Computational simulations and high-temperature measurements of velocities near the surface of a mold were carried out by using the rod deflection method to study the effects of various operating parameters on the flow...Computational simulations and high-temperature measurements of velocities near the surface of a mold were carried out by using the rod deflection method to study the effects of various operating parameters on the flow field in slab continuous casting(CC)molds with narrow widths for the production of automobile exposed panels.Reasonable agreement between the calculated results and measured subsurface velocities of liquid steel was obtained under different operating parameters of the CC process.The simulation results reveal that the flow field in the horizontal plane located 50 mm from the meniscus can be used as the characteristic flow field to optimize the flow field of molten steel in the mold.Increases in casting speed can increase the subsurface velocity of molten steel and shift the position of the vortex core downward in the downward circulation zone.The flow field of liquid steel in a 1040 mm-wide slab CC mold can be improved by an Ar gas flow rate of 7 L·min^−1 and casting speed of 1.7 m·min^−1.Under the present experimental conditions,the double-roll flow pattern is generally stable at a submerged entry nozzle immersion depth of 170 mm.展开更多
Uncaria rhynchophylla has been widely used to treat central nervous system diseases for a long history.After investigation of U.rhynchophylla,eleven monoterpene indole alkaloids,including four new compounds uncarialin...Uncaria rhynchophylla has been widely used to treat central nervous system diseases for a long history.After investigation of U.rhynchophylla,eleven monoterpene indole alkaloids,including four new compounds uncarialins J-M(1-4)and seven known analogues(5-11),were isolated and identified.Their structural characterization was conducted using HRESIMS,1D and 2D NMR,electronic circular dichroism(ECD)spectra,and quantum chemical computations.Compounds 1,2,7,and 9-11 displayed significant ag-onistic effects towards 5-HT_(1A) receptor,and their EC_(50) values were 7.86,732,2.24,1.18,1.52,and 3.75μmol/L,respectively.Furthermore,in vivo experimental results fully revealed that hirsuteine(7)displayed a significant antidepression effect in unpredictable chronic mild stress(UCMS)-induced depression mice mainly via regulating 5-HT_(1A) signaling pathway.Molecular docking and site-directed amino acid mutation verified that amino acid residues Aspll6 and Asn386 were the binding sites of hirsuteine(7)with 5-HT_(1A) receptor.In addition,pre-treatment of mice with WAY 100635 also blocked the anti-depression effect of hirsuteine(7),which further demonstrated that 5-HT_(1A) receptor was a potential target of hirsuteine(7)to effectively treat depression.These findings indicated the therapeutic material basis of U.rhynchophylla and the anti-depression underlying mechanism of hirsuteine(7),and further provided the useful guidance for the development of hirsuteine(7)as a potential antidepressant candidate.展开更多
基金This work was financially supported by the Hunan Valin Lianyuan Iron&Steel Co.,Ltd.,China(No.18H00582).The authors are grateful to Hunan Valin Lianyuan Iron&Steel Co.,Ltd.,China for their assistance with the industrial measurement of velocities near the mold surface.
文摘Computational simulations and high-temperature measurements of velocities near the surface of a mold were carried out by using the rod deflection method to study the effects of various operating parameters on the flow field in slab continuous casting(CC)molds with narrow widths for the production of automobile exposed panels.Reasonable agreement between the calculated results and measured subsurface velocities of liquid steel was obtained under different operating parameters of the CC process.The simulation results reveal that the flow field in the horizontal plane located 50 mm from the meniscus can be used as the characteristic flow field to optimize the flow field of molten steel in the mold.Increases in casting speed can increase the subsurface velocity of molten steel and shift the position of the vortex core downward in the downward circulation zone.The flow field of liquid steel in a 1040 mm-wide slab CC mold can be improved by an Ar gas flow rate of 7 L·min^−1 and casting speed of 1.7 m·min^−1.Under the present experimental conditions,the double-roll flow pattern is generally stable at a submerged entry nozzle immersion depth of 170 mm.
基金the Dalian Science and Technology Leading Talents Project(No.2019RD15)the Distinguished Professor of Liaoning Province,the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(No.CNLZD1801)+2 种基金the Natural Science Foundation of Liaoning Province(No.2020-MS-256)the Dalian Young Star of Science and Technology(No.2019RQ123)the Shanghai"Rising Stars of Medical Talent" Youth Development Program-Youth Medical Talents-Clinical Pharmacist Program(No.SHWJRS(2019)_072).
文摘Uncaria rhynchophylla has been widely used to treat central nervous system diseases for a long history.After investigation of U.rhynchophylla,eleven monoterpene indole alkaloids,including four new compounds uncarialins J-M(1-4)and seven known analogues(5-11),were isolated and identified.Their structural characterization was conducted using HRESIMS,1D and 2D NMR,electronic circular dichroism(ECD)spectra,and quantum chemical computations.Compounds 1,2,7,and 9-11 displayed significant ag-onistic effects towards 5-HT_(1A) receptor,and their EC_(50) values were 7.86,732,2.24,1.18,1.52,and 3.75μmol/L,respectively.Furthermore,in vivo experimental results fully revealed that hirsuteine(7)displayed a significant antidepression effect in unpredictable chronic mild stress(UCMS)-induced depression mice mainly via regulating 5-HT_(1A) signaling pathway.Molecular docking and site-directed amino acid mutation verified that amino acid residues Aspll6 and Asn386 were the binding sites of hirsuteine(7)with 5-HT_(1A) receptor.In addition,pre-treatment of mice with WAY 100635 also blocked the anti-depression effect of hirsuteine(7),which further demonstrated that 5-HT_(1A) receptor was a potential target of hirsuteine(7)to effectively treat depression.These findings indicated the therapeutic material basis of U.rhynchophylla and the anti-depression underlying mechanism of hirsuteine(7),and further provided the useful guidance for the development of hirsuteine(7)as a potential antidepressant candidate.
