This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced u...This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced ulcerative colitis in mice.Compared to control group,DSS induction decreased body weight of mice,indexes of Shannon,Simpson,Chao1 and Faith_pd,and increased disease activity index(DAI)and levels of interleukin 1β(IL-1β),IL-6,tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ);And this induction also led to an increase in Proteobacteria,Verrucomicrobia and Actinobacteria at phylum level,harmful bacterial species richness at genus level,and relative richness of S.sciuri,Desulfovibrio C21_c20,R.gnavus and Akkermansia muciniphila at species level,and a decrease in Firmicutes at phylum level and relative richness of B.acidifaciens in mice.LAB-RRTJ increased body weight of mice with DSS induced ulcerative colitis(UC)and indexes of Shannon,Simpson,Chao1 and Faith_pd,reduced DAI and the content of four infl ammatory factors and improved gut microbiota imbalance in DSS induced UC mice.Besides,the number of operational taxonomic units(OTUs)increased,α-diversity andβ-diversity were restored and similar to those in mice in the control group after LAB-RRTJ treatment.Compared with the positive drug treatment group,LAB-RRTJ has a better effect on regulating gut microbiota diversity in colitis mice.Correlation analysis showed that infl ammatory factors were positively correlated with harmful bacteria and negatively correlated with beneficial bacteria which commonly found in some colitis mice.Taken together,our study demonstrated that LAB-RRTJ could alleviate DSS-induced colitis in mice through the modulation of infl ammatory cytokines and gut microbiota composition.展开更多
Over the past decade,the first-principles-aided thermodynamic models have become standard theoretical tools in research on structural stability and evolution of transition-metal heterogeneous catalysts under reaction ...Over the past decade,the first-principles-aided thermodynamic models have become standard theoretical tools in research on structural stability and evolution of transition-metal heterogeneous catalysts under reaction environment.Advances in first-principles-aided thermodynamic models mean it is now possible to enable the operando computational modeling,which provides a deep insight into mechanism behind structural stability and evolution,and paves the way for high-through screening for promising transition-metal heterogeneous catalysts.Here,we briefly review the framework and foundation of first-principles-aided thermodynamic models and highlight its contribution to stability analysis on catalysts and identification of reaction-induced structural evolution of catalyst under reaction environment.The present review is helpful for understanding the ongoing developments of first-principles-aided thermodynamic models,which can be employed to screen high-stability catalysts and predict their structural reconstruction in future rational catalyst design.展开更多
Our recent theoretical studies have screened out CuCs-doped Ag-based promising catalysts for ethylene epoxidation[ACS Catal.11,3371(2021)].The theoretical results were based on surface modeling,while in the actual rea...Our recent theoretical studies have screened out CuCs-doped Ag-based promising catalysts for ethylene epoxidation[ACS Catal.11,3371(2021)].The theoretical results were based on surface modeling,while in the actual reaction process Ag catalysts are particle shaped.In this work,we combine density functional theory(DFT),Wulff construction theory,and micro kinetic analysis to study the catalytic performance of Ag catalysts at the particle model.It demonstrates that the CuCs-doped Ag catalysts are superior to pure Ag catalysts in terms of selectivity and activity,which is further proved by experimental validation.The characterization analysis finds that both Cu and Cs dopant promote particle growth as well as particle dispersion,resulting in a grain boundary-rich Ag particle.Besides,CuCs also facilitate electrophilic atomic oxygen formation on catalyst surface,which is benefitial for ethylene oxide formation and desorption.Our work provides a case study for catalyst design by combining theory and experiment.展开更多
To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been reported.Viral and bacterial infections are the common causes of lung and respiratory diseases.1 H...To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been reported.Viral and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still unknown.Histological staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid samples.Whole-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of viruses.Previous studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian populations.Therefore,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.展开更多
Identification of an active center of catalysts under realistic working conditions of oxygen reduction reaction(ORR)still remains a great challenge and unclear.Herein,we synthesize the Cu single atom embedded on nitro...Identification of an active center of catalysts under realistic working conditions of oxygen reduction reaction(ORR)still remains a great challenge and unclear.Herein,we synthesize the Cu single atom embedded on nitrogen-doped graphene-like matrix electrocatalyst(abbreviated as SA-Cu/NG).The results show that SA-Cu/NG possesses a higher ORR capability than 20%Pt/C at alkaline solution while the inferior activity to 20%Pt/C at acidic medium.Based on the experiment and simulation calculation,we identify the atomic structure of Cu-N_(2)C_(2) in SA-Cu/NG and for the first time unravels that the oxygenreconstituted Cu-N_(2)C_(2)-O structure is really the active species of alkaline ORR,while the oxygen reconstitution does not happen at acidic medium.The finding of oxygen-reconstituted active species of SA-Cu/NG at alkaline media successfully unveils the bottleneck puzzle of why the performance of ORR catalysts at alkaline solution is better than that at acidic media,which provides new physical insight into the development of new ORR catalysts.展开更多
基金supported by Rosa roxburghii industry development program of Guizhou Province,China(QCN2019-261)the National Natural Science Foundation of China(31260379)the National Natural Science Foundation of China(31960485).
文摘This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced ulcerative colitis in mice.Compared to control group,DSS induction decreased body weight of mice,indexes of Shannon,Simpson,Chao1 and Faith_pd,and increased disease activity index(DAI)and levels of interleukin 1β(IL-1β),IL-6,tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ);And this induction also led to an increase in Proteobacteria,Verrucomicrobia and Actinobacteria at phylum level,harmful bacterial species richness at genus level,and relative richness of S.sciuri,Desulfovibrio C21_c20,R.gnavus and Akkermansia muciniphila at species level,and a decrease in Firmicutes at phylum level and relative richness of B.acidifaciens in mice.LAB-RRTJ increased body weight of mice with DSS induced ulcerative colitis(UC)and indexes of Shannon,Simpson,Chao1 and Faith_pd,reduced DAI and the content of four infl ammatory factors and improved gut microbiota imbalance in DSS induced UC mice.Besides,the number of operational taxonomic units(OTUs)increased,α-diversity andβ-diversity were restored and similar to those in mice in the control group after LAB-RRTJ treatment.Compared with the positive drug treatment group,LAB-RRTJ has a better effect on regulating gut microbiota diversity in colitis mice.Correlation analysis showed that infl ammatory factors were positively correlated with harmful bacteria and negatively correlated with beneficial bacteria which commonly found in some colitis mice.Taken together,our study demonstrated that LAB-RRTJ could alleviate DSS-induced colitis in mice through the modulation of infl ammatory cytokines and gut microbiota composition.
基金supported by the National Natural Science Foundation of China(Grant Nos.21822801)China Postdoctoral Science Foundation(2019TQ0021)the Fundamental Research Funds for the Central Universities(XK18021 and XK180301)。
文摘Over the past decade,the first-principles-aided thermodynamic models have become standard theoretical tools in research on structural stability and evolution of transition-metal heterogeneous catalysts under reaction environment.Advances in first-principles-aided thermodynamic models mean it is now possible to enable the operando computational modeling,which provides a deep insight into mechanism behind structural stability and evolution,and paves the way for high-through screening for promising transition-metal heterogeneous catalysts.Here,we briefly review the framework and foundation of first-principles-aided thermodynamic models and highlight its contribution to stability analysis on catalysts and identification of reaction-induced structural evolution of catalyst under reaction environment.The present review is helpful for understanding the ongoing developments of first-principles-aided thermodynamic models,which can be employed to screen high-stability catalysts and predict their structural reconstruction in future rational catalyst design.
基金This work is supported by PetroChina Innovation Foundation(2019D-5007-0403).
文摘Our recent theoretical studies have screened out CuCs-doped Ag-based promising catalysts for ethylene epoxidation[ACS Catal.11,3371(2021)].The theoretical results were based on surface modeling,while in the actual reaction process Ag catalysts are particle shaped.In this work,we combine density functional theory(DFT),Wulff construction theory,and micro kinetic analysis to study the catalytic performance of Ag catalysts at the particle model.It demonstrates that the CuCs-doped Ag catalysts are superior to pure Ag catalysts in terms of selectivity and activity,which is further proved by experimental validation.The characterization analysis finds that both Cu and Cs dopant promote particle growth as well as particle dispersion,resulting in a grain boundary-rich Ag particle.Besides,CuCs also facilitate electrophilic atomic oxygen formation on catalyst surface,which is benefitial for ethylene oxide formation and desorption.Our work provides a case study for catalyst design by combining theory and experiment.
文摘To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been reported.Viral and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still unknown.Histological staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid samples.Whole-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of viruses.Previous studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian populations.Therefore,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.
基金This work is supported by the National Key Research and Development Project from MOST(2019YFA0210300)Outstanding Talent Fund from Beijing University of Chemical Technology.
文摘Identification of an active center of catalysts under realistic working conditions of oxygen reduction reaction(ORR)still remains a great challenge and unclear.Herein,we synthesize the Cu single atom embedded on nitrogen-doped graphene-like matrix electrocatalyst(abbreviated as SA-Cu/NG).The results show that SA-Cu/NG possesses a higher ORR capability than 20%Pt/C at alkaline solution while the inferior activity to 20%Pt/C at acidic medium.Based on the experiment and simulation calculation,we identify the atomic structure of Cu-N_(2)C_(2) in SA-Cu/NG and for the first time unravels that the oxygenreconstituted Cu-N_(2)C_(2)-O structure is really the active species of alkaline ORR,while the oxygen reconstitution does not happen at acidic medium.The finding of oxygen-reconstituted active species of SA-Cu/NG at alkaline media successfully unveils the bottleneck puzzle of why the performance of ORR catalysts at alkaline solution is better than that at acidic media,which provides new physical insight into the development of new ORR catalysts.
