NMR serves as an important technique for probing rock pore space,such as pore structure characterization,fluid identification,and petrophysical property testing,due to the reusability of cores,convenience in sample pr...NMR serves as an important technique for probing rock pore space,such as pore structure characterization,fluid identification,and petrophysical property testing,due to the reusability of cores,convenience in sample processing,and time efficiency in laboratory tests.In practice,NMR signal collection is normally achieved through polarized nuclei relaxation which releases crucial relaxation messages for result interpretation.The impetus of this work is to help engineers and researchers with petroleum background obtain new insights into NMR principals and extend existing methodologies for characterization of unconventional formations.This article first gives a brief description of the development history of relaxation theories and models for porous media.Then,the widely used NMR techniques for characterizing petrophysical properties and pore structures are presented.Meanwhile,limitations and deficiencies of them are summarized.Finally,future work on improving these insufficiencies and approaches of enhancement applicability for NMR technologies are discussed.展开更多
AIM: To evaluate the diagnostic value of B-scan ultrasound and explore the cytological characteristics of patients with vitreoretinal lymphoma(VRL) and primary central nervous system lymphoma(PCNSL).METHODS: The clini...AIM: To evaluate the diagnostic value of B-scan ultrasound and explore the cytological characteristics of patients with vitreoretinal lymphoma(VRL) and primary central nervous system lymphoma(PCNSL).METHODS: The clinical data and pathologic specimens from patients with VRL diagnosed at the North Huashan Hospital from 2016 to 2017 were retrospectively reviewed. The patients were diagnosed by slit lamp ophthalmoscopy, B-scan ultrasound, cytology of the vitreous, which was obtained by vitrectomy, and cytokine measurements of interleukin(IL)-10 and IL-6.RESULTS: Twenty-six eyes(19.4%) out of 134 eyes of 67 patients(47 men and 20 women) with PCNSL were diagnosed with VRL by B-scan ultrasound, and 14 eyes(10.4%) were diagnosed by slit lamp ophthalmoscopy. Twenty-four eyes(17.9%) of 17 patients were confirmed as having VRL with cytology. No difference in the association between intracranial lesion location and ocular involvement was found. VRL patients had higher levels of vitreous IL-10 and IL-10/IL-6 when compared with macular hole cases, but the difference was not statistically significant.CONCLUSION: A total of 25.4% of the PCNSL patients had VRL, B-scan ultrasound examination had characteristic features and is recommended over slit lamp ophthalmoscopy for the screening diagnosis of PCNSL with intraocular involvement. Moreover, the cytological and immunohistochemical analyses performed after 25-gauge diagnostic vitrectomy were accurate diagnostic techniques.展开更多
Camouflaged targets are a type of nonsalient target with high foreground and background fusion and minimal target feature information,making target recognition extremely difficult.Most detection algorithms for camoufl...Camouflaged targets are a type of nonsalient target with high foreground and background fusion and minimal target feature information,making target recognition extremely difficult.Most detection algorithms for camouflaged targets use only the target’s single-band information,resulting in low detection accuracy and a high missed detection rate.We present a multimodal image fusion camouflaged target detection technique (MIF-YOLOv5) in this paper.First,we provide a multimodal image input to achieve pixel-level fusion of the camouflaged target’s optical and infrared images to improve the effective feature information of the camouflaged target.Second,a loss function is created,and the K-Means++clustering technique is used to optimize the target anchor frame in the dataset to increase camouflage personnel detection accuracy and robustness.Finally,a comprehensive detection index of camouflaged targets is proposed to compare the overall effectiveness of various approaches.More crucially,we create a multispectral camouflage target dataset to test the suggested technique.Experimental results show that the proposed method has the best comprehensive detection performance,with a detection accuracy of 96.5%,a recognition probability of92.5%,a parameter number increase of 1×10^(4),a theoretical calculation amount increase of 0.03 GFLOPs,and a comprehensive detection index of 0.85.The advantage of this method in terms of detection accuracy is also apparent in performance comparisons with other target algorithms.展开更多
Meloxicam-β-cyclodextrin （ME-β-CD） inclusion complex was prepared by a fluid-bed coating technique upon solvent removal and simultaneous depositing onto the surface of nonpareil pellets and using PVP K30 as a bind...Meloxicam-β-cyclodextrin （ME-β-CD） inclusion complex was prepared by a fluid-bed coating technique upon solvent removal and simultaneous depositing onto the surface of nonpareil pellets and using PVP K30 as a binding agent to facilitate good coating. The resultant pellets were spherical and intact in shape with good flowability and friability. SEM analysis showed that the pellets were smooth and had a tightly coated inclusion complex layer. In vitro dissolution of the inclusion complex pellets in pH 7.4 phosphate buffer was dramatically enhanced at an ME/CD ratio of 1/1. DSC and powder X-ray diffractometry proved the absence of crystallinity in the ME/CD inclusion complexes. Moreover, Fourier transform-infrared spectrometry together with Raman spectrometry indicated that the thiazole ring of ME was possibly included in the cavity of β-CD.展开更多
A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosens...A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosensitizer.The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.展开更多
基金financially supported by the National Science Foundation for Distinguished Young Scholars(51525404)the National Science and Technology Major Project(No.2016ZX05002002)the National Science and Technology Major Project(2016ZX05048-004-006)。
文摘NMR serves as an important technique for probing rock pore space,such as pore structure characterization,fluid identification,and petrophysical property testing,due to the reusability of cores,convenience in sample processing,and time efficiency in laboratory tests.In practice,NMR signal collection is normally achieved through polarized nuclei relaxation which releases crucial relaxation messages for result interpretation.The impetus of this work is to help engineers and researchers with petroleum background obtain new insights into NMR principals and extend existing methodologies for characterization of unconventional formations.This article first gives a brief description of the development history of relaxation theories and models for porous media.Then,the widely used NMR techniques for characterizing petrophysical properties and pore structures are presented.Meanwhile,limitations and deficiencies of them are summarized.Finally,future work on improving these insufficiencies and approaches of enhancement applicability for NMR technologies are discussed.
基金Supported by the National Natural Science Foundation of China(No.81700123)the Shanghai Hospital Development Centre(No.16CR2043B)
文摘AIM: To evaluate the diagnostic value of B-scan ultrasound and explore the cytological characteristics of patients with vitreoretinal lymphoma(VRL) and primary central nervous system lymphoma(PCNSL).METHODS: The clinical data and pathologic specimens from patients with VRL diagnosed at the North Huashan Hospital from 2016 to 2017 were retrospectively reviewed. The patients were diagnosed by slit lamp ophthalmoscopy, B-scan ultrasound, cytology of the vitreous, which was obtained by vitrectomy, and cytokine measurements of interleukin(IL)-10 and IL-6.RESULTS: Twenty-six eyes(19.4%) out of 134 eyes of 67 patients(47 men and 20 women) with PCNSL were diagnosed with VRL by B-scan ultrasound, and 14 eyes(10.4%) were diagnosed by slit lamp ophthalmoscopy. Twenty-four eyes(17.9%) of 17 patients were confirmed as having VRL with cytology. No difference in the association between intracranial lesion location and ocular involvement was found. VRL patients had higher levels of vitreous IL-10 and IL-10/IL-6 when compared with macular hole cases, but the difference was not statistically significant.CONCLUSION: A total of 25.4% of the PCNSL patients had VRL, B-scan ultrasound examination had characteristic features and is recommended over slit lamp ophthalmoscopy for the screening diagnosis of PCNSL with intraocular involvement. Moreover, the cytological and immunohistochemical analyses performed after 25-gauge diagnostic vitrectomy were accurate diagnostic techniques.
基金Project supported by the Shandong Provincial Natural Science Foundation of China(No.ZR2020MF015)the Aerospace Science and Technology Innovation Institute Stabilization Support Project(No.ZY0110020009)。
文摘Camouflaged targets are a type of nonsalient target with high foreground and background fusion and minimal target feature information,making target recognition extremely difficult.Most detection algorithms for camouflaged targets use only the target’s single-band information,resulting in low detection accuracy and a high missed detection rate.We present a multimodal image fusion camouflaged target detection technique (MIF-YOLOv5) in this paper.First,we provide a multimodal image input to achieve pixel-level fusion of the camouflaged target’s optical and infrared images to improve the effective feature information of the camouflaged target.Second,a loss function is created,and the K-Means++clustering technique is used to optimize the target anchor frame in the dataset to increase camouflage personnel detection accuracy and robustness.Finally,a comprehensive detection index of camouflaged targets is proposed to compare the overall effectiveness of various approaches.More crucially,we create a multispectral camouflage target dataset to test the suggested technique.Experimental results show that the proposed method has the best comprehensive detection performance,with a detection accuracy of 96.5%,a recognition probability of92.5%,a parameter number increase of 1×10^(4),a theoretical calculation amount increase of 0.03 GFLOPs,and a comprehensive detection index of 0.85.The advantage of this method in terms of detection accuracy is also apparent in performance comparisons with other target algorithms.
基金the School of Pharmacy,Hehai University,for financial support
文摘Meloxicam-β-cyclodextrin （ME-β-CD） inclusion complex was prepared by a fluid-bed coating technique upon solvent removal and simultaneous depositing onto the surface of nonpareil pellets and using PVP K30 as a binding agent to facilitate good coating. The resultant pellets were spherical and intact in shape with good flowability and friability. SEM analysis showed that the pellets were smooth and had a tightly coated inclusion complex layer. In vitro dissolution of the inclusion complex pellets in pH 7.4 phosphate buffer was dramatically enhanced at an ME/CD ratio of 1/1. DSC and powder X-ray diffractometry proved the absence of crystallinity in the ME/CD inclusion complexes. Moreover, Fourier transform-infrared spectrometry together with Raman spectrometry indicated that the thiazole ring of ME was possibly included in the cavity of β-CD.
基金supported by the Natural Science Foundation of China(Nos.21701054,21877049)Guangdong Natural Science Foundation(No.2017A030310409)+6 种基金the Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province(No.2017KF06)Major Program for Tackling Key Problems of Industrial Technology in Guangzhou(No.201902020013)Pearl River Nova Program of Guangzhou(No.201906010077)Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province(Nos.GDOE-2019-A31,2020-035)Fundamental Research Funds for the Central UniversitiesGuangdong Provincial Key Laboratory Fund of Functional Supramolecular Coordination Materials and ApplicationsK.C.Wong Education Foundation。
文摘A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent regulation.To the best of our knowledge,this is the first osmium-based coordination complex radiosensitizer.The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.
