China's local colleges and universities are the main force of China's higher education.Due to the limited construction funds,weak discipline foundation and other reasons,China's local colleges and universi...China's local colleges and universities are the main force of China's higher education.Due to the limited construction funds,weak discipline foundation and other reasons,China's local colleges and universities generally face the embarrassment of weak discipline.How to break the constraints of the traditional management system,concentrate and efficiently allocate limited resources to achieve the overall improvement of the discipline construction level,the successful experience of China's special economic zones provides model reference and construction guidance for Chinese local universities.This study takes the subject special zones of local universities in China as the research object,chooses the theoretical system of economics and institutional theory as the logical starting point of the research,constructs the research framework of three dimensions of idea value,system design and action strategy,takes the reform of special economic zones as the institutional model and practice reference,and carries out the research from five dimensions of reform subject,logic,path,idea and strategy.Explore the effective development path of the rise of discipline construction.展开更多
Objective： The safety of the simultaneous resection of synchronous colorectal cancer liver metastases （SCRLM） is still being debated. However, this simultaneous operative approach is more commonly adopted at presen...Objective： The safety of the simultaneous resection of synchronous colorectal cancer liver metastases （SCRLM） is still being debated. However, this simultaneous operative approach is more commonly adopted at present than in the past. Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study.Methods： All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study. Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy.Results： Among the 73 patients diagnosed with SCRLM, simultaneous coloreetal and hepatic resection was performed in 60 patients （82.2%）, while delayed hepatic resection was performed in 13 patients （17.8%）. The mortality rate was zero. The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection （46% vs. 23%, P=0.166）. The duration of operating time （240 vs. 420 min, P〈0.05） and postoperative hospital stay time （11 vs. 18 days, P〈0.05） were shorter in the simultaneous resection group. After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively. The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups （P=0.037）. Median disease-free survival （DFS） times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group. DFS differed significantly between the two groups. Coenclusions： Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the longtime survival of patients.展开更多
Objective：This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods：The ...Objective：This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods：The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes：clear cell carcinoma（CCC）,giant cell carcinoma（GCC）,sarcomatoid carcinoma（SC）,and combined hepatocellular-cholangiocarcinoma（CHC）between October 1998 and August 2015 were reviewed.Their survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma（HCC）（early-and advanced-stage HCC）during the same period.Results：The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC group.Also,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC group.The SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC group.No statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival analysis.The incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the prognosis.Conclusions：CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC.However,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis.展开更多
Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We a...Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance.展开更多
Objectives： To explore the prognostic relevance of the number and ratio of metastatic lymph nodes in resected Carcinoma of the ampulla of Vater （CAV）. Methods： The clinical data of 155 patients who underwent pancr...Objectives： To explore the prognostic relevance of the number and ratio of metastatic lymph nodes in resected Carcinoma of the ampulla of Vater （CAV）. Methods： The clinical data of 155 patients who underwent pancreaticoduodenectomy （PD） for cancer of the ampulla of Vater between January 1990 and December 2010 were retrospectively analyzed. Kaplan- Meier method was used in survival analysis and Log rank method in comparison. Multivariate analysis was performed using Cox proportional hazards model. Results： Among these 155 patients, the in-hospital mortality rate was 4.5%, lymph node positive disease was 21.3%, and the 5-year survival rate was 51.6%. Patients with a lymph node ratio （LNR） 〉20% were more likely to have tumor differentiation, depth of duodenal involvement, depth of pancreatic invasion, T-stage and TNM-Stage. The number of the metastatic lymph nodes is important prognostic factors of the CAV. Univariate analysis showed that the factors associated with the prognosis included tumor size （P=0.036）, tumor differentiation （P=0.019）, LNR （P=0.032）, mtmber of metastatic lymph nodes （P=0.024）, lymph node metastasis （P=0.03）, depth of pancreatic invasion （P=0.001）, T-stage （P=0.002）, TNM stage （P=0.001）, elevated CA 19-9 （P=0.000）, and jaundice （P=0.021）. Multivariate analysis showed that the factors associated with the prognosis were the number of metastatic lymph nodes （P=0.032; RR： 1.283; 95% CI： 1.022-1.611）, tumor size （P=0.043; RR： 1.736; 95% CI： 1.017-2.963）, and elevated CA 19-9 （P=0.003; RR： 3.247; 95% CI： 1.504-7.010）. Conclusions： LNR is a useful factor for predicting the prognosis of the radical treatment for CAV,, whereas the number of metastatic lymph nodes is the most important factor. Further research on the locations, number, and LNR will be clinically meaningful to improve survival in patients with CAV.展开更多
Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed ...Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed on professional cross-presenting CD8α^+dendritic cells(DCs).展开更多
Development of modern agriculture has higher and higher requirements on quality of peasants.This study,on the basis of connotations of modern agriculture,current situation and problems of Chinese peasants,and contradi...Development of modern agriculture has higher and higher requirements on quality of peasants.This study,on the basis of connotations of modern agriculture,current situation and problems of Chinese peasants,and contradictions between modern agricultural development and peasants' quality,specifies requirements of modern agriculture on new peasants,proposes corresponding suggestions to promote the cultivation of new Chinese peasants.展开更多
Resurrection plants, which are the ＂gifts＂ of natural evolution, are ideal models for studying the genetic basis of plant desiccation tolerance. Here, we report a high-quality genome assembly of 301 Mb for the diplo...Resurrection plants, which are the ＂gifts＂ of natural evolution, are ideal models for studying the genetic basis of plant desiccation tolerance. Here, we report a high-quality genome assembly of 301 Mb for the diploid spike moss Selaginella tamariscina, a primitive vascular resurrection plant. We predicated 27 761 protein-coding genes from the assembled S. tarnariscina genome, 11.38% （2363） of which showed signifi- cant expression changes in response to desiccation. Approximately 60.58% of the S. tamariscina genome was annotated as repetitive DNA, which is an almost 2-fold increase of that in the genome of desiccation- sensitive Selaginella moellendorffii. Genomic and transcriptomic analyses highlight the unique evolution and complex regulations of the desiccation response in S. tamariscina, including species-specific expan- sion of the oleosin and pentatricopeptide repeat gene families, unique genes and pathways for reactive oxygen species generation and scavenging, and enhanced abscisic acid （ABA） biosynthesis and potentially distinct regulation of ABA signaling and response. Comparative analysis of chloroplast genomes of several Selaginella species revealed a unique structural rearrangement and the complete loss of chloroplast NAD（P） H dehydrogenase （NDH） genes in S. tamariscina, suggesting a link between the absence of the NDH com- plex and desiccation tolerance. Taken together, our comparative genomic and transcriptomic analyses reveal common and species-specific desiccation tolerance strategies in S. tamariscina, providing signifi- cant insights into the desiccation tolerance mechanism and the evolution of resurrection plants.展开更多
Over the past 30 years,there has been continuous progress in global science and technology.However,many agricultural products still heavily rely on traditional methods of manual and mechanical harvesting,facing challe...Over the past 30 years,there has been continuous progress in global science and technology.However,many agricultural products still heavily rely on traditional methods of manual and mechanical harvesting,facing challenges such as high costs and low efficiency.To address these challenges,researchers have developed various harvesting robots to handle diverse tasks in complex farm environments.This study analyzed pertinent papers on harvesting robots retrieved from the Web of Science(WOS)core database and the China National Knowledge Infrastructure(CNKI)database,spanning the years 1993 to 2022.Using specialized software such as CiteSpace and VOSviewer,a bibliometric analysis was conducted to examine the research progress and hotspots in the field of harvesting robots.The analysis of 517 English papers indicated a continuous expansion in the research scale of harvesting robots.Furthermore,the research history can be divided into three distinct periods.Currently,research on harvesting robots is experiencing a rapid growth phase,with the number of related papers steadily increasing each year.In the year 2022 alone,151 English papers were published.This growth is attributed to close collaborations among different countries/regions,institutions,and authors.China,the United States,and Japan play crucial roles in the research of harvesting robots.Notably,China has published 326 English papers,ranking first globally.Through analysis,it was also found that Chinese papers focused on harvesting robots earlier,thereby promoting the development of agricultural robots.Additionally,bibliometric analysis revealed that the research hotspots of harvesting robots mainly include system and structure design,object recognition and localization,and multi-robot coordination,among others.In the future,development trends of harvesting robots will focus on:1)diversifying robot types,2)expanding application scenarios,3)enhancing overall performance to reduce losses,and 4)reducing manufacturing costs.In conclusion,through a comprehensive bibliometric analysis,this study has provided valuable insights to advance the automation of harvesting.展开更多
Background:The prognosis of hepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT)is extremely poor.The clinical outcome of preoperative radiotherapy(RT)is still controversial.This study aimed to compare t...Background:The prognosis of hepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT)is extremely poor.The clinical outcome of preoperative radiotherapy(RT)is still controversial.This study aimed to compare the clinical outcomes of combined neoadjuvant RT and hepatectomy with hepatectomy alone for HCC with PVTT.Methods:Comprehensive database searches were performed in PubMed,the Cochrane Library,EMBASE,and the Web of Science to retrieve studies published from the database creation to July 1,2020.Only comparative studies that measured survival between neoadjuvant RT followed by hepatectomy and hepatectomy alone were included.The characteristics of the included studies and patients were extracted,and the included data are presented as relative ratio(RR)estimates with 95%confidence intervals(CIs)for all outcomes.The RRs of each study were pooled using a fixed or random effects model with Review Manager(the Cochrane Collaboration,Oxford,UK)version 5.3.The response rate to RT and the overall survival(OS)rate in neoadjuvant RT followed by hepatectomy and hepatectomy alone were measured.Results:One randomized and two non-randomized controlled trials with 302 patients were included.Most patients were classified as Child-Pugh A,and Type II and III PVTT were the most common types.After RT,29(22.8%)patients were evaluated as partial response(PR)and had a positive RT response,but nine(7.1%)had progressive disease(PD).Neoadjuvant RT followed by hepatectomy was received by 127(42.1%)patients after excluding 15(5.0%)patients with severe complications or PD after RT,and 160(53.0%)patients received hepatectomy alone.In the randomized controlled trial(RCT),the 1-year OS rate in the neoadjuvant RT group and the surgery alone group was 75.2%and 43.1%,respectively(P<0.001).In the two non-randomized studies,a meta-analysis with a fixed effects model showed a longer OS in patients undergoing neoadjuvant RT followed by hepatectomy compared with hepatectomy alone at 1-year follow-up(RR=2.02;95%CI:1.45-2.80;P<0.0001).Conclusions:This systematic review showed that neoadjuvant RT followed by hepatectomy in patients with resectable HCC and PVTT was associated with a longer OS than patients who received hepatectomy alone.展开更多
Research on the extrusion of natural polymers(food,feed,etc.)is relatively new due to the complex physicochemical transformations of raw materials,although plastics melt conveying and transport have been well studied....Research on the extrusion of natural polymers(food,feed,etc.)is relatively new due to the complex physicochemical transformations of raw materials,although plastics melt conveying and transport have been well studied.The structure and composition,rheological behavior as well as extrusion processing of natural polymer are much more complicated.In this study,a quasi-three-dimensional(3D)fluid flow model for non-Newtonian,non-isothermal and undeveloped temperature was developed,the model prediction being in reasonably good agreement with the experiment.Results show that the influence of moisture content,among other process variables,is the most significant,followed by screw speed.Some interaction exists between these two variables and the screw speed effect becomes marginal at high moisture contents.In addition,viscosity change in the channel was studied.展开更多
This paper investigates the power sharing and voltage regulation issues of islanded single-/three-phase microgrids(S/T-MGs)where both sources and loads are unbalanced and the presence of adversarial cyber-attacks agai...This paper investigates the power sharing and voltage regulation issues of islanded single-/three-phase microgrids(S/T-MGs)where both sources and loads are unbalanced and the presence of adversarial cyber-attacks against sensors of distributed generator(DG)units is considered.Firstly,each DG unit is modeled as a heterogeneous linear dynamic agent with disturbances caused by sources and loads,then the problem is formulated as a distributed containment control problem.After that,to guarantee satisfactory power sharing and voltage control performance asymptotically achieved for the S/T-MGs,an attack-resilient distributed secondary control approach is developed by designing a distributed adaptive observer.With this approach,the effect of the cyber-attacks can be neutralized to ensure system stability and preserve bounded voltage synchronization.Simulation results are presented to demonstrate the effectiveness of the proposed control approach.展开更多
The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first confirmed in November 2021 in South Africa^([1])and is more transmissible than other sub-variants.^([2])The influence of Omic...The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first confirmed in November 2021 in South Africa^([1])and is more transmissible than other sub-variants.^([2])The influence of Omicron in children has been recognized with increased hospital admission rate than Delta wave.^([3,4])But severe clinical outcomes and comorbidity of Omicron are less than Delta in children.^([5])Hospitalized children during the Omicron period were more likely to be younger than that in the pre-Omicron period.^([6])展开更多
This paper proposes a novel virtual inertia controller for converters in power systems,whichcan solve the system’s nonlinearity for frequency support.First,the system dynamics are formulatedas a nonlinear state-space...This paper proposes a novel virtual inertia controller for converters in power systems,whichcan solve the system’s nonlinearity for frequency support.First,the system dynamics are formulatedas a nonlinear state-space,in which the reciprocal of inertia is modeled as controlinput.Correspondingly,a cost function is defined by considering frequency deviation andrate of change of the frequency,which can preserve a tradeoff between critical frequencylimits and respective control energy.Following,the optimal frequency regulation problemis solved by using an online adaptive dynamic programming method,where the actor andcritic neural networks are constructed to approximate the optimal control input and optimalcost function,respectively.After that,the small-signal analysis is provided to identify the stabilityof the converter under the proposed controller.Finally,simulation results verify thatthe frequency response of the system is significantly improved,while retaining more DC sideenergy.展开更多
The Chishui River Valley is a microscale ecology-preservation area with industrial clusters.The significance of evaluating vehicular emissions has been gradually highlighted with the rapid development of the local tra...The Chishui River Valley is a microscale ecology-preservation area with industrial clusters.The significance of evaluating vehicular emissions has been gradually highlighted with the rapid development of the local transportation and tourism sectors.This study provides the first estimates based on both bottom-up and top-down approaches.The annual total emissions of CO,NOx,hydrocarbons(HC),PM10,and PM2.5 in 2019 were 347.8,189.6,46.3,6.9,and 6.3 Mg,respectively.Trucks contributed the most(55%)to the NOx emissions,followed by heavy-duty passenger vehicles(26%).In contrast,light-duty passenger vehicles and motorcycles generated 75%of the HC emissions.The superior accuracy of highly spatial and temporal bottom-up estimates versus top-down estimates is validated by the similar variation trends of hourly emission intensities and enhanced concentrations relative to background observations for both NOx and CO,with Pearson correlation coefficients between the intensities and concentrations ranging from 0.79 to 0.85.Historical HC emissions peaked in 2013,followed by a sharp decline in 2014 and a continuous rise since then,whereas NOx emissions have kept increasing since 2010.These indicated the necessity and urgency of effective vehicular emission mitigations.Based on scenario analysis,traffic restrictions combined with upgrading the emission standards of admitted vehicles will possess huge emission reduction potentials.Future recommendations about establishing a low emission zone in the valley and supporting policies were introduced.展开更多
文摘China's local colleges and universities are the main force of China's higher education.Due to the limited construction funds,weak discipline foundation and other reasons,China's local colleges and universities generally face the embarrassment of weak discipline.How to break the constraints of the traditional management system,concentrate and efficiently allocate limited resources to achieve the overall improvement of the discipline construction level,the successful experience of China's special economic zones provides model reference and construction guidance for Chinese local universities.This study takes the subject special zones of local universities in China as the research object,chooses the theoretical system of economics and institutional theory as the logical starting point of the research,constructs the research framework of three dimensions of idea value,system design and action strategy,takes the reform of special economic zones as the institutional model and practice reference,and carries out the research from five dimensions of reform subject,logic,path,idea and strategy.Explore the effective development path of the rise of discipline construction.
基金supported by the National High-Tech R&D Program (863 Program) of China (2015AA020408)the National Natural Science Foundation of China (81201967, 31470073)+2 种基金the Beijing Natural Science Foundation (7132193, 7144238)the Capital Health Research and Development of Special (2014-1-4022)Beijing Nova Program (No.2009A69)
文摘Objective： The safety of the simultaneous resection of synchronous colorectal cancer liver metastases （SCRLM） is still being debated. However, this simultaneous operative approach is more commonly adopted at present than in the past. Therefore, we compared simultaneous hepatic resection with delayed hepatic resection in this study.Methods： All patients with SCRLM diagnosed before initial treatment between January 2009 and September 2013 were retrospectively included in our study. Short-term and long-term outcomes were compared in patients who underwent simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy.Results： Among the 73 patients diagnosed with SCRLM, simultaneous coloreetal and hepatic resection was performed in 60 patients （82.2%）, while delayed hepatic resection was performed in 13 patients （17.8%）. The mortality rate was zero. The postoperative complication rate after delayed resection was higher than, but not significantly different from, that after simultaneous resection （46% vs. 23%, P=0.166）. The duration of operating time （240 vs. 420 min, P〈0.05） and postoperative hospital stay time （11 vs. 18 days, P〈0.05） were shorter in the simultaneous resection group. After the initial treatments were given, the 1-, 2-, and 3-year survival rates in the simultaneous resection group were 77%, 59%, and 53%, respectively, whereas those in the delayed resection group were 67%, 42%, and 10%, respectively. The 5-year survival rate in the simultaneous resection group was 23%; overall survival differed significantly between the two groups （P=0.037）. Median disease-free survival （DFS） times were 19.1 months in the simultaneous resection group and 8.8 months in the delayed resection group. DFS differed significantly between the two groups. Coenclusions： Simultaneous colorectal and hepatic resection is safe and exhibits advantages in the longtime survival of patients.
基金financially supported by the State Key Project on Infection Diseases of China (No.2018ZX10723204-005)the National Natural Science Foundation of China (No.81672461)+3 种基金the National Hightech R&D (863) Program of China (No.2015AA020408)the Capital Health Research and Development of Special(No.2018-1-4021)the CAMS Innovation Fund for Medical Sciences (CIFMS) (No.2016-I2M-1-001)the CAMS Innovation Fund for Medical Sciences (CIFMS) (No.2017-12M-4-002)
文摘Objective：This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods：The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes：clear cell carcinoma（CCC）,giant cell carcinoma（GCC）,sarcomatoid carcinoma（SC）,and combined hepatocellular-cholangiocarcinoma（CHC）between October 1998 and August 2015 were reviewed.Their survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma（HCC）（early-and advanced-stage HCC）during the same period.Results：The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC group.Also,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC group.The SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC group.No statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival analysis.The incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the prognosis.Conclusions：CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC.However,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis.
基金supported by State Key Projects Specialized on Infectious Diseases (No. 2017ZX10201201-006)Key research projects for precision medicine (No. 2017YFC0908103)+1 种基金Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences (CIFMS, No. 2019-I2M-2-004, 2016-I2M-1-007, 2019-I2M-1-003)National Natural Science Foundation Fund (No. 81972628, No. 81974492)。
文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance.
文摘Objectives： To explore the prognostic relevance of the number and ratio of metastatic lymph nodes in resected Carcinoma of the ampulla of Vater （CAV）. Methods： The clinical data of 155 patients who underwent pancreaticoduodenectomy （PD） for cancer of the ampulla of Vater between January 1990 and December 2010 were retrospectively analyzed. Kaplan- Meier method was used in survival analysis and Log rank method in comparison. Multivariate analysis was performed using Cox proportional hazards model. Results： Among these 155 patients, the in-hospital mortality rate was 4.5%, lymph node positive disease was 21.3%, and the 5-year survival rate was 51.6%. Patients with a lymph node ratio （LNR） 〉20% were more likely to have tumor differentiation, depth of duodenal involvement, depth of pancreatic invasion, T-stage and TNM-Stage. The number of the metastatic lymph nodes is important prognostic factors of the CAV. Univariate analysis showed that the factors associated with the prognosis included tumor size （P=0.036）, tumor differentiation （P=0.019）, LNR （P=0.032）, mtmber of metastatic lymph nodes （P=0.024）, lymph node metastasis （P=0.03）, depth of pancreatic invasion （P=0.001）, T-stage （P=0.002）, TNM stage （P=0.001）, elevated CA 19-9 （P=0.000）, and jaundice （P=0.021）. Multivariate analysis showed that the factors associated with the prognosis were the number of metastatic lymph nodes （P=0.032; RR： 1.283; 95% CI： 1.022-1.611）, tumor size （P=0.043; RR： 1.736; 95% CI： 1.017-2.963）, and elevated CA 19-9 （P=0.003; RR： 3.247; 95% CI： 1.504-7.010）. Conclusions： LNR is a useful factor for predicting the prognosis of the radical treatment for CAV,, whereas the number of metastatic lymph nodes is the most important factor. Further research on the locations, number, and LNR will be clinically meaningful to improve survival in patients with CAV.
文摘Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed on professional cross-presenting CD8α^+dendritic cells(DCs).
基金Supported by Educational Reform Project of Jiangsu Provincial Education Department(2011JSJG198)
文摘Development of modern agriculture has higher and higher requirements on quality of peasants.This study,on the basis of connotations of modern agriculture,current situation and problems of Chinese peasants,and contradictions between modern agricultural development and peasants' quality,specifies requirements of modern agriculture on new peasants,proposes corresponding suggestions to promote the cultivation of new Chinese peasants.
文摘Resurrection plants, which are the ＂gifts＂ of natural evolution, are ideal models for studying the genetic basis of plant desiccation tolerance. Here, we report a high-quality genome assembly of 301 Mb for the diploid spike moss Selaginella tamariscina, a primitive vascular resurrection plant. We predicated 27 761 protein-coding genes from the assembled S. tarnariscina genome, 11.38% （2363） of which showed signifi- cant expression changes in response to desiccation. Approximately 60.58% of the S. tamariscina genome was annotated as repetitive DNA, which is an almost 2-fold increase of that in the genome of desiccation- sensitive Selaginella moellendorffii. Genomic and transcriptomic analyses highlight the unique evolution and complex regulations of the desiccation response in S. tamariscina, including species-specific expan- sion of the oleosin and pentatricopeptide repeat gene families, unique genes and pathways for reactive oxygen species generation and scavenging, and enhanced abscisic acid （ABA） biosynthesis and potentially distinct regulation of ABA signaling and response. Comparative analysis of chloroplast genomes of several Selaginella species revealed a unique structural rearrangement and the complete loss of chloroplast NAD（P） H dehydrogenase （NDH） genes in S. tamariscina, suggesting a link between the absence of the NDH com- plex and desiccation tolerance. Taken together, our comparative genomic and transcriptomic analyses reveal common and species-specific desiccation tolerance strategies in S. tamariscina, providing signifi- cant insights into the desiccation tolerance mechanism and the evolution of resurrection plants.
基金financially supported by the Qinchuangyuan Project of Shaanxi Province(Grant No.2023KXJ-016)the National Natural Science Foundation of China(Grant No.32272001)the Shaanxi Key Research and Development Project(Grant No.2023-ZDLNY-62 and No.2022NY-205).
文摘Over the past 30 years,there has been continuous progress in global science and technology.However,many agricultural products still heavily rely on traditional methods of manual and mechanical harvesting,facing challenges such as high costs and low efficiency.To address these challenges,researchers have developed various harvesting robots to handle diverse tasks in complex farm environments.This study analyzed pertinent papers on harvesting robots retrieved from the Web of Science(WOS)core database and the China National Knowledge Infrastructure(CNKI)database,spanning the years 1993 to 2022.Using specialized software such as CiteSpace and VOSviewer,a bibliometric analysis was conducted to examine the research progress and hotspots in the field of harvesting robots.The analysis of 517 English papers indicated a continuous expansion in the research scale of harvesting robots.Furthermore,the research history can be divided into three distinct periods.Currently,research on harvesting robots is experiencing a rapid growth phase,with the number of related papers steadily increasing each year.In the year 2022 alone,151 English papers were published.This growth is attributed to close collaborations among different countries/regions,institutions,and authors.China,the United States,and Japan play crucial roles in the research of harvesting robots.Notably,China has published 326 English papers,ranking first globally.Through analysis,it was also found that Chinese papers focused on harvesting robots earlier,thereby promoting the development of agricultural robots.Additionally,bibliometric analysis revealed that the research hotspots of harvesting robots mainly include system and structure design,object recognition and localization,and multi-robot coordination,among others.In the future,development trends of harvesting robots will focus on:1)diversifying robot types,2)expanding application scenarios,3)enhancing overall performance to reduce losses,and 4)reducing manufacturing costs.In conclusion,through a comprehensive bibliometric analysis,this study has provided valuable insights to advance the automation of harvesting.
基金supported the Capital Health Research and Development of Special Fund Program(No.2018-1-4021)the National Natural Science Foundation of China(No.81672461)+1 种基金the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS)(Nos.2016-I2M-1-001 and 2017-12M-4-002)Sanming Project of Medicine in Shenzhen(No.SZSM202011010).
文摘Background:The prognosis of hepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT)is extremely poor.The clinical outcome of preoperative radiotherapy(RT)is still controversial.This study aimed to compare the clinical outcomes of combined neoadjuvant RT and hepatectomy with hepatectomy alone for HCC with PVTT.Methods:Comprehensive database searches were performed in PubMed,the Cochrane Library,EMBASE,and the Web of Science to retrieve studies published from the database creation to July 1,2020.Only comparative studies that measured survival between neoadjuvant RT followed by hepatectomy and hepatectomy alone were included.The characteristics of the included studies and patients were extracted,and the included data are presented as relative ratio(RR)estimates with 95%confidence intervals(CIs)for all outcomes.The RRs of each study were pooled using a fixed or random effects model with Review Manager(the Cochrane Collaboration,Oxford,UK)version 5.3.The response rate to RT and the overall survival(OS)rate in neoadjuvant RT followed by hepatectomy and hepatectomy alone were measured.Results:One randomized and two non-randomized controlled trials with 302 patients were included.Most patients were classified as Child-Pugh A,and Type II and III PVTT were the most common types.After RT,29(22.8%)patients were evaluated as partial response(PR)and had a positive RT response,but nine(7.1%)had progressive disease(PD).Neoadjuvant RT followed by hepatectomy was received by 127(42.1%)patients after excluding 15(5.0%)patients with severe complications or PD after RT,and 160(53.0%)patients received hepatectomy alone.In the randomized controlled trial(RCT),the 1-year OS rate in the neoadjuvant RT group and the surgery alone group was 75.2%and 43.1%,respectively(P<0.001).In the two non-randomized studies,a meta-analysis with a fixed effects model showed a longer OS in patients undergoing neoadjuvant RT followed by hepatectomy compared with hepatectomy alone at 1-year follow-up(RR=2.02;95%CI:1.45-2.80;P<0.0001).Conclusions:This systematic review showed that neoadjuvant RT followed by hepatectomy in patients with resectable HCC and PVTT was associated with a longer OS than patients who received hepatectomy alone.
文摘Research on the extrusion of natural polymers(food,feed,etc.)is relatively new due to the complex physicochemical transformations of raw materials,although plastics melt conveying and transport have been well studied.The structure and composition,rheological behavior as well as extrusion processing of natural polymer are much more complicated.In this study,a quasi-three-dimensional(3D)fluid flow model for non-Newtonian,non-isothermal and undeveloped temperature was developed,the model prediction being in reasonably good agreement with the experiment.Results show that the influence of moisture content,among other process variables,is the most significant,followed by screw speed.Some interaction exists between these two variables and the screw speed effect becomes marginal at high moisture contents.In addition,viscosity change in the channel was studied.
基金This work was supported in part by the National Natural Science Foundation of China(No.51907098)in part by the China Postdoctoral Science Foundation(No.2020T130337).
文摘This paper investigates the power sharing and voltage regulation issues of islanded single-/three-phase microgrids(S/T-MGs)where both sources and loads are unbalanced and the presence of adversarial cyber-attacks against sensors of distributed generator(DG)units is considered.Firstly,each DG unit is modeled as a heterogeneous linear dynamic agent with disturbances caused by sources and loads,then the problem is formulated as a distributed containment control problem.After that,to guarantee satisfactory power sharing and voltage control performance asymptotically achieved for the S/T-MGs,an attack-resilient distributed secondary control approach is developed by designing a distributed adaptive observer.With this approach,the effect of the cyber-attacks can be neutralized to ensure system stability and preserve bounded voltage synchronization.Simulation results are presented to demonstrate the effectiveness of the proposed control approach.
基金funded by the National Key Research and Development Program of China(Nos.2021YFC2701800 and 2021YFC2701801)the Shanghai Municipal Science and Technology Major Project(No.ZD2021CY001).
文摘The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first confirmed in November 2021 in South Africa^([1])and is more transmissible than other sub-variants.^([2])The influence of Omicron in children has been recognized with increased hospital admission rate than Delta wave.^([3,4])But severe clinical outcomes and comorbidity of Omicron are less than Delta in children.^([5])Hospitalized children during the Omicron period were more likely to be younger than that in the pre-Omicron period.^([6])
基金the National Key Research and Development Program of China[2018YFA0702200]National transformative subject:Intelligent evolution mechanism and design of distributed information energy system,National Natural Science Foundation of China[62073065,51907098]China Postdoctoral Science Foundation[2020T130337].
文摘This paper proposes a novel virtual inertia controller for converters in power systems,whichcan solve the system’s nonlinearity for frequency support.First,the system dynamics are formulatedas a nonlinear state-space,in which the reciprocal of inertia is modeled as controlinput.Correspondingly,a cost function is defined by considering frequency deviation andrate of change of the frequency,which can preserve a tradeoff between critical frequencylimits and respective control energy.Following,the optimal frequency regulation problemis solved by using an online adaptive dynamic programming method,where the actor andcritic neural networks are constructed to approximate the optimal control input and optimalcost function,respectively.After that,the small-signal analysis is provided to identify the stabilityof the converter under the proposed controller.Finally,simulation results verify thatthe frequency response of the system is significantly improved,while retaining more DC sideenergy.
基金supported by the National Natural Science Foundation of China(Nos.42061130213 and 41822505)the special fund from the State Key Joint Laboratory of Environment Simulation and Pollution Control(No.20L01ESPC)and the Tsinghua University-Toyota Research Center.Huan Liu was supported by the Royal Society of the UK through the Newton Advanced Fellowship(No.NAF\R1\201166)and the Tsinghua University Initiative Scientific Research Program(No.2019Z02CAU).
文摘The Chishui River Valley is a microscale ecology-preservation area with industrial clusters.The significance of evaluating vehicular emissions has been gradually highlighted with the rapid development of the local transportation and tourism sectors.This study provides the first estimates based on both bottom-up and top-down approaches.The annual total emissions of CO,NOx,hydrocarbons(HC),PM10,and PM2.5 in 2019 were 347.8,189.6,46.3,6.9,and 6.3 Mg,respectively.Trucks contributed the most(55%)to the NOx emissions,followed by heavy-duty passenger vehicles(26%).In contrast,light-duty passenger vehicles and motorcycles generated 75%of the HC emissions.The superior accuracy of highly spatial and temporal bottom-up estimates versus top-down estimates is validated by the similar variation trends of hourly emission intensities and enhanced concentrations relative to background observations for both NOx and CO,with Pearson correlation coefficients between the intensities and concentrations ranging from 0.79 to 0.85.Historical HC emissions peaked in 2013,followed by a sharp decline in 2014 and a continuous rise since then,whereas NOx emissions have kept increasing since 2010.These indicated the necessity and urgency of effective vehicular emission mitigations.Based on scenario analysis,traffic restrictions combined with upgrading the emission standards of admitted vehicles will possess huge emission reduction potentials.Future recommendations about establishing a low emission zone in the valley and supporting policies were introduced.
