As the performance of dedicated facilities has continually improved, large numbers of pulsar candidates are being received, which makes selecting valuable pulsar signals from the candidates challenging. In this paper,...As the performance of dedicated facilities has continually improved, large numbers of pulsar candidates are being received, which makes selecting valuable pulsar signals from the candidates challenging. In this paper, we describe the design for a deep convolutional neural network(CNN) with 11 layers for classifying pulsar candidates. Compared to artificially designed features, the CNN chooses the subintegrations plot and sub-bands plot for each candidate as inputs without carrying biases. To address the imbalance problem, a data augmentation method based on synthetic minority samples is proposed according to the characteristics of pulsars. The maximum pulses of pulsar candidates were first translated to the same position, and then new samples were generated by adding up multiple subplots of pulsars. The data augmentation method is simple and effective for obtaining varied and representative samples which keep pulsar characteristics. In experiments on the HTRU 1 dataset, it is shown that this model can achieve recall of 0.962 and precision of 0.963.展开更多
BACKGROUND Several studies have reported the prognostic value of ultrasound elastography(UE)in patients receiving neoadjuvant chemotherapy(NACT)for breast cancer.However,the assessment of parameters differed between s...BACKGROUND Several studies have reported the prognostic value of ultrasound elastography(UE)in patients receiving neoadjuvant chemotherapy(NACT)for breast cancer.However,the assessment of parameters differed between shear-wave elastography and strain elastography in terms of measured elasticity parameter and mode of imaging.It is important,therefore,to assess the accuracy of the two modes of elastography.AIM To assess the accuracy of UE for predicting the pathologic complete response(pCR)in breast cancer patients following NACT.METHODS A comprehensive and systematic search was performed in the databases of MEDLINE,EMBASE,SCOPUS,PubMed Central,CINAHL,Web of Science and Cochrane library from inception until December 2020.Meta-analysis was performed using STATA software“Midas”package.RESULTS A total of 14 studies with 989 patients were included.The pooled sensitivities were 86%[95%confidence interval(CI):76%-92%]for UE,77%(95%CI:68%-84%)for shear-wave elasto-graphy,and 92%(95%CI:73%-98%)for strain-wave elastography.The pooled score specificities were 86%(95%CI:80%-90%)for UE,84%(95%CI:72%-91%)for shear-wave elasticity,and 87%(95%CI:81%-92%)for strain-wave elastography.A significant heterogeneity was found among studies based on the chi-square test results and an I2 statistic>75%.CONCLUSION Strain-wave type of UE can accurately predict the pCR following NACT amongst breast cancer patients.Studies exploring its accuracy in different ethnic populations are required to strengthen the evidence.展开更多
The small and medium-sized river basins along southeast coast of China hold comparatively abundant water resources.However,the rapid resources urbanization in recent years has produced a series of water problems such ...The small and medium-sized river basins along southeast coast of China hold comparatively abundant water resources.However,the rapid resources urbanization in recent years has produced a series of water problems such as deterioration of river water quality,water shortage and exacerbated floods,which have constrained urban economic development.By applying the principle of triple supply-demand equilibrium,this paper focuses on the estimation of levels of water supply and demand in 2030 at different guarantee probabilities,with a case study of Xiamen city.The results show that water shortage and inefficient utilization are main problems in the city,as the future water supply looks daunting,and a water shortage may hit nearly 2×10^(8)m^(3)in an extraordinarily dry year.Based on current water supply-demand gap and its trend,this paper proposes countermeasures and suggestions for developing and utilizing groundwater resources and improving the utilization rate of water resources,which can supply as a reference for other southeast middle-to-small-sized basin cities in terms of sustainable water resources and water environment protection.展开更多
Background： The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited...Background： The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. Methods： A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected. We calculated the prevalence and recorded the clinical characteristics of the patients with malignancy after morcellation application. A total of 62 cases were finally pathologically confirmed as malignant postoperatively. Additionally, the medical records of the 62 patients were analyzed in details. Results： The proportion of postoperative malignancy after morcellation application was 0.18% （62/33,723） for patients who underwent laparoscopic myomectomy. Nearly 62.9% （39/62） of patients had demonstrated blood flow signals in the uterine fibroids before surgery. And, 23 （37.1%） patients showed rapid growth at the final preoperative ultrasound. With respect to the pathological types, 38 （61.3%） patients had detectable endometrial stromal sarcoma, 13 （21.0%） had detectable uterine leiomyosarcoma, only 3 （3.2%） had detectable carcinosarcoma, and 5 （8.1%） patients with leiomyoma had an undetermined malignant potential. Conclusions： The proportion of malignancy is low after using moreellation in patients who undergo laparoscopie myomectomy. Patients with fast-growing uterine fibroids and abnormal ultrasonic tumor blood flow should be considered for malignant potential, and morcellation should be avoided.展开更多
文摘As the performance of dedicated facilities has continually improved, large numbers of pulsar candidates are being received, which makes selecting valuable pulsar signals from the candidates challenging. In this paper, we describe the design for a deep convolutional neural network(CNN) with 11 layers for classifying pulsar candidates. Compared to artificially designed features, the CNN chooses the subintegrations plot and sub-bands plot for each candidate as inputs without carrying biases. To address the imbalance problem, a data augmentation method based on synthetic minority samples is proposed according to the characteristics of pulsars. The maximum pulses of pulsar candidates were first translated to the same position, and then new samples were generated by adding up multiple subplots of pulsars. The data augmentation method is simple and effective for obtaining varied and representative samples which keep pulsar characteristics. In experiments on the HTRU 1 dataset, it is shown that this model can achieve recall of 0.962 and precision of 0.963.
文摘BACKGROUND Several studies have reported the prognostic value of ultrasound elastography(UE)in patients receiving neoadjuvant chemotherapy(NACT)for breast cancer.However,the assessment of parameters differed between shear-wave elastography and strain elastography in terms of measured elasticity parameter and mode of imaging.It is important,therefore,to assess the accuracy of the two modes of elastography.AIM To assess the accuracy of UE for predicting the pathologic complete response(pCR)in breast cancer patients following NACT.METHODS A comprehensive and systematic search was performed in the databases of MEDLINE,EMBASE,SCOPUS,PubMed Central,CINAHL,Web of Science and Cochrane library from inception until December 2020.Meta-analysis was performed using STATA software“Midas”package.RESULTS A total of 14 studies with 989 patients were included.The pooled sensitivities were 86%[95%confidence interval(CI):76%-92%]for UE,77%(95%CI:68%-84%)for shear-wave elasto-graphy,and 92%(95%CI:73%-98%)for strain-wave elastography.The pooled score specificities were 86%(95%CI:80%-90%)for UE,84%(95%CI:72%-91%)for shear-wave elasticity,and 87%(95%CI:81%-92%)for strain-wave elastography.A significant heterogeneity was found among studies based on the chi-square test results and an I2 statistic>75%.CONCLUSION Strain-wave type of UE can accurately predict the pCR following NACT amongst breast cancer patients.Studies exploring its accuracy in different ethnic populations are required to strengthen the evidence.
基金This paper was funded by the Geological Survey Project of China Geological Survey"Comprehensive Geological Survey of Xiamen-Zhangzhou-Quanzhou City"(DD20190303).
文摘The small and medium-sized river basins along southeast coast of China hold comparatively abundant water resources.However,the rapid resources urbanization in recent years has produced a series of water problems such as deterioration of river water quality,water shortage and exacerbated floods,which have constrained urban economic development.By applying the principle of triple supply-demand equilibrium,this paper focuses on the estimation of levels of water supply and demand in 2030 at different guarantee probabilities,with a case study of Xiamen city.The results show that water shortage and inefficient utilization are main problems in the city,as the future water supply looks daunting,and a water shortage may hit nearly 2×10^(8)m^(3)in an extraordinarily dry year.Based on current water supply-demand gap and its trend,this paper proposes countermeasures and suggestions for developing and utilizing groundwater resources and improving the utilization rate of water resources,which can supply as a reference for other southeast middle-to-small-sized basin cities in terms of sustainable water resources and water environment protection.
文摘Background： The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy. Methods： A national multicenter study was performed in China. From 2002 to 2014, 33,723 cases were retrospectively selected. We calculated the prevalence and recorded the clinical characteristics of the patients with malignancy after morcellation application. A total of 62 cases were finally pathologically confirmed as malignant postoperatively. Additionally, the medical records of the 62 patients were analyzed in details. Results： The proportion of postoperative malignancy after morcellation application was 0.18% （62/33,723） for patients who underwent laparoscopic myomectomy. Nearly 62.9% （39/62） of patients had demonstrated blood flow signals in the uterine fibroids before surgery. And, 23 （37.1%） patients showed rapid growth at the final preoperative ultrasound. With respect to the pathological types, 38 （61.3%） patients had detectable endometrial stromal sarcoma, 13 （21.0%） had detectable uterine leiomyosarcoma, only 3 （3.2%） had detectable carcinosarcoma, and 5 （8.1%） patients with leiomyoma had an undetermined malignant potential. Conclusions： The proportion of malignancy is low after using moreellation in patients who undergo laparoscopie myomectomy. Patients with fast-growing uterine fibroids and abnormal ultrasonic tumor blood flow should be considered for malignant potential, and morcellation should be avoided.
