RIG-I （retinoid acid-inducible gene-I）, a putative RNA helicase with a cytoplasmic caspase-recrultment domain （CARD）, was identified as a pattem-recognition receptor （PRR） that mediates antiviral immunity by ind...RIG-I （retinoid acid-inducible gene-I）, a putative RNA helicase with a cytoplasmic caspase-recrultment domain （CARD）, was identified as a pattem-recognition receptor （PRR） that mediates antiviral immunity by inducing type I interferon production. To further study the biological function of RIG-I, we generated Rig-I^-/- mice through homologous recombination, taking a different strategy to the previously reported strategy. Our Rig-I^-/- mice are viable and fertile. Histological analysis shows that Rig-I^-/ mice develop a colitis-like phenotype and increased susceptibility to dextran sulfate sodium-induced colitis. Accordingly, the size and number of Peyer＇s patches dramatically decreased in mutant mice. The peripheral T-cell subsets in mutant mice are characterized by an increase in effector T cells and a decrease in naive T cells, indicating an important role for Rig-I in the regulation ofT-cell activation. It was further found that Rig-I deficiency leads to the downregulation of G protein αi2 subunit （Gαi2） in various tissues, including T and B lymphocytes. By contrast, upregulation of Rig-I in NB4 cells that are treated with ATRA is accompanied by elevated Gαi2 expression. Moreover, Gαi2 promoter activity is increased in co-transfected NIH3T3 cells in a Rig-I dose-dependent manner. All these findings suggest that Rig-I has crucial roles in the regulation of Gαi2 expression and T-cell activation. The development of colitis may be, at least in part, associated with downregulation of Gαi2 and disturbed T-cell homeostasis.展开更多
Dear Editor： The emergence of multidrug-resistant tuberculosis （MDR-TB） is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis （M. tuberculosis） that is resistant to isoniazid and rifampicin,...Dear Editor： The emergence of multidrug-resistant tuberculosis （MDR-TB） is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis （M. tuberculosis） that is resistant to isoniazid and rifampicin, with or with- out resistance to other anti-tuberculosis drugs. Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease. Bacterial burden is not strictly corre- lated with disease progression, and several hallmarks of severe tuberculosis suggest that insufficiently controlled inflammation plays an important role in pathogenesis.展开更多
A novel molten salt extraction process consisting of chlorination roasting and molten salt electrolysis was proposed to develop a more efficient and environmental friendly technology for recovering lead from spent lea...A novel molten salt extraction process consisting of chlorination roasting and molten salt electrolysis was proposed to develop a more efficient and environmental friendly technology for recovering lead from spent lead acid batteries(LABs).The feasibility of this process was firstly assessed based on thermodynamics fundamentals.The electrochemical behavior of Pb(II)on a tungsten electrode in the eutectic NaCl−KCl melts at 700℃ was then investigated in detail by transient electrochemical techniques.The results indicated that the reduction reaction of Pb(II)in NaCl−KCl melts was a one-step process exchanging two electrons,and it was determined to be a quasi-reversible diffusion-controlled process.Finally,potentiostatic electrolysis was carried out at−0.6 V(vs Ag/AgCl)in the NaCl−KCl−PbCl2 melts,and the obtained cathodic product was identified as pure Pb by X-ray diffraction analysis.This investigation demonstrated that it is practically feasible to produce pure Pb metal by electrochemical reduction of PbCl2 in eutectic NaCl−KCl melts,and has provided important fundamental for the further study on lead recovery from spent LABs via molten salt extraction process.展开更多
Fasudil, a selective rho kinase(ROCK) inhibitor, has been reported to play a beneficial role in systemic inflammation in acute lung injury, but its mechanism for ameliorating pulmonary edema and inflammation remains u...Fasudil, a selective rho kinase(ROCK) inhibitor, has been reported to play a beneficial role in systemic inflammation in acute lung injury, but its mechanism for ameliorating pulmonary edema and inflammation remains unclear. Using hematoxylin-and-eosin(H&E) staining, immunohistochemistry, enzyme-linked immunosorbent assay,quantitative real time PCR and Western blotting, we found that fasudil attenuated LPS-induced lung injury, decreased lung edema, and suppressed inflammatory responses including leukocyte infiltration and IL-6 production. Further,fasudil upregulated LPS-induced aquaporin 5 reduction and inhibited NF-κB activation in the lungs of mice. Our results suggest that fasudil could restore the expression of aquaporin 5 to eliminate LPS-induced lung edema and prevent LPS-induced pulmonary inflammation by blocking the inflammatory pathway. Collectively, blockade of the ROCK pathway by fasudil may be a potential strategy for the treatment of acute lung injury.展开更多
A process comprising selective chlorination and molten salt electrolysis was proposed to develop an efficient and environmental-friendly technology for zinc recovery from metallurgical dusts.The theoretical feasibilit...A process comprising selective chlorination and molten salt electrolysis was proposed to develop an efficient and environmental-friendly technology for zinc recovery from metallurgical dusts.The theoretical feasibility of this technology was firstly estimated based on thermodynamic fundamentals.Subsequently,the electrochemical behavior of Zn^(2+)on tungsten electrode was investigated in molten NaCl-KCl eutectic at 973 K by many electrochemical transient methods.The results showed that the reduction of Zn^(2+)on tungsten electrode was found to be a one-step process exchanging two electrons with the initial reduction potential of-0.74 V(vs Ag/AgCl),and the electrode process was considered as quasi-reversible and controlled by diffusion.The diffusion coefficient of Zn^(2+)ions in the melts was determined in the order of 10^(-5)cm^(2)/s.Finally,the electrolytic preparation of zinc was carried out by potentiostatic electrolysis in molten NaCl-KCl-ZnCl_(2)eutectic at-1.6 V(vs Ag/AgCl).Spheroidic granular metal with silver-white luster was attained after electrolysis for 9.5 h,and identified as pure Zn.The present study confirms that it is practically feasible to extract pure zinc metal by direct electrolysis of ZnCl_(2)in molten NaCl-KCl eutectic,and provides a valuable theoretical reference for the efficient recovery of zinc from metallurgical dusts.展开更多
The development of the new energy vehicle industry has become a key force driving the goals of carbon peak and carbon neutralization.To better guide future strategies,this study investigates the dual impact of subsidy...The development of the new energy vehicle industry has become a key force driving the goals of carbon peak and carbon neutralization.To better guide future strategies,this study investigates the dual impact of subsidy and dual-integral policies on the performance of new energy vehicle enterprises.This study first theorizes the influential mechanism according to the institutional-based approach and technical innovation theory,and then collects data from listed companies in the new energy vehicle industry from 2016 to 2020.The hypotheses are examined using a two-way fixed-effects model.The findings show that:(1)subsidy policies are can still improve enterprise performance,but not through green technology innovation;(2)the dual-credit policy can improve enterprise performance through green technology innovation;and(3)under current policy conditions,with subsidies declining annually,the interaction effects between the subsidy and dual-integral policies will also decrease.Thus,this study suggests that non-monetary industrial policy,represented by the dual credit policy is a more effective alternative to government subsidies.展开更多
China has large population but little land.Such objective conditions determine that it is required to adhere to the policy path of"cherishing,rationally utilizing land and practically protecting cultivated land&q...China has large population but little land.Such objective conditions determine that it is required to adhere to the policy path of"cherishing,rationally utilizing land and practically protecting cultivated land".Due to the relatively immature technology in the early stage of resource development in China,extensive utilization of resources leads to serious pollution,and the situation of the restoration of contaminated sites is severe.After nearly 20 years of a large number of pollution,land restoration there have been a lot of achievements in research and practice,but in the era of big data development,prevention and cure of soil pollution in China,there are a number of problems in the development of science and technology,this paper put forward the corresponding recommendations and opinions for the existing problems,in order to provide decision support for using big data to repair contaminated sites.展开更多
The longitudinal ultrasonic velocity （V1）, attenuation （α1）, magnetization and resistivity of single phase polycrystalline La1/3Sr2/3CoO3 were measured as a function of temperature from 20 K to 300 K. The resisti...The longitudinal ultrasonic velocity （V1）, attenuation （α1）, magnetization and resistivity of single phase polycrystalline La1/3Sr2/3CoO3 were measured as a function of temperature from 20 K to 300 K. The resistivity shows metallic behavior in the whole temperature range and a kink at 235 K was observed, which coincides with the ferromagnetic transition temperature （Tc）. As the temperature cools down from Tc, the V1 softens conspicuously at beginning and reaches a minimum at 120 K. After that the V1 dramatically stiffens below 120 K accompanied by a wide attenuation peak. The analysis of the results suggests that these ultrasonic anomalies ;nay correspond to local lattice distortions via the Jahn-Teller effect of intermediate spin Co^3＋.展开更多
Based on the DEM raster image data with a resolution of 60 m×60 m in the Sanjiangyuan region,the topographic heterogeneity in the Sanjiangyuan region was analyzed by calculating and processing the topographic rel...Based on the DEM raster image data with a resolution of 60 m×60 m in the Sanjiangyuan region,the topographic heterogeneity in the Sanjiangyuan region was analyzed by calculating and processing the topographic relief,elevation standard deviation,terrain heterogeneity and surface roughness indexes.The results show that the overall terrain elevation of the Sanjiangyuan area is high,and the surface undulations are large.The southern and southeastern parts of the region are the places with the most dramatic terrain changes.The absolute values of terrain undulations,elevation standard deviation and surface roughness are large.In the central and western regions,the terrain change is small,the relief degree is small,the elevation standard deviation and the surface roughness are small.展开更多
Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health threat.Persistent HBV infection remains the principal cause of liver cirrh...Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health threat.Persistent HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.展开更多
As a stress hormone existing in the human body,cortisol can reflect the psychological stress and health status in daily life,and is a potential biomarker of the body’s stress response.To effectively collect sweat and...As a stress hormone existing in the human body,cortisol can reflect the psychological stress and health status in daily life,and is a potential biomarker of the body’s stress response.To effectively collect sweat and accurately identify the target,this paper reports a flexible wearable cortisol detection device with outstanding reliability and sensitivity.Molecular imprinted polymer(MIP)ensures cortisol specificity.And carbon nanotubes(CNT)on electrodes increase sensitivity,expanding the detection range to 10^(−3) to 10^(4) nM,with sensitivity at 189.2 nA/lg(nM).In addition,porous chitosan hydrogel(PCSH)collects sweat effectively,its adhesive properties and 80%swelling rate offer a low-cost alternative to microfluidics.Flexible printed circuit board(FPCB)and serpentine electrode(SE)ensure device durability.This non-invasive,highly sensitive device offers a novel method for mental stress monitoring and clinical diagnosis,advancing human physiological state monitoring.展开更多
The temperature tuning of BaGa_(4)Se_(7)(BGSe)was demonstrated for the first time,to the best of our knowledge.When the temperature of BGSe(56.3°,0°)was raised from 30℃ to 140℃,the idler light under type ...The temperature tuning of BaGa_(4)Se_(7)(BGSe)was demonstrated for the first time,to the best of our knowledge.When the temperature of BGSe(56.3°,0°)was raised from 30℃ to 140℃,the idler light under type Ⅰ raised from 3637 nm to 3989 nm,the tunable range reached 352 nm,and Δλ_(2)=ΔT reached 3.20 nm/℃.We calculated the phase matching curve of BGSe when Φ and T took different values.The relationship between θ and Δλ_(2)=ΔT was obtained by fixing Φ at 0°.The maximum Δλ_(2)=ΔT and its corresponding(θ,Φ)phase matching type were reported under different fixed λ_(2)(3μm,3.2μm,...,5μm).展开更多
Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement.China has pledged to peak CO_(2) emissions before 2030 and achieve carbon neutrality before 2060,and a"...Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement.China has pledged to peak CO_(2) emissions before 2030 and achieve carbon neutrality before 2060,and a"1+N"policy framework has been built to guide the implementations.Scientific and technological innovation has been emphasized as one of the key strategies to establish an innovation system,strengthen research,and promote applications of green and low-carbon technologies[1].Despite numerous studies and policies on decarbonization technologies,studies focusing on technological development pathways for China’s carbon neutrality are needed[2].展开更多
The linewidth of the BaGa_(4)Se_(7)(BGSe)optical parametric oscillator(OPO)was narrowed for the first time,to the best of our knowledge,by inserting a Fabry-Perot(FP)etalon into an L-shaped cavity.When a 15 mm long BG...The linewidth of the BaGa_(4)Se_(7)(BGSe)optical parametric oscillator(OPO)was narrowed for the first time,to the best of our knowledge,by inserting a Fabry-Perot(FP)etalon into an L-shaped cavity.When a 15 mm long BGSe(56.3°,0°)was pumped by a 1064 nm laser,the peak wavelength was〜3529 nm,and the linewidth was 4.53 nm[3.64 cm^(-1)]under type I phase matching.After inserting a 350μm thick FP etalon,the linewidth was decreased to 1.27-2.05 nm.When the tilt angle of the etalon was 2.34°,the linewidth was 2.05 nm[1.65 cm^(-1)],and the peak wavelength was still〜3529 nm.When the tilt angle of the etalon was 3.90°,the peak wavelength was 3534.9 nm,and the linewidth was 1.27 nm(1.02 cm^(-1)),which was the narrowest linewidth of a BGSe OPO,to the best of our knowledge.The beam quality was also improved after inserting the FP etalon.展开更多
The gravity p-median model is an important improvement to the widely-used p-median model. However, there is still a debate on its validity in empirical applications. Previous studies even doubt the significance of the...The gravity p-median model is an important improvement to the widely-used p-median model. However, there is still a debate on its validity in empirical applications. Previous studies even doubt the significance of the gravity p-median model. Using a case study of tertiary hospitals in Shenzhen, China, this study re-examines the difference between the gravity p-median model with the p-median model, by decomposing the difference between the two models into gravity rule and variant attraction. This study also proposes a modified gravity p-median model by incorporating a distance threshold. The empirical results support the validity of the gravity p-median model, and also reveal that only when the attractions of candidate facility locations are variable will the gravity p-median model lead to different results with the p-median model. The difference between the modified gravity p-median model and the gravity p-median model is also examined. Moreover, the impacts of the distance-decay parameter and distance threshold on solutions are investigated. Results indicate that a larger distance-decay parameter tends to result in a more dispersed distribution of optimal facilities and a smaller average travel time, and a smaller distance threshold can better promote the spatial equity of facilities. The proposed method can also be applied in studies of other types of facilities or in other areas.展开更多
Tbeacrine （1,3,7,9-tetramethyluric acid）, a purine alkaloid similar to caffeine in its chemical structure, is isolated from edible Camellia assamica vat. kucha and has various pharmacological activities including hy...Tbeacrine （1,3,7,9-tetramethyluric acid）, a purine alkaloid similar to caffeine in its chemical structure, is isolated from edible Camellia assamica vat. kucha and has various pharmacological activities including hypnotic effects, anti-depressant effects, anti-inflammatory and analgesic effects, and a protective effect against stress-provoked liver damage. A rapid and simple assay is required to quantify theacrine in biological samples for pharmacokinetic studies in small animals. This study aimed to establish an enzyme-linked immunosorbent assay （ELISA） for theacrine quantification in blood. Herein, we successfully obtained monoclonal antibodies （MAbs） against theacrine, MAbs C11B5, and developed an ELISA method for the fast determination of theacrine in mouse blood. The range for calibration of theacrine by ELISA was 0.156-100 μg mL-1. The half maximum inhibitory concentration （IC50） value was 1.55 μg mL-1. The ELISA method lays a good foundation for the further research.展开更多
Artificial intelligence,an emerging technology,widely exists in the field of engineering science and technology.Due to its high efficiency and precision,artificial intelligence is increasingly used in the optimal cont...Artificial intelligence,an emerging technology,widely exists in the field of engineering science and technology.Due to its high efficiency and precision,artificial intelligence is increasingly used in the optimal control of water treatment and seawater desalination.Generally,the design of a desalination system includes four processes:site selection,energy prediction,desalination technology selection and systematic parameter optimization.To a large extent,these choices depend on the experience and relevant criteria of researchers and experts.However,facing the scientific and technological progress and growing expectations,it is impossible to solve such complex nonlinear problems by simple experience and mathematical models,but artificial intelligence is good at this.In this paper,we synthetically analyzed and summarized the application of artificial intelligence in the field of seawater desalination with renewable energy.Artificial intelligence application in desalination is mainly divided into four aspects:expert decision-making,optimization,prediction and control by sequence.The features of artificial intelligence employed in the design of desalination systems not only realize the maximum of efficiency and minimum of cost,but release the human resources.After analyzing the four processes of desalination,it is found that artificial neural network and genetic algorithm are more widespread and mature than other algorithms in dealing with multi-objective nonlinear problems.This paper overviewed the application of artificial intelligence technologies in decision-making,optimization,prediction and control throughout the four processes of desalination designs.Finally,the application and future development prospect of artificial intelligence in the field of seawater desalination are summarized.展开更多
文摘RIG-I （retinoid acid-inducible gene-I）, a putative RNA helicase with a cytoplasmic caspase-recrultment domain （CARD）, was identified as a pattem-recognition receptor （PRR） that mediates antiviral immunity by inducing type I interferon production. To further study the biological function of RIG-I, we generated Rig-I^-/- mice through homologous recombination, taking a different strategy to the previously reported strategy. Our Rig-I^-/- mice are viable and fertile. Histological analysis shows that Rig-I^-/ mice develop a colitis-like phenotype and increased susceptibility to dextran sulfate sodium-induced colitis. Accordingly, the size and number of Peyer＇s patches dramatically decreased in mutant mice. The peripheral T-cell subsets in mutant mice are characterized by an increase in effector T cells and a decrease in naive T cells, indicating an important role for Rig-I in the regulation ofT-cell activation. It was further found that Rig-I deficiency leads to the downregulation of G protein αi2 subunit （Gαi2） in various tissues, including T and B lymphocytes. By contrast, upregulation of Rig-I in NB4 cells that are treated with ATRA is accompanied by elevated Gαi2 expression. Moreover, Gαi2 promoter activity is increased in co-transfected NIH3T3 cells in a Rig-I dose-dependent manner. All these findings suggest that Rig-I has crucial roles in the regulation of Gαi2 expression and T-cell activation. The development of colitis may be, at least in part, associated with downregulation of Gαi2 and disturbed T-cell homeostasis.
文摘Dear Editor： The emergence of multidrug-resistant tuberculosis （MDR-TB） is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis （M. tuberculosis） that is resistant to isoniazid and rifampicin, with or with- out resistance to other anti-tuberculosis drugs. Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease. Bacterial burden is not strictly corre- lated with disease progression, and several hallmarks of severe tuberculosis suggest that insufficiently controlled inflammation plays an important role in pathogenesis.
基金Project(gxyq2018012)supported by the Developing Program Foundation for the Excellent Youth Talents of Higher Education of Anhui Province,ChinaProject(SKF19-05)supported by Foundation of Anhui Province Key Laboratory of Metallurgical Engineering&Resources Recycling,ChinaProjects(51904003,U1703130)supported by the National Natural Science Foundation of China。
文摘A novel molten salt extraction process consisting of chlorination roasting and molten salt electrolysis was proposed to develop a more efficient and environmental friendly technology for recovering lead from spent lead acid batteries(LABs).The feasibility of this process was firstly assessed based on thermodynamics fundamentals.The electrochemical behavior of Pb(II)on a tungsten electrode in the eutectic NaCl−KCl melts at 700℃ was then investigated in detail by transient electrochemical techniques.The results indicated that the reduction reaction of Pb(II)in NaCl−KCl melts was a one-step process exchanging two electrons,and it was determined to be a quasi-reversible diffusion-controlled process.Finally,potentiostatic electrolysis was carried out at−0.6 V(vs Ag/AgCl)in the NaCl−KCl−PbCl2 melts,and the obtained cathodic product was identified as pure Pb by X-ray diffraction analysis.This investigation demonstrated that it is practically feasible to produce pure Pb metal by electrochemical reduction of PbCl2 in eutectic NaCl−KCl melts,and has provided important fundamental for the further study on lead recovery from spent LABs via molten salt extraction process.
基金supported by the National Natural Science Foundation of China (No. 81273571)Jiangsu Clinical Research Center for Respiratory Diseases Project under grant No.BL2012012a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (No.JX10231802)
文摘Fasudil, a selective rho kinase(ROCK) inhibitor, has been reported to play a beneficial role in systemic inflammation in acute lung injury, but its mechanism for ameliorating pulmonary edema and inflammation remains unclear. Using hematoxylin-and-eosin(H&E) staining, immunohistochemistry, enzyme-linked immunosorbent assay,quantitative real time PCR and Western blotting, we found that fasudil attenuated LPS-induced lung injury, decreased lung edema, and suppressed inflammatory responses including leukocyte infiltration and IL-6 production. Further,fasudil upregulated LPS-induced aquaporin 5 reduction and inhibited NF-κB activation in the lungs of mice. Our results suggest that fasudil could restore the expression of aquaporin 5 to eliminate LPS-induced lung edema and prevent LPS-induced pulmonary inflammation by blocking the inflammatory pathway. Collectively, blockade of the ROCK pathway by fasudil may be a potential strategy for the treatment of acute lung injury.
基金the financial support from the Natural Science Foundation of Anhui Province, China (No. 2008085ME170)the Anhui Special Support Plan, China (No. T000609)the National Natural Science Foundation of China (No. 51204002
文摘A process comprising selective chlorination and molten salt electrolysis was proposed to develop an efficient and environmental-friendly technology for zinc recovery from metallurgical dusts.The theoretical feasibility of this technology was firstly estimated based on thermodynamic fundamentals.Subsequently,the electrochemical behavior of Zn^(2+)on tungsten electrode was investigated in molten NaCl-KCl eutectic at 973 K by many electrochemical transient methods.The results showed that the reduction of Zn^(2+)on tungsten electrode was found to be a one-step process exchanging two electrons with the initial reduction potential of-0.74 V(vs Ag/AgCl),and the electrode process was considered as quasi-reversible and controlled by diffusion.The diffusion coefficient of Zn^(2+)ions in the melts was determined in the order of 10^(-5)cm^(2)/s.Finally,the electrolytic preparation of zinc was carried out by potentiostatic electrolysis in molten NaCl-KCl-ZnCl_(2)eutectic at-1.6 V(vs Ag/AgCl).Spheroidic granular metal with silver-white luster was attained after electrolysis for 9.5 h,and identified as pure Zn.The present study confirms that it is practically feasible to extract pure zinc metal by direct electrolysis of ZnCl_(2)in molten NaCl-KCl eutectic,and provides a valuable theoretical reference for the efficient recovery of zinc from metallurgical dusts.
基金This research is supported by the National Natural Science Foundation of China[Grant number.71801190].
文摘The development of the new energy vehicle industry has become a key force driving the goals of carbon peak and carbon neutralization.To better guide future strategies,this study investigates the dual impact of subsidy and dual-integral policies on the performance of new energy vehicle enterprises.This study first theorizes the influential mechanism according to the institutional-based approach and technical innovation theory,and then collects data from listed companies in the new energy vehicle industry from 2016 to 2020.The hypotheses are examined using a two-way fixed-effects model.The findings show that:(1)subsidy policies are can still improve enterprise performance,but not through green technology innovation;(2)the dual-credit policy can improve enterprise performance through green technology innovation;and(3)under current policy conditions,with subsidies declining annually,the interaction effects between the subsidy and dual-integral policies will also decrease.Thus,this study suggests that non-monetary industrial policy,represented by the dual credit policy is a more effective alternative to government subsidies.
基金the Technology Innovation Leading Program of Shaanxi Province(2021CGBX-03).
文摘China has large population but little land.Such objective conditions determine that it is required to adhere to the policy path of"cherishing,rationally utilizing land and practically protecting cultivated land".Due to the relatively immature technology in the early stage of resource development in China,extensive utilization of resources leads to serious pollution,and the situation of the restoration of contaminated sites is severe.After nearly 20 years of a large number of pollution,land restoration there have been a lot of achievements in research and practice,but in the era of big data development,prevention and cure of soil pollution in China,there are a number of problems in the development of science and technology,this paper put forward the corresponding recommendations and opinions for the existing problems,in order to provide decision support for using big data to repair contaminated sites.
基金This work was supported by the National Natural Science Foundation of China （No.10774136）.
文摘The longitudinal ultrasonic velocity （V1）, attenuation （α1）, magnetization and resistivity of single phase polycrystalline La1/3Sr2/3CoO3 were measured as a function of temperature from 20 K to 300 K. The resistivity shows metallic behavior in the whole temperature range and a kink at 235 K was observed, which coincides with the ferromagnetic transition temperature （Tc）. As the temperature cools down from Tc, the V1 softens conspicuously at beginning and reaches a minimum at 120 K. After that the V1 dramatically stiffens below 120 K accompanied by a wide attenuation peak. The analysis of the results suggests that these ultrasonic anomalies ;nay correspond to local lattice distortions via the Jahn-Teller effect of intermediate spin Co^3＋.
基金Project of Shaanxi Provincial Land Engineering Construction Group(DJNY2021-32).
文摘Based on the DEM raster image data with a resolution of 60 m×60 m in the Sanjiangyuan region,the topographic heterogeneity in the Sanjiangyuan region was analyzed by calculating and processing the topographic relief,elevation standard deviation,terrain heterogeneity and surface roughness indexes.The results show that the overall terrain elevation of the Sanjiangyuan area is high,and the surface undulations are large.The southern and southeastern parts of the region are the places with the most dramatic terrain changes.The absolute values of terrain undulations,elevation standard deviation and surface roughness are large.In the central and western regions,the terrain change is small,the relief degree is small,the elevation standard deviation and the surface roughness are small.
基金funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900)the Ministry of Science and Technology of China(No.2019YFA0802103)+3 种基金the National Natural Science Foundation of China(No.92253302)the Department of Science and Technology of Zhejiang Province(No.2021C03104)the Guangzhou Science Innovation and Development Program(No.201803010092)athe Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006).
文摘Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health threat.Persistent HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.
基金supported by the Natural Science Foundation of Shandong Province(No.ZR2022QF120)Qingdao Postdoctoral Fund(No.QDBSH20230101005)Shandong Province Youth Innovation and Technology Support Plan for Higher Education Institutions(No.2023KJ362).
文摘As a stress hormone existing in the human body,cortisol can reflect the psychological stress and health status in daily life,and is a potential biomarker of the body’s stress response.To effectively collect sweat and accurately identify the target,this paper reports a flexible wearable cortisol detection device with outstanding reliability and sensitivity.Molecular imprinted polymer(MIP)ensures cortisol specificity.And carbon nanotubes(CNT)on electrodes increase sensitivity,expanding the detection range to 10^(−3) to 10^(4) nM,with sensitivity at 189.2 nA/lg(nM).In addition,porous chitosan hydrogel(PCSH)collects sweat effectively,its adhesive properties and 80%swelling rate offer a low-cost alternative to microfluidics.Flexible printed circuit board(FPCB)and serpentine electrode(SE)ensure device durability.This non-invasive,highly sensitive device offers a novel method for mental stress monitoring and clinical diagnosis,advancing human physiological state monitoring.
基金supported by the Director Foundation of State Key Laboratory of Pulsed Power Laser Technology(Nos.SKL2019ZR03 and SKL2019ZR06)the Open Research Foundation of State Key Laboratory of Pulsed Power Laser Technology(No.SKL2019KF05)the Natural Science Foundation of Anhui Province(No.1908085MF199)。
文摘The temperature tuning of BaGa_(4)Se_(7)(BGSe)was demonstrated for the first time,to the best of our knowledge.When the temperature of BGSe(56.3°,0°)was raised from 30℃ to 140℃,the idler light under type Ⅰ raised from 3637 nm to 3989 nm,the tunable range reached 352 nm,and Δλ_(2)=ΔT reached 3.20 nm/℃.We calculated the phase matching curve of BGSe when Φ and T took different values.The relationship between θ and Δλ_(2)=ΔT was obtained by fixing Φ at 0°.The maximum Δλ_(2)=ΔT and its corresponding(θ,Φ)phase matching type were reported under different fixed λ_(2)(3μm,3.2μm,...,5μm).
基金support on data research and technological deployment provided by the Administrative Centre for China’s Agenda 21,Ministry of Science and Technology of the People’s Republic of Chinathe funding provided by the National Natural Science Foundation of China(72140005 and 51621003)。
文摘Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement.China has pledged to peak CO_(2) emissions before 2030 and achieve carbon neutrality before 2060,and a"1+N"policy framework has been built to guide the implementations.Scientific and technological innovation has been emphasized as one of the key strategies to establish an innovation system,strengthen research,and promote applications of green and low-carbon technologies[1].Despite numerous studies and policies on decarbonization technologies,studies focusing on technological development pathways for China’s carbon neutrality are needed[2].
基金This work was supported by the Director Foundation of State Key Laboratory of Pulsed Power Laser Technology(No.SKL2019ZR06)Open Research Foundation of State Key Laboratory of Pulsed Power Laser Technology(No.SKL2019KF05).
文摘The linewidth of the BaGa_(4)Se_(7)(BGSe)optical parametric oscillator(OPO)was narrowed for the first time,to the best of our knowledge,by inserting a Fabry-Perot(FP)etalon into an L-shaped cavity.When a 15 mm long BGSe(56.3°,0°)was pumped by a 1064 nm laser,the peak wavelength was〜3529 nm,and the linewidth was 4.53 nm[3.64 cm^(-1)]under type I phase matching.After inserting a 350μm thick FP etalon,the linewidth was decreased to 1.27-2.05 nm.When the tilt angle of the etalon was 2.34°,the linewidth was 2.05 nm[1.65 cm^(-1)],and the peak wavelength was still〜3529 nm.When the tilt angle of the etalon was 3.90°,the peak wavelength was 3534.9 nm,and the linewidth was 1.27 nm(1.02 cm^(-1)),which was the narrowest linewidth of a BGSe OPO,to the best of our knowledge.The beam quality was also improved after inserting the FP etalon.
基金Supported by the Urban China Initiative (UCI) through the UCI grant 2017
文摘The gravity p-median model is an important improvement to the widely-used p-median model. However, there is still a debate on its validity in empirical applications. Previous studies even doubt the significance of the gravity p-median model. Using a case study of tertiary hospitals in Shenzhen, China, this study re-examines the difference between the gravity p-median model with the p-median model, by decomposing the difference between the two models into gravity rule and variant attraction. This study also proposes a modified gravity p-median model by incorporating a distance threshold. The empirical results support the validity of the gravity p-median model, and also reveal that only when the attractions of candidate facility locations are variable will the gravity p-median model lead to different results with the p-median model. The difference between the modified gravity p-median model and the gravity p-median model is also examined. Moreover, the impacts of the distance-decay parameter and distance threshold on solutions are investigated. Results indicate that a larger distance-decay parameter tends to result in a more dispersed distribution of optimal facilities and a smaller average travel time, and a smaller distance threshold can better promote the spatial equity of facilities. The proposed method can also be applied in studies of other types of facilities or in other areas.
基金funds including the National Natural Science Foundation of China (Nos.81473590,No.81274115,No.81473119)China-Japan Friendship Hospital Youth Science and Technology Excellence Project (No.2014-QNYC-B-10)+1 种基金Program for New Century Excellent Talents in University of the Chinese Ministry of Education (No.NCET-11-0606)Program for Excellent Talents of Beijing Municipal Party Committee Organization Department of the Communist Party of China (No.2013D009999000001)
文摘Tbeacrine （1,3,7,9-tetramethyluric acid）, a purine alkaloid similar to caffeine in its chemical structure, is isolated from edible Camellia assamica vat. kucha and has various pharmacological activities including hypnotic effects, anti-depressant effects, anti-inflammatory and analgesic effects, and a protective effect against stress-provoked liver damage. A rapid and simple assay is required to quantify theacrine in biological samples for pharmacokinetic studies in small animals. This study aimed to establish an enzyme-linked immunosorbent assay （ELISA） for theacrine quantification in blood. Herein, we successfully obtained monoclonal antibodies （MAbs） against theacrine, MAbs C11B5, and developed an ELISA method for the fast determination of theacrine in mouse blood. The range for calibration of theacrine by ELISA was 0.156-100 μg mL-1. The half maximum inhibitory concentration （IC50） value was 1.55 μg mL-1. The ELISA method lays a good foundation for the further research.
基金This work is supported by the National Science Foundation of China(No.51976013,No.52006124)the Beijing Institute of Technology Research Fund Program for Young Scholars(No.XSQD-202103005).
文摘Artificial intelligence,an emerging technology,widely exists in the field of engineering science and technology.Due to its high efficiency and precision,artificial intelligence is increasingly used in the optimal control of water treatment and seawater desalination.Generally,the design of a desalination system includes four processes:site selection,energy prediction,desalination technology selection and systematic parameter optimization.To a large extent,these choices depend on the experience and relevant criteria of researchers and experts.However,facing the scientific and technological progress and growing expectations,it is impossible to solve such complex nonlinear problems by simple experience and mathematical models,but artificial intelligence is good at this.In this paper,we synthetically analyzed and summarized the application of artificial intelligence in the field of seawater desalination with renewable energy.Artificial intelligence application in desalination is mainly divided into four aspects:expert decision-making,optimization,prediction and control by sequence.The features of artificial intelligence employed in the design of desalination systems not only realize the maximum of efficiency and minimum of cost,but release the human resources.After analyzing the four processes of desalination,it is found that artificial neural network and genetic algorithm are more widespread and mature than other algorithms in dealing with multi-objective nonlinear problems.This paper overviewed the application of artificial intelligence technologies in decision-making,optimization,prediction and control throughout the four processes of desalination designs.Finally,the application and future development prospect of artificial intelligence in the field of seawater desalination are summarized.
