BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s...BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among others.The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system.The prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic costs.Currently,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and biologics.However,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse reactions.AIM To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.METHODS This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases.Chinese and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine.The quality of the included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using RevMan 5.4 software.RESULTS The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases.The combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective method to reduce the possibility of postoperative recurrence in patients with rheumatic immune diseases.However,due to the limited number and quality of the studies included,these results should be interpreted with caution.CONCLUSION Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective and safe treatment option for patients with rheumatic immune diseases and can be considered a clinical choice.However,more high-quality research is needed to validate this conclusion and provide more solid evidence for clinical practice.展开更多
Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Sha...Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Shanghai.The synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected performances.After a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products Administration.The characteristics of the accelerator and treatment systems are described in this article.展开更多
A front-end electronics of dose monitor has been developed for measuring irradiation dose to the patient in Shanghai Advanced Proton Therapy Facility.The parallel plate ionization chamber is used for the dose monitori...A front-end electronics of dose monitor has been developed for measuring irradiation dose to the patient in Shanghai Advanced Proton Therapy Facility.The parallel plate ionization chamber is used for the dose monitoring.Unlike the traditional method of recycling capacitor integration and voltage-to-frequency conversion,this dose monitor electronics uses the trans-impedance amplifier and analog-to-digital conversion method.It performs satisfactorily,with the integral nonlinearity of less than ±0.04 nA in the range of-400 to 50 nA and the resolution of about±0.6 nA.展开更多
Background In the field of particle therapy,the method of pencil beam scanning is of great potential for clinical application,now and in the future.Purpose The authors made strong effort to develop a spot scanning sys...Background In the field of particle therapy,the method of pencil beam scanning is of great potential for clinical application,now and in the future.Purpose The authors made strong effort to develop a spot scanning system for Shanghai Proton Therapy Facility.Design parameters and basic layout of the system are introduced.Methods Functionalities and specifications of crucial devices are described in detail.Most of the devices in the system were designed in house by the authors themselves,including scanning nozzle,scanning magnets and their power supplies,beam monitors,irradiation control modules and safety interlock modules.During the technical commissioning stage in the fix beam room,the spot scanning system was tested and verified.Results Under conditions of the maximum dose rate and minimum dose rate,a)repeatability of the single spot dose is less than±0.1%;b)nonlinearity of the single spot dose is less than±0.1%;c)FWHM for spot size in air at isocenter varies from 8mm to 12mm for full energy,consistent with the design values;d)lateral dose distribution achieves a flatness of less than 2%for multiple proton energies.Conclusion According to the results of technical commissioning,the spot scanning system is capable of producing a pre-scribed 3D dose distribution for target tumor successfully.展开更多
Anterior communicating artery(ACoA)aneurysms account for the largest proportion of intracranial aneurysms and are the most likely to rupture.[1]The main treatment methods are endovascular embolization and traditional ...Anterior communicating artery(ACoA)aneurysms account for the largest proportion of intracranial aneurysms and are the most likely to rupture.[1]The main treatment methods are endovascular embolization and traditional craniotomy clipping.[2]With the rapid development of interventional materials and technologies in the last two decades,many medical centers have adopted endovascular embolization as the preferred treatment for intracranial aneurysms.However,some aneurysms still require traditional craniotomy clipping.Transsphenoidal endoscopy technology has also developed rapidly in recent years.[3]Because intracranial aneurysms are mostly within the circle of Willis and occur on the ventral side of the skull base,a few neurosurgeons have tried to use an endoscopic endonasal approach(EEA)for clipping.[4-6]However,the number of cases reported in the literature is small and more anatomical studies are needed to deeply analyze the approach and technique.展开更多
文摘BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among others.The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system.The prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic costs.Currently,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and biologics.However,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse reactions.AIM To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.METHODS This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases.Chinese and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine.The quality of the included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using RevMan 5.4 software.RESULTS The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases.The combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective method to reduce the possibility of postoperative recurrence in patients with rheumatic immune diseases.However,due to the limited number and quality of the studies included,these results should be interpreted with caution.CONCLUSION Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective and safe treatment option for patients with rheumatic immune diseases and can be considered a clinical choice.However,more high-quality research is needed to validate this conclusion and provide more solid evidence for clinical practice.
文摘Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Shanghai.The synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected performances.After a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products Administration.The characteristics of the accelerator and treatment systems are described in this article.
文摘A front-end electronics of dose monitor has been developed for measuring irradiation dose to the patient in Shanghai Advanced Proton Therapy Facility.The parallel plate ionization chamber is used for the dose monitoring.Unlike the traditional method of recycling capacitor integration and voltage-to-frequency conversion,this dose monitor electronics uses the trans-impedance amplifier and analog-to-digital conversion method.It performs satisfactorily,with the integral nonlinearity of less than ±0.04 nA in the range of-400 to 50 nA and the resolution of about±0.6 nA.
基金supported by the Youth Innovation Promotion Association CAS(No.2016238)
文摘Background In the field of particle therapy,the method of pencil beam scanning is of great potential for clinical application,now and in the future.Purpose The authors made strong effort to develop a spot scanning system for Shanghai Proton Therapy Facility.Design parameters and basic layout of the system are introduced.Methods Functionalities and specifications of crucial devices are described in detail.Most of the devices in the system were designed in house by the authors themselves,including scanning nozzle,scanning magnets and their power supplies,beam monitors,irradiation control modules and safety interlock modules.During the technical commissioning stage in the fix beam room,the spot scanning system was tested and verified.Results Under conditions of the maximum dose rate and minimum dose rate,a)repeatability of the single spot dose is less than±0.1%;b)nonlinearity of the single spot dose is less than±0.1%;c)FWHM for spot size in air at isocenter varies from 8mm to 12mm for full energy,consistent with the design values;d)lateral dose distribution achieves a flatness of less than 2%for multiple proton energies.Conclusion According to the results of technical commissioning,the spot scanning system is capable of producing a pre-scribed 3D dose distribution for target tumor successfully.
基金The research is funded by grants from the Science and Technology Program of Guangzhou,China(No.201804010316)the Medical Scientific Research Foundation of Guangdong Province,China(No.A2018387).
文摘Anterior communicating artery(ACoA)aneurysms account for the largest proportion of intracranial aneurysms and are the most likely to rupture.[1]The main treatment methods are endovascular embolization and traditional craniotomy clipping.[2]With the rapid development of interventional materials and technologies in the last two decades,many medical centers have adopted endovascular embolization as the preferred treatment for intracranial aneurysms.However,some aneurysms still require traditional craniotomy clipping.Transsphenoidal endoscopy technology has also developed rapidly in recent years.[3]Because intracranial aneurysms are mostly within the circle of Willis and occur on the ventral side of the skull base,a few neurosurgeons have tried to use an endoscopic endonasal approach(EEA)for clipping.[4-6]However,the number of cases reported in the literature is small and more anatomical studies are needed to deeply analyze the approach and technique.
