The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constru...The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. In this review, we highlight the challenges facing those seeking to create artificial tubular tissue with its associated complex macro- and microscopic architecture. Current biofabrication approaches, including 3D printing techniques, are reviewed and future directions suggested.展开更多
We proposed and demonstrated a kinetically interlocking multiple-units supramolecular polymer-ization strategy.Through rationally designed multi-ple-units monomers,the degree of polymerization(X w)detected was more th...We proposed and demonstrated a kinetically interlocking multiple-units supramolecular polymer-ization strategy.Through rationally designed multi-ple-units monomers,the degree of polymerization(X w)detected was more than 50 with a polydispersi-ty index of∼1.4.The prepared polymers were stable when diluted to 20μM or lower concentrations.展开更多
基金We acknowledge the funding support from UK Engineering and Physical Sciences Research Council （EPSRC） on the Doctoral Prize Fellowship （Grant No. EP/N509760/1） for IH and the EngD studentship （Grant No. EP/L015595/1） for JL. JZS is funded by Overseas Scholarship Council and Ministry of Education in China. We also acknowledge the funding support from China-UK Research and Innovation Partnership Fund： Newton Fund Ph.D. placement programme. We thank the National Natural Science Foundation of China （No. 21534007）, and the Beijing Municipal Science ＆ Technology Commission for their financial support.
文摘The therapeutic replacement of diseased tubular tissue is hindered by the availability and suitability of current donor, autologous and synthetically derived protheses. Artificially created, tissue engineered, constructs have the potential to alleviate these concerns with reduced autoimmune response, high anatomical accuracy, long-term patency and growth potential. The advent of 3D bioprinting technology has further supplemented the technological toolbox, opening up new biofabrication research opportunities and expanding the therapeutic potential of the field. In this review, we highlight the challenges facing those seeking to create artificial tubular tissue with its associated complex macro- and microscopic architecture. Current biofabrication approaches, including 3D printing techniques, are reviewed and future directions suggested.
基金This work was supported by the National Natural Science Foundation of China(No.21890731 and 21821001).
文摘We proposed and demonstrated a kinetically interlocking multiple-units supramolecular polymer-ization strategy.Through rationally designed multi-ple-units monomers,the degree of polymerization(X w)detected was more than 50 with a polydispersi-ty index of∼1.4.The prepared polymers were stable when diluted to 20μM or lower concentrations.
