This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cance...This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by surgery.The primary endpoint was major pathological response(MPR)rate.Thirty patients in arm A and 21 in arm B were enrolled.Surgery rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 resections.Of these patients,the MPR and pathological complete response rates were both 20.0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 21.2–86.3)and 11.1%(95%CI 0.3–48.2)in arm B,respectively.The corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3).With a median follow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm B.Grade 3 or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm B.Biomarker analysis showed baseline TYROBP expression was predictive of treatment response in arm B.Neoadjuvant camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.展开更多
The exploration of eco-friendly insulating gas to substitute the most potent greenhouse gas sulphur hexafluoride(SF6)has consistently garnered significant attention.Herein,the au-thors evaluated the feasibility of uti...The exploration of eco-friendly insulating gas to substitute the most potent greenhouse gas sulphur hexafluoride(SF6)has consistently garnered significant attention.Herein,the au-thors evaluated the feasibility of utilising perfluoromethyl vinyl ether(PMVE,C_(3)F_(6)O)as a new branch of eco-friendly insulating gas for the first time.The primary dielectric and stability characteristics of PMVE regarding AC breakdown,partial discharge,dielectric recovery,and decomposition properties were revealed under various gas pressure and electrical field conditions.It was found that PMVE demonstrated superior dielectric strength,with the AC breakdown and PD inception voltage(PDIV)1.10 and 1.14 times that of pure SF_(6).Furthermore,the dielectric strength of PMVE exhibits stability even after undergoing 100 cycles of AC breakdowns,and there is no observable formation of solid precipitation on the electrode surface.The discharge decomposition of PMVE mainly generates fluorocarbon(CF_(4),C_(2)F_(6),C_(3)F_(6),C_(3)F_(8),etc.)and CO.Overall,the exceptional insulation stabilityandno absence of solidprecipitation featuresendow PMVE tobe utilised as a new eco-friendly gas for SF_(6)-free gas-insulated equipment.展开更多
The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliab...The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliability and gas–solid interface discharge decomposition characteristics of the gas–solid film insulation structure in GIT is indispensable.The authors simulated the gas–solid film insulation structure in GIT and explored the interface partial discharge(PD)characteristics of C4F7N/CO_(2)gas mixture with polyethylene terephthalate(PET).The effect of gas pressure,mixing ratio on gas–solid interface gas decomposition,PET degradation was investigated,and the interaction mechanism was analysed.It is found that the interface PD generated three degradation regions on a PET film.The gas–solid interface reaction in the electrode contact region and the discharge development trace was significantly higher than that of halation region.The content of gas decomposition products decreases with the increase of gas pressure and the PD intensity of SF6-PET is inferior to that of C_(4)F_(7)N/CO_(2)under the same condition.Relevant results provide reference for the development and application of C_(4)F_(7)N/CO_(2)based GIT.展开更多
基金supported by the National Natural Science Foundation of China(No.82125001)the Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD33)+2 种基金the Foundation of Shanghai Pulmonary Hospital(No.FKLY20004 and FKCX2304)the Beijing XiSiKe Clinical Oncology Research Foundation(No.YHR2019-0451)Jiangsu Hengrui Pharmaceuticals Co.,Ltd.We thank all the participants who made the study possible.
文摘This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by surgery.The primary endpoint was major pathological response(MPR)rate.Thirty patients in arm A and 21 in arm B were enrolled.Surgery rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 resections.Of these patients,the MPR and pathological complete response rates were both 20.0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 21.2–86.3)and 11.1%(95%CI 0.3–48.2)in arm B,respectively.The corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3).With a median follow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm B.Grade 3 or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm B.Biomarker analysis showed baseline TYROBP expression was predictive of treatment response in arm B.Neoadjuvant camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.
基金National Natural Science Foundation of China,Grant/Award Number:52377156。
文摘The exploration of eco-friendly insulating gas to substitute the most potent greenhouse gas sulphur hexafluoride(SF6)has consistently garnered significant attention.Herein,the au-thors evaluated the feasibility of utilising perfluoromethyl vinyl ether(PMVE,C_(3)F_(6)O)as a new branch of eco-friendly insulating gas for the first time.The primary dielectric and stability characteristics of PMVE regarding AC breakdown,partial discharge,dielectric recovery,and decomposition properties were revealed under various gas pressure and electrical field conditions.It was found that PMVE demonstrated superior dielectric strength,with the AC breakdown and PD inception voltage(PDIV)1.10 and 1.14 times that of pure SF_(6).Furthermore,the dielectric strength of PMVE exhibits stability even after undergoing 100 cycles of AC breakdowns,and there is no observable formation of solid precipitation on the electrode surface.The discharge decomposition of PMVE mainly generates fluorocarbon(CF_(4),C_(2)F_(6),C_(3)F_(6),C_(3)F_(8),etc.)and CO.Overall,the exceptional insulation stabilityandno absence of solidprecipitation featuresendow PMVE tobe utilised as a new eco-friendly gas for SF_(6)-free gas-insulated equipment.
基金National Natural Science Foundation of China,Grant/Award Number:51977159China Postdoctoral Science Foundation,Grant/Award Number:2022M712446。
文摘The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliability and gas–solid interface discharge decomposition characteristics of the gas–solid film insulation structure in GIT is indispensable.The authors simulated the gas–solid film insulation structure in GIT and explored the interface partial discharge(PD)characteristics of C4F7N/CO_(2)gas mixture with polyethylene terephthalate(PET).The effect of gas pressure,mixing ratio on gas–solid interface gas decomposition,PET degradation was investigated,and the interaction mechanism was analysed.It is found that the interface PD generated three degradation regions on a PET film.The gas–solid interface reaction in the electrode contact region and the discharge development trace was significantly higher than that of halation region.The content of gas decomposition products decreases with the increase of gas pressure and the PD intensity of SF6-PET is inferior to that of C_(4)F_(7)N/CO_(2)under the same condition.Relevant results provide reference for the development and application of C_(4)F_(7)N/CO_(2)based GIT.
