Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the in...Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity distribution.This is mainly due to the lack of measurement technology with high spatial and temporal resolution.Here,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging technology.Simultaneous acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in vivo.Our results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions.展开更多
Water seepage in soil is a fundamental problem involving various scientific and engineering fields.According to the literature,low-velocity water seepage in low-permeability porous media,such as clay,does not follow D...Water seepage in soil is a fundamental problem involving various scientific and engineering fields.According to the literature,low-velocity water seepage in low-permeability porous media,such as clay,does not follow Darcy's law,also known as pre-Darcy flow.The formation of immovable water due to water adsorption on the pore wall is believed to be responsible for the formation of pre-Darcy flow.However,this view lacks direct solid evidence.To investigate the pre-Darcy water flow in clay,head permeability experiments are conducted on six clay samples with different densities.The results indicate that water seepage in clay at low hydraulic gradients does not follow Darcy's law.A clear nonlinear relationship between flow velocity and hydraulic gradient is observed.Water flow in clay can be divided into the pre-Darcy flow and Darcy flow regions by the critical hydraulic gradient,which is 10-12 for the Albic soil with dry density between 1.3 g/cm^(3)and 1.8 g/cm^(3).According to the disjoining pressure theory,immovable water due to water adsorption on the pore wall is the primary reason for water flow deviating from Darcy's law in clay.The results indicate that the percentage of movable water ranges from 39.7%to 59.3%for the six samples at a hydraulic gradient of 1.As the hydraulic gradient increases,the percentage of moveable water also increases.Additionally,there is a strong correlation between the percentage of movable water and the variation in hydraulic conductivity with the hydraulic gradient.Furthermore,a quantitative relationship between the percentage of movable water and the hydraulic conductivity has been established.The results of this study suggest that water adsorption on the pore wall not only affects the water movability,but is also closely related to the pre-Darcy flow phenomenon in clay.展开更多
Background:With the rapid aging of China’s population and the increasing prevalence of comorbidities in the elderly,psychological crises have become more common.This study aims to investigate the present status of ps...Background:With the rapid aging of China’s population and the increasing prevalence of comorbidities in the elderly,psychological crises have become more common.This study aims to investigate the present status of psychological vulnerability,aging attitudes,and life meaning in elderly patients with comorbidities.Methods:A total of 685 elderly inpatients and outpatients at Renmin Hospital of Wuhan University between July and December 2022 were selected using the simple random sampling method.Social demographic data were collected,and the Attitudes to aging Questionnaire(AAQ),the Chinese Life Meaning Questionnaire(C-MLQ),and the Psychological Vulnerability Scale(C-PVS)were used for the analysis.A total of 685 questionnaires were received,and 602 valid questionnaires were collected,with an effective rate of 87.88%.Data analysis was performed using SPSS V25.0 and AMOS V24.0.Results:The total scores of psychological vulnerability,aging attitudes,and life meaning were 69.4±12.8,80.2±13.5 and 39.2±8.3,respectively.The psychological vulnerability was significantly negatively correlated with life meaning and aging attitudes(r=-0.351,-0.264;p<0.01).There was a significant positive correlation between aging attitudes and life meaning(r=0.515;p<0.01).Life meaning played a partial mediating role between psychological vulnerability and aging attitudes(β=3.070,p<0.05).Conclusion:This study found that the psychological vulnerability in elderly patients with comorbidities was at the lower level,which was related to the elderly patients’aging attitudes and their current status of life meaning.The level of psychological vulnerability in elderly patients with senile-related comorbidities needs to be further improved.Medical workers should pay attention to the psychological vulnerability of elderly patients and improve the identification of psychological crises of such patients.展开更多
Background:Lung Adenocarcinoma(LUAD)is the leading cause of death from lung cancer.Cuproptosis is the latest discovered way of programmed cell death,and Cuproptosis-Related Gene(CRG)is associated with the risk of LUAD...Background:Lung Adenocarcinoma(LUAD)is the leading cause of death from lung cancer.Cuproptosis is the latest discovered way of programmed cell death,and Cuproptosis-Related Gene(CRG)is associated with the risk of LUAD.At present,there are few research of LUAD and Cuproptosis focuses on Long non-coding RNA(LncRNA).As genomics advances,LncRNA emerges as a potential target for understanding tumor progression and prognosis,offering prospects for biological targeted therapy.Therefore,this study provides new biomarkers and therapeutic targets for LUAD from the perspective of LncRNA.Methods:Gene expression,clinical outcome and gene mutation data of LUAD patients were downloaded from TCGA database.Spearman correlation was used to analyze the correlation between LncRNA and CRG.Univariate Cox,multivariate Cox and LASSO Cox regression analysis were used to construct a prognostic model of Cuproptosis-LncRNAs.GO and KEGG enrichment and immune function analysis were performed on differentially expressed genes between different risk groups.Then,immune escape analysis was performed on LUAD patients with different TIDE score.Finally,drug sensitivity analysis was performed on these differentially expressed genes.Results:A total of 2244 Cuproptosis-LncRNAs were found.Through the application of univariate Cox regression analysis,multivariate Cox regression analysis,and LASSO Cox regression analysis,a prognostic model was developed,integrating 15 Cuproptosis-LncRNAs to assess the risk of mortality.Following that,the model underwent assessment through risk score analysis,Kaplan-Meier survival analysis,risk distribution,and evaluation of survival outcomes.The results revealed an AUC value of 0.755 for the model,surpassing the AUC of other clinical pathological features.The results of KEGG analysis showed that the differentially expressed genes in different model groups were mainly involved in Amoebiasis,Fat digestion and absorption,and other signaling pathways.The results of TMB showed that the prognostic model of TMB combined with risk score could well evaluate the prognosis of patients.The TIDE scores did not exhibit a notable distinction between the two risk models.Analysis of drug sensitivity revealed that individuals in the low-risk category demonstrated greater responsiveness to 5-Fluorouracil,Axitinib,Bexarotene,and other drugs compared to those in the high-risk group.Conclusion:Our research offers a valuable reference for predicting the prognosis of LUAD,contributing to a better understanding of the future elucidation of the process and mechanism of Cuproptosis-LncRNAs in LUAD.展开更多
This paper discusses the optimization strategy of education and teaching quality assurance systems in applied colleges and universities under the background of digital intelligence.It first summarizes the relevant the...This paper discusses the optimization strategy of education and teaching quality assurance systems in applied colleges and universities under the background of digital intelligence.It first summarizes the relevant theories of digital intelligence transformation and analyzes the impact of digital intelligence transformation on higher education.Secondly,this paper puts forward the principles of constructing the quality assurance system of applied colleges,including strengthening the quality assurance consciousness,improving teachers’digital literacy,and implementing digital intelligence governance.From the practical perspective,this paper expounds on strategies such as optimizing educational teaching resource allocation,constructing a diversified evaluation system of teaching quality,strengthening the construction and training of teaching staff,and innovating teaching management methods.Specific optimization measures are put forward,such as improving policies,regulations,and system guarantees,strengthening cooperation between schools and enterprises,integrating industry,school,and research,building an educational information platform,and improving the monitoring and feedback mechanism of educational quality.展开更多
Background:The relationship between tea intake(TI)and sleep disorders(SDs)has been a topic of interest for some time,but there remains a lack of data showing a causal relationship.We aimed to use a two-sample Mendelia...Background:The relationship between tea intake(TI)and sleep disorders(SDs)has been a topic of interest for some time,but there remains a lack of data showing a causal relationship.We aimed to use a two-sample Mendelian randomization study to determine whether there is a causal link between TI and SDs.Methods:We collected data regarding TI,with a focus on green tea intake(GTI),herbal tea intake(HTI),and rooibos tea intake(RTI);and data regarding SDs and insomnia from genome-wide association studies.We analyzed these data using an inverse variance-weighted two-sample Mendelian randomization study,by means of the TwoSampleMR package in R4.2.3 software.Results:We found no genetic causal relationships of TI,GTI,HTI,or RTI with insomnia.The odds ratios(ORs)for these relationships were as follows:TI:OR=0.61,95%confidence interval(CI):0.29–1.28;GTI:OR=1.04,95%CI:0.95–1.14;HTI:OR=0.98,95%CI:0.82–1.17;and RTI:OR=1.04,95%CI:0.99–1.09.In addition,there were no genetic causal relationships of TI,GTI,HTI,or RTI with SDs.The OR values for these relationships were as follows:TI:OR=0.6,95%CI:0.34–1.06;GTI:OR=1,95%CI:0.93–1.07;HTI:OR=0.89,95%CI:0.66–1.2;and RTI:OR=1.02,95%CI:0.98–1.06.Conclusion:We found no causal relationships of TI with SDs or insomnia,irrespective of the type of tea consumed.However,additional Mendelian randomization studies are required to further explore the relationships of the timing and quantity of tea consumption with SDs and insomnia.展开更多
Background:Telemedicine refers to the use of information technology by medical institutions to directly provide diagnostic and therapeutic services to patients outside the healthcare facility.It encompasses various as...Background:Telemedicine refers to the use of information technology by medical institutions to directly provide diagnostic and therapeutic services to patients outside the healthcare facility.It encompasses various aspects such as remote diagnosis,remote monitoring,remote consultation,and remote outpatient services.Numerous articles have evaluated its role in controlling diseases like hypertension,diabetes,atrial fibrillation,and ischemic stroke.However,the existing literature exhibits varying quality and sample sizes,lacking robust convincing power and systematic effectiveness evaluation.Methods:Following The Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 guidelines,we identified articles on remote medical intervention in ischemic stroke through databases including Web of Science,PubMed,EMBASE,Cochrane Library,CNKI,Weipu,and Wanfang.The search spanned from the inception of the databases to June 30,2022.Two researchers independently assessed literature quality,extracted data,and conducted meta-analysis using RevMan 5.3 software.Results:Ten articles,involving 5092 patients,were included.Meta-analysis results indicate that telemedicine can effectively enhance compliance with doctors’advice in ischemic stroke patients.Telemedicine is also associated with reduced stroke recurrence,moderate to severe disability,systolic and diastolic blood pressure,National Institutes of Health Stroke Scale scores,and Modified Rankin Scale scores.Additionally,telemedicine demonstrates effectiveness in improving Fugl-Meyer motor function assessment and the Barthel Index of activity of daily living in ischemic stroke patients.However,telemedicine does not significantly reduce stroke hospitalization in the past year and the death rate.Conclusion:In comparison to traditional healthcare,telemedicine exhibits advantages in improving compliance and enhancing functionality in ischemic stroke patients.It is worth promoting telemedicine for better management of ischemic stroke patients.However,this study does not explain how telemedicine improves the functionality of ischemic stroke patients,indicating a need for further research.展开更多
The rapid development of electric vehicles and mobile electronic devices is the main driving force to improve advanced high-performance lithium ion batteries(LIBs).The capacity,rate performance and cycle stability of ...The rapid development of electric vehicles and mobile electronic devices is the main driving force to improve advanced high-performance lithium ion batteries(LIBs).The capacity,rate performance and cycle stability of LIBs rely directly on the electrode materials.As far as the development of the advanced LIBs electrode is concerned,the improvement of anode materials is more urgent than the cathode materials.Industrial production of anode materials superior to commercial graphite still faces some challenges.This review sets out the most basic LIBs anode material design.The reaction principles and structural design of carbon materials,various transition metal oxides,silicon and germanium are summarized,and then the progress of other anode materials are analyzed.Due to the rapid development of metal organic frameworks(MOFs)in energy storage and conversion in recent years,the synthesis process and energy storage mechanism of nanostructures derived from MOF precursors are also discussed.From the perspective of novel structural design,the progress of various MOFs-derived materials for alleviating the volume expansion of anode materials is discussed.Finally,challenges for the future development of advanced anode materials for LIBs will be considered.展开更多
Using self-researched gas drainage borehole stability dynamic monitoring device, three-dimensional deformation characteristics of borehole under steady vertical load were researched experimentally and systematically. ...Using self-researched gas drainage borehole stability dynamic monitoring device, three-dimensional deformation characteristics of borehole under steady vertical load were researched experimentally and systematically. This research indicated that under the action of steady loading, the mechanical deformation path of the simulated gas drainage borehole is gradually complicated, and the decay of the borehole circumferential strain is an important characterization of the prediction and early warning of borehole instability and collapse. The horizontal position of borehole occurs compressive strain, and the vertical of which occurs tensile strain under the action of vertical stress. At the initial stage of loading, the vertical strain is more sensitive than that in the horizontal direction. After a certain period of time, the horizontal strain is gradually higher than the vertical one, and the intersection of the borehole horizontal diameter and the hole wall is the stress concentration point. With the increase of the depth of hole, the strain shows a gradual decay trend as a whole, and the vertical strain decays more observably, but there is no absolute position correlation between the amount of strain decay and the increase in borehole depth,and the area within 1.5 times the orifice size is the borehole stress concentration zone.展开更多
Biomass-derived carbon materials are widely applied in the energy storage and conversion fields due to their rich sources,low price and environmental friendliness.Herein,a unique pumpkin-like MoPMoS_(2)@Aspergillus ni...Biomass-derived carbon materials are widely applied in the energy storage and conversion fields due to their rich sources,low price and environmental friendliness.Herein,a unique pumpkin-like MoPMoS_(2)@Aspergillus niger spore-derived N-doped carbon(SNC)composite has been prepared via a simple hydrothermal and subsequent phosphorization process.Interestingly,the resulting MoP-MoS_(2)@SNC well inherits the pristine morphology of spore carbon,similar to the natural pumpkin,with hollow interiors and uneven protrusions on the surface.The special structure allows it to have sufficient space to fully contact the electrolyte and greatly reduces the ion transport distance.The theory calculations further demonstrate that the formed MoP-MoS_(2)heterostructure can enhance the adsorption of K ions and electronic couplings.With these unique advantages,the MoP-MoS_(2)@SNC anode for potassium storage shows a high reversible capability of 286.2 mAh g&(-1) at 100 mA g^(-1) after 100 cycles and superior rate performance.The enhanced electrochemical performance is mainly related to the unique pumpkin-like morphology of SNC and the construction of MoP-MoS_(2)heterostructure,as well as their perfect coupling.This study provides a feasible design idea for developing green,low-cost,and high-performance electrode materials for next-generation energy storage.展开更多
Dynamic performance on solids flow with water in deviated tubing is essential for the reliability of pump and normal operation of horizontal and directional wells.Compared with coal-water flow in vertical tubing and s...Dynamic performance on solids flow with water in deviated tubing is essential for the reliability of pump and normal operation of horizontal and directional wells.Compared with coal-water flow in vertical tubing and sand-oil flow with high production in deviated tubing,solids deposition with water shows obvious non-symmetric distributions in deviated tubing from simulations and experiments.The mathematical model of two phase flow was developed under coupling conditions of deviated tubing,low flow rate and viscosity based on the kinetic theory of granular flow and first-order discrete scheme.The results show that solid-water stratified flow in deviated tubing can be divided into two zones of suspension bed and the moving bed throughout the flow field.The solid flowing velocity with water is negative and particles slide down at the bottom of moving bed zone.The process of solids flow with water in deviated tubing will produce pressure loss and consume the kinetic energy.The thickness of deposited layer and the flowing velocity of solids flow downward with water at the moving bed zone enhance with the decreased inlet flow rate and the increased particle size,tubing inside diameter(ID)and inclination angle.Solids are easier into suspension from the upper part of moving bed zone to suspension bed zone and more solid particles flow with water towards the tubing outlet with the increase of inlet flowing velocity.The decision is made to reduce the screen width,tubing ID and inclination angle to maintain to be greater than critical deposition velocity in order to prevent solids settling.And it provides the theoretical basis and technical reserves for solid control and offers an effective approach to enhance tubing cleaning in deviated strings.展开更多
Motivated to understand the pressure-buildup characteristics in a circumstance of a water droplet immerged inside a heavy liquid metal pool,which is a key phenomenon during a Steam Generator Tube Rupture accident of L...Motivated to understand the pressure-buildup characteristics in a circumstance of a water droplet immerged inside a heavy liquid metal pool,which is a key phenomenon during a Steam Generator Tube Rupture accident of Lead-cooled Fast Reactor,many experiments have been conducted by injecting water lumps into a molten lead pool at Sun Yat-sen University.In order to deepen the understanding of the influence of melt material,this lead experiment was compared with a Lead-Bismuth-Eutectic(LBE)experiment in the literature.For both experiments,a steam explosion occurred in a small part of the experi-mental runs,which generally leads to strengthened pressure buildup.Regarding the non-explosion experimental cases,the impact of all parameters employed in lead experiments(i.e.,water lump volume,water lump shape,molten pool depth,and temperature of water and melt)on the pressure buildup is non-negligible and similar to that in our previous experiments using LBE.Notably,limited pressure buildup with an increase in water lump volume was also observed.A slightly more violent pressure buildup tends to appear in the lead experiments than in the LBE experiments under the same experimental conditions,which may be due to the higher thermal conductivity of lead than of LBE.In a few experimental runs with a relatively low melt temperature close to the melting point of lead,local solidification of liquid lead was observed,restricting pressure buildup.For the lead and LBE experiments,the calculated melt kinetic energy conversion efficiencyηhas a relatively small value(not exceeding 1.6%),and theηvalues have an overall positive correlation with the impulse on the molten pool.展开更多
To study the interaction between molten noneutectic alloys and subcooled water during severe nuclear accidents,an experimental investigation was carried out by injecting molten lead–bismuth non-eutectic alloy(LBNE,70...To study the interaction between molten noneutectic alloys and subcooled water during severe nuclear accidents,an experimental investigation was carried out by injecting molten lead–bismuth non-eutectic alloy(LBNE,70%Pb-30%Bi)into the water in a free-fall style using the visualized thermo-hydraulic characteristics in melt coolant interaction(VTMCI)facility.The effects of various experimental parameters,including water temperature,melt temperature,melt penetration velocity,and water depth,on the molten LBNE jet fragmentation characteristics were studied.The research shows that compared with lead–bismuth eutectic,larger fragments,less spherical fragments,and more porous debris beds are generated for LBNE.Higher water or melt temperatures facilitate molten LBNE fragmentation,resulting in higher debris bed sphericity and lower debris bed porosity.A higher melt temperature leads to smaller fragment sizes,except that a cake-like debris bed is formed for very high alloy superheat and very low water subcooling.More approximate spherical particles were generated in the film boiling zone than in the thermal interaction zone.Fragment size decreases with an increase in the melt penetration velocity,but the debris bed porosity and sphericity variation was not obvious.The effect of water depth on molten LBNE fragmentation behavior was not obvious under the current experimental conditions.Compared with other fragmentation theories,the Weber number theory better predicted the fragment volume mean diameter.In addition,a melt-jet behavior mode diagram that describes the competition between the hydrodynamic and thermal interactions and diagrams of debris bed porosity and sphericity that show the influence of thermal factors were analyzed in this study.展开更多
Multiphoton microscopy(MPM)is a powerful imaging technology for brain research.The imaging depth in MPM is partly determined by emission wavelength of fluorescent labels.It has been demonstrated that a longer emission...Multiphoton microscopy(MPM)is a powerful imaging technology for brain research.The imaging depth in MPM is partly determined by emission wavelength of fluorescent labels.It has been demonstrated that a longer emission wavelength is favorable for signal detection as imaging depth increases.However,there has been no comparison with near-infrared(NIR)emission.In order to quantitatively analyze the effect of emission wavelength on 3-photon imaging of mouse brains in vivo,we utilize the same excitation wavelength to excite a single fluorescent dye and simultaneously collect NIR and orange-red emission fluorescence at 828 nm and 620 nm,respectively.Both experimental and simulation results show that as the imaging depth increases,NIR emission decays less than orange-red fluorescent emission.These results show that it is preferable to shift the emission wavelength to NIR to enable more e±cient signal collection deep in the brain.展开更多
BACKGROUND Soft tissue tuberculosis is rare and insidious,with most patients presenting with a localized enlarged mass or swelling,which may be factors associated with delayed diagnosis and treatment.In recent years,n...BACKGROUND Soft tissue tuberculosis is rare and insidious,with most patients presenting with a localized enlarged mass or swelling,which may be factors associated with delayed diagnosis and treatment.In recent years,next-generation sequencing has rapidly evolved and has been successfully applied to numerous areas of basic and clinical research.A literature search revealed that the use of next-generation sequencing in the diagnosis of soft tissue tuberculosis has been rarely reported.CASE SUMMARY A 44-year-old man presented with recurrent swelling and ulcers on the left thigh.Magnetic resonance imaging suggested a soft tissue abscess.The lesion was surgically removed and tissue biopsy and culture were performed;however,no organism growth was detected.Finally,Mycobacterium tuberculosis was confirmed as the pathogen responsible for infection through next-generation sequencing analysis of the surgical specimen.The patient received a standardized anti-tuberculosis treatment and showed clinical improvement.We also performed a literature review on soft tissue tuberculosis using studies published in the past 10 years.CONCLUSION This case highlights the importance of next-generation sequencing for the early diagnosis of soft tissue tuberculosis,which can provide guidance for clinical treatment and improve prognosis.展开更多
This study carries out a complete analysis of time-space solution of hy- drodynamics of pentagonal/decagonal quasicrystals. The behaviors of wave propagation for phonons and diffusion for phasons and coupling between ...This study carries out a complete analysis of time-space solution of hy- drodynamics of pentagonal/decagonal quasicrystals. The behaviors of wave propagation for phonons and diffusion for phasons and coupling between phonon-phason fields are explored explicitly. Comprehensive discussion on physical time-space variations of all hydrodynamic field variables of the alloy quasicrystals is given. The computational spec- imen is simple, convenient in testing computational results, and provides a possibility that is easy to test experimentally. The quantitative results of mass density, viscosity ve- locities, phonon displacements, phason displacements, phonon stresses, phason stresses, viscosity stresses, and their time-space variations help us understand the motion of solid quasicrystals in a hydrodynamic condition （long-wavelength and low-frequency）. The analysis presented in this paper can be used for octagonal and dodecagonal quasicrys- tals and is easily extended to other two-dimensional quasicrystals and three-dimensional icosahedral quasicrystals. Some problems explored by the computational results are also discussed.展开更多
基金funded by the National Natural Science Foundation of China(Grant/Award Numbers 62075135 and 61975126)the Science and Technology Innovation Commission of Shenzhen(Grant/Award Numbers JCYJ20190808174819083 and JCYJ20190808175201640)Shenzhen Science and Technology Planning Project(ZDSYS 20210623092006020).
文摘Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity distribution.This is mainly due to the lack of measurement technology with high spatial and temporal resolution.Here,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging technology.Simultaneous acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in vivo.Our results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions.
基金funding support from the China National Science Foundation(Grant Nos.42072280,U2244215,41172205).
文摘Water seepage in soil is a fundamental problem involving various scientific and engineering fields.According to the literature,low-velocity water seepage in low-permeability porous media,such as clay,does not follow Darcy's law,also known as pre-Darcy flow.The formation of immovable water due to water adsorption on the pore wall is believed to be responsible for the formation of pre-Darcy flow.However,this view lacks direct solid evidence.To investigate the pre-Darcy water flow in clay,head permeability experiments are conducted on six clay samples with different densities.The results indicate that water seepage in clay at low hydraulic gradients does not follow Darcy's law.A clear nonlinear relationship between flow velocity and hydraulic gradient is observed.Water flow in clay can be divided into the pre-Darcy flow and Darcy flow regions by the critical hydraulic gradient,which is 10-12 for the Albic soil with dry density between 1.3 g/cm^(3)and 1.8 g/cm^(3).According to the disjoining pressure theory,immovable water due to water adsorption on the pore wall is the primary reason for water flow deviating from Darcy's law in clay.The results indicate that the percentage of movable water ranges from 39.7%to 59.3%for the six samples at a hydraulic gradient of 1.As the hydraulic gradient increases,the percentage of moveable water also increases.Additionally,there is a strong correlation between the percentage of movable water and the variation in hydraulic conductivity with the hydraulic gradient.Furthermore,a quantitative relationship between the percentage of movable water and the hydraulic conductivity has been established.The results of this study suggest that water adsorption on the pore wall not only affects the water movability,but is also closely related to the pre-Darcy flow phenomenon in clay.
基金2023 Hubei Provincial Key Laboratory Open Project-Nursing Special Project:2023KFH017Current Status Survey and Interventional Research on Alexithymia in Elderly Cancer Patients(Chaired by Lili Zhang)+3 种基金Wuhan University Clinical Nursing Special Research Cultivation Fund Project:LCHL202307Constructing a Long-Term Care Model Based on Narrative Transport Model to Identify and Reduce the Vulnerability of Psychological Crises in Elderly Patients with Comorbidities(Chaired by Lili Zhang)2022 Hubei Provincial Key Laboratory Open Project-Nursing Special Project:2022KFH030Empirical Study on the Construction and Application of a Frailty Risk Warning Model for Hospitalized Elderly Patients(Chaired by Jiaojiao Wu).
文摘Background:With the rapid aging of China’s population and the increasing prevalence of comorbidities in the elderly,psychological crises have become more common.This study aims to investigate the present status of psychological vulnerability,aging attitudes,and life meaning in elderly patients with comorbidities.Methods:A total of 685 elderly inpatients and outpatients at Renmin Hospital of Wuhan University between July and December 2022 were selected using the simple random sampling method.Social demographic data were collected,and the Attitudes to aging Questionnaire(AAQ),the Chinese Life Meaning Questionnaire(C-MLQ),and the Psychological Vulnerability Scale(C-PVS)were used for the analysis.A total of 685 questionnaires were received,and 602 valid questionnaires were collected,with an effective rate of 87.88%.Data analysis was performed using SPSS V25.0 and AMOS V24.0.Results:The total scores of psychological vulnerability,aging attitudes,and life meaning were 69.4±12.8,80.2±13.5 and 39.2±8.3,respectively.The psychological vulnerability was significantly negatively correlated with life meaning and aging attitudes(r=-0.351,-0.264;p<0.01).There was a significant positive correlation between aging attitudes and life meaning(r=0.515;p<0.01).Life meaning played a partial mediating role between psychological vulnerability and aging attitudes(β=3.070,p<0.05).Conclusion:This study found that the psychological vulnerability in elderly patients with comorbidities was at the lower level,which was related to the elderly patients’aging attitudes and their current status of life meaning.The level of psychological vulnerability in elderly patients with senile-related comorbidities needs to be further improved.Medical workers should pay attention to the psychological vulnerability of elderly patients and improve the identification of psychological crises of such patients.
文摘Background:Lung Adenocarcinoma(LUAD)is the leading cause of death from lung cancer.Cuproptosis is the latest discovered way of programmed cell death,and Cuproptosis-Related Gene(CRG)is associated with the risk of LUAD.At present,there are few research of LUAD and Cuproptosis focuses on Long non-coding RNA(LncRNA).As genomics advances,LncRNA emerges as a potential target for understanding tumor progression and prognosis,offering prospects for biological targeted therapy.Therefore,this study provides new biomarkers and therapeutic targets for LUAD from the perspective of LncRNA.Methods:Gene expression,clinical outcome and gene mutation data of LUAD patients were downloaded from TCGA database.Spearman correlation was used to analyze the correlation between LncRNA and CRG.Univariate Cox,multivariate Cox and LASSO Cox regression analysis were used to construct a prognostic model of Cuproptosis-LncRNAs.GO and KEGG enrichment and immune function analysis were performed on differentially expressed genes between different risk groups.Then,immune escape analysis was performed on LUAD patients with different TIDE score.Finally,drug sensitivity analysis was performed on these differentially expressed genes.Results:A total of 2244 Cuproptosis-LncRNAs were found.Through the application of univariate Cox regression analysis,multivariate Cox regression analysis,and LASSO Cox regression analysis,a prognostic model was developed,integrating 15 Cuproptosis-LncRNAs to assess the risk of mortality.Following that,the model underwent assessment through risk score analysis,Kaplan-Meier survival analysis,risk distribution,and evaluation of survival outcomes.The results revealed an AUC value of 0.755 for the model,surpassing the AUC of other clinical pathological features.The results of KEGG analysis showed that the differentially expressed genes in different model groups were mainly involved in Amoebiasis,Fat digestion and absorption,and other signaling pathways.The results of TMB showed that the prognostic model of TMB combined with risk score could well evaluate the prognosis of patients.The TIDE scores did not exhibit a notable distinction between the two risk models.Analysis of drug sensitivity revealed that individuals in the low-risk category demonstrated greater responsiveness to 5-Fluorouracil,Axitinib,Bexarotene,and other drugs compared to those in the high-risk group.Conclusion:Our research offers a valuable reference for predicting the prognosis of LUAD,contributing to a better understanding of the future elucidation of the process and mechanism of Cuproptosis-LncRNAs in LUAD.
基金2023 Annual Funded Projects for Educational Scientific Research at Xuzhou University of Technology“Construction and Practice of the Quality Assurance System for Education and Teaching in Applied Undergraduate Colleges under the Background of Digitalization”(YGJ2345)。
文摘This paper discusses the optimization strategy of education and teaching quality assurance systems in applied colleges and universities under the background of digital intelligence.It first summarizes the relevant theories of digital intelligence transformation and analyzes the impact of digital intelligence transformation on higher education.Secondly,this paper puts forward the principles of constructing the quality assurance system of applied colleges,including strengthening the quality assurance consciousness,improving teachers’digital literacy,and implementing digital intelligence governance.From the practical perspective,this paper expounds on strategies such as optimizing educational teaching resource allocation,constructing a diversified evaluation system of teaching quality,strengthening the construction and training of teaching staff,and innovating teaching management methods.Specific optimization measures are put forward,such as improving policies,regulations,and system guarantees,strengthening cooperation between schools and enterprises,integrating industry,school,and research,building an educational information platform,and improving the monitoring and feedback mechanism of educational quality.
基金supported by 2021 Construction project of key disciplines of Traditional Chinese Medicine(clinical)in Guangdong Province([2021]No.129)2020 Foshan City’s‘14th Five-Year’key specialized projects of traditional Chinese medicine(No.15).Foshan self-financing science and technology plan project(2320001009048).
文摘Background:The relationship between tea intake(TI)and sleep disorders(SDs)has been a topic of interest for some time,but there remains a lack of data showing a causal relationship.We aimed to use a two-sample Mendelian randomization study to determine whether there is a causal link between TI and SDs.Methods:We collected data regarding TI,with a focus on green tea intake(GTI),herbal tea intake(HTI),and rooibos tea intake(RTI);and data regarding SDs and insomnia from genome-wide association studies.We analyzed these data using an inverse variance-weighted two-sample Mendelian randomization study,by means of the TwoSampleMR package in R4.2.3 software.Results:We found no genetic causal relationships of TI,GTI,HTI,or RTI with insomnia.The odds ratios(ORs)for these relationships were as follows:TI:OR=0.61,95%confidence interval(CI):0.29–1.28;GTI:OR=1.04,95%CI:0.95–1.14;HTI:OR=0.98,95%CI:0.82–1.17;and RTI:OR=1.04,95%CI:0.99–1.09.In addition,there were no genetic causal relationships of TI,GTI,HTI,or RTI with SDs.The OR values for these relationships were as follows:TI:OR=0.6,95%CI:0.34–1.06;GTI:OR=1,95%CI:0.93–1.07;HTI:OR=0.89,95%CI:0.66–1.2;and RTI:OR=1.02,95%CI:0.98–1.06.Conclusion:We found no causal relationships of TI with SDs or insomnia,irrespective of the type of tea consumed.However,additional Mendelian randomization studies are required to further explore the relationships of the timing and quantity of tea consumption with SDs and insomnia.
基金supported by 2021 Construction project of key disciplines of Traditional Chinese Medicine(clinical)in Guangdong Province([2021]No.129)2020 Foshan City’s‘14th Five-Year’key specialized projects of traditional Chinese medicine(No.15).Foshan self-financing science and technology plan project(2320001009048).
文摘Background:Telemedicine refers to the use of information technology by medical institutions to directly provide diagnostic and therapeutic services to patients outside the healthcare facility.It encompasses various aspects such as remote diagnosis,remote monitoring,remote consultation,and remote outpatient services.Numerous articles have evaluated its role in controlling diseases like hypertension,diabetes,atrial fibrillation,and ischemic stroke.However,the existing literature exhibits varying quality and sample sizes,lacking robust convincing power and systematic effectiveness evaluation.Methods:Following The Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 guidelines,we identified articles on remote medical intervention in ischemic stroke through databases including Web of Science,PubMed,EMBASE,Cochrane Library,CNKI,Weipu,and Wanfang.The search spanned from the inception of the databases to June 30,2022.Two researchers independently assessed literature quality,extracted data,and conducted meta-analysis using RevMan 5.3 software.Results:Ten articles,involving 5092 patients,were included.Meta-analysis results indicate that telemedicine can effectively enhance compliance with doctors’advice in ischemic stroke patients.Telemedicine is also associated with reduced stroke recurrence,moderate to severe disability,systolic and diastolic blood pressure,National Institutes of Health Stroke Scale scores,and Modified Rankin Scale scores.Additionally,telemedicine demonstrates effectiveness in improving Fugl-Meyer motor function assessment and the Barthel Index of activity of daily living in ischemic stroke patients.However,telemedicine does not significantly reduce stroke hospitalization in the past year and the death rate.Conclusion:In comparison to traditional healthcare,telemedicine exhibits advantages in improving compliance and enhancing functionality in ischemic stroke patients.It is worth promoting telemedicine for better management of ischemic stroke patients.However,this study does not explain how telemedicine improves the functionality of ischemic stroke patients,indicating a need for further research.
基金financial support from the National Natural Science Foundation of China(81671737)the support from‘Sponsored by Shanghai Pujiang Program’(18PJD020)the Interdisciplinary Program of Shanghai Jiao Tong University(YG2019QNB31)。
文摘The rapid development of electric vehicles and mobile electronic devices is the main driving force to improve advanced high-performance lithium ion batteries(LIBs).The capacity,rate performance and cycle stability of LIBs rely directly on the electrode materials.As far as the development of the advanced LIBs electrode is concerned,the improvement of anode materials is more urgent than the cathode materials.Industrial production of anode materials superior to commercial graphite still faces some challenges.This review sets out the most basic LIBs anode material design.The reaction principles and structural design of carbon materials,various transition metal oxides,silicon and germanium are summarized,and then the progress of other anode materials are analyzed.Due to the rapid development of metal organic frameworks(MOFs)in energy storage and conversion in recent years,the synthesis process and energy storage mechanism of nanostructures derived from MOF precursors are also discussed.From the perspective of novel structural design,the progress of various MOFs-derived materials for alleviating the volume expansion of anode materials is discussed.Finally,challenges for the future development of advanced anode materials for LIBs will be considered.
基金financial support of Distinguished scholars of yueqi (NO. 800015Z1179)National Science Fund subsidized project (51474220)Basic scientific research project of the CPC Central Committee (NO. 2009QZ03)
文摘Using self-researched gas drainage borehole stability dynamic monitoring device, three-dimensional deformation characteristics of borehole under steady vertical load were researched experimentally and systematically. This research indicated that under the action of steady loading, the mechanical deformation path of the simulated gas drainage borehole is gradually complicated, and the decay of the borehole circumferential strain is an important characterization of the prediction and early warning of borehole instability and collapse. The horizontal position of borehole occurs compressive strain, and the vertical of which occurs tensile strain under the action of vertical stress. At the initial stage of loading, the vertical strain is more sensitive than that in the horizontal direction. After a certain period of time, the horizontal strain is gradually higher than the vertical one, and the intersection of the borehole horizontal diameter and the hole wall is the stress concentration point. With the increase of the depth of hole, the strain shows a gradual decay trend as a whole, and the vertical strain decays more observably, but there is no absolute position correlation between the amount of strain decay and the increase in borehole depth,and the area within 1.5 times the orifice size is the borehole stress concentration zone.
基金the support from the Shuguang Program supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(18SG035)the Basic Research Program of Shanghai Municipal Government(21JC1406002)the Shanghai Engineering Research Center of Advanced Thermal Functional Materials(Shanghai Polytechnic University)。
文摘Biomass-derived carbon materials are widely applied in the energy storage and conversion fields due to their rich sources,low price and environmental friendliness.Herein,a unique pumpkin-like MoPMoS_(2)@Aspergillus niger spore-derived N-doped carbon(SNC)composite has been prepared via a simple hydrothermal and subsequent phosphorization process.Interestingly,the resulting MoP-MoS_(2)@SNC well inherits the pristine morphology of spore carbon,similar to the natural pumpkin,with hollow interiors and uneven protrusions on the surface.The special structure allows it to have sufficient space to fully contact the electrolyte and greatly reduces the ion transport distance.The theory calculations further demonstrate that the formed MoP-MoS_(2)heterostructure can enhance the adsorption of K ions and electronic couplings.With these unique advantages,the MoP-MoS_(2)@SNC anode for potassium storage shows a high reversible capability of 286.2 mAh g&(-1) at 100 mA g^(-1) after 100 cycles and superior rate performance.The enhanced electrochemical performance is mainly related to the unique pumpkin-like morphology of SNC and the construction of MoP-MoS_(2)heterostructure,as well as their perfect coupling.This study provides a feasible design idea for developing green,low-cost,and high-performance electrode materials for next-generation energy storage.
基金funded by National Natural Science Foundation of China(Grant No.52074161)National Science and Technology Major Project of China(Grant No.2016ZX05065-001)+2 种基金Taishan Scholar Project of Shandong Province(Grant No.tsqn202211177)Shandong Provincial Plan for Introduction and Cultivation of Young Pioneers in Colleges and Universities(Grant No.2021-QingChuang-30613019)Natural Science Foundation of Shandong Province(Grant No.ZR2022ME173).
文摘Dynamic performance on solids flow with water in deviated tubing is essential for the reliability of pump and normal operation of horizontal and directional wells.Compared with coal-water flow in vertical tubing and sand-oil flow with high production in deviated tubing,solids deposition with water shows obvious non-symmetric distributions in deviated tubing from simulations and experiments.The mathematical model of two phase flow was developed under coupling conditions of deviated tubing,low flow rate and viscosity based on the kinetic theory of granular flow and first-order discrete scheme.The results show that solid-water stratified flow in deviated tubing can be divided into two zones of suspension bed and the moving bed throughout the flow field.The solid flowing velocity with water is negative and particles slide down at the bottom of moving bed zone.The process of solids flow with water in deviated tubing will produce pressure loss and consume the kinetic energy.The thickness of deposited layer and the flowing velocity of solids flow downward with water at the moving bed zone enhance with the decreased inlet flow rate and the increased particle size,tubing inside diameter(ID)and inclination angle.Solids are easier into suspension from the upper part of moving bed zone to suspension bed zone and more solid particles flow with water towards the tubing outlet with the increase of inlet flowing velocity.The decision is made to reduce the screen width,tubing ID and inclination angle to maintain to be greater than critical deposition velocity in order to prevent solids settling.And it provides the theoretical basis and technical reserves for solid control and offers an effective approach to enhance tubing cleaning in deviated strings.
基金supported by the Basic and Applied Basic Research Foundation of Guangdong Province (Nos.2021A1515010343 and 2022A1515011582)the Science and Technology Program of Guangdong Province (Nos.2021A0505030026 and 2022A0505050029).
文摘Motivated to understand the pressure-buildup characteristics in a circumstance of a water droplet immerged inside a heavy liquid metal pool,which is a key phenomenon during a Steam Generator Tube Rupture accident of Lead-cooled Fast Reactor,many experiments have been conducted by injecting water lumps into a molten lead pool at Sun Yat-sen University.In order to deepen the understanding of the influence of melt material,this lead experiment was compared with a Lead-Bismuth-Eutectic(LBE)experiment in the literature.For both experiments,a steam explosion occurred in a small part of the experi-mental runs,which generally leads to strengthened pressure buildup.Regarding the non-explosion experimental cases,the impact of all parameters employed in lead experiments(i.e.,water lump volume,water lump shape,molten pool depth,and temperature of water and melt)on the pressure buildup is non-negligible and similar to that in our previous experiments using LBE.Notably,limited pressure buildup with an increase in water lump volume was also observed.A slightly more violent pressure buildup tends to appear in the lead experiments than in the LBE experiments under the same experimental conditions,which may be due to the higher thermal conductivity of lead than of LBE.In a few experimental runs with a relatively low melt temperature close to the melting point of lead,local solidification of liquid lead was observed,restricting pressure buildup.For the lead and LBE experiments,the calculated melt kinetic energy conversion efficiencyηhas a relatively small value(not exceeding 1.6%),and theηvalues have an overall positive correlation with the impulse on the molten pool.
基金the Science and Technology Program of Guangdong Province(No.2021A0505030026)Basic and Applied Basic Research Foundation of Guangdong Province(No.2021A1515010343).
文摘To study the interaction between molten noneutectic alloys and subcooled water during severe nuclear accidents,an experimental investigation was carried out by injecting molten lead–bismuth non-eutectic alloy(LBNE,70%Pb-30%Bi)into the water in a free-fall style using the visualized thermo-hydraulic characteristics in melt coolant interaction(VTMCI)facility.The effects of various experimental parameters,including water temperature,melt temperature,melt penetration velocity,and water depth,on the molten LBNE jet fragmentation characteristics were studied.The research shows that compared with lead–bismuth eutectic,larger fragments,less spherical fragments,and more porous debris beds are generated for LBNE.Higher water or melt temperatures facilitate molten LBNE fragmentation,resulting in higher debris bed sphericity and lower debris bed porosity.A higher melt temperature leads to smaller fragment sizes,except that a cake-like debris bed is formed for very high alloy superheat and very low water subcooling.More approximate spherical particles were generated in the film boiling zone than in the thermal interaction zone.Fragment size decreases with an increase in the melt penetration velocity,but the debris bed porosity and sphericity variation was not obvious.The effect of water depth on molten LBNE fragmentation behavior was not obvious under the current experimental conditions.Compared with other fragmentation theories,the Weber number theory better predicted the fragment volume mean diameter.In addition,a melt-jet behavior mode diagram that describes the competition between the hydrodynamic and thermal interactions and diagrams of debris bed porosity and sphericity that show the influence of thermal factors were analyzed in this study.
基金work is funded by the National Natural Sci-ence Foundation of China(Grant/Award Numbers 62075135 and 61975126)Shenzhen Science and Technology Planning Project(ZDSYS2021-0623092006020)+2 种基金Key R&D Program of Shandong Province(Grant Number 2021CXGC010202)the Science and Technology Innovation Commission of Shenzhen(Grant/Award Numbers JCYJ201908-08174819083 and JCYJ20190808175201640)and Natural Science Foundation of Shandong Province(Grant Number ZR2022MA046)Major Innovation Projects for Integrating Science,Education&Industry of Qilu University of Technology(Shan-dong Academy of Sciences,Grant Number 2022JBZ01-04).
文摘Multiphoton microscopy(MPM)is a powerful imaging technology for brain research.The imaging depth in MPM is partly determined by emission wavelength of fluorescent labels.It has been demonstrated that a longer emission wavelength is favorable for signal detection as imaging depth increases.However,there has been no comparison with near-infrared(NIR)emission.In order to quantitatively analyze the effect of emission wavelength on 3-photon imaging of mouse brains in vivo,we utilize the same excitation wavelength to excite a single fluorescent dye and simultaneously collect NIR and orange-red emission fluorescence at 828 nm and 620 nm,respectively.Both experimental and simulation results show that as the imaging depth increases,NIR emission decays less than orange-red fluorescent emission.These results show that it is preferable to shift the emission wavelength to NIR to enable more e±cient signal collection deep in the brain.
基金Supported by the National Natural Science Foundation of China,No.82272544。
文摘BACKGROUND Soft tissue tuberculosis is rare and insidious,with most patients presenting with a localized enlarged mass or swelling,which may be factors associated with delayed diagnosis and treatment.In recent years,next-generation sequencing has rapidly evolved and has been successfully applied to numerous areas of basic and clinical research.A literature search revealed that the use of next-generation sequencing in the diagnosis of soft tissue tuberculosis has been rarely reported.CASE SUMMARY A 44-year-old man presented with recurrent swelling and ulcers on the left thigh.Magnetic resonance imaging suggested a soft tissue abscess.The lesion was surgically removed and tissue biopsy and culture were performed;however,no organism growth was detected.Finally,Mycobacterium tuberculosis was confirmed as the pathogen responsible for infection through next-generation sequencing analysis of the surgical specimen.The patient received a standardized anti-tuberculosis treatment and showed clinical improvement.We also performed a literature review on soft tissue tuberculosis using studies published in the past 10 years.CONCLUSION This case highlights the importance of next-generation sequencing for the early diagnosis of soft tissue tuberculosis,which can provide guidance for clinical treatment and improve prognosis.
基金Project supported by the National Natural Science Foundation of China(No.11272053)
文摘This study carries out a complete analysis of time-space solution of hy- drodynamics of pentagonal/decagonal quasicrystals. The behaviors of wave propagation for phonons and diffusion for phasons and coupling between phonon-phason fields are explored explicitly. Comprehensive discussion on physical time-space variations of all hydrodynamic field variables of the alloy quasicrystals is given. The computational spec- imen is simple, convenient in testing computational results, and provides a possibility that is easy to test experimentally. The quantitative results of mass density, viscosity ve- locities, phonon displacements, phason displacements, phonon stresses, phason stresses, viscosity stresses, and their time-space variations help us understand the motion of solid quasicrystals in a hydrodynamic condition （long-wavelength and low-frequency）. The analysis presented in this paper can be used for octagonal and dodecagonal quasicrys- tals and is easily extended to other two-dimensional quasicrystals and three-dimensional icosahedral quasicrystals. Some problems explored by the computational results are also discussed.
