As a companion paper to Zhou RX et al.(2020),this study describes application of the automatic detection and analysis module to identify all the tweek atmospherics detectible in the WHU ELF/VLF receiver data collected...As a companion paper to Zhou RX et al.(2020),this study describes application of the automatic detection and analysis module to identify all the tweek atmospherics detectible in the WHU ELF/VLF receiver data collected at Suizhou station during the period of 3 February through 29 February 2016.Detailed analysis of the identified low-latitude tweek events reveals that the occurrence rate varies considerably—from 800 to 6000 tweeks per day,and exhibits a strong diurnal and local time dependence,the peak occurring before local midnight.The diurnal variation of identified tweeks was similar to that of the lightning data obtained by the World-Wide Lightning Location Network(WWLLN)..Estimates of the propagation distance and ionospheric reflection height of tweek atmospherics suggest that the majority(~92%)of the low latitude tweeks originate from the lightning activity within a radius of 4000 km and that they are very likely to reflect from the lower ionospheric D-region at the height range of 75–85 km.At these lower ionospheric reflection altitudes,~74%of the corresponding electron densities from the tweek spectral measurements are within 24.5–27.5 cm^-3.The daily variation of estimated D-region electron densities in the considered period(February 2016)also exhibits a small overall increasing trend from early to later in the month.展开更多
The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from t...The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from the sprite-producing lightning were measured at five ground stations, making it possible to locate and identify the individual causative lightning discharges for different elements in this dancing sprite event. The results of our analyses indicate that the sprites were produced above the trailing stratiform region of the MCS, and their parent strokes were located mainly in the peripheral area of the stratiform. The lateral offset between sprites and causative strokes ranges from a few km to more than 50 km. In a particularly bright sprite, with a distinct halo feature and streamers descending down to an altitude of approximately 48 km, the sprite current signal identified in the electric sferic, measured at a range of about 1,110 km, peaked at approximately 1 ms after the return stroke.展开更多
As a dispersive wave mode produced by lightning strokes, tweek atmospherics provide important hints of lower ionospheric(i.e., D-region) electron density. Based on data accumulation from the WHU ELF/VLF receiver syste...As a dispersive wave mode produced by lightning strokes, tweek atmospherics provide important hints of lower ionospheric(i.e., D-region) electron density. Based on data accumulation from the WHU ELF/VLF receiver system, we develop an automatic detection module in terms of the maximum-entropy-spectral-estimation(MESE) method to identify unambiguous instances of low latitude tweeks.We justify the feasibility of our procedure through a detailed analysis of the data observed at the Suizhou Station(31.57°N, 113.32°E) on17 February 2016. A total of 3961 tweeks were registered by visual inspection;the automatic detection method captured 4342 tweeks, of which 3361 were correct ones, producing a correctness percentage of 77.4%(= 3361/4342) and a false alarm rate of 22.6%(= 981/4342).A Short-Time Fourier Transformation(STFT) was also applied to trace the power spectral profiles of identified tweeks and to evaluate the tweek propagation distance. It is found that the fitting accuracy of the frequency–time curve and the relative difference of propagation distance between the two methods through the slope and through the intercept can be used to further improve the accuracy of automatic tweek identification. We suggest that our automatic tweek detection and analysis method therefore supplies a valuable means to investigate features of low latitude tweek atmospherics and associated ionospheric parameters comprehensively.展开更多
Using wave measurements from the EMFISIS instrument onboard Van Allen Probes,we investigate statistically the spatial distributions of the intensity of plasmaspheric hiss waves.To reproduce these empirical results,we ...Using wave measurements from the EMFISIS instrument onboard Van Allen Probes,we investigate statistically the spatial distributions of the intensity of plasmaspheric hiss waves.To reproduce these empirical results,we establish a fitting model that is a thirdorder polynomial function of L-shell,magnetic local time(MLT),magnetic latitude(MLAT),and AE*.Quantitative comparisons indicate that the model’s fitting functions can reflect favorably the major empirical features of the global distribution of hiss wave intensity,including substorm dependence and the MLT asymmetry.Our results therefore provide a useful analytic model that can be readily employed in future simulations of global radiation belt electron dynamics under the impact of plasmaspheric hiss waves in geospace.展开更多
Objective: To explore the value of IgM and IgG contents for the diagnosis and judgment of mycoplasma pneumonia in children. Methods: 560 children with mycoplasma pneumonia who received inpatient treatment in our hospi...Objective: To explore the value of IgM and IgG contents for the diagnosis and judgment of mycoplasma pneumonia in children. Methods: 560 children with mycoplasma pneumonia who received inpatient treatment in our hospital between October 2016 and October 2017 were selected as mycoplasma pneumonia group, and 200 healthy children who received vaccination in our hospital during the same period were selected as normal control group. The differences in peripheral blood IgM and IgG contents as well as serum inflammatory factor and pulmonary surfactant protein contents were compared between the two groups, and Pearson test was used to evaluate the inner link of peripheral blood IgM and IgG contents with inflammatory factors and pulmonary surfactant proteins in children with mycoplasma pneumonia. Results: Peripheral blood IgM and IgG contents of mycoplasma pneumonia group were higher than those of normal control group;serum inflammatory factors MCP-4, IL-5, IL-13, IL-17, IL-18 and IL-23 contents were higher than those of normal control group;serum pulmonary surfactant proteins SP-A, SP-B, SP-C and SP-D contents were higher than those of normal control group. Correlation analysis showed that peripheral blood IgM and IgG contents in children with mycoplasma pneumonia were positively correlated with the contents of inflammatory factors and pulmonary surfactant proteins. Conclusion: Peripheral blood IgM and IgG contents are abnormally high in children with mycoplasma pneumonia, and they are closely related to the inflammatory response and lung injury degree.展开更多
The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy.The phosphatidylinositol transfer protein alpha/beta isoform(PITPα/β)has been reported...The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy.The phosphatidylinositol transfer protein alpha/beta isoform(PITPα/β)has been reported to play an essential role in integrating phosphoinositide trafficking and lipid metabolism in diverse cellular processes but remains unexplored as a potential target for cancer treatment.Herein,data analysis of clinical cancer samples revealed that PITPα/βexpression is closely correlated with the poor prognosis.Target identification by chemical proteomic methods revealed that microcolin H,a naturally occurring marine lipopeptide,directly binds PITPα/βand displays antiproliferative activity on different types of tumour cell lines.Furthermore,we identified that microcolin H treatment increased the conversion of LC3I to LC3II,accompanied by a reduction of the level of p62 in cancer cells,leading to autophagic cell death.Moreover,microcolin H showed preeminent antitumour efficacy in nude mouse subcutaneous tumour models with low toxicity.Our discoveries revealed that by targeting PITPα/β,microcolin H induced autophagic cell death in tumours with efficient anti-proliferating activity,which sheds light on PITPα/βas a promising therapeutic target for cancer treatment.展开更多
基金supported by the National Natural Science Foundation of China (Grants Nos. 41674163, 41474141, 41204120,41304127, 41304130, and 41574160)the Projects funded by China Postdoctoral Science Foundation (Grants Nos. 2013M542051, 2014T70732)+2 种基金the Hubei Province Natural Science Excellent Youth Foundation (2016CFA044)The project Supported by the Specialized Research Fund for State Key Laboratoriesthe 985 funded project of School of Electronic information, Wuhan University。
文摘As a companion paper to Zhou RX et al.(2020),this study describes application of the automatic detection and analysis module to identify all the tweek atmospherics detectible in the WHU ELF/VLF receiver data collected at Suizhou station during the period of 3 February through 29 February 2016.Detailed analysis of the identified low-latitude tweek events reveals that the occurrence rate varies considerably—from 800 to 6000 tweeks per day,and exhibits a strong diurnal and local time dependence,the peak occurring before local midnight.The diurnal variation of identified tweeks was similar to that of the lightning data obtained by the World-Wide Lightning Location Network(WWLLN)..Estimates of the propagation distance and ionospheric reflection height of tweek atmospherics suggest that the majority(~92%)of the low latitude tweeks originate from the lightning activity within a radius of 4000 km and that they are very likely to reflect from the lower ionospheric D-region at the height range of 75–85 km.At these lower ionospheric reflection altitudes,~74%of the corresponding electron densities from the tweek spectral measurements are within 24.5–27.5 cm^-3.The daily variation of estimated D-region electron densities in the considered period(February 2016)also exhibits a small overall increasing trend from early to later in the month.
基金supported by the National Key Basic Research and Development Program (2017YFC1501501)National Natural Science Foundation of China (41574179, 41875006)+4 种基金National Natural Science Foundation for Excellent Youth of China (41622501)"The Hundred Talents Program" of Chinese Academy of Sciences (2013068)supported by funding from the NOAA Office of Global Programs for the Global Precipitation Climatology Project (GPCP)by NASA via the Tropical Rainfall Measuring Mission (TRMM)supported by NASA's HQ Earth S cience Data Systems (ESDS) Program
文摘The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from the sprite-producing lightning were measured at five ground stations, making it possible to locate and identify the individual causative lightning discharges for different elements in this dancing sprite event. The results of our analyses indicate that the sprites were produced above the trailing stratiform region of the MCS, and their parent strokes were located mainly in the peripheral area of the stratiform. The lateral offset between sprites and causative strokes ranges from a few km to more than 50 km. In a particularly bright sprite, with a distinct halo feature and streamers descending down to an altitude of approximately 48 km, the sprite current signal identified in the electric sferic, measured at a range of about 1,110 km, peaked at approximately 1 ms after the return stroke.
基金supported by the National Natural Science Foundation of China (Grants Nos. 41674163, 41474141, 41204120, 41304127, 41304130, and 41574160)the Projects funded by China Postdoctoral Science Foundation (Grants Nos. 2013M542051, 2014T70732)+2 种基金the Hubei Province Natural Science Excellent Youth Foundation (2016CFA044)the Project Supported by the Specialized Research Fund for State Key Laboratoriesthe 985 funded project of School of Electronic information, Wuhan University
文摘As a dispersive wave mode produced by lightning strokes, tweek atmospherics provide important hints of lower ionospheric(i.e., D-region) electron density. Based on data accumulation from the WHU ELF/VLF receiver system, we develop an automatic detection module in terms of the maximum-entropy-spectral-estimation(MESE) method to identify unambiguous instances of low latitude tweeks.We justify the feasibility of our procedure through a detailed analysis of the data observed at the Suizhou Station(31.57°N, 113.32°E) on17 February 2016. A total of 3961 tweeks were registered by visual inspection;the automatic detection method captured 4342 tweeks, of which 3361 were correct ones, producing a correctness percentage of 77.4%(= 3361/4342) and a false alarm rate of 22.6%(= 981/4342).A Short-Time Fourier Transformation(STFT) was also applied to trace the power spectral profiles of identified tweeks and to evaluate the tweek propagation distance. It is found that the fitting accuracy of the frequency–time curve and the relative difference of propagation distance between the two methods through the slope and through the intercept can be used to further improve the accuracy of automatic tweek identification. We suggest that our automatic tweek detection and analysis method therefore supplies a valuable means to investigate features of low latitude tweek atmospherics and associated ionospheric parameters comprehensively.
基金supported by the B-type Strategic Priority Program of the Chinese Academy of Sciences (Grant No. XDB41000000)the NSFC grants 41674163, 41974186, 41704162, 41904144, and 41904143+1 种基金the pre-research projects on Civil Aerospace Technologies No. D020308, D020104 and D020303funded by China National Space Administration。
文摘Using wave measurements from the EMFISIS instrument onboard Van Allen Probes,we investigate statistically the spatial distributions of the intensity of plasmaspheric hiss waves.To reproduce these empirical results,we establish a fitting model that is a thirdorder polynomial function of L-shell,magnetic local time(MLT),magnetic latitude(MLAT),and AE*.Quantitative comparisons indicate that the model’s fitting functions can reflect favorably the major empirical features of the global distribution of hiss wave intensity,including substorm dependence and the MLT asymmetry.Our results therefore provide a useful analytic model that can be readily employed in future simulations of global radiation belt electron dynamics under the impact of plasmaspheric hiss waves in geospace.
文摘Objective: To explore the value of IgM and IgG contents for the diagnosis and judgment of mycoplasma pneumonia in children. Methods: 560 children with mycoplasma pneumonia who received inpatient treatment in our hospital between October 2016 and October 2017 were selected as mycoplasma pneumonia group, and 200 healthy children who received vaccination in our hospital during the same period were selected as normal control group. The differences in peripheral blood IgM and IgG contents as well as serum inflammatory factor and pulmonary surfactant protein contents were compared between the two groups, and Pearson test was used to evaluate the inner link of peripheral blood IgM and IgG contents with inflammatory factors and pulmonary surfactant proteins in children with mycoplasma pneumonia. Results: Peripheral blood IgM and IgG contents of mycoplasma pneumonia group were higher than those of normal control group;serum inflammatory factors MCP-4, IL-5, IL-13, IL-17, IL-18 and IL-23 contents were higher than those of normal control group;serum pulmonary surfactant proteins SP-A, SP-B, SP-C and SP-D contents were higher than those of normal control group. Correlation analysis showed that peripheral blood IgM and IgG contents in children with mycoplasma pneumonia were positively correlated with the contents of inflammatory factors and pulmonary surfactant proteins. Conclusion: Peripheral blood IgM and IgG contents are abnormally high in children with mycoplasma pneumonia, and they are closely related to the inflammatory response and lung injury degree.
基金supported by the Program for the Ministry of Education“Peptide Drugs”Innovation Team(No.IRT_15R27,China)the National Natural Science Foundation of China(21807053)+1 种基金the CAMS Innovation Fund for Medical Sciences(CIFMS,Nos.2019-I2M-5-074,2021-I2M-1-026,2021-I2M-3-001,2022-I2M-2-002,China)the Fundamental Research Funds for the Central Universities(No.lzujbky-2023-11,lzujbky-2023-ct02,lzujbky-2023-it19,China).
文摘The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy.The phosphatidylinositol transfer protein alpha/beta isoform(PITPα/β)has been reported to play an essential role in integrating phosphoinositide trafficking and lipid metabolism in diverse cellular processes but remains unexplored as a potential target for cancer treatment.Herein,data analysis of clinical cancer samples revealed that PITPα/βexpression is closely correlated with the poor prognosis.Target identification by chemical proteomic methods revealed that microcolin H,a naturally occurring marine lipopeptide,directly binds PITPα/βand displays antiproliferative activity on different types of tumour cell lines.Furthermore,we identified that microcolin H treatment increased the conversion of LC3I to LC3II,accompanied by a reduction of the level of p62 in cancer cells,leading to autophagic cell death.Moreover,microcolin H showed preeminent antitumour efficacy in nude mouse subcutaneous tumour models with low toxicity.Our discoveries revealed that by targeting PITPα/β,microcolin H induced autophagic cell death in tumours with efficient anti-proliferating activity,which sheds light on PITPα/βas a promising therapeutic target for cancer treatment.
