Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334...Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334 consecutive patients with SAP who underwent first PCI following multi-slice computer tomography （MSCT） were enrolled from our institution between January 2007 and June 2012. The CAC score was calculated according to the standard Agatston calcium scoring algorithm. Complex PCI was defined as use of high pressure bal-loon, kissing balloon and/or rotablator. Procedure-related complications included dissection, occlusion, perforation, no/slow flow and emer-gency coronary artery bypass grafting. Main adverse cardiac events （MACE） were defined as a combined end point of death, non-fatal myo-cardial infarction, target lesion revascularization and rehospitalization for cardiac ischemic events. Results Patients with a CAC score〉300 （n=145） had significantly higher PCI complexity （13.1%vs. 5.8%, P=0.017） and rate of procedure-related complications （17.2%vs. 7.4%, P=0.005） than patients with a CAC score≤300 （n=189）. After a median follow-up of 22.5 months （4-72 months）, patients with a CAC score≤300 differ greatly than those patients with CAC score＆gt;300 in cumulative non-events survival rates （88.9 vs. 79.0%, Log rank 4.577, P=0.032）. After adjusted for other factors, the risk of MACE was significantly higher [hazard ratio （HR）：4.3, 95%confidence inter-val （95%CI）：2.4-8.2, P=0.038] in patients with a CAC score〉300 compared to patients with a lower CAC score. Conclusions The CAC score is an independent predictor for MACE in SAP patients who underwent PCI and indicates complexity of PCI and proce-dure-related complications.展开更多
A novel vacuolar Na+/H+ exchanger, CgNHX1, was cloned from a halophytic species Chenopodium glaucum by using reverse transcriptase-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE) techniq...A novel vacuolar Na+/H+ exchanger, CgNHX1, was cloned from a halophytic species Chenopodium glaucum by using reverse transcriptase-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE) technique. Sequence alignment and phylogenetic analysis of 22 NHX genes from GenBank as well as the new CgNHX1 gene indicate that NHX genes shared a great degree of similarity, regardless of their glycophytic or halophytic origin. Expression of the CgNHX1 gene was induced by NaCl and peaked at 400 mmol/L NaCl. Overexpression of NHX1 genes in rice enhanced their tolerance to salt stress. However, there is no significant difference in salt tolerance among the transgenic rice plants overexpressing the NHX1 genes from either glycophytic or halophytic species. The Na+ content of both the wild type (WT) and transgenic plants increased when exposed to 50 and 100 mmol/L NaCl, and the Na+ concentration in transgenic plants was marginally higher than that of WT. Our data demonstrate that the overexpression of the NHX1 gene from either glycophytic or halophytic species resulted in the enhanced tolerance to salt stress at a similar level, suggesting that NHX gene per se might not be the reason accounting for the difference in salt tolerance between glycophytes and halophytes.展开更多
The Crimean-congo hemorrhagic fever virus(CCHFV)is a geographically widespread fatal pathogen. Identification of the epitope regions of the virus is important for the diagnosis and epidemiological studies of CCHFV inf...The Crimean-congo hemorrhagic fever virus(CCHFV)is a geographically widespread fatal pathogen. Identification of the epitope regions of the virus is important for the diagnosis and epidemiological studies of CCHFV infections.In this study,expression vectors carrying series truncated fragments of the NP(nucleocapsid protein)gene from the S fragment of CCHFV strain YL04057 were constructed.The recombinant proteins were expressed in E.coli and purified for detection.The antigenic of the truncated fragments of NP was detected with a polyclonal serum(rabbit)and 2 monoclonal(mAbs)(14B7 and 43E5)against CCHFV by Western-blot analyses. The results showed that the three expressed constructs,which all contained the region 235AA to 305AA could be detected by mAbs polyclonal serum.The results suggest that region 235-305 aa of NP is a highly antigenic region and is highly conserved in the NP protein.展开更多
The spin-dependent electronic transport properties of a zigzag zinc oxide(ZnO) nanoribbon are studied by using density functional theory with non-equilibrium Green's functions. We calculate the spin-polarized band...The spin-dependent electronic transport properties of a zigzag zinc oxide(ZnO) nanoribbon are studied by using density functional theory with non-equilibrium Green's functions. We calculate the spin-polarized band structure, projected density of states, Bloch states, and transmission spectrum of the ZnO nanoribbon. It is determined that all Bloch states are located at the edge of the ZnO nanoribbon. The spin-up transmission eigenchannels are contributed from Zn 4s orbital,whereas the spin-down transmission eigenchannels are contributed from Zn 4s and O 2p orbitals. By analyzing the current-voltage curves for the opposite spins of the ZnO nanoribbon device, negative differential resistance(NDR) and spin filter effect are observed. Moreover, by constructing the ZnO nanoribbon modified by the Zn-edge defect, the spin-up current is severely suppressed because of the destruction of the spin-up transmission eigenchannels. However, the spin-down current is preserved, thus resulting in the perfect spin filter effect. Our results indicate that the ZnO nanoribbon modulated by the edge defect is a practical design for a spin filter.展开更多
Van Hove singularities in proximity to the Fermi level promote electronic interactions and generate diverse competing instabilities.It is also known that a nontrivial Berry phase derived from spin–orbit coupling can ...Van Hove singularities in proximity to the Fermi level promote electronic interactions and generate diverse competing instabilities.It is also known that a nontrivial Berry phase derived from spin–orbit coupling can introduce an intriguing decoration into the interactions and thus alter correlated phenomena.However,it is unclear how and what type of new physics can emerge in a system featured by the interplay between van Hove singularities(VHSs)and the Berry phase.Here,based on a general Rashba model on the square lattice,we comprehensively explore such an interplay and its significant influence on the competing electronic instabilities by performing a parquet renormalization group analysis.Despite the existence of a variety of comparable fluctuations in the particle–particle and particle-hole channels associated with higher-order VHSs,we find that the chiral p±ip pairings emerge as two stable fixed trajectories within the generic interaction parameter space,namely the system becomes a robust topological superconductor.The chiral pairings stem from the hopping interaction induced by the nontrivial Berry phase.The possible experimental realization and implications are discussed.Our work sheds new light on the correlated states in quantum materials with strong spin–orbit coupling(SOC)and offers fresh insights into the exploration of topological superconductivity.展开更多
Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of A...Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.展开更多
Recently,CrAs based superconductors have attracted much attention.CrAs itself is a 3D antiferromagnet(AFM),which becomes superconducting(SC)under modest pressure with T_C^2 K[1].Subsequently,a new family of quasi-lD s...Recently,CrAs based superconductors have attracted much attention.CrAs itself is a 3D antiferromagnet(AFM),which becomes superconducting(SC)under modest pressure with T_C^2 K[1].Subsequently,a new family of quasi-lD superconductors A_2Cr_3As_3(A=K,Rb,Cs)has been discovered at ambient pressure with T_c up to 6.1 K[2-4].The key building block of展开更多
It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease...It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease.Here,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and placebo.After performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by DII.Furthermore,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol metabolism.We assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear regression.Our study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target drug.Modular methods facilitate the discovery of network pharmacologicalmechanisms and the advancement of precision medicine.(ClinicalTrials.gov identifier:NCTO1681316).展开更多
High transition temperatureeTcTsuperconductivity in cuprates remains to be one of the most challenging topics in condensed matter physics[1–5].Despite worldwide efforts in the past 30 years since its
In a superconducting topological insulator, a superconducting vortex line can trap a one-dimensional topological band with localized Majorana zero modes at the ends. Here, we study the effect of hexagonal warping and ...In a superconducting topological insulator, a superconducting vortex line can trap a one-dimensional topological band with localized Majorana zero modes at the ends. Here, we study the effect of hexagonal warping and its corresponding symmetry-breaking effect on vortex phase transition. We perform both analytical calculations based on a semiclassical formula and numerical calculations based on full quantum mechanics using the Bogoliubov-de Gennes equation. We find that the hexagonal warping term extends the topological region of the vortex line as the chemical potential changes and leads to MZMs, even in the absence of topological surface states.展开更多
We study topological vortex phases in iron-based superconductors. Besides the previously known vortex end Majorana zero modes(MZMs) phase stemming from the existence of a three dimensional(3 D) strong topological insu...We study topological vortex phases in iron-based superconductors. Besides the previously known vortex end Majorana zero modes(MZMs) phase stemming from the existence of a three dimensional(3 D) strong topological insulator state, we show that there is another topologically nontrivial phase as iron-based superconductors can be doped superconducting 3 D weak topological insulators(WTIs). The vortex bound states in a superconducting 3 D WTI exhibit two different types of quantum states, a robust nodal superconducting phase with pairs of bulk MZMs and a full-gap topologically nontrivial superconducting phase which has single vortex end MZM in a certain range of doping level. Moreover, we predict and summarize various topological phases in iron-based superconductors, and find that carrier doping and interlayer coupling can drive systems to have phase transitions between these different topological phases.展开更多
Background:Dengue is a re-emerging public health problem and mosquito-borne infectious disease that is transmitted mainly by A edes aegypti and Ae.albopictus.Early diagnosis,isolation,and treatment of patients are cri...Background:Dengue is a re-emerging public health problem and mosquito-borne infectious disease that is transmitted mainly by A edes aegypti and Ae.albopictus.Early diagnosis,isolation,and treatment of patients are critical steps for dengue epidemic control,especially to prevent secondary transmission of dengue virus(DENV).However,little is known about defervescent dengue patients as a source of infection.Methods:This case study describes 1268 dengue patients hospitalized at Guangzhou Eighth People's Hospital from June 2013 to December 2014.The viral loads of each individual were measured using real-time reverse transcription-polymerase chain reaction.Ae.aegypti and Ae.albopictus were exposed to blood meal with gradated dengue viral loads to characterize the relationship between viremia in dengue patients and the vector competence of vector mosquitoes.Results:The viral numbers in the blood were measured,ranging from 108 to 103 copies/ml from day 1 to day 12 after fever onset Vector competence analysis o fA e.aegypti and Ae.albopictus indicated that viremia>104 copies/ml can still infect vector mosquitoes,which implied that the defervescent dengue patients might be a source of infection.Conclusions:The results of this study indicate that some defervescent dengue patients still have sufficient viral load to infect vector mosquitoes.Therefore,the protection against mosquito biting for these people should be extended to prevent secondary transmission events.展开更多
文摘Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334 consecutive patients with SAP who underwent first PCI following multi-slice computer tomography （MSCT） were enrolled from our institution between January 2007 and June 2012. The CAC score was calculated according to the standard Agatston calcium scoring algorithm. Complex PCI was defined as use of high pressure bal-loon, kissing balloon and/or rotablator. Procedure-related complications included dissection, occlusion, perforation, no/slow flow and emer-gency coronary artery bypass grafting. Main adverse cardiac events （MACE） were defined as a combined end point of death, non-fatal myo-cardial infarction, target lesion revascularization and rehospitalization for cardiac ischemic events. Results Patients with a CAC score〉300 （n=145） had significantly higher PCI complexity （13.1%vs. 5.8%, P=0.017） and rate of procedure-related complications （17.2%vs. 7.4%, P=0.005） than patients with a CAC score≤300 （n=189）. After a median follow-up of 22.5 months （4-72 months）, patients with a CAC score≤300 differ greatly than those patients with CAC score＆gt;300 in cumulative non-events survival rates （88.9 vs. 79.0%, Log rank 4.577, P=0.032）. After adjusted for other factors, the risk of MACE was significantly higher [hazard ratio （HR）：4.3, 95%confidence inter-val （95%CI）：2.4-8.2, P=0.038] in patients with a CAC score〉300 compared to patients with a lower CAC score. Conclusions The CAC score is an independent predictor for MACE in SAP patients who underwent PCI and indicates complexity of PCI and proce-dure-related complications.
基金Project supported by the National Natural Science Foundation of China (Nos. 30471118 and 30460015)the Key Project of Educa-tion Ministry of China (No. 205178)
文摘A novel vacuolar Na+/H+ exchanger, CgNHX1, was cloned from a halophytic species Chenopodium glaucum by using reverse transcriptase-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE) technique. Sequence alignment and phylogenetic analysis of 22 NHX genes from GenBank as well as the new CgNHX1 gene indicate that NHX genes shared a great degree of similarity, regardless of their glycophytic or halophytic origin. Expression of the CgNHX1 gene was induced by NaCl and peaked at 400 mmol/L NaCl. Overexpression of NHX1 genes in rice enhanced their tolerance to salt stress. However, there is no significant difference in salt tolerance among the transgenic rice plants overexpressing the NHX1 genes from either glycophytic or halophytic species. The Na+ content of both the wild type (WT) and transgenic plants increased when exposed to 50 and 100 mmol/L NaCl, and the Na+ concentration in transgenic plants was marginally higher than that of WT. Our data demonstrate that the overexpression of the NHX1 gene from either glycophytic or halophytic species resulted in the enhanced tolerance to salt stress at a similar level, suggesting that NHX gene per se might not be the reason accounting for the difference in salt tolerance between glycophytes and halophytes.
基金National Key Technologies R&D Program of China during the 10th Five-Year Plan Period(2003BA712A08-03)The Knowledge Innovation Program of the Chinese Academy of Sciences(KSCX2-YW-N-065)+1 种基金The Foundation scientific and technological project from MOST(2007FY210700)The NSFC Grant(30860255)
文摘The Crimean-congo hemorrhagic fever virus(CCHFV)is a geographically widespread fatal pathogen. Identification of the epitope regions of the virus is important for the diagnosis and epidemiological studies of CCHFV infections.In this study,expression vectors carrying series truncated fragments of the NP(nucleocapsid protein)gene from the S fragment of CCHFV strain YL04057 were constructed.The recombinant proteins were expressed in E.coli and purified for detection.The antigenic of the truncated fragments of NP was detected with a polyclonal serum(rabbit)and 2 monoclonal(mAbs)(14B7 and 43E5)against CCHFV by Western-blot analyses. The results showed that the three expressed constructs,which all contained the region 235AA to 305AA could be detected by mAbs polyclonal serum.The results suggest that region 235-305 aa of NP is a highly antigenic region and is highly conserved in the NP protein.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61664008 and 11604286)the Scientific Technological Innovation Team of Yan’an City,China(Grant No.2017CXTD-01)
文摘The spin-dependent electronic transport properties of a zigzag zinc oxide(ZnO) nanoribbon are studied by using density functional theory with non-equilibrium Green's functions. We calculate the spin-polarized band structure, projected density of states, Bloch states, and transmission spectrum of the ZnO nanoribbon. It is determined that all Bloch states are located at the edge of the ZnO nanoribbon. The spin-up transmission eigenchannels are contributed from Zn 4s orbital,whereas the spin-down transmission eigenchannels are contributed from Zn 4s and O 2p orbitals. By analyzing the current-voltage curves for the opposite spins of the ZnO nanoribbon device, negative differential resistance(NDR) and spin filter effect are observed. Moreover, by constructing the ZnO nanoribbon modified by the Zn-edge defect, the spin-up current is severely suppressed because of the destruction of the spin-up transmission eigenchannels. However, the spin-down current is preserved, thus resulting in the perfect spin filter effect. Our results indicate that the ZnO nanoribbon modulated by the edge defect is a practical design for a spin filter.
基金supports by the Ministry of Science and Technology(2022YFA1403901)the National Natural Science Foundation of China(11920101005,11888101,and 12047503)+2 种基金the New Cornerstone Investigator Programpartially supported by Chinese Academy of Sciences under contract No.JZHKYPT-2021–08supports from China Postdoctoral Science Foundation Fellowship(2022M723112)。
文摘Van Hove singularities in proximity to the Fermi level promote electronic interactions and generate diverse competing instabilities.It is also known that a nontrivial Berry phase derived from spin–orbit coupling can introduce an intriguing decoration into the interactions and thus alter correlated phenomena.However,it is unclear how and what type of new physics can emerge in a system featured by the interplay between van Hove singularities(VHSs)and the Berry phase.Here,based on a general Rashba model on the square lattice,we comprehensively explore such an interplay and its significant influence on the competing electronic instabilities by performing a parquet renormalization group analysis.Despite the existence of a variety of comparable fluctuations in the particle–particle and particle-hole channels associated with higher-order VHSs,we find that the chiral p±ip pairings emerge as two stable fixed trajectories within the generic interaction parameter space,namely the system becomes a robust topological superconductor.The chiral pairings stem from the hopping interaction induced by the nontrivial Berry phase.The possible experimental realization and implications are discussed.Our work sheds new light on the correlated states in quantum materials with strong spin–orbit coupling(SOC)and offers fresh insights into the exploration of topological superconductivity.
基金supported by National Science and Technology Major Project (2013ZX10002005 and 2017ZX10203202).
文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.
基金supported in part by the National Key R&D Program of China (2016YFA0300202)the National Basic Research Program of China (2014CB921201 and 2014CB921203)+1 种基金the National Natural Science Foundation of China (11374256, 11274269 and 11274006)the Natural Science Foundation of Zhejiang Province (LR12A04003)
文摘Recently,CrAs based superconductors have attracted much attention.CrAs itself is a 3D antiferromagnet(AFM),which becomes superconducting(SC)under modest pressure with T_C^2 K[1].Subsequently,a new family of quasi-lD superconductors A_2Cr_3As_3(A=K,Rb,Cs)has been discovered at ambient pressure with T_c up to 6.1 K[2-4].The key building block of
基金funded by China National Science and Technology Major Project for"Significant New Drugs Development"(2011ZX09304-07)National Natural Science Foundation of China(81673833)China Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ0908029).
文摘It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease.Here,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and placebo.After performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by DII.Furthermore,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol metabolism.We assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear regression.Our study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target drug.Modular methods facilitate the discovery of network pharmacologicalmechanisms and the advancement of precision medicine.(ClinicalTrials.gov identifier:NCTO1681316).
文摘High transition temperatureeTcTsuperconductivity in cuprates remains to be one of the most challenging topics in condensed matter physics[1–5].Despite worldwide efforts in the past 30 years since its
基金supported by the Air Force Office of Scientific Research(AFOSR)(Grant No.FA9550-14-1-0168)supported by the National Natural Science Foundation of China(Grant No.11674278)+1 种基金the National Basic Research Program of China(Grant No.2014CB921203)the CAS Center for Excellence in Topological Quantum Computation,and the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB28000000)
文摘In a superconducting topological insulator, a superconducting vortex line can trap a one-dimensional topological band with localized Majorana zero modes at the ends. Here, we study the effect of hexagonal warping and its corresponding symmetry-breaking effect on vortex phase transition. We perform both analytical calculations based on a semiclassical formula and numerical calculations based on full quantum mechanics using the Bogoliubov-de Gennes equation. We find that the hexagonal warping term extends the topological region of the vortex line as the chemical potential changes and leads to MZMs, even in the absence of topological surface states.
基金supported by the National Basic Research Program of China (2014CB921203, 2015CB921300, and 2017YFA0303100)the National Natural Science Foundation of China (11334012 and 11674278)the Strategic Priority Research Program of CAS (XDB07000000)
文摘We study topological vortex phases in iron-based superconductors. Besides the previously known vortex end Majorana zero modes(MZMs) phase stemming from the existence of a three dimensional(3 D) strong topological insulator state, we show that there is another topologically nontrivial phase as iron-based superconductors can be doped superconducting 3 D weak topological insulators(WTIs). The vortex bound states in a superconducting 3 D WTI exhibit two different types of quantum states, a robust nodal superconducting phase with pairs of bulk MZMs and a full-gap topologically nontrivial superconducting phase which has single vortex end MZM in a certain range of doping level. Moreover, we predict and summarize various topological phases in iron-based superconductors, and find that carrier doping and interlayer coupling can drive systems to have phase transitions between these different topological phases.
文摘Background:Dengue is a re-emerging public health problem and mosquito-borne infectious disease that is transmitted mainly by A edes aegypti and Ae.albopictus.Early diagnosis,isolation,and treatment of patients are critical steps for dengue epidemic control,especially to prevent secondary transmission of dengue virus(DENV).However,little is known about defervescent dengue patients as a source of infection.Methods:This case study describes 1268 dengue patients hospitalized at Guangzhou Eighth People's Hospital from June 2013 to December 2014.The viral loads of each individual were measured using real-time reverse transcription-polymerase chain reaction.Ae.aegypti and Ae.albopictus were exposed to blood meal with gradated dengue viral loads to characterize the relationship between viremia in dengue patients and the vector competence of vector mosquitoes.Results:The viral numbers in the blood were measured,ranging from 108 to 103 copies/ml from day 1 to day 12 after fever onset Vector competence analysis o fA e.aegypti and Ae.albopictus indicated that viremia>104 copies/ml can still infect vector mosquitoes,which implied that the defervescent dengue patients might be a source of infection.Conclusions:The results of this study indicate that some defervescent dengue patients still have sufficient viral load to infect vector mosquitoes.Therefore,the protection against mosquito biting for these people should be extended to prevent secondary transmission events.
