Currently,conventional single-sided friction stir welding is primarily suitable for joining thin plate aluminum alloys,and its application to thick plates is still challenging in terms of welding efficiency and joint ...Currently,conventional single-sided friction stir welding is primarily suitable for joining thin plate aluminum alloys,and its application to thick plates is still challenging in terms of welding efficiency and joint mechanical properties.Simultaneous double-sided friction stir welding(SDS-FSW)is a high-efficiency joining technique specifically developed for welding thick plates.However,there is little research on the influence of SDS-FSW process parameters on the joint mechanical properties.In this study,a 12 mm thick AA6061-T6 aluminum alloy and dual robot welding equipment are used to conduct SDS-FSW experiments exploring the influence of rotational speedωand welding speed v on the mechanical properties and microstructure.The results show that when the welding parameters areω=800 r/min and v=60–80 mm/min,smooth and defect-free thick plate aluminum alloy SDS-FSW joints can be obtained,and the macroscopic morphology of the joints is distributed in a“dumbbell”shape.The grain size in the weld nugget zone increases with increasing welding heat input.The microhardness distribution in the joint displays a“W”shape,and the hardness value of the weld nugget zone can reach 67%to 86%of that of the base metal(BM).The junction between the thermo-mechanically affected zone and the heat affected zone is the weakest region of the joint,with the lowest hardness being approximately 51%of that of the BM.When the welding parameters areω=800 r/min and v=140 mm/min,the SDS-FSW joint has the highest tensile strength,reaching 78.43%of the BM strength and exhibiting ductile fracture characteristics.This research indicates that acceptable weld strength in thick aluminum alloys can be achieved via the SDS-FSW joining mechanism,highlighting its significant potential for industrial applications.展开更多
A hierarchically‐structured nylon 6 (PA6) nanofiber membrane decorated with silver nanoparticles (Ag NPs) was fabricated by electrospinning and impregnation methods. The as‐fabricated hierarchically‐structured Ag/P...A hierarchically‐structured nylon 6 (PA6) nanofiber membrane decorated with silver nanoparticles (Ag NPs) was fabricated by electrospinning and impregnation methods. The as‐fabricated hierarchically‐structured Ag/PA6 nanofiber membrane (HS‐Ag/PA6 NM) exhibits a morphology in which Ag NPs are deposited on the surfaces of both thick fibers and thin fibers. The content and size of theAg NPs can be controlled by varying the concentration of the silver colloid solution. Compared with the non‐hierarchically‐structured Ag/PA6 nanofiber membrane, HS‐Ag/PA6 NM has a higher specificsurface area and exhibits a higher degradation rate for methylene blue of 81.8%–98.1% within2 h. HS‐Ag/PA6 NM can be easily recycled and exhibits good reusability. It retains a degradation rate for methylene blue of 83.5% after five consecutive cycles. The hierarchically‐structured nanofiber membrane is therefore a potential nanocatalyst.展开更多
Objective:The purpose of this study was to assess the efficacy and safety of Chinese herbal medicine(CHM)in the treatment of chronic heart failure(CHF)patients according to syndrome differentiation.Methods:In this mul...Objective:The purpose of this study was to assess the efficacy and safety of Chinese herbal medicine(CHM)in the treatment of chronic heart failure(CHF)patients according to syndrome differentiation.Methods:In this multicenter,randomized,double-blind,placebo-controlled clinical trial,a total of 220 CHF patients were assigned to receive CHM or placebo granules without decoction according to syndrome differentiation in addition to their standard western treatment for 4 weeks.The change in the left ventricular ejection fraction(LVEF)was the primary outcome,and the changes in the TCM syndrome scores(TCM-SS)and New York Heart Association functional classification(NYHA-FC)were the secondary outcomes.展开更多
Background:Chronic heart failure(CHF)is characterized by insufficient blood supply from heart to meet the body’s metabolic demands.Integrating Western and traditional Chinese medicine to treat CHF has proved a valida...Background:Chronic heart failure(CHF)is characterized by insufficient blood supply from heart to meet the body’s metabolic demands.Integrating Western and traditional Chinese medicine to treat CHF has proved a validated therapeutic approach.In recent years,metabolomics has been regarded as a potential platform to provide biomarkers for diseasesubtypes.Objective:To examine 38 patients,combined NMR plasma metabolomics and traditional Chinese medicine diagnosis in order to identify diagnostic biomarkers for two CHF syndrome subtypes.Methods:After processing the spectra,orthogonal partial least square discriminant analysis was performed,and the contributing NMR signals were analyzed using Y-scrambling statistical validation with good reliability.Results:Plasma metabolic patterns of yin deficiency and yang deficiency patients were clearly discriminated.The yin-deficiency group had increased level of lactate,glycoprotein,lipoprotein and lower levels of glucose,valine and proline.The yang-deficiency group had higher levels of lactate,glycoprotein and pyruvic acid,and lower levels of glucose and lipoprotein.Potential biomarkers of CHF based on the two traditional Chinese medicine syndromes indicated alternative modes of metabolites and metabolic pathways in the disease,e.g.dysfunction of energy utilization and disturbance in fatty acids,amino acids.Conclusion:This study suggests that combining metabolomics with traditional Chinese medicine diagnosis can reveal metabolic signatures for CHF syndrome subtypes.The plasma metabolites identified might be of special clinical relevance for subtypes of CHF,which could lead to further understanding of mechanisms involved and an improvement in personalized treatment for CHF.展开更多
Objective:To find the target genes in combination of astragalus root(Astragalus membranaceus)and spindle tree wings(Euonymus alatus(THUNB.)SIEB.)(Qijian Heji)with the function of regulating blood glucose levels in kk ...Objective:To find the target genes in combination of astragalus root(Astragalus membranaceus)and spindle tree wings(Euonymus alatus(THUNB.)SIEB.)(Qijian Heji)with the function of regulating blood glucose levels in kk mice by real-time fluorescence quantitative PCR(RT-PCR).To achieve the primary exploration on the material basis for Qijian Heji to improve the blood glucose levels of type 2 diabetic kk mice.Methods:We applied RT-PCR to detecting the expression of gene targets in kidney tissues of type 2 diabetes model kk mice.The detected gene targets were predicted by the network pharmacology method in the early stage of the project.Through the observation of the hypoglycemic effect of different ratios of Qijian Heji,the optimal proportion was determined and then used to conduct research of material basis.Results:Continuous administration of Qijian Heji(astragalus root:spindle tree wings Z 3:1)for six weeks resulted in significantly lowering blood glucose levels in mice in the fourth week,dropping from 33.3 to 21.9 mmol/L;this lower level was maintained in the fifth to sixth weeks.Blood glucose values in the positive drug group decreased from 33.3 to 21.85 mmol/L in the fourth week and maintained steady decreasing in the fifth and sixth weeks.Conclusion:Qijian Heji,with proportion of 3:1,could significantly reduce the blood glucose values in kk mice,animal experiment results verified the accurate prediction of network pharmacology,and at the same time,it is verified there was a certain therapeutic effect about the combination of the two herbs on reducing the glucose value.Animal experiments and RT-PCR results showed that Qijian Heji conducted a hypoglycemic effect by modulating estrogen receptor(ESR1)and renin(REN)expression.展开更多
Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pre...Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pressure(BP)in hypertensive rats with a liver-fire hyperactivity pattern by observing changes in BP as well as physiochemical indexes in plasma.Methods:Sixteen male spontaneous hypertensive rats(SHR)with a liver-fire hyperactivity pattern were randomly divided into a control group and a Jue tone group.The rats in the Jue tone group were treated with Jue tone(55e65 dB,played by the five elements of music rhythm instrument,a kind of physiotherapy regimen music played by Shen Wu)once a day for 4 weeks.The BP levels in each group were measured twice a week,on Monday and Friday.The levels of angiotensin II(Ang-II),thromboxane B2(TXB2),endothelin-1(ET-1),calcitonin gene-related peptide(cGRP),norepinephrine(NE),cortisol(CORT),and 5-hydroxytryptamine(5-HT).in plasma were detected by enzyme-linked immunosorbent assay after 4 weeks of intervention.Results:BP and the levels of TXB2 and ET-1 in the plasma of the treatment group were significantly lower than those of the control group,while the level of cGRP was significantly higher.Conclusion:Jue tone can reduce the BP of hypertensive rats with a liver-fire hyperactivity pattern.The mechanism may correlate with a reduction in TXB2 and ET-1 and an increase in cGRP with the reduction of reactive oxygen species(ROS).展开更多
Patterns in species geographic range size are relatively well-known for vertebrates,but still poorly known for plants.Contrasts of these patterns between groups have rarely been investigated.With a detailed flora and ...Patterns in species geographic range size are relatively well-known for vertebrates,but still poorly known for plants.Contrasts of these patterns between groups have rarely been investigated.With a detailed flora and fauna distribution database of Xinjiang,China,we used regression methods,redundancy analysis and random forests to explore the relationship of environment and body size with the geographic range size of plants,mammals and birds in Xinjiang and contrast these patterns between plants and animals.We found positive correlations between species range size and body size.The range size of plants was more influenced by water variables,while that of mammals and birds was largely influenced by temperature variables.The productivity variable,i.e.,Enhanced Vegetation Index(EVI)was far more correlated with range size than climatic variables for both plants and animals,suggesting that vegetation productivity inferred from remote sensing data may be a good predictor of species range size for both plants and animals.展开更多
Objective:To evaluate the effect of Qishen granule(QSG)on heart failure(HF)and the potential mechanisms involved in animal models.Methods:Studies of QSG in animals with HF were identified by searches of eight database...Objective:To evaluate the effect of Qishen granule(QSG)on heart failure(HF)and the potential mechanisms involved in animal models.Methods:Studies of QSG in animals with HF were identified by searches of eight databases up to August 1,2019.Two authors independently reviewed each study and the Collaborative Approach to Metaanalysis and Review of Animal Data from Experimental Studies 10-item checklist was used for quality assessment.The primary outcomes were indicators of left ventricular ejection fraction and/or left ventricular fractional shortening.The secondary outcome measures were ventricular structure,hemodynamics,myocardial injury-related indicators,and the mechanisms whereby QSG ameliorates HF.A metaanalysis was performed and all the data were analyzed using RevMan 5.3 software.Results:Thirteen studies containing a total of 240 animals met the criteria for the meta-analysis.The quality score of the studies ranged from three to six points.The meta-analysis showed a significant effect of QSG to improve cardiac function,inhibit ventricular remodeling,improve circulation,and attenuate myocardial injury.The possible mechanisms was identified to be suppression of the renin-angiotensinaldosterone system,which has anti-fibrotic,anti-apoptotic,anti-inflammatory,and anti-oxidative effects in the myocardium,the prevention of calcium overload,and the promotion of myocardial energy metabolism.Conclusion:Our review shows that QSG has a cardioprotective effect in animal models of CHF.However,due to the relatively poor quality of the included studies and the differences between humans and animal models,the results should be interpreted with caution.展开更多
Objective:To evaluate the efficacy of traditional Chinese herbs on heart failure(HF)using nuclear magnetic resonance(NMR)metabolomics.Methods:Plasma metabolomics was conducted on both patients with HF and healthy cont...Objective:To evaluate the efficacy of traditional Chinese herbs on heart failure(HF)using nuclear magnetic resonance(NMR)metabolomics.Methods:Plasma metabolomics was conducted on both patients with HF and healthy controls.The partial least squares model was applied to determine potential metabolic markers and related metabolic pathways of the disease.HF patients with the traditional Chinese syndrome pattern of qi deficiency and blood stasis were divided into two groups,and treated,respectively,with conventional medicine and a combination of conventional and Chinese herbs,aimed at tonifying qi and activating blood.Healthy participants served as a control group for comparison.Results and conclusion:Both conventional and herbal treatments appear to regulate disorders of amino acid and glucose metabolism.Combined treatment appears to be more comprehensive,indicating that herbal and conventional medicines exert their effects through different mechanisms in treating HF.It can be further inferred that herbs that tonify qi and activate blood may regulate different essential metabolites.展开更多
Objective:To investigate the biological basis of“depression with liver-qi stagnation and spleen deficiency syndrome”.Methods:A digital gene expression profiling method was conducted to explore global changes in the ...Objective:To investigate the biological basis of“depression with liver-qi stagnation and spleen deficiency syndrome”.Methods:A digital gene expression profiling method was conducted to explore global changes in the mRNA transcriptome in a rat model of depression with liver-qi stagnation and spleen deficiency syndrome.Real-time quantitative polymerase chain reaction(q-PCR)was performed to verify the five genes most interest based on the Kyoto Encyclopedia of Genes and Genome(KEGG)analysis.Sini San,which disperses stagnated liver qi and strengthens the spleen,was administered to the model rats to observe whether it could reverse these genetic changes in the liver.Results:Forty-six differentially expressed genes were identified.Three of the five genes of most interestdHnf4a,Hnf4g and Cyp1a1dbased on KEGG analysis,were confirmed by realtime q-PCR.Sini San reduced the gene expression changes of Hnf4a,Hnf4g and Cyp1a1 in the rat model.Conclusions:Hnf4a,Hnf4g and Cyp1a1 are involved in“depression with liver-qi stagnation and spleen deficiency syndrome”.These findings indicate that depressed rats with liver-qi stagnation and spleen deficiency syndrome are at risk of liver diseases.Furthermore,our results will inform exploration of the etiology of depression and help in the development of effective therapeutic strategies.展开更多
Cancer patients by immune checkpoint therapy have achieved long-term remission,with no recurrence of clinical symptoms of cancer for many years.Nevertheless,more than half of cancer patients are not responsive to this...Cancer patients by immune checkpoint therapy have achieved long-term remission,with no recurrence of clinical symptoms of cancer for many years.Nevertheless,more than half of cancer patients are not responsive to this therapy due to immune exhaustion.Here,we report a novel gene engineered exosome which is rationally designed by engineering PD1 gene and simultaneously enveloping an immune adjuvant imiquimod(PD1-Imi Exo)for boosting response of cancer immune checkpoint blockage therapy.The results showed that PD1-Imi Exo had a vesicular round shape(approximately 139 nm),revealed a significant targeting and a strong binding effect with both cancer cell and dendritic cell,and demonstrated a remarkable therapeutic efficacy in the melanoma-bearing mice and in the breast cancer-bearing mice.The mechanism was associated with two facts that PD1-Imi Exo blocked the binding of CD8^(+)T cell with cancer cell,displaying a PD1/PDL1 immune checkpoint blockage effect,and that imiquimod released from PD1-Imi Exo promoted the maturation of immature dendritic cell,exhibiting a reversing effect on the immune exhaustion through activating and restoring function of CD8^(+)T cell.In conclusion,the gene engineered exosome could be used for reversing T cell exhaustion in cancer immunotherapy.This study also offers a promising new strategy for enhancing PD1/PDL1 therapeutic efficacy,preventing tumor recurrence or metastasis after surgery by rebuilding the patients’immunity,thus consolidating the overall prognosis.展开更多
Urban greenery is widely recognised as a strategy to mitigate urban overheating,and its shading capacity is crucial for improving microclimate and thermal comfort.Nevertheless,research on modelling the vegetation cano...Urban greenery is widely recognised as a strategy to mitigate urban overheating,and its shading capacity is crucial for improving microclimate and thermal comfort.Nevertheless,research on modelling the vegetation canopy radiation transfer(VCRT)process for the microscale is lacking,and most existing VCRT models are taken out from mesoscale models.In this study,we used canopy morphology and structure as an entry point to construct a VCRT model for the microscale,from the mesoscale model.Firstly,100 m and 1000 m were defined as the critical scales by scaling,and the effect of leaf distribution on VCRT was analysed.The VCRT model was made applicable to the microscale by introducing a scattered radiation source term and 6 leaf inclination distribution(LID)functions,and the results showed that the proposed model could improve the accuracy of canopy radiation absorptivity by about 11%.In addition,both leaf area index(LAI)and LID had significant effects on VCRT,and vegetation with LAI above 2 and spreading leaves had better shading effects.It is worth noting that urban greenery has an exciting potential for thermal comfort improvement,with the potential to regulate even extremely hot weather from near"very hot"(148 W/m^(2))to almost"comfortable"(69 W/m^(2)).This study is a catalyst for improving the predictability of the VCRT process for microclimate and thermal comfort,providing theoretical support and implications for mitigating urban overheating and enhancing urban thermal resilience.展开更多
Cylindrical vector beams(CVBs)with special polarization distribution have been extensively investigated due to the unique ways of interacting with matter.Although several configurations have been developed to generate...Cylindrical vector beams(CVBs)with special polarization distribution have been extensively investigated due to the unique ways of interacting with matter.Although several configurations have been developed to generate CVBs,such as Q-plates and subwavelength gratings,the bandwidth of a single CVB is inherently narrow due to the phase geometry,which would limit its application for femtosecond lasers.Here,a broadband CVB mode converter based on an acoustically induced fiber grating(AIFG)and a tuning method of dispersion turning point(DTP)is demonstrated both theoretically and experimentally with the 3-dB bandwidth of 125 nm,which is more than 10 times that of conventional AIFGs.Not only can the DTP wavelength be tuned from the original 1500 nm to 1650 nm by thinning the fiber,but also the stable generation of a single broadband HE_(21)^(odd/even) mode can be controllably implemented by adjusting the polarization state of the incident light,owing to the larger beat length difference between HE21 and other CV modes.Additionally,the femtosecond CVBs and orbital angular momentum(OAM)modes are successfully generated and amplified by combining the broadband AIFG with a figure-9 mode-locked fiber laser.Meanwhile,it is verified by simulation that the choice of broadband CV mode and the tunability of DTP wavelength can be realized by designing ring-core fibers with different structures,which can furthermore improve the flexibility of generating high purity CVBs.This study provides a highly controllable technique for the generation of broadband CVBs and OAMs paving the way for high-capacity CVBs communication.展开更多
Complex field environments,diverse crop conditions,and varying feed rate fluctuations commonly result in a decline in the threshing performance and the clogging of the threshing cylinder for maize harvesters.In order ...Complex field environments,diverse crop conditions,and varying feed rate fluctuations commonly result in a decline in the threshing performance and the clogging of the threshing cylinder for maize harvesters.In order to overcome these problems,an electric-hydraulic concave clearance automatic control system for the threshing unit was developed based on the maize feed rate monitoring,which can automatically realize the best match between the concave clearance and diverse feed rates during harvesting.The threshing performance of the electric-hydraulic control system was evaluated for varying and uneven maize feed rate fluctuations,such as the feed rate increased(6-8-10 kg/s),the feed rate decreased after an increase(6-10-8 kg/s,8-10-6 kg/s),the feed rate increased after a decrease(8-6-10 kg/s,10-6-8 kg/s),and the feed rate decreased(10-8-6 kg/s).In particular,the threshing rotor shaft peak torque,the range of threshing rotor shaft torque,the rate of broken grains(BGR),and the rate of unthreshed grains(UGR)with and without the electric-hydraulic control system were tested.Treatments with the electric-hydraulic control system were adjustable concave clearance with the value of 45 mm,50 mm,and 55 mm.Treatments without the electric-hydraulic control system were constant concave clearance(50 mm).Results demonstrate that the threshing unit with the electric-hydraulic control system outperformed the one without the electric-hydraulic control system,with threshing rotor peak torque,the range of threshing rotor axis torque,the BGR,and the UGR decreasing by 18.38%,38.27%,2.08%,and 0.10%,respectively.Moreover,the rate of broken grains was lower than 5.00%,better than the national standard.Thus,the feed rate fluctuations and timely adjustment of the concave clearance were able to avoid blocking the rotor and improve the threshing performance compared to the constant concave clearance.展开更多
Cisplatin is broad-spectrum chemotherapeutic agent that has been widely used for the treatment of a variety of malignant tumors including breast cancer.However,the cisplatin chemoresistance,which derives from the inac...Cisplatin is broad-spectrum chemotherapeutic agent that has been widely used for the treatment of a variety of malignant tumors including breast cancer.However,the cisplatin chemoresistance,which derives from the inactivation by glutathione(GSH)depletion,remains a scientific issue to solve.Here,we report a novel type of smart disulfide switchable nanoparticles complexing cisplatin(switch NPs-cisplatin)that is rationally designed,and engineered by synthesizing a hyaluronic acid disulfide bonded polyaspartic acid(HA-ss-Pasp)and complexing cisplatin.The results showed that the switch NPs-cisplatin had a nanoscale of particle size(150 nm),higher drug encapsulation efficiency(>90%),and suitable drug release profile.They demonstrated evident pH responsiveness and GSH responsiveness,and targeting effect in the resistant breast cancer cells.Furthermore,they were able to block the cisplatin depletion by GSH in the resistant cancer cells,thereby circumventing the chemoresistance.Consequently,switch NPs-cisplatin displayed a remarkable killing effect in the resistant breast cancer cells in vitro,and in the resistant breast cancer-bearing mice.In conclusion,switch NPs-cisplatin could be used as a smart formulation of cisplatin for overcoming the chemoresistance of breast cancer.The present study also offers a universal drug delivery carrier platform for highly efficient but low systemic toxic chemotherapy.展开更多
Based on the two most recent assessments of Chinese higher plants in 2013 and 2020,of 34,450 and 39,330 species,respectively,we analysed the threatened status of Chinese higher plants.In 2020,around 4,088(10.39%)of th...Based on the two most recent assessments of Chinese higher plants in 2013 and 2020,of 34,450 and 39,330 species,respectively,we analysed the threatened status of Chinese higher plants.In 2020,around 4,088(10.39%)of the assessed species in China are threatened,2,875(7.31%)Near Threatened,27,593(70.16%)not currently threatened and categorised as Least Concern and 4,752(12.08%)categorised as Data Deficient.While in 2013,3,767(10.93%)of the assessed higher plants in China are threatened,2,723(7.90%)Near Threatened,24,296(70.53%)Least Concern and 3,612(10.48%)Data Deficient.Estimates of the Red List Index in the two years show different patterns when using different weighting methods with the equal steps weighting method showing a slight decrease(0.91675-0.91495)and the extinction risk weighting method showing a slight increase(0.98792-0.98797).We inferred that China's threatened plant species were likely/relatively effectively protected.However,attention should also be given to the non-threatened species in the future as an additional strategy for their conservation,to maintain their non-threatened status.展开更多
With the continuous improvement of agricultural mechanization,soil compaction becomes more and more serious.Serious soil compaction has been considered as an important negative factor affecting crop growth and yield.T...With the continuous improvement of agricultural mechanization,soil compaction becomes more and more serious.Serious soil compaction has been considered as an important negative factor affecting crop growth and yield.The measurement of soil compactness is a common method to measure the soil compaction level.In order to solve the problems of discontinuous sampling,time-consuming and poor real-time soil compactness measurement,a real-time measurement method of soil compactness based on fertilizing shovel was proposed,and the mathematical model between fertilizing shovel arm deformation and soil compactness was established.Based on the interaction mechanism between fertilizing shovel and soil,through the force analysis of fertilizing shovel,it was found that the deformation of fertilizing shovel arm was positively correlated with the sum of soil compactness(SSC)within the range of tillage depth.In order to verify the theoretical analysis results and the detection accuracy of strain gauge,the static bench test was carried out.The test results showed that the strain gauge signal for measuring the deformation of the fertilizing shovel arm was significantly correlated with the applied force.The fitting curve of the linear correlation coefficient was 0.999,the maximum detection error was 0.68 kg,and the detecting accuracy was within the tolerance of 0.57%.Through field orthogonal experiments with four working depths and four compaction levels,a mathematical model of the strain gauge signal and the SSC within the range of tillage depth was established.The experiment showed that compared with the other three depths,the linear correlation coefficient at the tillage depth of 5 cm(TD5)was the lowest,and the slope of the fitting curve was obviously different from the other three depths,so the 5 cm data were excluded when modeling.The model between mean signal value and mean SSC within the range of tillage depth was established based on the data of sampling points with tillage depths of 7.5 cm(TD7.5),10 cm(TD10),and 12.5 cm(TD12.5).The linear correlation coefficient(R^(2))of the model between mean signal value and mean SSC which eliminated 5 cm data was 0.980 and the root mean square error(RMSE)was 143.57 kPa.Compared with the linear model before averaging,the R^(2) was improved by 8.65%,and the RMSE was reduced by 52.39%.This system can realize the real-time and continuous measurement of soil compactness and provide data support for follow-up intelligent agricultural operations.展开更多
Vector vortex beams(VVBs) have attracted considerable attention due to their unique polarization distribution and helical phase wavefront. We first attempt to retrieve the modal coefficients of hybrid VVBs measured by...Vector vortex beams(VVBs) have attracted considerable attention due to their unique polarization distribution and helical phase wavefront. We first attempt to retrieve the modal coefficients of hybrid VVBs measured by their multiplex polarized intensities using the deep learning(DL)-based stochastic parallel gradient descent(SPGD) algorithm. The Xception-based DL model with multi-view images can make an accurate prediction of modal coefficients that are validated by the theoretical calculations of the waveplate angles, demonstrating a high correlation of 99.65%. The universality of the algorithm to highorder vector-eigenmodes(VMs) decomposition is proved to enable the precise reconstruction of modal patterns generated by mode-selective couplers, which promotes the accurate characteristics of VVBs in laser beam characterization and fiber mode-division multiplexing.展开更多
基金Supported by National Key R&D program of China(Grant No.2019YFA0709004)。
文摘Currently,conventional single-sided friction stir welding is primarily suitable for joining thin plate aluminum alloys,and its application to thick plates is still challenging in terms of welding efficiency and joint mechanical properties.Simultaneous double-sided friction stir welding(SDS-FSW)is a high-efficiency joining technique specifically developed for welding thick plates.However,there is little research on the influence of SDS-FSW process parameters on the joint mechanical properties.In this study,a 12 mm thick AA6061-T6 aluminum alloy and dual robot welding equipment are used to conduct SDS-FSW experiments exploring the influence of rotational speedωand welding speed v on the mechanical properties and microstructure.The results show that when the welding parameters areω=800 r/min and v=60–80 mm/min,smooth and defect-free thick plate aluminum alloy SDS-FSW joints can be obtained,and the macroscopic morphology of the joints is distributed in a“dumbbell”shape.The grain size in the weld nugget zone increases with increasing welding heat input.The microhardness distribution in the joint displays a“W”shape,and the hardness value of the weld nugget zone can reach 67%to 86%of that of the base metal(BM).The junction between the thermo-mechanically affected zone and the heat affected zone is the weakest region of the joint,with the lowest hardness being approximately 51%of that of the BM.When the welding parameters areω=800 r/min and v=140 mm/min,the SDS-FSW joint has the highest tensile strength,reaching 78.43%of the BM strength and exhibiting ductile fracture characteristics.This research indicates that acceptable weld strength in thick aluminum alloys can be achieved via the SDS-FSW joining mechanism,highlighting its significant potential for industrial applications.
基金supported by the National Natural Science Foundation of China (51673148)National Basic Research Program of China (2014CB660813)+2 种基金National Key Technology Support Program (2015BAE01B03)Innovation Fund for Technology of China (14C26211200298)Innovation Fund for Technology of Tianjin (14TXGCCX00014,14ZXCXGX00776)~~
文摘A hierarchically‐structured nylon 6 (PA6) nanofiber membrane decorated with silver nanoparticles (Ag NPs) was fabricated by electrospinning and impregnation methods. The as‐fabricated hierarchically‐structured Ag/PA6 nanofiber membrane (HS‐Ag/PA6 NM) exhibits a morphology in which Ag NPs are deposited on the surfaces of both thick fibers and thin fibers. The content and size of theAg NPs can be controlled by varying the concentration of the silver colloid solution. Compared with the non‐hierarchically‐structured Ag/PA6 nanofiber membrane, HS‐Ag/PA6 NM has a higher specificsurface area and exhibits a higher degradation rate for methylene blue of 81.8%–98.1% within2 h. HS‐Ag/PA6 NM can be easily recycled and exhibits good reusability. It retains a degradation rate for methylene blue of 83.5% after five consecutive cycles. The hierarchically‐structured nanofiber membrane is therefore a potential nanocatalyst.
基金the National Department Public Benefit Research Foundation(200807007)the National Basic Research Program of China(973 Program under grant 2011CB505106)+3 种基金the International Science and Technology Cooperation of China(2008DFA30610)the National“Twelfth Five-Year”Plan for Science and Technology Support(2012BAI29B07)the Foundation of Beijing University of Chinese Medicine Basic Scientific Research Business Expenses(2011-CXTD-06)the National Science Foundation of China(30902020 and 81173463).
文摘Objective:The purpose of this study was to assess the efficacy and safety of Chinese herbal medicine(CHM)in the treatment of chronic heart failure(CHF)patients according to syndrome differentiation.Methods:In this multicenter,randomized,double-blind,placebo-controlled clinical trial,a total of 220 CHF patients were assigned to receive CHM or placebo granules without decoction according to syndrome differentiation in addition to their standard western treatment for 4 weeks.The change in the left ventricular ejection fraction(LVEF)was the primary outcome,and the changes in the TCM syndrome scores(TCM-SS)and New York Heart Association functional classification(NYHA-FC)were the secondary outcomes.
基金The National High Technology Research and Development Program(No.2008007)National Science Foundation of China(No.81302914,81473521)+1 种基金Foundation of Beijing University of Chinese Medicine Basic Scientific Research Business Expenses(No.2011-CXTD-06)the Beijing Common special construction projects.
文摘Background:Chronic heart failure(CHF)is characterized by insufficient blood supply from heart to meet the body’s metabolic demands.Integrating Western and traditional Chinese medicine to treat CHF has proved a validated therapeutic approach.In recent years,metabolomics has been regarded as a potential platform to provide biomarkers for diseasesubtypes.Objective:To examine 38 patients,combined NMR plasma metabolomics and traditional Chinese medicine diagnosis in order to identify diagnostic biomarkers for two CHF syndrome subtypes.Methods:After processing the spectra,orthogonal partial least square discriminant analysis was performed,and the contributing NMR signals were analyzed using Y-scrambling statistical validation with good reliability.Results:Plasma metabolic patterns of yin deficiency and yang deficiency patients were clearly discriminated.The yin-deficiency group had increased level of lactate,glycoprotein,lipoprotein and lower levels of glucose,valine and proline.The yang-deficiency group had higher levels of lactate,glycoprotein and pyruvic acid,and lower levels of glucose and lipoprotein.Potential biomarkers of CHF based on the two traditional Chinese medicine syndromes indicated alternative modes of metabolites and metabolic pathways in the disease,e.g.dysfunction of energy utilization and disturbance in fatty acids,amino acids.Conclusion:This study suggests that combining metabolomics with traditional Chinese medicine diagnosis can reveal metabolic signatures for CHF syndrome subtypes.The plasma metabolites identified might be of special clinical relevance for subtypes of CHF,which could lead to further understanding of mechanisms involved and an improvement in personalized treatment for CHF.
基金the National Natural Science Foundation of China.(No.81102730 and No.81302914)Postgraduate Project of Beijing University of Chinese Medicine(No.2015-JYB-XS044).
文摘Objective:To find the target genes in combination of astragalus root(Astragalus membranaceus)and spindle tree wings(Euonymus alatus(THUNB.)SIEB.)(Qijian Heji)with the function of regulating blood glucose levels in kk mice by real-time fluorescence quantitative PCR(RT-PCR).To achieve the primary exploration on the material basis for Qijian Heji to improve the blood glucose levels of type 2 diabetic kk mice.Methods:We applied RT-PCR to detecting the expression of gene targets in kidney tissues of type 2 diabetes model kk mice.The detected gene targets were predicted by the network pharmacology method in the early stage of the project.Through the observation of the hypoglycemic effect of different ratios of Qijian Heji,the optimal proportion was determined and then used to conduct research of material basis.Results:Continuous administration of Qijian Heji(astragalus root:spindle tree wings Z 3:1)for six weeks resulted in significantly lowering blood glucose levels in mice in the fourth week,dropping from 33.3 to 21.9 mmol/L;this lower level was maintained in the fifth to sixth weeks.Blood glucose values in the positive drug group decreased from 33.3 to 21.85 mmol/L in the fourth week and maintained steady decreasing in the fifth and sixth weeks.Conclusion:Qijian Heji,with proportion of 3:1,could significantly reduce the blood glucose values in kk mice,animal experiment results verified the accurate prediction of network pharmacology,and at the same time,it is verified there was a certain therapeutic effect about the combination of the two herbs on reducing the glucose value.Animal experiments and RT-PCR results showed that Qijian Heji conducted a hypoglycemic effect by modulating estrogen receptor(ESR1)and renin(REN)expression.
基金The work was supported by Vertical Science Development Foundation of BUCM(2019-ZXFZJJ-039)National Innovation Training Program(201610026039)National Natural Science Foundation of China(81503382,81473521).
文摘Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pressure(BP)in hypertensive rats with a liver-fire hyperactivity pattern by observing changes in BP as well as physiochemical indexes in plasma.Methods:Sixteen male spontaneous hypertensive rats(SHR)with a liver-fire hyperactivity pattern were randomly divided into a control group and a Jue tone group.The rats in the Jue tone group were treated with Jue tone(55e65 dB,played by the five elements of music rhythm instrument,a kind of physiotherapy regimen music played by Shen Wu)once a day for 4 weeks.The BP levels in each group were measured twice a week,on Monday and Friday.The levels of angiotensin II(Ang-II),thromboxane B2(TXB2),endothelin-1(ET-1),calcitonin gene-related peptide(cGRP),norepinephrine(NE),cortisol(CORT),and 5-hydroxytryptamine(5-HT).in plasma were detected by enzyme-linked immunosorbent assay after 4 weeks of intervention.Results:BP and the levels of TXB2 and ET-1 in the plasma of the treatment group were significantly lower than those of the control group,while the level of cGRP was significantly higher.Conclusion:Jue tone can reduce the BP of hypertensive rats with a liver-fire hyperactivity pattern.The mechanism may correlate with a reduction in TXB2 and ET-1 and an increase in cGRP with the reduction of reactive oxygen species(ROS).
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA26010101)the National Key Research and Development Program of China(2020YFC0832800)+1 种基金National Natural Science Foundation of China(41801366,52101405)NSFC-RS exchange project between China and UK(42011530175)。
文摘Patterns in species geographic range size are relatively well-known for vertebrates,but still poorly known for plants.Contrasts of these patterns between groups have rarely been investigated.With a detailed flora and fauna distribution database of Xinjiang,China,we used regression methods,redundancy analysis and random forests to explore the relationship of environment and body size with the geographic range size of plants,mammals and birds in Xinjiang and contrast these patterns between plants and animals.We found positive correlations between species range size and body size.The range size of plants was more influenced by water variables,while that of mammals and birds was largely influenced by temperature variables.The productivity variable,i.e.,Enhanced Vegetation Index(EVI)was far more correlated with range size than climatic variables for both plants and animals,suggesting that vegetation productivity inferred from remote sensing data may be a good predictor of species range size for both plants and animals.
基金the National Natural Science Foundation of China(81973697)the National Key R&D Program of China(2017YFC1700102).
文摘Objective:To evaluate the effect of Qishen granule(QSG)on heart failure(HF)and the potential mechanisms involved in animal models.Methods:Studies of QSG in animals with HF were identified by searches of eight databases up to August 1,2019.Two authors independently reviewed each study and the Collaborative Approach to Metaanalysis and Review of Animal Data from Experimental Studies 10-item checklist was used for quality assessment.The primary outcomes were indicators of left ventricular ejection fraction and/or left ventricular fractional shortening.The secondary outcome measures were ventricular structure,hemodynamics,myocardial injury-related indicators,and the mechanisms whereby QSG ameliorates HF.A metaanalysis was performed and all the data were analyzed using RevMan 5.3 software.Results:Thirteen studies containing a total of 240 animals met the criteria for the meta-analysis.The quality score of the studies ranged from three to six points.The meta-analysis showed a significant effect of QSG to improve cardiac function,inhibit ventricular remodeling,improve circulation,and attenuate myocardial injury.The possible mechanisms was identified to be suppression of the renin-angiotensinaldosterone system,which has anti-fibrotic,anti-apoptotic,anti-inflammatory,and anti-oxidative effects in the myocardium,the prevention of calcium overload,and the promotion of myocardial energy metabolism.Conclusion:Our review shows that QSG has a cardioprotective effect in animal models of CHF.However,due to the relatively poor quality of the included studies and the differences between humans and animal models,the results should be interpreted with caution.
基金supported by the Special Project of the Chinese Administration of Traditional Chinese Medicine(537/01204,200807007 by Wei Wang).
文摘Objective:To evaluate the efficacy of traditional Chinese herbs on heart failure(HF)using nuclear magnetic resonance(NMR)metabolomics.Methods:Plasma metabolomics was conducted on both patients with HF and healthy controls.The partial least squares model was applied to determine potential metabolic markers and related metabolic pathways of the disease.HF patients with the traditional Chinese syndrome pattern of qi deficiency and blood stasis were divided into two groups,and treated,respectively,with conventional medicine and a combination of conventional and Chinese herbs,aimed at tonifying qi and activating blood.Healthy participants served as a control group for comparison.Results and conclusion:Both conventional and herbal treatments appear to regulate disorders of amino acid and glucose metabolism.Combined treatment appears to be more comprehensive,indicating that herbal and conventional medicines exert their effects through different mechanisms in treating HF.It can be further inferred that herbs that tonify qi and activate blood may regulate different essential metabolites.
基金This work was supported by a grant from the National Basic Research Program of China(973 Program No.2011CB505106).
文摘Objective:To investigate the biological basis of“depression with liver-qi stagnation and spleen deficiency syndrome”.Methods:A digital gene expression profiling method was conducted to explore global changes in the mRNA transcriptome in a rat model of depression with liver-qi stagnation and spleen deficiency syndrome.Real-time quantitative polymerase chain reaction(q-PCR)was performed to verify the five genes most interest based on the Kyoto Encyclopedia of Genes and Genome(KEGG)analysis.Sini San,which disperses stagnated liver qi and strengthens the spleen,was administered to the model rats to observe whether it could reverse these genetic changes in the liver.Results:Forty-six differentially expressed genes were identified.Three of the five genes of most interestdHnf4a,Hnf4g and Cyp1a1dbased on KEGG analysis,were confirmed by realtime q-PCR.Sini San reduced the gene expression changes of Hnf4a,Hnf4g and Cyp1a1 in the rat model.Conclusions:Hnf4a,Hnf4g and Cyp1a1 are involved in“depression with liver-qi stagnation and spleen deficiency syndrome”.These findings indicate that depressed rats with liver-qi stagnation and spleen deficiency syndrome are at risk of liver diseases.Furthermore,our results will inform exploration of the etiology of depression and help in the development of effective therapeutic strategies.
基金supported by the National Natural Science Foundation of China(No.82173752 and No.81874303).
文摘Cancer patients by immune checkpoint therapy have achieved long-term remission,with no recurrence of clinical symptoms of cancer for many years.Nevertheless,more than half of cancer patients are not responsive to this therapy due to immune exhaustion.Here,we report a novel gene engineered exosome which is rationally designed by engineering PD1 gene and simultaneously enveloping an immune adjuvant imiquimod(PD1-Imi Exo)for boosting response of cancer immune checkpoint blockage therapy.The results showed that PD1-Imi Exo had a vesicular round shape(approximately 139 nm),revealed a significant targeting and a strong binding effect with both cancer cell and dendritic cell,and demonstrated a remarkable therapeutic efficacy in the melanoma-bearing mice and in the breast cancer-bearing mice.The mechanism was associated with two facts that PD1-Imi Exo blocked the binding of CD8^(+)T cell with cancer cell,displaying a PD1/PDL1 immune checkpoint blockage effect,and that imiquimod released from PD1-Imi Exo promoted the maturation of immature dendritic cell,exhibiting a reversing effect on the immune exhaustion through activating and restoring function of CD8^(+)T cell.In conclusion,the gene engineered exosome could be used for reversing T cell exhaustion in cancer immunotherapy.This study also offers a promising new strategy for enhancing PD1/PDL1 therapeutic efficacy,preventing tumor recurrence or metastasis after surgery by rebuilding the patients’immunity,thus consolidating the overall prognosis.
基金supported by the Natural Science Foundation of Chongqing(No.2024NSCQ-MSX3704)Youth Project of Science and Technology Research Program of Chongqing Education Commission of China(Project No.KJQN202101418)Fundamental Research Funds for the Central Universities(Project No.SWU-KQ24027).
文摘Urban greenery is widely recognised as a strategy to mitigate urban overheating,and its shading capacity is crucial for improving microclimate and thermal comfort.Nevertheless,research on modelling the vegetation canopy radiation transfer(VCRT)process for the microscale is lacking,and most existing VCRT models are taken out from mesoscale models.In this study,we used canopy morphology and structure as an entry point to construct a VCRT model for the microscale,from the mesoscale model.Firstly,100 m and 1000 m were defined as the critical scales by scaling,and the effect of leaf distribution on VCRT was analysed.The VCRT model was made applicable to the microscale by introducing a scattered radiation source term and 6 leaf inclination distribution(LID)functions,and the results showed that the proposed model could improve the accuracy of canopy radiation absorptivity by about 11%.In addition,both leaf area index(LAI)and LID had significant effects on VCRT,and vegetation with LAI above 2 and spreading leaves had better shading effects.It is worth noting that urban greenery has an exciting potential for thermal comfort improvement,with the potential to regulate even extremely hot weather from near"very hot"(148 W/m^(2))to almost"comfortable"(69 W/m^(2)).This study is a catalyst for improving the predictability of the VCRT process for microclimate and thermal comfort,providing theoretical support and implications for mitigating urban overheating and enhancing urban thermal resilience.
基金National Natural Science Foundation of China(12274281,62275148,U2241237)Open Research Fund of State Key Laboratory of Advanced Optical Communication Systems and Networks,Shanghai Jiao Tong University(2023GZKF021)+1 种基金Jiangsu Province’s Industry Outlook and Key Core Technologies-Key Projects(BE2022055-4)111 Project(D20031).
文摘Cylindrical vector beams(CVBs)with special polarization distribution have been extensively investigated due to the unique ways of interacting with matter.Although several configurations have been developed to generate CVBs,such as Q-plates and subwavelength gratings,the bandwidth of a single CVB is inherently narrow due to the phase geometry,which would limit its application for femtosecond lasers.Here,a broadband CVB mode converter based on an acoustically induced fiber grating(AIFG)and a tuning method of dispersion turning point(DTP)is demonstrated both theoretically and experimentally with the 3-dB bandwidth of 125 nm,which is more than 10 times that of conventional AIFGs.Not only can the DTP wavelength be tuned from the original 1500 nm to 1650 nm by thinning the fiber,but also the stable generation of a single broadband HE_(21)^(odd/even) mode can be controllably implemented by adjusting the polarization state of the incident light,owing to the larger beat length difference between HE21 and other CV modes.Additionally,the femtosecond CVBs and orbital angular momentum(OAM)modes are successfully generated and amplified by combining the broadband AIFG with a figure-9 mode-locked fiber laser.Meanwhile,it is verified by simulation that the choice of broadband CV mode and the tunability of DTP wavelength can be realized by designing ring-core fibers with different structures,which can furthermore improve the flexibility of generating high purity CVBs.This study provides a highly controllable technique for the generation of broadband CVBs and OAMs paving the way for high-capacity CVBs communication.
基金This study was financially supported by the China Agriculture Research System of MOF and MARA,Mount Tai Industry Leading Talents Project(LJNY201708)the Soil-Machine-Plant Key Laboratory of the Ministry of Agriculture of China.
文摘Complex field environments,diverse crop conditions,and varying feed rate fluctuations commonly result in a decline in the threshing performance and the clogging of the threshing cylinder for maize harvesters.In order to overcome these problems,an electric-hydraulic concave clearance automatic control system for the threshing unit was developed based on the maize feed rate monitoring,which can automatically realize the best match between the concave clearance and diverse feed rates during harvesting.The threshing performance of the electric-hydraulic control system was evaluated for varying and uneven maize feed rate fluctuations,such as the feed rate increased(6-8-10 kg/s),the feed rate decreased after an increase(6-10-8 kg/s,8-10-6 kg/s),the feed rate increased after a decrease(8-6-10 kg/s,10-6-8 kg/s),and the feed rate decreased(10-8-6 kg/s).In particular,the threshing rotor shaft peak torque,the range of threshing rotor shaft torque,the rate of broken grains(BGR),and the rate of unthreshed grains(UGR)with and without the electric-hydraulic control system were tested.Treatments with the electric-hydraulic control system were adjustable concave clearance with the value of 45 mm,50 mm,and 55 mm.Treatments without the electric-hydraulic control system were constant concave clearance(50 mm).Results demonstrate that the threshing unit with the electric-hydraulic control system outperformed the one without the electric-hydraulic control system,with threshing rotor peak torque,the range of threshing rotor axis torque,the BGR,and the UGR decreasing by 18.38%,38.27%,2.08%,and 0.10%,respectively.Moreover,the rate of broken grains was lower than 5.00%,better than the national standard.Thus,the feed rate fluctuations and timely adjustment of the concave clearance were able to avoid blocking the rotor and improve the threshing performance compared to the constant concave clearance.
基金supported by the National Natural Science Foundation of China(Nos.81874303,82173752)。
文摘Cisplatin is broad-spectrum chemotherapeutic agent that has been widely used for the treatment of a variety of malignant tumors including breast cancer.However,the cisplatin chemoresistance,which derives from the inactivation by glutathione(GSH)depletion,remains a scientific issue to solve.Here,we report a novel type of smart disulfide switchable nanoparticles complexing cisplatin(switch NPs-cisplatin)that is rationally designed,and engineered by synthesizing a hyaluronic acid disulfide bonded polyaspartic acid(HA-ss-Pasp)and complexing cisplatin.The results showed that the switch NPs-cisplatin had a nanoscale of particle size(150 nm),higher drug encapsulation efficiency(>90%),and suitable drug release profile.They demonstrated evident pH responsiveness and GSH responsiveness,and targeting effect in the resistant breast cancer cells.Furthermore,they were able to block the cisplatin depletion by GSH in the resistant cancer cells,thereby circumventing the chemoresistance.Consequently,switch NPs-cisplatin displayed a remarkable killing effect in the resistant breast cancer cells in vitro,and in the resistant breast cancer-bearing mice.In conclusion,switch NPs-cisplatin could be used as a smart formulation of cisplatin for overcoming the chemoresistance of breast cancer.The present study also offers a universal drug delivery carrier platform for highly efficient but low systemic toxic chemotherapy.
基金funded by the Natural Science Foundation of Hunan Province,China(2023JJ40443)the Outstanding Youth Project of Hunan Provincial Education Department(22B0088 and 22B0055)+1 种基金the Joint Fund for Regional Innovation and Development of the National Natural Science Foundation(U22A20570)the Science and Technology Innovation Program of Hunan Province(2022RC4027),China.
文摘Based on the two most recent assessments of Chinese higher plants in 2013 and 2020,of 34,450 and 39,330 species,respectively,we analysed the threatened status of Chinese higher plants.In 2020,around 4,088(10.39%)of the assessed species in China are threatened,2,875(7.31%)Near Threatened,27,593(70.16%)not currently threatened and categorised as Least Concern and 4,752(12.08%)categorised as Data Deficient.While in 2013,3,767(10.93%)of the assessed higher plants in China are threatened,2,723(7.90%)Near Threatened,24,296(70.53%)Least Concern and 3,612(10.48%)Data Deficient.Estimates of the Red List Index in the two years show different patterns when using different weighting methods with the equal steps weighting method showing a slight decrease(0.91675-0.91495)and the extinction risk weighting method showing a slight increase(0.98792-0.98797).We inferred that China's threatened plant species were likely/relatively effectively protected.However,attention should also be given to the non-threatened species in the future as an additional strategy for their conservation,to maintain their non-threatened status.
基金supported in part by the earmarked fund for CARS(CARS-02)the Soil-Machine-Plant Key Laboratory of the Ministry of Agriculture of Chinathe Project of introducing talents in urgent need in Key Supporting Areas of Shandong Province in 2021.
文摘With the continuous improvement of agricultural mechanization,soil compaction becomes more and more serious.Serious soil compaction has been considered as an important negative factor affecting crop growth and yield.The measurement of soil compactness is a common method to measure the soil compaction level.In order to solve the problems of discontinuous sampling,time-consuming and poor real-time soil compactness measurement,a real-time measurement method of soil compactness based on fertilizing shovel was proposed,and the mathematical model between fertilizing shovel arm deformation and soil compactness was established.Based on the interaction mechanism between fertilizing shovel and soil,through the force analysis of fertilizing shovel,it was found that the deformation of fertilizing shovel arm was positively correlated with the sum of soil compactness(SSC)within the range of tillage depth.In order to verify the theoretical analysis results and the detection accuracy of strain gauge,the static bench test was carried out.The test results showed that the strain gauge signal for measuring the deformation of the fertilizing shovel arm was significantly correlated with the applied force.The fitting curve of the linear correlation coefficient was 0.999,the maximum detection error was 0.68 kg,and the detecting accuracy was within the tolerance of 0.57%.Through field orthogonal experiments with four working depths and four compaction levels,a mathematical model of the strain gauge signal and the SSC within the range of tillage depth was established.The experiment showed that compared with the other three depths,the linear correlation coefficient at the tillage depth of 5 cm(TD5)was the lowest,and the slope of the fitting curve was obviously different from the other three depths,so the 5 cm data were excluded when modeling.The model between mean signal value and mean SSC within the range of tillage depth was established based on the data of sampling points with tillage depths of 7.5 cm(TD7.5),10 cm(TD10),and 12.5 cm(TD12.5).The linear correlation coefficient(R^(2))of the model between mean signal value and mean SSC which eliminated 5 cm data was 0.980 and the root mean square error(RMSE)was 143.57 kPa.Compared with the linear model before averaging,the R^(2) was improved by 8.65%,and the RMSE was reduced by 52.39%.This system can realize the real-time and continuous measurement of soil compactness and provide data support for follow-up intelligent agricultural operations.
基金supported by the National Natural Science Foundation of China (Nos.12274281,U2241237,and 62275148)the Open Research Fund of State Key Laboratory of Advanced Optical Communication Systems and Networks,Shanghai Jiao Tong University (No.2023GZKF021)+1 种基金the Jiangsu Provincial Industry Outlook and Key Core Technologies Key Projects (No.BE2022055-4)111 Project (No.D20031)。
文摘Vector vortex beams(VVBs) have attracted considerable attention due to their unique polarization distribution and helical phase wavefront. We first attempt to retrieve the modal coefficients of hybrid VVBs measured by their multiplex polarized intensities using the deep learning(DL)-based stochastic parallel gradient descent(SPGD) algorithm. The Xception-based DL model with multi-view images can make an accurate prediction of modal coefficients that are validated by the theoretical calculations of the waveplate angles, demonstrating a high correlation of 99.65%. The universality of the algorithm to highorder vector-eigenmodes(VMs) decomposition is proved to enable the precise reconstruction of modal patterns generated by mode-selective couplers, which promotes the accurate characteristics of VVBs in laser beam characterization and fiber mode-division multiplexing.
