Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct me...Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct medication for preventing neuron loss after reperfusion to mitigate longlasting brain injury.Extrasynaptic N-methyl-Daspartate receptors (esNMDARs) are the major cause of ischemic neuronal death.However,there is no inhibitor selectively ta rgeting esNMDARs without compromising the function of other"beneficial"syna ptic NMDARs.展开更多
In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation ...In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation of gravity before the Alxa Zuoqi M5.8 earthquake. The relationship between gravity variation and the Alxa Zuoqi M5.8 earthquake was analyzed. The results showed that： （1） the severe variation in gravity field at the test sites before the Alxa Zuoqi M5.8 earthquake, as well as the subsequent accelerated rising, might be an earthquake precursor; （2） the Alxa Zuoqi M5.8 earthquake occurred at the turning point where the high-gravity gradient zone changed from the NE direction to NW.展开更多
Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-o...Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-oxidative ageing differs,such that the UV ageing performance cannot be determined based on the thermal-oxidative ageing performance.Previous researches mainly focused on the chemical composite and technical performance changes of asphalt binder during UV ageing,and the UV light parameters effect on the ageing rate of asphalt binder.However,the theory for characterizing and explaining the development of UV ageing depth does not get too much attentions,and the UV ageing mechanism of asphalt binder is not very clear.Therefore,it cannot guide to develop or select the good methods or anti-UV ageing additives for asphalt binders.This paper focuses on the latest researches of the mechanisms and anti-ageing methods of asphalt binders.With the increase of UV ageing time,the UV ageing of asphalt binder develops gradually from the surface to inner part.There are various methods,such as low-penetration grade asphalt,less air void ratio,UV stabilizers and UV light absorbers,that can improve the UV ageing resistance of asphalt binders.A new theory of sensitive wavelengths of asphalt UV ageing is proposed,which can enrich the basic theory of asphalt UV ageing.Depending on this theory,different wavelengths of UV light have different ageing effects on asphalt binder.The composite anti-UV ageing additives with barrier and specific absorption effects on UV light is proposed,and may have better improvement effect on the anti-UV ageing performance of asphalt binder.展开更多
Ischemic stroke is a devastating disease that affects millions of patients worldwide.Unfortunately,there are no effective medications for mitigating brain injury after ischemic stroke.TRP channels are evolutionally an...Ischemic stroke is a devastating disease that affects millions of patients worldwide.Unfortunately,there are no effective medications for mitigating brain injury after ischemic stroke.TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury.To date,many members of the TRP superfamily have been reported to contribute to ischemic brain injury,including the TRPC subfamily(1,3,4,5,6,7),TRPV subfamily(1,2,3,4)and TRPM subfamily(2,4,7).These TRP channels share structural similarities but have distinct channel functions and properties.Their activation during ischemic stroke can be beneficial,detrimental,or even both.In this review,we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.展开更多
Small berries including strawberry and blueberry are extensively consumed fruits with great economic values due to their characteristic flavor and appearance as well as potential health benefits.This review elaborated...Small berries including strawberry and blueberry are extensively consumed fruits with great economic values due to their characteristic flavor and appearance as well as potential health benefits.This review elaborated the optical non-destructive techniques viz.Vis-NIR spectroscopy,computer vision system,hyperspectral imaging,multispectral imaging,laser-induced method and thermal imaging,and their applications for quality and safety control of small berry fruits.The discussion regarding the photoacoustic technique,X-ray technique,Terahertz spectroscopy,odor imaging,micro-destructive testing and smart mobile terminal-based analyzer was also presented.Furthermore,we proposed our personal understanding of the technical challenges and further trends for these optical non-destructive techniques:1)owing to the relatively low detection limit,the so-called micro-destructive techniques may be alternative to the traditional non-destructive techniques in both practical and fundamental research;2)we suggest that the research articles like“collecting data first,and then modeling the relevant properties of agricultural products by machine learning”should be less produced in related fields.That's because such research methods are likely to be suspected of“cheating”.It is recommended that some modeling competitions can be carried out in the agricultural engineering field to avoid or reduce the“cheating”model.展开更多
基金National Institute of Health (R01-HL143750)American Heart Association (19TPA34890022) to LY。
文摘Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct medication for preventing neuron loss after reperfusion to mitigate longlasting brain injury.Extrasynaptic N-methyl-Daspartate receptors (esNMDARs) are the major cause of ischemic neuronal death.However,there is no inhibitor selectively ta rgeting esNMDARs without compromising the function of other"beneficial"syna ptic NMDARs.
基金supported by the China Earthquake Administration Earthquake Tracking Task Orientation(2016020202,2016010216,and 2016010220)the“Three Combination”project of the China Earthquake Administration(163201)+2 种基金the National Natural Science Foundation of China(41204058,41474064,and 41374088)the special earthquake research,China Earthquake Administration(201508009-08)the Director,Foundation of Institute of Seismology,China Earthquake Administration(IS201326123)
文摘In this study, a classic survey adjustment computation method was used for data obtained in the Inner Mongolia and Ningxia gravimetric networks between September 2013 and April 2015 so as to investigate the variation of gravity before the Alxa Zuoqi M5.8 earthquake. The relationship between gravity variation and the Alxa Zuoqi M5.8 earthquake was analyzed. The results showed that： （1） the severe variation in gravity field at the test sites before the Alxa Zuoqi M5.8 earthquake, as well as the subsequent accelerated rising, might be an earthquake precursor; （2） the Alxa Zuoqi M5.8 earthquake occurred at the turning point where the high-gravity gradient zone changed from the NE direction to NW.
基金The authors acknowledge the financial supported by National Natural Science Foundation of China(No.52108415 and No.51808517)the National Key R&D Program of China(No.2018YFB1600200)+5 种基金the Key Technical Innovation Projects of Hubei Province(No.2019AEE023)the Key R&D Program of Hubei Province(No.2020BCB064)the State Key Laboratory of Silicate Materials for Architectures(Wuhan University of Technology)(No.SYSJJ2022-21),the Transportation Technology Project of Department of Transport of Hubei Province(No.2022-11-1-10)the European Union's Horizon 2020 Research and Innovation Programme Under the Marie Skłodowska-Curie Grant Agreement(No.101030767)the Scientific Research Fund Project of Wuhan Institute of Technology(No.K2021032)the Open Fund of National&Local Joint Engineering Laboratory of Traffic Civil Engineering Materials,Chongqing Jiaotong University(No.LHSYS-2020-004).
文摘Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-oxidative ageing differs,such that the UV ageing performance cannot be determined based on the thermal-oxidative ageing performance.Previous researches mainly focused on the chemical composite and technical performance changes of asphalt binder during UV ageing,and the UV light parameters effect on the ageing rate of asphalt binder.However,the theory for characterizing and explaining the development of UV ageing depth does not get too much attentions,and the UV ageing mechanism of asphalt binder is not very clear.Therefore,it cannot guide to develop or select the good methods or anti-UV ageing additives for asphalt binders.This paper focuses on the latest researches of the mechanisms and anti-ageing methods of asphalt binders.With the increase of UV ageing time,the UV ageing of asphalt binder develops gradually from the surface to inner part.There are various methods,such as low-penetration grade asphalt,less air void ratio,UV stabilizers and UV light absorbers,that can improve the UV ageing resistance of asphalt binders.A new theory of sensitive wavelengths of asphalt UV ageing is proposed,which can enrich the basic theory of asphalt UV ageing.Depending on this theory,different wavelengths of UV light have different ageing effects on asphalt binder.The composite anti-UV ageing additives with barrier and specific absorption effects on UV light is proposed,and may have better improvement effect on the anti-UV ageing performance of asphalt binder.
基金partially supported by the National Institute of Health(R01-HL143750 and R01NS131661)American Heart Association(19TPA34890022)to LYthe Connecticut Institute for the Brain and Cognitive Sciences Seed Grant(402194)to PZ.
文摘Ischemic stroke is a devastating disease that affects millions of patients worldwide.Unfortunately,there are no effective medications for mitigating brain injury after ischemic stroke.TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury.To date,many members of the TRP superfamily have been reported to contribute to ischemic brain injury,including the TRPC subfamily(1,3,4,5,6,7),TRPV subfamily(1,2,3,4)and TRPM subfamily(2,4,7).These TRP channels share structural similarities but have distinct channel functions and properties.Their activation during ischemic stroke can be beneficial,detrimental,or even both.In this review,we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.
基金This work was supported by the Shanghai Sailing Program under Grant 19YF1414100the China Postdoctoral Science Foundation funded project under Grant 2016M600315+1 种基金the Innovation Fund Project for Graduate Student of Shanghai(JWCXSL1401)the STCSM(No.18DZ2270700).
文摘Small berries including strawberry and blueberry are extensively consumed fruits with great economic values due to their characteristic flavor and appearance as well as potential health benefits.This review elaborated the optical non-destructive techniques viz.Vis-NIR spectroscopy,computer vision system,hyperspectral imaging,multispectral imaging,laser-induced method and thermal imaging,and their applications for quality and safety control of small berry fruits.The discussion regarding the photoacoustic technique,X-ray technique,Terahertz spectroscopy,odor imaging,micro-destructive testing and smart mobile terminal-based analyzer was also presented.Furthermore,we proposed our personal understanding of the technical challenges and further trends for these optical non-destructive techniques:1)owing to the relatively low detection limit,the so-called micro-destructive techniques may be alternative to the traditional non-destructive techniques in both practical and fundamental research;2)we suggest that the research articles like“collecting data first,and then modeling the relevant properties of agricultural products by machine learning”should be less produced in related fields.That's because such research methods are likely to be suspected of“cheating”.It is recommended that some modeling competitions can be carried out in the agricultural engineering field to avoid or reduce the“cheating”model.
