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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit
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作者 Mai-Qing Shi Jun Chen +6 位作者 Fu-Hai Ji Hao Zhou ke peng Jun Wang Chun-Lei Fan Xu Wang Yang Wang 《World Journal of Clinical Cases》 SCIE 2025年第7期28-38,共11页
BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevanc... BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains uncertain.AIM To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic shock.METHODS In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were analyzed.Patients were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with normonatremia.Moreover,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of IAH.Notably,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the ICU.It is highly recommended that hypernatremia be considered a potentially important prognostic indicator for the outcome of septic shock. 展开更多
关键词 HYPERNATREMIA Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation IMMUNOSUPPRESSION Catabolism syndrome Chronic critical illness Prognosis
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Methodological exploration on the construction of a traditional Chinese medicine nursing expert consensus based on evidence--taking stroke as an example 被引量:2
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作者 Xuejing Li ke peng +4 位作者 Meiqi Meng Liu Han Dan Yang Junqiang Zhao Yufang Hao 《Journal of Traditional Chinese Medical Sciences》 2022年第2期128-134,共7页
Objective: To explore the methodology of the evidence-based expert consensus formulation process of traditional Chinese medicine(TCM) nursing taking stroke as an example.Methods: First, preliminary and comprehensive p... Objective: To explore the methodology of the evidence-based expert consensus formulation process of traditional Chinese medicine(TCM) nursing taking stroke as an example.Methods: First, preliminary and comprehensive presentation of all stroke-related symptoms and corresponding TCM nursing techniques involved were revealed through bibliometric analysis. Then, selection of stroke symptoms and TCM nursing techniques for inclusion in the consensus was performed using an expert consultation method. Next, we determined the search strategy for a precise evidence search;conducted an evaluation of evidence quality and the grade of the evidence;and completed evidence extraction, evidence analysis, and evidence synthesis based on the included symptoms and TCM nursing techniques. The Delphi method was then applied to determine the strength of each recommendation and the choice of nursing care points by referring to the Grading of Recommendations, Assessment, Development, and Evaluations grid. Finally, we conducted an external expert validation of the Delphi results to form an expert consensus guideline.Results: Through the bibliometric analysis, 22 stroke symptoms and 18 TCM nursing techniques were identified in the literature. Then, after expert consultation, 22 symptoms and 111 pairs of symptoms combined with TCM nursing techniques were selected for the evidence search. Evidence integration yielded 10 stroke symptoms corresponding to 29 bodies of evidence;these 10 symptoms were retained through the Delphi consultation, and recommendation strength results for 26 recommendations were obtained. A total of 9 symptoms were further retained for expert external validation to form 24 recommendations, with a recommendation process score range of 7.64-9.99 points and a more scientific and standardized recommendation-formation process.Conclusion: Owing to the current limited conditions of evidence-based resources for TCM nursing, the present consensus-building process represents only a preliminary exploration of an evidence-based expert consensus for TCM nursing to provide a reference for a more scientific and standardized methodology. 展开更多
关键词 Traditional Chinese medicine nursing EVIDENCE STROKE HEMIPLEGIA Expert consensus Delphi method
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液滴冲击过程动态接触角模型研究
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作者 王翔宇 柯鹏 杜锋 《应用数学和力学》 CSCD 北大核心 2024年第9期1133-1146,共14页
基于计算流体力学(CFD)模拟液滴冲击壁面,对于理解液滴在固体壁面铺展的动力学行为有重要的意义,可以为超疏水结构设计及防除冰涂层开发提供技术支撑,其中的难点在于如何在模型中准确刻画接触线及动态接触角的演化过程.总结了四种典型... 基于计算流体力学(CFD)模拟液滴冲击壁面,对于理解液滴在固体壁面铺展的动力学行为有重要的意义,可以为超疏水结构设计及防除冰涂层开发提供技术支撑,其中的难点在于如何在模型中准确刻画接触线及动态接触角的演化过程.总结了四种典型的动态接触角模型,从理论上分析了其应用范围,借助FLUENT中的UDF功能,将动态接触角模型应用于壁面边界条件.首先对液滴冲击光滑壁面的动力学过程进行了数值模拟研究,通过定量分析液滴形态的各项参数变化并与实验结果对比表明,Seebergh动态接触角模型更适用于模拟低毛细数下液滴的运动,Kistler模型与Jiang模型应用范围更广并且可以较准确地描述高毛细数下液滴的运动.随后基于Kistler动态接触角模型,对液滴在微结构表面的冲击与铺展过程进行了仿真研究,发现应用动态接触角模型会导致液滴内部流场在表面张力起主导作用的阶段内发生变化,并且在平衡状态下液滴接触角的模拟值与理论值相近. 展开更多
关键词 液滴冲击 动态接触角 铺展系数 高度系数 微结构壁面
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Improved High Speed Flame Detection Method Based on YOLOv7 被引量:6
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作者 Hongwen Du Wenzhong Zhu +1 位作者 ke peng Weifu Li 《Open Journal of Applied Sciences》 CAS 2022年第12期2004-2018,共15页
In order to solve the problems of the traditional flame detection method, such as low detection accuracy, slow detection speed and lack of real-time detection ability. An improved high speed flame detection method bas... In order to solve the problems of the traditional flame detection method, such as low detection accuracy, slow detection speed and lack of real-time detection ability. An improved high speed flame detection method based on YOLOv7 is proposed. Based on YOLOv7 and combined with ConvNeXtBlock, CN-B network module was constructed, and YOLOv7-CN-B flame detection method was proposed. Compared with the YOLOv7 method, this flame detection method is lighter and has stronger flame feature extraction ability. 2059 open flame data sets labeled with single flame categories were used to avoid the enhancement effect brought by high-quality data sets, so that the comparative experimental effect completely depended on the performance of the flame detection method itself. The results show that the accuracy of YOLOv7-CN-B method is improved by 5% and mAP is improved by 2.1% compared with YOLOv7 method. The detection speed reached 149.25 FPS, and the single detection speed reached 11.9 ms. The experimental results show that the YOLOv7-CN-B method has better performance than the mainstream algorithm. 展开更多
关键词 Light Weight Detection of Flame YOLOv7-CN-B YOLOv7 ConvNeXt
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拦阻着舰过程中不同百分位人体颈部损伤风险的差异对比 被引量:6
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作者 柯鹏 诸斌 +2 位作者 柳松杨 李鸣皋 赵鑫 《医用生物力学》 EI CAS CSCD 北大核心 2018年第5期383-389,共7页
目的对比拦阻着舰过程中不同百分位人体颈部损伤风险的差异。方法利用已建立的人椅背带系统动力学模型和头颈部力学模型,采用文献中典型拦阻着舰过程座椅底部的加速度曲线作为输入条件,开展数值仿真,验证模型的正确性,并得到假人颈部各... 目的对比拦阻着舰过程中不同百分位人体颈部损伤风险的差异。方法利用已建立的人椅背带系统动力学模型和头颈部力学模型,采用文献中典型拦阻着舰过程座椅底部的加速度曲线作为输入条件,开展数值仿真,验证模型的正确性,并得到假人颈部各关节的轴向力、剪切力和弯矩等力学参数。结果第95百分位假人的剪切损伤Nkm指数高于第5百分位假人。假人上、下部颈椎的Nij指数小于0. 2,Nkm指数约为0. 65。结论在拦阻着舰过程中,人体颈部更容易产生由于关节剪切力导致的损伤。研究结果可为评估不同百分位人体在典型拦阻着舰过程中的颈部损伤风险提供数据支持。 展开更多
关键词 颈部损伤 飞行员 拦阻着舰
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拦阻着舰过程中不同百分位人体运动幅度的差异研究 被引量:2
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作者 李鸣皋 柳松杨 +1 位作者 柯鹏 赵鑫 《航天医学与医学工程》 CAS CSCD 北大核心 2017年第6期406-410,共5页
目的拦阻着舰会产生较大的持续性载荷,给飞行员的生理健康和操控工效带来不利影响,同时人体各部位的运动有可能导致它们与座舱及其内置设备碰撞,有必要评估其中的安全隐患。方法使用已建立的包含刚性座椅模型第5,50,95共3种百分位,Hybri... 目的拦阻着舰会产生较大的持续性载荷,给飞行员的生理健康和操控工效带来不利影响,同时人体各部位的运动有可能导致它们与座舱及其内置设备碰撞,有必要评估其中的安全隐患。方法使用已建立的包含刚性座椅模型第5,50,95共3种百分位,HybridⅢ假人有限元模型以及六点式背带约束系统的多刚体-有限元混合人椅背带系统动力学模型开展动力学仿真,评估人体头部和四肢在典型拦阻着舰过程中的运动范围。结果采用文献中公开的典型拦阻着舰过程飞机座椅底部加速度曲线作为输入条件,获得典型拦阻着舰过程中3种不同百分位假人头部、手部和足部的位移数据。结论本文仿真数据可以为改进飞行员背带约束系统和优化座舱仪表布布局提供支持。 展开更多
关键词 舰载机 拦阻着舰 人椅背带系统 碰撞 安全性
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Research on Telecom Customer Churn Prediction Based on GA-XGBoost and SHAP 被引量:1
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作者 ke peng Yan peng 《Journal of Computer and Communications》 2022年第11期107-120,共14页
To address the prominent problems faced by customer churn in telecom enterprise management, a telecom customer churn prediction model integrating GA-XGBoost and SHAP is proposed. By using the ADASYN algorithm for data... To address the prominent problems faced by customer churn in telecom enterprise management, a telecom customer churn prediction model integrating GA-XGBoost and SHAP is proposed. By using the ADASYN algorithm for data processing on the unbalanced sample set;based on the GA-XGBoost model, the XGBoost algorithm is used to construct the telecom customer churn prediction model, and the hyperparameters of the model are optimized by using the genetic algorithm. The experimental results show that compared with traditional machine learning methods such as GBDT, decision tree, KNN and single XGBoost model, the improved XGBoost model has better performance in recall, F1 value and AUC value;the GA-XGBoost model is integrated with SHAP framework to analyze and explain the important features affecting telecom customer churn, which is more in line with the telecom industry to predict customer the actual situation of churn. 展开更多
关键词 GA-XGBoost Algorithm SHAP Genetic Algorithm Customer Churn PREDICTION Machine Learning
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舰载机起降过程中飞行员响应的视景仿真 被引量:2
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作者 柯鹏 徐成林 +2 位作者 柳松杨 李鸣皋 赵鑫 《系统仿真学报》 CAS CSCD 北大核心 2019年第1期59-64,共6页
针对舰载机起降过程中飞行员动力学响应问题,提出了基于生物力学仿真和虚拟视景仿真的研究思路和实现方法,将起降过程中飞行员人体的生物力学计算与飞行场景的三维虚拟视景仿真结合起来,设计并开发了一体化的虚拟平台,具备数据管理与分... 针对舰载机起降过程中飞行员动力学响应问题,提出了基于生物力学仿真和虚拟视景仿真的研究思路和实现方法,将起降过程中飞行员人体的生物力学计算与飞行场景的三维虚拟视景仿真结合起来,设计并开发了一体化的虚拟平台,具备数据管理与分析、人体响应的生物动力学计算、关键计算结果同步分析、起降过程和人体响应的三维虚拟视景等功能。应用本平台对公开文献的实际舰载机飞行员人体试验过程进行了仿真验证,仿真结果与文献试验数据基本吻合,本平台还可以用于各种其他类型的人员训练系统的仿真和设计分析。 展开更多
关键词 舰载机 飞行员 动力学 视景仿真
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Clinical Value of Platelet-Related Parameters and Monocyte Counts in Patients with Oculomotor Myasthenia Gravis
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作者 Yaping Sun Xianglin Cheng ke peng 《Case Reports in Clinical Medicine》 2024年第12期572-580,共9页
Background: Our study aimed to investigate the clinical value of platelet parameters and the number of Monocytes (MONO) in the peripheral blood of patients with Ocular Myasthenia Gravis (OMG). Methods: Fifty patients ... Background: Our study aimed to investigate the clinical value of platelet parameters and the number of Monocytes (MONO) in the peripheral blood of patients with Ocular Myasthenia Gravis (OMG). Methods: Fifty patients discharged from the Department of Neurology of the First People’s Hospital of Jingzhou City with the diagnosis of OMG from January 1, 2020, to December 31, 2023, were selected as the experimental group, and healthy medical examiners were selected as the control group during the same period. The differences in peripheral blood mononuclear cell count and platelet-related parameters between the two groups were compared. ROC curves were drawn to analyze the clinical value of the studied indexes in patients with OMG. Results: Patients with OMG had significantly higher monocyte counts and narrower platelet distributions compared with normal adults;further logistic regression analysis revealed that higher monocyte counts and narrower Platelet Distribution Width (PDW) may be independent influences on the occurrence of OMG (p Conclusion: Peripheral blood mononuclear cell count and PDW have some diagnostic value in OMG. 展开更多
关键词 Ocular Myasthenia Gravis Mononuclear Cell Platelet Distribution Width
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“适航基础”课程思政的思考与实践 被引量:1
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作者 柯鹏 张曙光 《教育教学论坛》 2023年第5期91-94,共4页
适航取证是我国大飞机翱翔蓝天的重要前提,“适航基础”是飞行器适航技术专业的核心基础课,对融合思想政治教育引导学生的同时提升个人修养和素质,有重要的教育意义。首先,简介了“适航基础”课程的发展历程和课程内涵,阐述了它对航空... 适航取证是我国大飞机翱翔蓝天的重要前提,“适航基础”是飞行器适航技术专业的核心基础课,对融合思想政治教育引导学生的同时提升个人修养和素质,有重要的教育意义。首先,简介了“适航基础”课程的发展历程和课程内涵,阐述了它对航空和适航专业人才培养的支撑作用。其次,围绕课程内容探索来阐述思想政治教育教学目标,围绕家国情怀、科学素养和法治意识优化课程思政的教学内容和方法。最后,进行教学改革探索,形成思想政治教育教学案例,将课程知识内容和思想政治教育案例有机融合,在潜移默化中激发学生爱党爱国、爱航空和爱适航的热情,树立航空报国的信念和社会主义核心价值观,为工科专业类课程思政提供一定的参考。 展开更多
关键词 适航 课程思政 适航技术 适航管理
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Supply Chain Demand Forecast Based on SSA-XGBoost Model
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作者 Shifeng Ni Yan peng +1 位作者 ke peng Zijian Liu 《Journal of Computer and Communications》 2022年第12期71-83,共13页
Supply chain management usually faces problems such as high empty rate of transportation, unreasonable inventory management, and large material consumption caused by inaccurate market demand forecasts. To solve these ... Supply chain management usually faces problems such as high empty rate of transportation, unreasonable inventory management, and large material consumption caused by inaccurate market demand forecasts. To solve these problems, using artificial intelligence and big data technology to achieve market demand forecasting and intelligent decision-making is becoming a strategic technology trend of supply chain management in the future. Firstly, this paper makes a visual analysis of the historical data of the Stock Keeping Unit (SKU);Then, the characteristic factors affecting the future demand are constructed from the storage level, product level, historical usage of SKU, etc;Finally, a supply chain demand forecasting algorithm based on SSA-XGBoost model has proposed around three aspects of feature engineering, parameter optimization and model integration, and is compared with other machine learning models. The experiment shows that the forecasting result of SSA-XGBoost forecasting model is highly consistent with the actual value, so it is of practical significance to adopt this forecasting model to solve the supply chain demand forecasting problem. 展开更多
关键词 Data Visualization Analysis SSA-XGBoost Supply Chain Demand Forecast
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血液肿瘤化疗后粒缺伴发热患者一线经验性抗感染治疗的临床疗效及治疗费用 被引量:8
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作者 胡丽娜 谢勉 +4 位作者 李国强 冯春 柯鹏 张新友 周继豪 《中国感染控制杂志》 CAS CSCD 北大核心 2020年第8期715-720,共6页
目的评价血液肿瘤化疗后中性粒细胞缺乏(粒缺)伴发热患者两种一线经验性抗感染治疗策略的优劣。方法回顾性分析2017年8月—2018年12月某院血液肿瘤化疗后粒缺伴发热病例的感染部位及病原菌分布情况,按一线抗感染治疗方案分为以碳青霉烯... 目的评价血液肿瘤化疗后中性粒细胞缺乏(粒缺)伴发热患者两种一线经验性抗感染治疗策略的优劣。方法回顾性分析2017年8月—2018年12月某院血液肿瘤化疗后粒缺伴发热病例的感染部位及病原菌分布情况,按一线抗感染治疗方案分为以碳青霉烯类药物为主治疗组(碳青霉烯类组)和以含酶β-内酰胺类抗生素为主治疗组(含酶β-内酰胺类组),对两组病例治疗疗效、住院总费用以及住院日数进行比较。结果共收集粒缺伴发热的病例103例,其中碳青霉烯类组为71例,含酶β-内酰胺类组32例。最常见的感染部位是呼吸道,其次为血液、胃肠道。检出病原菌47株,革兰阴性菌、革兰阳性菌、真菌分别占68.1%、12.8%、19.1%,以肺炎克雷伯菌占比最高为(25.5%),其次为大肠埃希菌(21.3%)和铜绿假单胞菌(8.5%)。碳青霉烯类组、含酶β-内酰胺类组患者治疗有效率分别为90.1%、71.9%,住院总费用分别为(59529.7±39771.3)、(49546.9±31641.1)元,住院日数分别为(28.7±7.9)、(26.2±6.3)d,两组治疗有效率比较,差异有统计学意义(P=0.038),两组患者住院总费用、住院日数比较,差异均无统计学意义(均P>0.05)。结论对血液肿瘤化疗后粒缺伴发热的患者,一线经验性应用碳青霉烯类为主的药物抗感染治疗的疗效优于应用含酶β-内酰胺类为主的药物,两组住院总费用以及住院日数差异不明显。 展开更多
关键词 中性粒细胞缺乏伴发热 感染部位 病原菌 治疗 住院总费用 住院日数
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黏结层及真空退火对NiCr-30%Cr3C2金属-陶瓷喷涂层性能的影响 被引量:2
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作者 柯鹏 蔡飞 +5 位作者 胡凯 张世宏 王硕煜 朱广宏 倪振航 胡小红 《材料工程》 EI CAS CSCD 北大核心 2019年第7期144-150,共7页
采用两种黏结层(电镀Ni+HVOFNiCr黏结层和电镀Ni黏结层),通过超音速火焰喷涂技术制备NiCr-30%Cr3C2(质量分数)金属-陶瓷涂层,并对含电镀Ni黏结层的涂层在不同温度(800,850,900℃)下进行真空退火处理。利用X射线衍射仪(XRD)、扫描电子显... 采用两种黏结层(电镀Ni+HVOFNiCr黏结层和电镀Ni黏结层),通过超音速火焰喷涂技术制备NiCr-30%Cr3C2(质量分数)金属-陶瓷涂层,并对含电镀Ni黏结层的涂层在不同温度(800,850,900℃)下进行真空退火处理。利用X射线衍射仪(XRD)、扫描电子显微镜(SEM)、电子拉伸试验机、销盘摩擦磨损仪(BOD)以及台阶仪研究了黏结层和退火处理对涂层的物相结构、结合强度和不同载荷下摩擦性能的影响。结果表明:采用Ni黏结层涂层的结合强度达64MPa,且退火后结合强度明显提升;20N载荷下,该涂层的耐磨性优于Ni-NiCr黏结层涂层,且退火后耐磨性明显提升;在5N载荷下,两种黏结层涂层的耐磨性相近,但退火后Ni黏结层涂层的耐磨性降低。 展开更多
关键词 超音速火焰喷涂 黏结层 退火处理 耐磨性 结合强度
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基于风洞试验的竞走项目编队气动减阻效应 被引量:2
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作者 胡齐 李波 +2 位作者 柯鹏 沈梦 洪平 《上海体育学院学报》 CSSCI 北大核心 2022年第3期62-71,共10页
目的探讨不同编队位置对核心运动员气动阻力的影响以及与单人竞走情况相比的气动减阻效果,并量化评估不同编队策略对竞走成绩的影响。方法选取由不同国家队竞走运动员人数组成的编队模拟不同竞走场景,通过风洞试验获取不同编队位置核心... 目的探讨不同编队位置对核心运动员气动阻力的影响以及与单人竞走情况相比的气动减阻效果,并量化评估不同编队策略对竞走成绩的影响。方法选取由不同国家队竞走运动员人数组成的编队模拟不同竞走场景,通过风洞试验获取不同编队位置核心运动员的气动阻力。风洞试验内容包括核心运动员单人测试、双人编队测试、3人编队测试、4人编队测试。结果与单人竞走情况相比,双人编队中核心运动员位于辅助运动员的正后方时气动阻力减小最为明显,减阻率可达64.9%,此编队站位为相对最佳双人编队;3人编队中核心运动员位于其他2名辅助运动员沿着运动方向连线的中间时气动阻力减小最为明显,减阻率可达79.9%,此编队站位为相对最佳3人编队;4人编队中核心运动员位于其他3名辅助运动员组成的V型编队的正后方时气动阻力减小最为明显,减阻率可达83.8%,此编队站位为相对最佳4人编队。在50 km竞走比赛中,与单人竞走成绩相比,若采用相对最佳双人编队策略,比赛成绩将至少提升约3.89%;若采用相对最佳3人编队策略,比赛成绩将至少提升约4.79%;若采用相对最佳4人编队策略,比赛成绩将至少提升约5.03%。结论不同编队位置下竞走项目核心运动员的气动减阻效应存在一定差异,研究不同编队的气动减阻效应能为减小核心运动员气动阻力、优化能量分配、改进团队协作策略、提高运动成绩提供重要的科学指导。 展开更多
关键词 竞走 风洞试验 编队 气动阻力 减阻
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BCL-2抑制剂在血液恶性肿瘤中的靶向治疗应用及作用机制 被引量:4
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作者 何晓晴 柯鹏(综述) 张新友(审校) 《实用肿瘤学杂志》 CAS 2022年第5期452-457,共6页
细胞凋亡受到抑制是血液恶性肿瘤细胞的突出特征。B细胞淋巴瘤-2(B-cell lymphoma-2,BCL-2)是细胞凋亡关键性蛋白调节因子,在多种血液恶性肿瘤中有不同程度的表达。高表达BCL-2的肿瘤细胞抗细胞凋亡能力显著增强,靶向抑制BCL-2成为抗血... 细胞凋亡受到抑制是血液恶性肿瘤细胞的突出特征。B细胞淋巴瘤-2(B-cell lymphoma-2,BCL-2)是细胞凋亡关键性蛋白调节因子,在多种血液恶性肿瘤中有不同程度的表达。高表达BCL-2的肿瘤细胞抗细胞凋亡能力显著增强,靶向抑制BCL-2成为抗血液肿瘤的研究热点之一。维奈克拉是首个获批上市的BCL-2抑制剂(BCL-2 inhibitor,BCL-2i),用于慢性淋巴细胞白血病、急性髓系白血病及骨髓增生异常综合征的治疗。研究表明维奈克拉对其他血液恶性肿瘤如B细胞非霍奇金淋巴瘤及多发性骨髓瘤也具有抗肿瘤活性。本文就BCL-2抗凋亡机制、BCL-2i在血液恶性肿瘤中的临床应用以及BCL-2i耐药的可能机制作一简要综述。 展开更多
关键词 B细胞淋巴瘤-2 细胞凋亡 维奈克拉 血液恶性肿瘤
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钢材低温轧制技术研发现状与展望 被引量:3
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作者 柯鹏 刘豪 +4 位作者 朱立荣 曹群 廖子剑 王海涛 龙坚战 《硬质合金》 CAS 2023年第4期319-327,共9页
低温轧制技术是将钢坯再加热温度降低至未再结晶奥氏体区以下、低于常规热轧温度的轧制技术,低温轧制技术可降低生产总能耗、提高钢坯力学性能、简化热处理工序,具有较高的经济效益、生产效率和产品竞争力。然而目前低温轧制技术仍然存... 低温轧制技术是将钢坯再加热温度降低至未再结晶奥氏体区以下、低于常规热轧温度的轧制技术,低温轧制技术可降低生产总能耗、提高钢坯力学性能、简化热处理工序,具有较高的经济效益、生产效率和产品竞争力。然而目前低温轧制技术仍然存在一些难题,如:轧机负荷大、产品塑性降低、轧辊失效频繁等。本文阐述了低温轧制技术的主要特点,从力学性能与表面质量两个角度分析了低温轧制技术对产品的影响,指出了低温轧制技术目前存在轧机负荷大和轧辊材料失效问题,提出了优化每道次的轧制量、根据扎件的性能特点调整轧制速率以及道次数量和提高轧辊材料耐热疲劳性能等方法以减轻轧机负荷,未来应对低温轧制技术在硬质合金轧辊性能、低温轧制过程中组织变化的机理等方面开展研究。 展开更多
关键词 低温轧制 能耗 绿色低碳 轧辊
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改进人工蜂群算法及其在边缘计算卸载的应用 被引量:8
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作者 章呈瑞 柯鹏 尹梅 《计算机工程与应用》 CSCD 北大核心 2022年第7期150-161,共12页
移动边缘计算(MEC)通过将算力下沉到网络边缘来降低计算时延和设备能耗。针对计算密集型和时延敏感型应用场景,提出了一种单多维动态种群策略的人工蜂群算法(OMABC)来实现计算任务的卸载。建立一个包含云服务器的边缘计算卸载模型,并构... 移动边缘计算(MEC)通过将算力下沉到网络边缘来降低计算时延和设备能耗。针对计算密集型和时延敏感型应用场景,提出了一种单多维动态种群策略的人工蜂群算法(OMABC)来实现计算任务的卸载。建立一个包含云服务器的边缘计算卸载模型,并构建一个以能耗为惩罚项的代价函数;将计算任务的卸载决策转化为人工蜂群算法对代价函数的寻优过程。通过仿真实验,在CEC 2017测试函数上验证了OMABC的有效性,并在边缘计算模型仿真中与本地卸载策略、随机卸载策略、基于粒子群算法(PSO)的卸载策略、基于人工蜂群算法(ABC)的卸载策略进行对比。实验结果表明,基于OMABC的边缘计算卸载策略能够有效降低MEC系统的时延及代价函数,提供更高效的服务。 展开更多
关键词 人工蜂群算法 移动边缘计算 计算卸载 多维更新 动态种群
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一种融合多种策略的改进鲸鱼优化算法 被引量:4
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作者 尹梅 柯鹏 章呈瑞 《武汉科技大学学报》 CAS 北大核心 2023年第2期145-152,共8页
针对标准鲸鱼优化算法容易陷入局部最优、收敛精度低的问题,提出一种融合动态划分等级策略和交叉存档策略的自适应鲸鱼优化算法,记为IWOA。首先引入自适应收敛因子,根据适应度值动态调整个体在迭代过程中的包围步长,平衡算法的探索和开... 针对标准鲸鱼优化算法容易陷入局部最优、收敛精度低的问题,提出一种融合动态划分等级策略和交叉存档策略的自适应鲸鱼优化算法,记为IWOA。首先引入自适应收敛因子,根据适应度值动态调整个体在迭代过程中的包围步长,平衡算法的探索和开发能力;然后对适应度不同的个体采用不同的自主学习策略,在增加种群多样性的同时加快算法的收敛速度;最后提出一种交叉存档策略,赋予陷入更新停滞的个体更好的位置,增强算法跳出局部最优的能力。在22个基准测试函数上的实验结果表明,IWOA在收敛速度和寻优精度等方面均有显著改善。在压力容器设计问题中的应用也表明IWOA可以有效解决复杂的非线性优化问题。 展开更多
关键词 鲸鱼优化算法 自适应收敛因子 动态划分等级策略 交叉存档
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基于冲量定理的高速空投假人最大动载计算模型研究 被引量:1
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作者 程炜 杨春信 +3 位作者 柯鹏 马坤昌 高春鹏 戚晓玲 《航空工程进展》 CSCD 2020年第6期789-795,共7页
假人高速空投试验旨在评估开伞过程中人体所受最大动载,由于该试验重复性差、成本高,有必要建立计算模型为系统设计提供理论依据。基于冲量定理建立最大动载计算模型,计算特定空投条件下假人最大动载;选取某典型假人高速空投系统作为算... 假人高速空投试验旨在评估开伞过程中人体所受最大动载,由于该试验重复性差、成本高,有必要建立计算模型为系统设计提供理论依据。基于冲量定理建立最大动载计算模型,计算特定空投条件下假人最大动载;选取某典型假人高速空投系统作为算例,开展基于多体动力学的系统仿真,并根据仿真结果确定计算模型的关键参数,给出最大动载计算模型的数学表达式。结果表明:本文模型可以快速有效确定假人最大动载,评估救生伞系统安全性,具有较高的工程应用价值。 展开更多
关键词 救生伞 假人动载 高速空投 多体动力学仿真 冲量定理
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Incidence and mortality of oral and oropharyngeal cancer in China, 2015 被引量:11
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作者 Lin Lei Rongshou Zheng +6 位作者 ke peng Lei Si Ji peng Weicong Cai Siwei Zhang Wenqiang Wei Jie He 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2020年第1期1-9,共9页
Objective: To report the incidence and mortality rates of oral and oropharyngeal cancer in Chinese population.Methods: Data were taken from a population-based cancer registry collected by the National Central Cancer R... Objective: To report the incidence and mortality rates of oral and oropharyngeal cancer in Chinese population.Methods: Data were taken from a population-based cancer registry collected by the National Central Cancer Registry of China(NCCRC) in 2015. The data collected from 501 local cancer registries in China were assessed using NCCRC screening methods and criteria. Incidence and mortality rates of oral and oropharyngeal cancer were stratified by age group, gender, and area. Age-standardized incidence and mortality rates were adjusted using the Chinese standard population in 2000 and Segi’s world population.Results: In 2015, it was estimated that there were 51,765 oral and oropharyngeal cancer incident cases and 23,830 deaths in China. The crude incidence rate of oral and oropharyngeal cancer was 3.77/100,000, and the agestandardized incidence rate by Chinese standard population and by Segi’s world standard population were 2.55/100,000 and 2.49/100,000, respectively. The crude mortality rate and the age-standardized mortality rates by Chinese standard population and by Segi’s world standard population were 1.73/100,000, 1.09/100,000 and1.08/100,000, respectively. Both incidence and mortality rates of oral and oropharyngeal cancer were higher in males and in urban areas. Residents in eastern areas had the highest incidence and mortality rates, followed by those from middle areas and western areas. The rates of oral and oropharyngeal cancer increased greatly with age,especially after the age of 40 years.Conclusions: This study reports the latest incidence and mortality rates of oral and oropharyngeal cancer in China. Prevention intervention including early detection, treatment, and regular follow-ups is encouraged to be set up to reduce incidence and mortality rates of oral and oropharyngeal cancer in the future. 展开更多
关键词 INCIDENCE MORTALITY CANCER REGISTRY ORAL and OROPHARYNGEAL CANCER China
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