Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which ...Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs.展开更多
On the background of the globalization, Chinese traditional martial arts facing a squeeze of strong Western culture is very difficult to develop. To actively explore a new development idea based on the Chinese traditi...On the background of the globalization, Chinese traditional martial arts facing a squeeze of strong Western culture is very difficult to develop. To actively explore a new development idea based on the Chinese traditional sports culture in new era, has become an urgent task to us. The traditional martial arts culture impacts on the global sports culture positively, however, crisis also exists because the technology effect and times＇ advantages by the modern civilization. To inherit and develop the Chinese Traditional Wushu culture, we＇ d better to make it popular in China, publicize and promote all over the world..展开更多
近几年我国柔性直流技术发展迅速,已建成多个高压大容量柔性直流工程。换流阀作为柔性直流系统的核心设备,其可靠性直接影响直流系统的稳定运行。自渝鄂工程开展柔性直流换流阀标准化设计与可靠性提升专项工作以来,国内换流阀可靠性得...近几年我国柔性直流技术发展迅速,已建成多个高压大容量柔性直流工程。换流阀作为柔性直流系统的核心设备,其可靠性直接影响直流系统的稳定运行。自渝鄂工程开展柔性直流换流阀标准化设计与可靠性提升专项工作以来,国内换流阀可靠性得到了明显提升,但随着设备运行时间的增加仍发生了多起因换流阀或阀控系统(valve base controller,VBC)故障导致子模块损坏或直流临停事故。该文通过梳理换流阀和阀控系统设计与功能配置情况、总结不同换流阀厂家技术路线差异并进行分析,最后提出相关建议,为下一阶段换流阀与阀控系统标准化设计与可靠性提升专项工作提供参考。展开更多
基金the Key R&D Program of Shandong Province(No.2020CXGC010703)the Key Project of the Natural Science Foundation of Shandong Province(No.ZR2020 KB021)。
文摘Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs.
文摘On the background of the globalization, Chinese traditional martial arts facing a squeeze of strong Western culture is very difficult to develop. To actively explore a new development idea based on the Chinese traditional sports culture in new era, has become an urgent task to us. The traditional martial arts culture impacts on the global sports culture positively, however, crisis also exists because the technology effect and times＇ advantages by the modern civilization. To inherit and develop the Chinese Traditional Wushu culture, we＇ d better to make it popular in China, publicize and promote all over the world..
文摘近几年我国柔性直流技术发展迅速,已建成多个高压大容量柔性直流工程。换流阀作为柔性直流系统的核心设备,其可靠性直接影响直流系统的稳定运行。自渝鄂工程开展柔性直流换流阀标准化设计与可靠性提升专项工作以来,国内换流阀可靠性得到了明显提升,但随着设备运行时间的增加仍发生了多起因换流阀或阀控系统(valve base controller,VBC)故障导致子模块损坏或直流临停事故。该文通过梳理换流阀和阀控系统设计与功能配置情况、总结不同换流阀厂家技术路线差异并进行分析,最后提出相关建议,为下一阶段换流阀与阀控系统标准化设计与可靠性提升专项工作提供参考。
