脑小血管病(Cerebral Small Vessel Disease,CSVD)的主要影像学表现包括腔隙性脑梗死、脑白质病变、微出血等,常并发糖调节受损及认知功能障碍等多种问题。目前关于脑小血管病与糖调节受损的相关性及其对认知功能的潜在影响是众多学者...脑小血管病(Cerebral Small Vessel Disease,CSVD)的主要影像学表现包括腔隙性脑梗死、脑白质病变、微出血等,常并发糖调节受损及认知功能障碍等多种问题。目前关于脑小血管病与糖调节受损的相关性及其对认知功能的潜在影响是众多学者研究的热点。持续糖调节受损不仅诱发全身性与局部的炎症反应,还可导致神经元损伤,加速脑小血管病进程并诱发认知功能障碍。本综述深入剖析脑小血管病与糖调节受损之间的分子机制及其在病理状态下的作用,旨在为开发新的治疗策略提供理论支撑。通过对相关研究文献的综合分析,强调了早期和干预糖调节受损的重要性,即有助于预防或延缓脑小血管病相关认知功能衰退,对提升脑小血管病患者预后和生活质量具有重大意义。展开更多
In order to solve the problems of low accuracy and poor variety adaptability of the current measurement method of the permeability and coating property of sizing paste in textile industry, taking starch and polyvinyl ...In order to solve the problems of low accuracy and poor variety adaptability of the current measurement method of the permeability and coating property of sizing paste in textile industry, taking starch and polyvinyl alcohol(PVA) as the representatives of the most commonly used textile sizes, various concentrations of fluorescent molecules fluorescein isothiocyanate(FITC) were used to label starch and PVA to prepare fluorescein(F)-starch and F-PVA fluorescent sizes with different degrees of labeling(DLs) for the first time, respectively. Then the starch and PVA derivatives were employed to size pure cotton warp yarns. After preparing the sections of the sized yarns, the permeability and coating percentage of starch and PVA paste to the yarns were calculated by using a fluorescence microscope and the Photoshop software, respectively. The results demonstrate that F-starch and F-PVA with appropriate DL of 0.791% and 0.161%, respectively, exhibit good fluorescence property and similar sizing performance to the sizing performance of unlabeled starch and PVA. It is considered that fluorescence labeling of sizing agents with fluorescein units can provide an innovative way for the accurate determination of the permeability and coating property of sizing paste to warp yarns.展开更多
Chitosan (CS) is one promising material as a temporary mechanical supporter for bone fracture internal fixation.In our previous work,we successfully fabricated CS rods through one in situ precipitation route.But bendi...Chitosan (CS) is one promising material as a temporary mechanical supporter for bone fracture internal fixation.In our previous work,we successfully fabricated CS rods through one in situ precipitation route.But bending strength and bending modulus of CS rods need to be improved to match the commercially available devices used for bone fracture internal fixation.In this research,CS rods were reinforced effectively through cross-linking reaction by using glutaraldehyde as the coupling reagent.Schiff’s base was detected by FTIR due to the chemical reaction between amino groups and aldehyde groups.Crystal plane space of CS rods became small during the formation of network structure.Microstructure was observed by SEM,indicating that layer-by-layer structure became much tighter after cross-linking reaction,and cracks in one layer turned around when they reached another layer to absorb energy.Bending strength and bending modulus of cross-linked CS rods could reach 186.3 MPa and 5.17 GPa,respectively.Compared with uncross-linked CS rods,they are increased by 101.6% and 26.1%,respectively.As a result,mechanical properties of CS rods are equivalent to the commercially available biodegradable devices.CS rods with excellent mechanical properties are a good candidate for bone fracture internal fixation.展开更多
文摘脑小血管病(Cerebral Small Vessel Disease,CSVD)的主要影像学表现包括腔隙性脑梗死、脑白质病变、微出血等,常并发糖调节受损及认知功能障碍等多种问题。目前关于脑小血管病与糖调节受损的相关性及其对认知功能的潜在影响是众多学者研究的热点。持续糖调节受损不仅诱发全身性与局部的炎症反应,还可导致神经元损伤,加速脑小血管病进程并诱发认知功能障碍。本综述深入剖析脑小血管病与糖调节受损之间的分子机制及其在病理状态下的作用,旨在为开发新的治疗策略提供理论支撑。通过对相关研究文献的综合分析,强调了早期和干预糖调节受损的重要性,即有助于预防或延缓脑小血管病相关认知功能衰退,对提升脑小血管病患者预后和生活质量具有重大意义。
基金National Natural Science Foundation of China(Nos.51573095 and 51873187)Project of Key Laboratory of Clean Dyeing and Finishing Technology of Zhejiang Province,China(No.QJRZ1902)+1 种基金Technological Research Project for Public Welfare of Zhejiang Province,China(No.LGG21E030005)Postdoctoral Research Program of Zhejiang Province in 2021,China。
文摘In order to solve the problems of low accuracy and poor variety adaptability of the current measurement method of the permeability and coating property of sizing paste in textile industry, taking starch and polyvinyl alcohol(PVA) as the representatives of the most commonly used textile sizes, various concentrations of fluorescent molecules fluorescein isothiocyanate(FITC) were used to label starch and PVA to prepare fluorescein(F)-starch and F-PVA fluorescent sizes with different degrees of labeling(DLs) for the first time, respectively. Then the starch and PVA derivatives were employed to size pure cotton warp yarns. After preparing the sections of the sized yarns, the permeability and coating percentage of starch and PVA paste to the yarns were calculated by using a fluorescence microscope and the Photoshop software, respectively. The results demonstrate that F-starch and F-PVA with appropriate DL of 0.791% and 0.161%, respectively, exhibit good fluorescence property and similar sizing performance to the sizing performance of unlabeled starch and PVA. It is considered that fluorescence labeling of sizing agents with fluorescein units can provide an innovative way for the accurate determination of the permeability and coating property of sizing paste to warp yarns.
基金supported by the National Natural Science Foundation of China (50333020 & 50773070)National Basic Research Program of China ((973 Program,2009CB930104)+1 种基金China Postdoctoral Science Foundation (20100480085)Grand Science and Technology Special Project of Zhejiang Province (2008C11087)
文摘Chitosan (CS) is one promising material as a temporary mechanical supporter for bone fracture internal fixation.In our previous work,we successfully fabricated CS rods through one in situ precipitation route.But bending strength and bending modulus of CS rods need to be improved to match the commercially available devices used for bone fracture internal fixation.In this research,CS rods were reinforced effectively through cross-linking reaction by using glutaraldehyde as the coupling reagent.Schiff’s base was detected by FTIR due to the chemical reaction between amino groups and aldehyde groups.Crystal plane space of CS rods became small during the formation of network structure.Microstructure was observed by SEM,indicating that layer-by-layer structure became much tighter after cross-linking reaction,and cracks in one layer turned around when they reached another layer to absorb energy.Bending strength and bending modulus of cross-linked CS rods could reach 186.3 MPa and 5.17 GPa,respectively.Compared with uncross-linked CS rods,they are increased by 101.6% and 26.1%,respectively.As a result,mechanical properties of CS rods are equivalent to the commercially available biodegradable devices.CS rods with excellent mechanical properties are a good candidate for bone fracture internal fixation.
