Mosquito-borne diseases,encompassing threats like dengue,Zika virus(ZIKV)infection,and malaria,pose a sig-nificant challenge to global public health security,evoking widespread concern.The gravity of the situation is ...Mosquito-borne diseases,encompassing threats like dengue,Zika virus(ZIKV)infection,and malaria,pose a sig-nificant challenge to global public health security,evoking widespread concern.The gravity of the situation is un-derscored by some staggering statistics:over 3.9 billion people in more than 120 countries confront the imminent threat of some of the most epidemiologically significant mosquito-borne viruses;in 2021 alone,malaria accounted for 247 million cases,resulting in an estimated 619,000 deaths globally.展开更多
Mosquito-borne diseases present a significant threat to human health,with the possibility of outbreaks of new mosquito-borne diseases always looming.Unfortunately,current measures to combat these diseases such as vacc...Mosquito-borne diseases present a significant threat to human health,with the possibility of outbreaks of new mosquito-borne diseases always looming.Unfortunately,current measures to combat these diseases such as vaccines and drugs are often either unavailable or ineffective.However,recent studies on microbiomes may reveal promising strategies to fight these diseases.In this review,we examine recent advances in our understanding of the effects of both the mosquito and vertebrate microbiomes on mosquito-borne diseases.We argue that the mosquito microbiome can have direct and indirect impacts on the transmission of these diseases,with mosquito symbiotic microorganisms,particularly Wolbachia bacteria,showing potential for controlling mosquito-borne diseases.Moreover,the skin microbiome of vertebrates plays a significant role in mosquito preferences,while the gut microbiome has an impact on the progression of mosquito-borne diseases in humans.As researchers continue to explore the role of microbiomes in mosquito-borne diseases,we highlight some promising future directions for this field.Ultimately,a better understanding of the interplay between mosquitoes,their hosts,pathogens,and the microbiomes of mosquitoes and hosts may hold the key to preventing and controlling mosquito-borne diseases.展开更多
基金supported by grants from the National Key Research and Development Plan of China(2021YFC2300200,2021YFC2302405,2022YFC2303200,and 2022YFC2303400)the National Natural Science Foundation of China(32188101 and 82102389)+4 种基金Tsinghua University Initiative Scientific Research Program(20233080060)Shenzhen San-Ming Project for Prevention and Research on Vector-borne Diseases(SZSM202211023)Yunnan Provincial Science and Technology Project at Southwest United Graduate School(202302A0370010)the New Cornerstone Science Foundation through the New Cornerstone Investigator Programthe Xplorer Prize from Tencent Foundation.
文摘Mosquito-borne diseases,encompassing threats like dengue,Zika virus(ZIKV)infection,and malaria,pose a sig-nificant challenge to global public health security,evoking widespread concern.The gravity of the situation is un-derscored by some staggering statistics:over 3.9 billion people in more than 120 countries confront the imminent threat of some of the most epidemiologically significant mosquito-borne viruses;in 2021 alone,malaria accounted for 247 million cases,resulting in an estimated 619,000 deaths globally.
基金This work was funded by the grants from the National Key R&D Program of China(Nos.2021YFC2300200,2018YFA0507202,2020YFC1200104,2021YFC2302405,2022YFC2303200,and 2022YFC2303400)National Natural Science Foundation of China(Nos.32188101,31825001,and 81961160737),Yunnan Chenggong expert workstation(Nos.202005AF150034)+2 种基金Innovation Team Project of Yunnan Science and Technology Department(Nos.202105AE160020)Tsinghua-Foshan Innovation Special Fund(TFISF)(Nos.2022THFS6124)Shenzhen San-Ming Project for prevention and research on vector-borne diseases.
文摘Mosquito-borne diseases present a significant threat to human health,with the possibility of outbreaks of new mosquito-borne diseases always looming.Unfortunately,current measures to combat these diseases such as vaccines and drugs are often either unavailable or ineffective.However,recent studies on microbiomes may reveal promising strategies to fight these diseases.In this review,we examine recent advances in our understanding of the effects of both the mosquito and vertebrate microbiomes on mosquito-borne diseases.We argue that the mosquito microbiome can have direct and indirect impacts on the transmission of these diseases,with mosquito symbiotic microorganisms,particularly Wolbachia bacteria,showing potential for controlling mosquito-borne diseases.Moreover,the skin microbiome of vertebrates plays a significant role in mosquito preferences,while the gut microbiome has an impact on the progression of mosquito-borne diseases in humans.As researchers continue to explore the role of microbiomes in mosquito-borne diseases,we highlight some promising future directions for this field.Ultimately,a better understanding of the interplay between mosquitoes,their hosts,pathogens,and the microbiomes of mosquitoes and hosts may hold the key to preventing and controlling mosquito-borne diseases.
