Guizhou Karst Plateau is located at the center of the karst region in Asia, where landslides are a typical disaster. Affected by the local karst environment, the landslides in this region have their own characteristic...Guizhou Karst Plateau is located at the center of the karst region in Asia, where landslides are a typical disaster. Affected by the local karst environment, the landslides in this region have their own characteristics. In this study, 3975 landslide records from inventories of the Guizhou karst plateau are studied. The geographical detector method is used to detect the dominant casual factor and predominant multi-factor combinations for the local landslides. The results show that landslides are prone to areas on slopes between 10° and 35°, of clay rock, in close proximity to gullies, and especially in areas of moderate vegetation, dryland, and mild rocky desertification. Continuous precipitation over 10 days has a great effect on landslide occurrence. Compared with the individual factors, the impact of two-factor interaction has greater explanatory power for landslide volume. The volume of earthquake-induced landslides is predominantly controlled by the interactions of faults and slopes, while that of humaninduced landslides is affected by the interactions of land cover and hydrological conditions. For rainfallinduced landslides, the dominant interactions vary in different regions. In the central karst basin, the interactions between faults and precipitation can explain over 90% of the variations in landslide volumes. In the southern hilly karst region, the interactions between lithology and slope can explain over 71% of the variations in landslide volume and those between fault and land-use can explain 50% of the variations of the landslide volumes in the northeastern mountainous karst region.展开更多
[Objective] The study aimed to carry out the regionalization of climate suitability about spring potato planting in Western Guizhou on the basis of GIS technology. [Method] Based on the climatic data of 15 meteorologi...[Objective] The study aimed to carry out the regionalization of climate suitability about spring potato planting in Western Guizhou on the basis of GIS technology. [Method] Based on the climatic data of 15 meteorological stations in Western Guizhou during the growing period of spring potato from March to August in 1978-2010, the regionalization indicators of climate suitability about spring potato planting were determined according to the correlation between climatic factors and meteorological yield of spring potato. Afterwards, on the basis of climitic data and corresponding basic geographical information like longitude, latitude, altitude, slope and aspect, the spatial analysis models of division indicators about spring potato planting in Western Guizhou were established by using GIS spatial overlay analysis and used to carry out the township-level regionalization of climate suitability about spring potato planting in Western Guizhou with 100 m×100 m grids. [Result] Based on the relationship between meteorological yield of spring potato and climatic factors in Western Guizhou from 1978 to 2010, eight climatic division indicators, including altitude, average temperature,>10 ℃ active accumulated temperature, precipitation and sunshine hours in the growth stage, average temperature in July, average temperature difference between day and night from July to August, and precipitation from May to July, were chosen for spring potato planting, and each indicator had three levels, namely the most suitable, suitable and sub-suitable. Meanwhile, Western Guizhou was grouped into three areas according to these indicators, including the most suitable area, suitable area and sub-suitable area, and their area accounted for 52%, 45% and 3% of total area of the whole province respectively. [Conclusion] The research could provide scientific references for the production layout and species selection of spring potato in Western Guizhou.展开更多
Objective·To investigate the role of mitochondrial solute carrier family 25 member 13(SLC25A13)on breast cancer development.Methods·SLC25A13 mRNA and protein expressions in invasive breast cancer tissues and...Objective·To investigate the role of mitochondrial solute carrier family 25 member 13(SLC25A13)on breast cancer development.Methods·SLC25A13 mRNA and protein expressions in invasive breast cancer tissues and normal breast tissues were from The Cancer Genome Atlas(TCGA)breast cancer dataset.Survival analysis was conducted online by Kaplan-Meier software.MCF-7 cell line was used for in vitro cell assay.Knockdown of SLC25A13 and sirtuin 2(SIRT2)were conducted by siRNA transfection.Cell viability was measured with trypan blue exclusion.Cell cycle arrest was determined by flow cytometry.The mRNA expression of SLC25A13 and P27 were detected by quantitative PCR.The protein level of SLC25A13,P27 and SIRT2 were detected by Western blotting.Protein half-life of P27 was assessed by Western blotting after cycloheximide treatment.Results·SLC25A13 was up-regulated in invasive breast cancer tissues.High expression of SLC25A13 correlated with poor overall survival and breast cancer recurrence.SLC25A13 knockdown inhibited MCF-7 cell cycle progression.P27 and SIRT2 both accumulated after SLC25A13 knockdown.P27 accumulation resulted from prolonged protein half-life.Knockdown of SIRT2 restored cell cycle arrest as well as P27 accumulation caused by SLC25A13 silencing.Conclusion·High expression of SLC25A13 may promote cell cycle progression via SIRT2 in breast cancer development.展开更多
Protected areas have become important tourism products that promoted as attractions by the tourism industry. Taking the Changbai Mountain Biosphere Reserve in Northeast China as a case, this study addresses visitor ne...Protected areas have become important tourism products that promoted as attractions by the tourism industry. Taking the Changbai Mountain Biosphere Reserve in Northeast China as a case, this study addresses visitor needs as a basis for developing a tourism strategy aimed at enhancing tourist opportunities at this reserve. A factor-cluster approach was employed to identify visitor segment profiles based on their visit motivations. Through random sampling, a pencil-and-paper questionnaire in Chinese language was collected from 637 domestic tourists in the study area. A principal components analysis of motivations revealed eight motivational factors, and four distinct groups of tourists – Nature travelers, Cultural landscape tourists, Food & shopping enthusiasts, and Eclectic adventurers – were identified. Understanding the differences in these visitor segments will help the management authority effectively analyze nature reserve attributes and provide alternative activities and services to tourists. Finally, within the dual framework of market segmentation and destination management some management recommendations and marketing implications are suggested.展开更多
This article seeks to develop a fuller understanding of the social and attraction motives of domestic tourists who visit the Changbai Mountain Biosphere Reserve(CMBR) in Northeastern China. To do so, ecotourists are c...This article seeks to develop a fuller understanding of the social and attraction motives of domestic tourists who visit the Changbai Mountain Biosphere Reserve(CMBR) in Northeastern China. To do so, ecotourists are compared to general travelers visiting this area. A questionnaire was employed to collect data on visitor characteristics and motivations, responses to which were then analyzed via descriptive statistics, T-tests and principal component factor analysis. Results showed that 16% of the visitors to this area were classified as ecotourists, while the remainder general travelers. Five motivations displayed significant differences(P<0.05) between these two types of tourists. Three social motives – boosting self-confidence, feeling at home away from home and being together with family – and two attraction motives – indoor sports and viewing unique landscapes of the CMBR(crater lake, waterfall, gorge and hot spring) – were significantly more important for general travelers(P<0.05); while two social motives of experiencing the tranquility of the natural setting and the natural beauty of the landscape were relatively more important for ecotourists(P<0.1). Results suggest that ecotourists have distinct and complicated attraction and social motives compared to general travelers visiting the CMBR. Results have useful implications for researchers interested in tourist motivations and behavior, as well as for managers who wish to focus their marketing strategies more effectively. National Park of South Africa. Uysal et al.(1994) assessed the travel motives of Australian tourists to U.S. national parks and nature areas and formed five groupings including ‘relaxation/hobbies', ‘novelty', ‘enhancement of kinship relationship', ‘escape', and ‘prestige'. Tao et al.(2004) analyzed motivations of Asian tourists travelling to Taiwan's Taroko National Park using a self-defined approach and found that the most significant benefits sought by self-defined ecotourists are ‘learning about nature' and ‘participating in recreation activities'. Beh and Bruyere(2007) analyzed visitor motivations in three Kenyan national reserves, identifying the three most prominent kinds of tourists as escapers, learners and spiritualists. Pan and Ryan(2007) used factor analysis to reveal five motivational dimensions –‘relaxation', ‘social needs', ‘a sense of belonging', ‘mastery skills', and ‘intellectual needs' – of visitors to the Pirongia Forest Park in New Zealand. Kruger and Saayman(2010) did a comparative study on travel motivations of tourists to Kruger and Tsitsikamma National Parks in South Africa and found that common motives of tourists were ‘escape and relaxation' as well as ‘knowledge seeking', ‘nostalgia' and ‘park attributes'. Despite these efforts, on an overall basis past literature on why visitors travel to national parks and nature areas is still rather limited. In China, a number of empirical studies on tourist motivations have been conducted since the early 1990s(Chen and Miao 2006; Dong 2011; Huang et al. 2011; Jeffrey and Xie 1994; Lu 1997; Ma et al. 2013; Zhang 2012). Some studies have focused on motivations of visitors to nature reserves(Li 2007), geological parks(Chen and Qiao 2010), world heritage sites(Su et al. 2005), and seismic memorial sites(Tang 2014). However, most previous research findings on tourist motivations are not comparable, reflecting the fact that visitors to different parks have quite different motives due to the attributes of particular destinations, the geographic locations of these parks, types of available activities, marketing strategies, and the complexity of travel motives(Chen and Qiao 2010; Pan and Ryan 2007). While it is true that certain motivations were shared in varying degrees by most tourists to these places – i.e., ‘appreciating natural landscapes', ‘family and education', ‘social needs', and ‘perceived prestige of visit' – most previous research has not focused on natural settings as destinations. Thus travel motivations of tourists to these areas must be further explored and clarified in relation to impacts on particular natural areas and patterns of market segmentation. As one of the earliest and largest natural reserves established in China, the Changbai Mountain Biosphere Reserve(CMBR) has long been a draw not only for domestic tourists but also for international visitors, and tourism to the area has been growing steadily since 1980. With the number of visitors to the reserve having climbed to 2.44 million in 2010(Statistical Communiqué of the Changbai Mountain Protection and Development Zone of Jilin Province 2011), it has become imperative for local government officials and reserve wardens to understand tourists' desires and interests when identifying tourism development opportunities. However, the existing literature still suffers from a lack of empirical studies that investigate why people travel to the CMBR and whether tourist motives differ between groups such as ecotourists and general travelers. The target population for this study consists of domestic visitors to the CMBR. The goals of this research include:(1) to identify the social and attraction motives of domestic tourists that influence decisions to visit the CMBR;(2) to explore whether there are any differences between the motivations of these two types of tourists; and(3) to provide some useful management implications for local government and tourism marketers.展开更多
基金supported by high-level innovative talents training in Guizhou province(2016 No.4026)the Chinese National Natural Science Fund(Grant Nos.41671101,41671098)the Pioneer Project of the Chinese Academy of Sciences(Grant No.XDA19040304)
文摘Guizhou Karst Plateau is located at the center of the karst region in Asia, where landslides are a typical disaster. Affected by the local karst environment, the landslides in this region have their own characteristics. In this study, 3975 landslide records from inventories of the Guizhou karst plateau are studied. The geographical detector method is used to detect the dominant casual factor and predominant multi-factor combinations for the local landslides. The results show that landslides are prone to areas on slopes between 10° and 35°, of clay rock, in close proximity to gullies, and especially in areas of moderate vegetation, dryland, and mild rocky desertification. Continuous precipitation over 10 days has a great effect on landslide occurrence. Compared with the individual factors, the impact of two-factor interaction has greater explanatory power for landslide volume. The volume of earthquake-induced landslides is predominantly controlled by the interactions of faults and slopes, while that of humaninduced landslides is affected by the interactions of land cover and hydrological conditions. For rainfallinduced landslides, the dominant interactions vary in different regions. In the central karst basin, the interactions between faults and precipitation can explain over 90% of the variations in landslide volumes. In the southern hilly karst region, the interactions between lithology and slope can explain over 71% of the variations in landslide volume and those between fault and land-use can explain 50% of the variations of the landslide volumes in the northeastern mountainous karst region.
基金Supported by Meteorological Anti-poverty Project of China Meteorological Administration(CMATG2009FP08)Open Foundation of Guizhou Meteorological Bureau(KF[2008]01)Land-saving Science and Technology Cooperation Agreement about Potato(52020-2009-01-01)
文摘[Objective] The study aimed to carry out the regionalization of climate suitability about spring potato planting in Western Guizhou on the basis of GIS technology. [Method] Based on the climatic data of 15 meteorological stations in Western Guizhou during the growing period of spring potato from March to August in 1978-2010, the regionalization indicators of climate suitability about spring potato planting were determined according to the correlation between climatic factors and meteorological yield of spring potato. Afterwards, on the basis of climitic data and corresponding basic geographical information like longitude, latitude, altitude, slope and aspect, the spatial analysis models of division indicators about spring potato planting in Western Guizhou were established by using GIS spatial overlay analysis and used to carry out the township-level regionalization of climate suitability about spring potato planting in Western Guizhou with 100 m×100 m grids. [Result] Based on the relationship between meteorological yield of spring potato and climatic factors in Western Guizhou from 1978 to 2010, eight climatic division indicators, including altitude, average temperature,>10 ℃ active accumulated temperature, precipitation and sunshine hours in the growth stage, average temperature in July, average temperature difference between day and night from July to August, and precipitation from May to July, were chosen for spring potato planting, and each indicator had three levels, namely the most suitable, suitable and sub-suitable. Meanwhile, Western Guizhou was grouped into three areas according to these indicators, including the most suitable area, suitable area and sub-suitable area, and their area accounted for 52%, 45% and 3% of total area of the whole province respectively. [Conclusion] The research could provide scientific references for the production layout and species selection of spring potato in Western Guizhou.
基金Morning Star Prograrm of Shanghai Municipal Science and Technology Commission,11QA1403700Shanghai College Experimental Technology Team Building PlanK.C.Wong Medical Fellowship Fund,Shanghai Jiao Tong University~~
文摘Objective·To investigate the role of mitochondrial solute carrier family 25 member 13(SLC25A13)on breast cancer development.Methods·SLC25A13 mRNA and protein expressions in invasive breast cancer tissues and normal breast tissues were from The Cancer Genome Atlas(TCGA)breast cancer dataset.Survival analysis was conducted online by Kaplan-Meier software.MCF-7 cell line was used for in vitro cell assay.Knockdown of SLC25A13 and sirtuin 2(SIRT2)were conducted by siRNA transfection.Cell viability was measured with trypan blue exclusion.Cell cycle arrest was determined by flow cytometry.The mRNA expression of SLC25A13 and P27 were detected by quantitative PCR.The protein level of SLC25A13,P27 and SIRT2 were detected by Western blotting.Protein half-life of P27 was assessed by Western blotting after cycloheximide treatment.Results·SLC25A13 was up-regulated in invasive breast cancer tissues.High expression of SLC25A13 correlated with poor overall survival and breast cancer recurrence.SLC25A13 knockdown inhibited MCF-7 cell cycle progression.P27 and SIRT2 both accumulated after SLC25A13 knockdown.P27 accumulation resulted from prolonged protein half-life.Knockdown of SIRT2 restored cell cycle arrest as well as P27 accumulation caused by SLC25A13 silencing.Conclusion·High expression of SLC25A13 may promote cell cycle progression via SIRT2 in breast cancer development.
基金supported by Open Research Fund Program of Changbai-Mountain Academy of Sciences (Grant No. 2016009)National Fund Nurture Program of College of Economics and Management in SYAU (Grant No. JGPY20170302)+1 种基金National Natural Science Foundation Youth Fund Program of China(Grant No. 31500386)Chinese Academy of Sciences Visiting Professorship for Senior International Scientists (Grant No. 2018VCA0038)
文摘Protected areas have become important tourism products that promoted as attractions by the tourism industry. Taking the Changbai Mountain Biosphere Reserve in Northeast China as a case, this study addresses visitor needs as a basis for developing a tourism strategy aimed at enhancing tourist opportunities at this reserve. A factor-cluster approach was employed to identify visitor segment profiles based on their visit motivations. Through random sampling, a pencil-and-paper questionnaire in Chinese language was collected from 637 domestic tourists in the study area. A principal components analysis of motivations revealed eight motivational factors, and four distinct groups of tourists – Nature travelers, Cultural landscape tourists, Food & shopping enthusiasts, and Eclectic adventurers – were identified. Understanding the differences in these visitor segments will help the management authority effectively analyze nature reserve attributes and provide alternative activities and services to tourists. Finally, within the dual framework of market segmentation and destination management some management recommendations and marketing implications are suggested.
基金supported by the National Forestry Public Welfare Program of China (201304216)the National Key Technologies R&D Program of China (2012BAD22B04)the National Key Laboratory Projects (LFSE2015-20)
文摘This article seeks to develop a fuller understanding of the social and attraction motives of domestic tourists who visit the Changbai Mountain Biosphere Reserve(CMBR) in Northeastern China. To do so, ecotourists are compared to general travelers visiting this area. A questionnaire was employed to collect data on visitor characteristics and motivations, responses to which were then analyzed via descriptive statistics, T-tests and principal component factor analysis. Results showed that 16% of the visitors to this area were classified as ecotourists, while the remainder general travelers. Five motivations displayed significant differences(P<0.05) between these two types of tourists. Three social motives – boosting self-confidence, feeling at home away from home and being together with family – and two attraction motives – indoor sports and viewing unique landscapes of the CMBR(crater lake, waterfall, gorge and hot spring) – were significantly more important for general travelers(P<0.05); while two social motives of experiencing the tranquility of the natural setting and the natural beauty of the landscape were relatively more important for ecotourists(P<0.1). Results suggest that ecotourists have distinct and complicated attraction and social motives compared to general travelers visiting the CMBR. Results have useful implications for researchers interested in tourist motivations and behavior, as well as for managers who wish to focus their marketing strategies more effectively. National Park of South Africa. Uysal et al.(1994) assessed the travel motives of Australian tourists to U.S. national parks and nature areas and formed five groupings including ‘relaxation/hobbies', ‘novelty', ‘enhancement of kinship relationship', ‘escape', and ‘prestige'. Tao et al.(2004) analyzed motivations of Asian tourists travelling to Taiwan's Taroko National Park using a self-defined approach and found that the most significant benefits sought by self-defined ecotourists are ‘learning about nature' and ‘participating in recreation activities'. Beh and Bruyere(2007) analyzed visitor motivations in three Kenyan national reserves, identifying the three most prominent kinds of tourists as escapers, learners and spiritualists. Pan and Ryan(2007) used factor analysis to reveal five motivational dimensions –‘relaxation', ‘social needs', ‘a sense of belonging', ‘mastery skills', and ‘intellectual needs' – of visitors to the Pirongia Forest Park in New Zealand. Kruger and Saayman(2010) did a comparative study on travel motivations of tourists to Kruger and Tsitsikamma National Parks in South Africa and found that common motives of tourists were ‘escape and relaxation' as well as ‘knowledge seeking', ‘nostalgia' and ‘park attributes'. Despite these efforts, on an overall basis past literature on why visitors travel to national parks and nature areas is still rather limited. In China, a number of empirical studies on tourist motivations have been conducted since the early 1990s(Chen and Miao 2006; Dong 2011; Huang et al. 2011; Jeffrey and Xie 1994; Lu 1997; Ma et al. 2013; Zhang 2012). Some studies have focused on motivations of visitors to nature reserves(Li 2007), geological parks(Chen and Qiao 2010), world heritage sites(Su et al. 2005), and seismic memorial sites(Tang 2014). However, most previous research findings on tourist motivations are not comparable, reflecting the fact that visitors to different parks have quite different motives due to the attributes of particular destinations, the geographic locations of these parks, types of available activities, marketing strategies, and the complexity of travel motives(Chen and Qiao 2010; Pan and Ryan 2007). While it is true that certain motivations were shared in varying degrees by most tourists to these places – i.e., ‘appreciating natural landscapes', ‘family and education', ‘social needs', and ‘perceived prestige of visit' – most previous research has not focused on natural settings as destinations. Thus travel motivations of tourists to these areas must be further explored and clarified in relation to impacts on particular natural areas and patterns of market segmentation. As one of the earliest and largest natural reserves established in China, the Changbai Mountain Biosphere Reserve(CMBR) has long been a draw not only for domestic tourists but also for international visitors, and tourism to the area has been growing steadily since 1980. With the number of visitors to the reserve having climbed to 2.44 million in 2010(Statistical Communiqué of the Changbai Mountain Protection and Development Zone of Jilin Province 2011), it has become imperative for local government officials and reserve wardens to understand tourists' desires and interests when identifying tourism development opportunities. However, the existing literature still suffers from a lack of empirical studies that investigate why people travel to the CMBR and whether tourist motives differ between groups such as ecotourists and general travelers. The target population for this study consists of domestic visitors to the CMBR. The goals of this research include:(1) to identify the social and attraction motives of domestic tourists that influence decisions to visit the CMBR;(2) to explore whether there are any differences between the motivations of these two types of tourists; and(3) to provide some useful management implications for local government and tourism marketers.
