Objective:This study investigates the effects of ginger on sperm dysmorphosis under heat stress using network pharmacology and molecular docking techniques.Methods:The core components,target sites,and primary pathways...Objective:This study investigates the effects of ginger on sperm dysmorphosis under heat stress using network pharmacology and molecular docking techniques.Methods:The core components,target sites,and primary pathways of ginger were predicted using the TCMSP database.Genes associated with sperm malformation and heat stress were identified through databases such as GeneCards and DisGeNET,followed by KEGG and GO analyses based on intersections with ginger targets.Core genes identified via Cytoscape software were subjected to molecular docking with ginger’s active components.Results:The principal active components of ginger identified includeβ-sitosterol and dihydrocapsaicin.Network pharmacology analysis suggested that ginger exerts its effects through pathways such as the prostate cancer signaling pathway,estrogen signaling pathway,inflammatory pathways,and nuclear receptor signal transduction.These pathways may ameliorate sperm malformation symptoms caused by heat stress.Conclusion:Integrating findings from network pharmacology and molecular docking,the active components of ginger potentially modulate the expression of heat shock proteins during heat stress via inflammatory and oxidative stress pathways.This modulation may protect spermatogenesis under heat stress and improve sperm malformation.展开更多
Granitoids and related pegmatitic rare-metal deposits are widespread in China’s Altay region,they used to be considered as Hercynian rocks and mineral deposits.Reported here are the^40Ar^39Ar ages of potassium-rich m...Granitoids and related pegmatitic rare-metal deposits are widespread in China’s Altay region,they used to be considered as Hercynian rocks and mineral deposits.Reported here are the^40Ar^39Ar ages of potassium-rich minerals (muscovite and microcline)in the Koktokay pegmatitic rare-metal orefield and whole-rock as well as quartz fluid-inclusion Rb-Sr isochron ages of granite and ores in the Shangkelan pegmatite rare-metal orefield. The ages indicate that there are Yanshanian Diagenetic Mineralization events happening in China’s Altay orogenic belt and that formation of the famous Koktokay No.3 pegmatitic rare-metal deposit endured about 30 Ma of magmatic crystallization differentiation.展开更多
Through studying geo-geochemical characteristics and determining Sm-Nd and Rb-Sr isotopical ages in the Kanggur magnetite-chlorite formation gold deposit, some conclusions can be achieved: Sm-Nd isochron age is (290.4...Through studying geo-geochemical characteristics and determining Sm-Nd and Rb-Sr isotopical ages in the Kanggur magnetite-chlorite formation gold deposit, some conclusions can be achieved: Sm-Nd isochron age is (290.4 ±7)Ma, Rb-Sr isochron age is (282.3 ±5)Ma, mineralization is Late Hercynian and the formation of this gold deposit is related to the macro-展开更多
基金Department of Science and Technology of Hunan Province(Project No.2024JJ8222)Double First-Class Bioengineering Applied Characteristic Disciplines in Higher Education in Hunan Province。
文摘Objective:This study investigates the effects of ginger on sperm dysmorphosis under heat stress using network pharmacology and molecular docking techniques.Methods:The core components,target sites,and primary pathways of ginger were predicted using the TCMSP database.Genes associated with sperm malformation and heat stress were identified through databases such as GeneCards and DisGeNET,followed by KEGG and GO analyses based on intersections with ginger targets.Core genes identified via Cytoscape software were subjected to molecular docking with ginger’s active components.Results:The principal active components of ginger identified includeβ-sitosterol and dihydrocapsaicin.Network pharmacology analysis suggested that ginger exerts its effects through pathways such as the prostate cancer signaling pathway,estrogen signaling pathway,inflammatory pathways,and nuclear receptor signal transduction.These pathways may ameliorate sperm malformation symptoms caused by heat stress.Conclusion:Integrating findings from network pharmacology and molecular docking,the active components of ginger potentially modulate the expression of heat shock proteins during heat stress via inflammatory and oxidative stress pathways.This modulation may protect spermatogenesis under heat stress and improve sperm malformation.
文摘Granitoids and related pegmatitic rare-metal deposits are widespread in China’s Altay region,they used to be considered as Hercynian rocks and mineral deposits.Reported here are the^40Ar^39Ar ages of potassium-rich minerals (muscovite and microcline)in the Koktokay pegmatitic rare-metal orefield and whole-rock as well as quartz fluid-inclusion Rb-Sr isochron ages of granite and ores in the Shangkelan pegmatite rare-metal orefield. The ages indicate that there are Yanshanian Diagenetic Mineralization events happening in China’s Altay orogenic belt and that formation of the famous Koktokay No.3 pegmatitic rare-metal deposit endured about 30 Ma of magmatic crystallization differentiation.
文摘Through studying geo-geochemical characteristics and determining Sm-Nd and Rb-Sr isotopical ages in the Kanggur magnetite-chlorite formation gold deposit, some conclusions can be achieved: Sm-Nd isochron age is (290.4 ±7)Ma, Rb-Sr isochron age is (282.3 ±5)Ma, mineralization is Late Hercynian and the formation of this gold deposit is related to the macro-
