Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics...Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability issues.Drugs injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of PsA.The limited treatment options for PsA present a challenge.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.82073439).
文摘Dear Editor,Treating psoriatic arthritis(PsA)is always difficult.Systemic treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability issues.Drugs injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of PsA.The limited treatment options for PsA present a challenge.
文摘利用直剪仪针对6种不同垂直压力(25、50、75、100、125、150 k Pa)下的大豆粮堆,在0. 6、1. 0、1. 2 mm/min 3种不同剪切速率条件下,进行了系统的试验研究。探讨了剪切速率和剪应力-剪位移曲线规律;分析了大豆粮堆的强度特性和内摩擦特性。结果表明:大豆粮堆剪切变形可分为线弹性阶段、应力强化阶段、颗粒压缩阶段。通过直剪试验测得大豆粮堆抗剪强度符合摩尔-库伦强度准则。大豆粮堆在25～150 k Pa垂直压力作用下,黏聚力随剪切速率的增大而减小,内摩擦角随剪切速率的增大而增大。在同种垂直压力下,剪切速率越大,剪应力增长越快;但最终会趋于一致。随着垂直压力的增加,大豆粮堆软化程度下降。
