efficacy and safety.Methods:A longitudinal,consecutive case-series,multicenter study with mixed prospective and retrospective data was conducted.The primary endpoint was progression-free survival(PFS),and the secondary endpoints included duration of treatment(DOT),overall survival(OS),objective response rate(ORR),disease control rate(DCR)and safety.Results:A total of 155 EGFR 21L858R mutant patients treated with first-line dacomitinib were included.The median follow-up time for these patients was 20.4 months.Among 134 patients with evaluable lesions,the ORR was 70.9%and the DCR was 96.3%.The median PFS was 16.3[95%confidence interval(95%CI),13.7−18.9]months.Multivariate Cox regression analysis suggested that the baseline brain metastasis(BM)status[with vs.without BM:hazard ratio(HR),1.331;95%CI,0.720−2.458;P=0.361]and initial doses(45 mg vs.30 mg:HR,0.837;95%CI,0.427−1.641;P=0.604)did not significantly affect the median PFS.The median DOT was 21.0(95%CI,17.5−24.6)months and the median OS was not reached.Genetic tests were performed in 64 patients after progression,among whom 29(45.3%)patients developed the EGFR 20T790M mutation.In addition,among the 46 patients who discontinued dacomitinib treatment after progression,31(67.4%)patients received subsequent third-generation EGFR-tyrosine kinase inhibitors.The most common grade 3−4 adverse events were rash(10.4%),diarrhea(9.1%),stomatitis(7.1%)and paronychia(4.5%).The incidence of grade 3−4 rash was significantly higher in the 45 mg group than that in the 30 mg group(21.9%vs.7.5%,P=0.042).Conclusions:First-line dacomitinib treatment demonstrated promising efficacy and tolerable adverse events among EGFR 21L858R mutant NSCLC patients in China.展开更多
文摘Zircon U-Pb dating, whole-rock geochemical analyses and Hf isotope are undertaken for the monzogranite in Niubiziliang area with the aim of constraining its formation time,petrogenesis and the regional tectonic setting. The zircons from monzogranite are euhedral-subhedral in shape,and display rhythm growth zoning,indicating a magmatic origin. LA-ICP-MS zircon U-Pb dating indicates the monzogranite formed most probably in the Late Devonian( 359. 0 ± 2. 6 Ma). The monzogranite has Si O2= 74. 69%--76. 11%,Al2O3=12. 07%--12. 81%,Na2 O + K2 O = 8. 24%--8. 70%,Na2 O / K2 O = 0. 60--0. 68,A / CNK > 1,which shows that it belongs to high-Si and high-K weakly peraluminous calc-alkaline series. The monzogranite is enriched in K,Rb,Th( LILEs) and La,Ce,Sm,Nd( LREEs); and depleted in Ba,U( HREEs) and Ta,Nb( HFSEs).Their zircon εHf( t) values range from 1. 21 to 3. 46,in response to their two-stage Hf model ages( TDM2) ranging from 1 034 Ma to 1 159 Ma,respectively,indicating that the primary magma was derived from the young crust in Meso-Neoproterozoic. Combined with the regional geological evolution background,it is considered that the Niubiziliang monzogranite formed the closure of North Qaidam ocean,which was the stretching stage product after the collision between Qaidam block and Qilian block.
文摘The study presents the results of U-Pb dating of zircons and whole-rock geochemical analyses of a syenogranite located in the western Niubiziliang area,China with the aim of determining its formation time,petrogenesis and the regional tectonic setting. Zircons within the syenogranite are euhedral-subhedral and display rhythmic growth zoning,indicating a magmatic origin. Zircon U-Pb data obtained by LA-ICP-MS indicate the syenogranite formed in the Late Permian (260.7±1.5 Ma). The w(SiO_2) of syenogranites is 70.82%--73.59%,w(Al_2O_3) is 13.49%--14.82%,and w(Na_2O + K_2O) is 7.85%--8.52%,and yield K_2O/Na_2O ratios of 1.06--1.26. Therefore,the syenogranites belong to the high-K calc-alkaline and metaluminous (A/CNK< 1,A/NK > 1) series which display I-type granites similarly. The syenogranites also show the geochemical characteristics of volcanic arc rocks,being enriched in large-ion lithophile elements (LILEs; K,Rb) and light rare-earth elements (LREEs; La,Ce,Sm,Nd),but depleted in high field strength elements( HFSEs; Ta,Nb,P,Ti). On the whole,trace element ratios are close to the mean of the Earth's crust,indicating a lowercrust magma source. The low Sr (161--214) ×10^(-6) and Yb (1.08--1.80)×10^(-6) concentrations indicate that plagioclase and hornblende are residual mineral phases in the source. The regional geology and whole-rock geochemistry suggest that the formation of the syenogranites was related to subduction of the Zongwulong Ocean crust,and the north margin of Qaidam Block during the Late Permian was in an active continental margin tectonic setting.
文摘Objective:To provide real-world evidence for the application of first-line dacomitinib treatment for epidermal growth factor receptor(EGFR)21L858R mutant non-small cell lung cancer(NSCLC)patients in China and to explore the factors influencing the efficacy and safety.Methods:A longitudinal,consecutive case-series,multicenter study with mixed prospective and retrospective data was conducted.The primary endpoint was progression-free survival(PFS),and the secondary endpoints included duration of treatment(DOT),overall survival(OS),objective response rate(ORR),disease control rate(DCR)and safety.Results:A total of 155 EGFR 21L858R mutant patients treated with first-line dacomitinib were included.The median follow-up time for these patients was 20.4 months.Among 134 patients with evaluable lesions,the ORR was 70.9%and the DCR was 96.3%.The median PFS was 16.3[95%confidence interval(95%CI),13.7−18.9]months.Multivariate Cox regression analysis suggested that the baseline brain metastasis(BM)status[with vs.without BM:hazard ratio(HR),1.331;95%CI,0.720−2.458;P=0.361]and initial doses(45 mg vs.30 mg:HR,0.837;95%CI,0.427−1.641;P=0.604)did not significantly affect the median PFS.The median DOT was 21.0(95%CI,17.5−24.6)months and the median OS was not reached.Genetic tests were performed in 64 patients after progression,among whom 29(45.3%)patients developed the EGFR 20T790M mutation.In addition,among the 46 patients who discontinued dacomitinib treatment after progression,31(67.4%)patients received subsequent third-generation EGFR-tyrosine kinase inhibitors.The most common grade 3−4 adverse events were rash(10.4%),diarrhea(9.1%),stomatitis(7.1%)and paronychia(4.5%).The incidence of grade 3−4 rash was significantly higher in the 45 mg group than that in the 30 mg group(21.9%vs.7.5%,P=0.042).Conclusions:First-line dacomitinib treatment demonstrated promising efficacy and tolerable adverse events among EGFR 21L858R mutant NSCLC patients in China.
