Ultrahigh dose-rate(FLASH)radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity.However,tumor recurrence largely impede the effectiveness of FLASH therapy.Overcoming tum...Ultrahigh dose-rate(FLASH)radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity.However,tumor recurrence largely impede the effectiveness of FLASH therapy.Overcoming tumor recurrence is crucial for practical FLASH applications.Here,we prepared an agarose-based thermosensitive hydrogel containing a mild photothermal agent(TPE-BBT)and a glutaminase inhibitor(CB-839).Within nanoparticles,TPE-BBT exhibits aggregation-induced emission peaked at 900 nm,while the unrestricted molecular motions endow TPE-BBT with a mild photothermy generation ability.The balanced photothermal effect and photoluminescence are ideal for phototheranostics.Upon 660-nm laser irradiation,the temperature-rising effect softens and hydrolyzes the hydrogel to release TPE-BBT and CB-839 into the tumor site for concurrent mild photothermal therapy and chemotherapy,jointly inhibiting homologous recombination repair of DNA.The enhanced FLASH radiotherapy efficiently kills the tumor tissue without recurrence and obvious systematic toxicity.This work deciphers the unrestricted molecular motions in bright organic fluorophores as a source of photothermy,and provides novel recurrence-resistant radiotherapy without adverse side effects.展开更多
Main observation and conclusion Fluorescent intelligent materials have attracted wide attention because of their great potential applications.One major hurdle for the development and application of fluorescent intelli...Main observation and conclusion Fluorescent intelligent materials have attracted wide attention because of their great potential applications.One major hurdle for the development and application of fluorescent intelligent materials is the aggregation-caused quenching effect in the solid state.Herein,tetraphenylethylene-based trithiocarbonate polymers with satisfactory molecular weights(Mw up to 24900)were synthesized through a one-pot polymerization route under mild conditions.The polymers were non-emissive due to the quenching effect of the trithiocarbonate group.However,upon UV irradiation,the polymers degraded and strong emission from the tetraphenylethylene unit was observed.Such a unique property endows them with great potential applications,such as photopatterning,anti-counterfeit labels,and UV detection.展开更多
White light,which contains polychromic visible components,affects the rhythm of organisms and has the potential for advanced applications of lighting,display,and communication.Compared with traditional incandescent bu...White light,which contains polychromic visible components,affects the rhythm of organisms and has the potential for advanced applications of lighting,display,and communication.Compared with traditional incandescent bulbs and inorganic diodes,pure organic materials are superior in terms of better compatibility,flexibility,structural diversity,and environmental friendliness.In the past few years,polychromic emission has been obtained based on organic aggregates,which provides a platform to achieve white-light emission.Several white-light emitters are sporadically reported,but the underlying mechanistic picture is still not fully established.Based on these considerations,we will focus on the single-component and multicomponent strategies to achieve efficient white-light emission from pure organic aggregates.Thereinto,single-component strategy is introduced from four parts:dual fluorescence,fluorescence and phosphorescence,dual phosphorescence with anti-Kasha’s behavior,and clusteroluminescence.Meanwhile,doping,supramolecular assembly,and cocrystallization are summarized as strategies for multicomponent systems.Beyond the construction strategies of white-light emitters,their advanced representative applications,such as organic light-emitting diodes,white luminescent dyes,circularly polarized luminescence,and encryption,are also prospected.It is expected that this review will draw a comprehensive picture of white-light emission from organic aggregates as well as their emerging applications.展开更多
基金supported by the National Natural Science Foundation of China (21788102 and 82303797)the Research Grants Council of Hong Kong (16306620,16303221,N_HKUST609/19,and C6014-20W)+4 种基金the Research Grants Council of the Hong Kong Special Administrative Region,China (HKUST PDFS2324-6S01)the Innovation and Technology Commission (ITC-CNERC14SC01 and ITCPD/17-9)the Science Technology Innovation Commission of Shenzhen Municipality (KQTD20210811090142053 and GJHZ20210705141810031)the Science and Technology Plan of Shenzhen (JCYJ20200109110608167 and JCYJ20220818103007014)the Guangxi Natural Science Foundation (2023GXNSFBA026137).
文摘Ultrahigh dose-rate(FLASH)radiotherapy is an emerging technology with excellent therapeutic effects and low biological toxicity.However,tumor recurrence largely impede the effectiveness of FLASH therapy.Overcoming tumor recurrence is crucial for practical FLASH applications.Here,we prepared an agarose-based thermosensitive hydrogel containing a mild photothermal agent(TPE-BBT)and a glutaminase inhibitor(CB-839).Within nanoparticles,TPE-BBT exhibits aggregation-induced emission peaked at 900 nm,while the unrestricted molecular motions endow TPE-BBT with a mild photothermy generation ability.The balanced photothermal effect and photoluminescence are ideal for phototheranostics.Upon 660-nm laser irradiation,the temperature-rising effect softens and hydrolyzes the hydrogel to release TPE-BBT and CB-839 into the tumor site for concurrent mild photothermal therapy and chemotherapy,jointly inhibiting homologous recombination repair of DNA.The enhanced FLASH radiotherapy efficiently kills the tumor tissue without recurrence and obvious systematic toxicity.This work deciphers the unrestricted molecular motions in bright organic fluorophores as a source of photothermy,and provides novel recurrence-resistant radiotherapy without adverse side effects.
基金support from the National Natural Science Foundation of China(No.21788102)the Research Grants Council of Hong Kong(Nos.16305618,16304819 and C6014-2000)+2 种基金the Innovation and Technology Commission(No.ITC-CNERC14SC01)the Science and Technology Plan of Shenzhen(Nos.JCYJ20160229205601482 and JCY20170818113602462)the National Science Foundation of Guangdong Province(No,2019B121205002).
文摘Main observation and conclusion Fluorescent intelligent materials have attracted wide attention because of their great potential applications.One major hurdle for the development and application of fluorescent intelligent materials is the aggregation-caused quenching effect in the solid state.Herein,tetraphenylethylene-based trithiocarbonate polymers with satisfactory molecular weights(Mw up to 24900)were synthesized through a one-pot polymerization route under mild conditions.The polymers were non-emissive due to the quenching effect of the trithiocarbonate group.However,upon UV irradiation,the polymers degraded and strong emission from the tetraphenylethylene unit was observed.Such a unique property endows them with great potential applications,such as photopatterning,anti-counterfeit labels,and UV detection.
基金partially supported by the National Natural Science Foundation of China (21788102)the Research Grants Council of Hong Kong (16305518, 16307020, C6014-20W, C6009-17G, and 16305618)+3 种基金the Innovation and Technology Commission (ITC-CNERC14SC01)the Natural Science Foundation of Guangdong Province (2019B121205002)the support from the Fundamental Research Funds for the Central Universities (2021QNA4032)the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, and the South China University of Technology (2019B030301003)
文摘White light,which contains polychromic visible components,affects the rhythm of organisms and has the potential for advanced applications of lighting,display,and communication.Compared with traditional incandescent bulbs and inorganic diodes,pure organic materials are superior in terms of better compatibility,flexibility,structural diversity,and environmental friendliness.In the past few years,polychromic emission has been obtained based on organic aggregates,which provides a platform to achieve white-light emission.Several white-light emitters are sporadically reported,but the underlying mechanistic picture is still not fully established.Based on these considerations,we will focus on the single-component and multicomponent strategies to achieve efficient white-light emission from pure organic aggregates.Thereinto,single-component strategy is introduced from four parts:dual fluorescence,fluorescence and phosphorescence,dual phosphorescence with anti-Kasha’s behavior,and clusteroluminescence.Meanwhile,doping,supramolecular assembly,and cocrystallization are summarized as strategies for multicomponent systems.Beyond the construction strategies of white-light emitters,their advanced representative applications,such as organic light-emitting diodes,white luminescent dyes,circularly polarized luminescence,and encryption,are also prospected.It is expected that this review will draw a comprehensive picture of white-light emission from organic aggregates as well as their emerging applications.
