In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry ou...In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.展开更多
AIM:To investigate the incidence of dry eye disease(DED)and relevant risk factors among patients infected with the severe acute respiratory syndrome coronavirus 2(SARSCoV-2)Omicron variant.METHODS:This cross-sectional...AIM:To investigate the incidence of dry eye disease(DED)and relevant risk factors among patients infected with the severe acute respiratory syndrome coronavirus 2(SARSCoV-2)Omicron variant.METHODS:This cross-sectional,observational analysis included 993 patients with corona virus disease 2019(COVID-19)treated at the National Exhibition and Convention Center(Shanghai)Fangcang Shelter Hospital,from April 10 to May 26,2022.Totally 944 uninfected control participants were recruited.All participants completed ocular surface disease index(OSDI)questionnaires,and DED symptoms were determined using OSDI scores.The demographic characteristics,length of hospital stay and in nasopharyngeal swabs were performed using questionnaires.SARS-CoV-2 Omicron variant infection was confirmed by nucleic acid-based detection in nasopharyngeal swabs using a 2019-nCoV nucleic acid detection kit.The risk factors for DED symptoms among patients with COVID-19 and control participants were determined by logistic regression analysis.RESULTS:Patients with COVID-19 showed a higher incidence of DED than controls(64.9%vs 55.1%,P<0.001).SARS-CoV-2 infection[odds ratios(ORs)(95%CI):1.271(1.038,1.556)],use of contact lenses[ORs(95%CI):9.350(3.676,23.783)],history of corneal refractive surgery[ORs(95%CI):2.047(1.494,2.804)],poor sleep quality[ORs(95%CI):2.657(2.029,3.480)],and video display terminal(VDT)use for more than 8h per day[ORs(95%CI):6.348(4.720,8.538)]were found to be risk factors for DED symptoms in patients with COVID-19 as well as controls.For patients with COVID-19,the length of hospital stay[ORs(95%CI):1.196(1.134,1.262)],use of contact lenses[ORs(95%CI):20.423(2.680,155.632)],history of corneal refractive surgery[ORs(95%CI):2.166(1.321,3.553)],poor sleep quality[ORs(95%CI):3.650(2.381,5.597)],and VDT use for more than 8h per day[ORs(95%CI):7.740(4.918,12.180)]were significant risk factors for DED symptoms.CONCLUSION:Patients with COVID-19 are more prone to develop symptomatic DED.SARS-CoV-2 infection and length of hospital stay are important risk factors for DED symptoms.展开更多
Campus network provides a critical stage to student service and campus administration,which assumes a paramount part in the strategy of‘Rejuvenating the Country through Science and Education’and‘Revitalizing China ...Campus network provides a critical stage to student service and campus administration,which assumes a paramount part in the strategy of‘Rejuvenating the Country through Science and Education’and‘Revitalizing China through Talented Persons’.However,with the rapid development and continuous expansion of campus network,network security needs to be an essential issue that could not be overlooked in campus network construction.In order to ensure the normal operation of various functions of the campus network,the security risk level of the campus network is supposed to be controlled within a reasonable range at any moment.Through literature research,theory analysis and other methods,this paper systematically combs the research on campus network security at home and abroad,analyzing and researching the campus network security issues from a theoretical perspective.A series of efficient solutions accordingly were also put forward.展开更多
With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell resolution.High-throughput single-cell sequencing can be utilized for multi-omi...With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell resolution.High-throughput single-cell sequencing can be utilized for multi-omics characterization of tumor cells,stromal cells or infiltrated immune cells to evaluate tumor progression,responses to environmental perturbations,heterogeneous composition of the tumor microenvironment,and complex intercellular interactions between these factors.Particularly,single-cell sequencing of T cell receptors,alone or in combination with single-cell RNA sequencing,is useful in the fields of tumor immunology and immunotherapy.Clinical insights obtained from single-cell analysis are critically important for exploring the biomarkers of disease progression or antitumor treatment,as well as for guiding precise clinical decision-making for patients with malignant tumors.In this review,we summarize the clinical applications of single-cell sequencing in the fields of tumor cell evolution,tumor immunology,and tumor immunotherapy.Additionally,we analyze the tumor cell response to antitumor treatment,heterogeneity of the tumor microenvironment,and response or resistance to immune checkpoint immunotherapy.The limitations of single-cell analysis in cancer research are also discussed.展开更多
Objective To summarize the diagnosis and treatment experience of children with intermittent hydronephrosis caused by ureteral fibroepithelial polyp(UFP).Methods From 2017 to 2020,cases of hydronephrosis caused by uret...Objective To summarize the diagnosis and treatment experience of children with intermittent hydronephrosis caused by ureteral fibroepithelial polyp(UFP).Methods From 2017 to 2020,cases of hydronephrosis caused by ureteral polyp in Anhui Provincial Children’s Hospital were retrospectively enrolled for investigation.Demographic data,clinical manifestations,operation details,pathology and outcomes were collected from patients’medical data for analysis.Results All seven cases of UFP were boys,including six cases on the left side of the ureter and one case on the right side,at the median age of 7.1 years(3-14 years),with abdominal intermittent pain as the first symptom.All cases underwent laparoscopic pyeloureteroplasty.All the operations were completed successfully;postoperative pathology indicated the presence of primary UFP.Postoperative follow-ups of 1-30 months showed satisfactory recovery and relief from hydronephrosis.Conclusions Laparoscopic pyeloureteroplasty or ureteroureterostomy is one of the optimal treatments for ureteral polyp at present.The surgical method should be determined according to the number of polyps,the length and the diameter of the affected ureter,and also the status of renal function of the patients.展开更多
基金Supported by Space Medical Experiment Project of China Manned Space Program(HYZHXM02003)。
文摘In the past two years,China’s space life science has made great progress.Space biomedical and life science programs have carried out ground-based research for the first batch of projects,and are preparing to carry out space-based experiments along with the construction of China’s space station.And space life science payload of the space station completed the development of positive samples.Thus,with the development of lunar exploration and Mars exploration projects,astrobiology research has also made a lot of basic achievements.On the basis of summarizing the development of space life science in China,this paper mainly introduces the important progress of payload technology and life science research.
基金Supported by the Natural Science Foundation of Chongqing(No.cstc2020jcyj-msxmX0241).
文摘AIM:To investigate the incidence of dry eye disease(DED)and relevant risk factors among patients infected with the severe acute respiratory syndrome coronavirus 2(SARSCoV-2)Omicron variant.METHODS:This cross-sectional,observational analysis included 993 patients with corona virus disease 2019(COVID-19)treated at the National Exhibition and Convention Center(Shanghai)Fangcang Shelter Hospital,from April 10 to May 26,2022.Totally 944 uninfected control participants were recruited.All participants completed ocular surface disease index(OSDI)questionnaires,and DED symptoms were determined using OSDI scores.The demographic characteristics,length of hospital stay and in nasopharyngeal swabs were performed using questionnaires.SARS-CoV-2 Omicron variant infection was confirmed by nucleic acid-based detection in nasopharyngeal swabs using a 2019-nCoV nucleic acid detection kit.The risk factors for DED symptoms among patients with COVID-19 and control participants were determined by logistic regression analysis.RESULTS:Patients with COVID-19 showed a higher incidence of DED than controls(64.9%vs 55.1%,P<0.001).SARS-CoV-2 infection[odds ratios(ORs)(95%CI):1.271(1.038,1.556)],use of contact lenses[ORs(95%CI):9.350(3.676,23.783)],history of corneal refractive surgery[ORs(95%CI):2.047(1.494,2.804)],poor sleep quality[ORs(95%CI):2.657(2.029,3.480)],and video display terminal(VDT)use for more than 8h per day[ORs(95%CI):6.348(4.720,8.538)]were found to be risk factors for DED symptoms in patients with COVID-19 as well as controls.For patients with COVID-19,the length of hospital stay[ORs(95%CI):1.196(1.134,1.262)],use of contact lenses[ORs(95%CI):20.423(2.680,155.632)],history of corneal refractive surgery[ORs(95%CI):2.166(1.321,3.553)],poor sleep quality[ORs(95%CI):3.650(2.381,5.597)],and VDT use for more than 8h per day[ORs(95%CI):7.740(4.918,12.180)]were significant risk factors for DED symptoms.CONCLUSION:Patients with COVID-19 are more prone to develop symptomatic DED.SARS-CoV-2 infection and length of hospital stay are important risk factors for DED symptoms.
基金sponsored by the JSPIGKZ Project (No.2911121110)Innovative and Entrepreneurial Doctor of Jiangsu Province (No.JSSCBS20210598)+1 种基金Jiangsu Provincial University Nature Science Foundation Project (No.2020KX007Z)Jiangsu Provincial Science and Technology Research Project (No.20KJB413002)。
文摘Campus network provides a critical stage to student service and campus administration,which assumes a paramount part in the strategy of‘Rejuvenating the Country through Science and Education’and‘Revitalizing China through Talented Persons’.However,with the rapid development and continuous expansion of campus network,network security needs to be an essential issue that could not be overlooked in campus network construction.In order to ensure the normal operation of various functions of the campus network,the security risk level of the campus network is supposed to be controlled within a reasonable range at any moment.Through literature research,theory analysis and other methods,this paper systematically combs the research on campus network security at home and abroad,analyzing and researching the campus network security issues from a theoretical perspective.A series of efficient solutions accordingly were also put forward.
文摘With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell resolution.High-throughput single-cell sequencing can be utilized for multi-omics characterization of tumor cells,stromal cells or infiltrated immune cells to evaluate tumor progression,responses to environmental perturbations,heterogeneous composition of the tumor microenvironment,and complex intercellular interactions between these factors.Particularly,single-cell sequencing of T cell receptors,alone or in combination with single-cell RNA sequencing,is useful in the fields of tumor immunology and immunotherapy.Clinical insights obtained from single-cell analysis are critically important for exploring the biomarkers of disease progression or antitumor treatment,as well as for guiding precise clinical decision-making for patients with malignant tumors.In this review,we summarize the clinical applications of single-cell sequencing in the fields of tumor cell evolution,tumor immunology,and tumor immunotherapy.Additionally,we analyze the tumor cell response to antitumor treatment,heterogeneity of the tumor microenvironment,and response or resistance to immune checkpoint immunotherapy.The limitations of single-cell analysis in cancer research are also discussed.
文摘Objective To summarize the diagnosis and treatment experience of children with intermittent hydronephrosis caused by ureteral fibroepithelial polyp(UFP).Methods From 2017 to 2020,cases of hydronephrosis caused by ureteral polyp in Anhui Provincial Children’s Hospital were retrospectively enrolled for investigation.Demographic data,clinical manifestations,operation details,pathology and outcomes were collected from patients’medical data for analysis.Results All seven cases of UFP were boys,including six cases on the left side of the ureter and one case on the right side,at the median age of 7.1 years(3-14 years),with abdominal intermittent pain as the first symptom.All cases underwent laparoscopic pyeloureteroplasty.All the operations were completed successfully;postoperative pathology indicated the presence of primary UFP.Postoperative follow-ups of 1-30 months showed satisfactory recovery and relief from hydronephrosis.Conclusions Laparoscopic pyeloureteroplasty or ureteroureterostomy is one of the optimal treatments for ureteral polyp at present.The surgical method should be determined according to the number of polyps,the length and the diameter of the affected ureter,and also the status of renal function of the patients.
