Prostate cancer is the second most common cancer in men,accounting for 14.1%of new cancer cases in 2020.The aggressiveness of prostate cancer is highly variable,depending on its grade and stage at the time of diagnosi...Prostate cancer is the second most common cancer in men,accounting for 14.1%of new cancer cases in 2020.The aggressiveness of prostate cancer is highly variable,depending on its grade and stage at the time of diagnosis.Despite recent advances in prostate cancer treatment,some patients still experience recurrence or even progression after undergoing radical treatment.Accurate initial staging and monitoring for recurrence determine patient management,which in turn affect patient prognosis and survival.Classical imaging has limitations in the diagnosis and treatment of prostate cancer,but the use of novel molecular probes has improved the detection rate,specificity,and accuracy of prostate cancer detection.Molecular probe-based imaging modalities allow the visualization and quantitative measurement of biological processes at the molecular and cellular levels in living systems.An increased understanding of tumor biology of prostate cancer and the discovery of new tumor biomarkers have allowed the exploration of additional molecular probe targets.The development of novel ligands and advances in nano-based delivery technologies have accelerated the research and development of molecular probes.Here,we summarize the use of molecular probes in positron emission tomography(PET),single-photon emission computed tomography(SPECT),magnetic resonance imaging(MRI),optical imaging,and ultrasound imaging,and provide a brief overview of important target molecules in prostate cancer.展开更多
The first photon bias of photon detection results in distortion of the photon waveform,which seriously affects the accurate acquisition of target information.A rapid universal recursive correction method is proposed,w...The first photon bias of photon detection results in distortion of the photon waveform,which seriously affects the accurate acquisition of target information.A rapid universal recursive correction method is proposed,which is suitable for multi-trigger and single-trigger modes of photon detection.The calculation time is 2 to 3 orders of magnitude faster than that of Xu et al.'s method.In the experiment,we have obtained good correction results for area targets and targets with varying depths.When the average number of echo photons is 0.89,the correlation distance of the correction waveform is reduced by 85%.展开更多
基金supported by the Medical Health Science and Technology Project of Zhejiang Provincial Health Com-mission(No.2022RC146)the Zhejiang Provincial Natural Science Foundation of China(No.LQ22H050003).
文摘Prostate cancer is the second most common cancer in men,accounting for 14.1%of new cancer cases in 2020.The aggressiveness of prostate cancer is highly variable,depending on its grade and stage at the time of diagnosis.Despite recent advances in prostate cancer treatment,some patients still experience recurrence or even progression after undergoing radical treatment.Accurate initial staging and monitoring for recurrence determine patient management,which in turn affect patient prognosis and survival.Classical imaging has limitations in the diagnosis and treatment of prostate cancer,but the use of novel molecular probes has improved the detection rate,specificity,and accuracy of prostate cancer detection.Molecular probe-based imaging modalities allow the visualization and quantitative measurement of biological processes at the molecular and cellular levels in living systems.An increased understanding of tumor biology of prostate cancer and the discovery of new tumor biomarkers have allowed the exploration of additional molecular probe targets.The development of novel ligands and advances in nano-based delivery technologies have accelerated the research and development of molecular probes.Here,we summarize the use of molecular probes in positron emission tomography(PET),single-photon emission computed tomography(SPECT),magnetic resonance imaging(MRI),optical imaging,and ultrasound imaging,and provide a brief overview of important target molecules in prostate cancer.
基金the National Natural Science Foundation of China(No.61871389)the Research Plan Project of the National University ofDefense Technology(No.ZK 18-01-02)。
文摘The first photon bias of photon detection results in distortion of the photon waveform,which seriously affects the accurate acquisition of target information.A rapid universal recursive correction method is proposed,which is suitable for multi-trigger and single-trigger modes of photon detection.The calculation time is 2 to 3 orders of magnitude faster than that of Xu et al.'s method.In the experiment,we have obtained good correction results for area targets and targets with varying depths.When the average number of echo photons is 0.89,the correlation distance of the correction waveform is reduced by 85%.
