Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic a...Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic alterations and predictive biomarkers in sera have not been defined.Here,we enrolled 34 treatment-naive patients with ESCC and collected their pre-and post-esophagectomy sera together with the sera from 34 healthy volunteers for a metabolomic survey.Our comprehensive analysis identified ESCC tumor-associated metabolic alterations as represented by a panel of 12 serum metabolites.Notably,postoperative abrosia and parenteral nutrition substantially perturbed the serum metabolome.Furthermore,we performed an examination using sera from carcinogen-induced mice at the dysplasia and ESCC stages and identified three ESCC tumor-associated metabolites conserved between mice and humans.Notably,among these metabolites,the level of pipecolic acid was observed to be progressively increased in mouse sera from dysplasia to cancerization,and it could be used to accurately discriminate between mice at the dysplasia stage and healthy control mice.Furthermore,this metabolite is essential for ESCC cells to restrain oxidative stress-induced DNA damage and cell proliferation arrest.Together,this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse,presented evidence for refining parenteral nutrition composition,and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis.展开更多
Nonreciprocal microwave devices,in which the transmission of waves is non-symmetric between two ports,are indispensable for the manipulation of information processing and communication.In this work,we show the nonreci...Nonreciprocal microwave devices,in which the transmission of waves is non-symmetric between two ports,are indispensable for the manipulation of information processing and communication.In this work,we show the nonreciprocal microwave transmission in a cavity magnonic system under the joint mechanism of phase modulation and magnon Kerr nonlinearity effect.In contrast to the schemes based on the standard phase modulation or magnon Kerr nonlinearity,we find that the joint mechanism enables the nonreciprocal transmission even at low power and makes us obtain a high nonreciprocal isolation ratio.Moreover,when two microwave modes are coupled to the magnon mode via a different coupling strength,the presented strong nonreciprocal response occurs,and it makes the nonreciprocal transmission manipulating by the magnetic field within a large adjustable range possible,which overcomes narrow operating bandwidths.This study may provide promising opportunities to realize nonreciprocal structures for wave transmission.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.31970708,81770147,81802891,and 82002953)the National Scientific and Technological Major Special Project of China(Grant No.2019ZX09201004-002-013)+11 种基金the National Thirteenth Five-Year Science and Technology Major Special Project for New Drug Innovation and Development(Grant No.2017ZX09304001)the Research fund of Shanghai Municipal Commission of Health(Grant No.20174Y0090)the Shanghai Rising-Star Program(Grant No.18QA1404100)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learningthe Shanghai Youth Talent Programthe Shanghai Municipal Key Clinical Specialty(Grant No.shslczdzk03701)the Three-Year Plan of Shanghai Municipality for Further Accelerating The Development of Traditional Chinese Medicine[Grant No.ZY(20182020)-CCCX-1016]the Shanghai Chenguang Program(Grant No.18CG47)the grant from Nantong Tumor Hospital(Grant No.BS201909)the Gaofeng Clinical Medicine Grant of Shanghai Municipal Education Commissionthe Health Commission of Pudong New Area Health and Family Planning Scientific Research Project(Grant No.PW2019E-1)the Xinling Scholar Program of Shanghai University of Traditional Chinese Medicine,China。
文摘Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic alterations and predictive biomarkers in sera have not been defined.Here,we enrolled 34 treatment-naive patients with ESCC and collected their pre-and post-esophagectomy sera together with the sera from 34 healthy volunteers for a metabolomic survey.Our comprehensive analysis identified ESCC tumor-associated metabolic alterations as represented by a panel of 12 serum metabolites.Notably,postoperative abrosia and parenteral nutrition substantially perturbed the serum metabolome.Furthermore,we performed an examination using sera from carcinogen-induced mice at the dysplasia and ESCC stages and identified three ESCC tumor-associated metabolites conserved between mice and humans.Notably,among these metabolites,the level of pipecolic acid was observed to be progressively increased in mouse sera from dysplasia to cancerization,and it could be used to accurately discriminate between mice at the dysplasia stage and healthy control mice.Furthermore,this metabolite is essential for ESCC cells to restrain oxidative stress-induced DNA damage and cell proliferation arrest.Together,this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse,presented evidence for refining parenteral nutrition composition,and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis.
基金the National Natural Science Foundation of China(Grant Nos.12105092 and 12022507)Program for Innovative Teams of Outstanding Young and Middle-aged Researchers in the Higher Education Institution of Hubei Province(No.T2020014).
文摘Nonreciprocal microwave devices,in which the transmission of waves is non-symmetric between two ports,are indispensable for the manipulation of information processing and communication.In this work,we show the nonreciprocal microwave transmission in a cavity magnonic system under the joint mechanism of phase modulation and magnon Kerr nonlinearity effect.In contrast to the schemes based on the standard phase modulation or magnon Kerr nonlinearity,we find that the joint mechanism enables the nonreciprocal transmission even at low power and makes us obtain a high nonreciprocal isolation ratio.Moreover,when two microwave modes are coupled to the magnon mode via a different coupling strength,the presented strong nonreciprocal response occurs,and it makes the nonreciprocal transmission manipulating by the magnetic field within a large adjustable range possible,which overcomes narrow operating bandwidths.This study may provide promising opportunities to realize nonreciprocal structures for wave transmission.
