Optical whispering-gallery-mode microcavities have attracted significant attention for their potential in ultrasensitive ultrasound sensing,despite always relying on expensive tunable lasers in applications.In this st...Optical whispering-gallery-mode microcavities have attracted significant attention for their potential in ultrasensitive ultrasound sensing,despite always relying on expensive tunable lasers in applications.In this study,we integrated an electrothermal tuning function inside the microcavity,enabling fast scanning of modes by applying voltages,which helps provide real-time searching and tracking of the optimal mode.Our device demonstrated a quality factor exceeding 10^(6)with a broad tuning range over 33 GHz.This structure achieved high sensitivity in ultrasound detection,with a noise equivalent pressure(NEP)of 3.35 m Pa/Hz^(1/2)at 20 MHz.We further reported the advantages of the mode thermal broadening effect for ultrasound detection,with successfully obtaining high-contrast photoacoustic images.Our research introduces an innovative approach for cost-effective,high-stability ultrasound detection with microcavity,showing great value for application in photoacoustic imaging.展开更多
Transparency and perfect absorption are two contradictory terms;a perfect absorber never permits waves to transmit through.However,this statement only remains true in the linear regime,where the nonlinearity has been ...Transparency and perfect absorption are two contradictory terms;a perfect absorber never permits waves to transmit through.However,this statement only remains true in the linear regime,where the nonlinearity has been omitted and the physical system like the perfect absorber is not affected by the incoming waves.Here we experimentally demonstrate an intriguing self-induced transparency effect in a perfectly absorbing optical microcavity,which perfectly absorbs any incoming waves at the low power level,but allows a portion of waves to be transmitted at the higher power due to the nonlinear coupling between the fundamental and its second harmonic modes.Moreover,the asymmetric scattering nature of the microcavity enables a chiral and unidirectional reflection in one of the input ports,this leads to asymmetric and chiral coherent control of the perfect absorption states through phase varying.More importantly,such chiral behaviors also empower the chiral emission of second-harmonic generation with a high distinct ratio in the transparency state.These results pave the way for controllable transparency in a wide range of fields in optics,microwaves,acoustics,mechanics,and matter waves.展开更多
Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the prostate.However,the cell types and associated changes that contribute to the development of pr...Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the prostate.However,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic tissues.Here,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular compositions.We identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune function.In addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and aging.These results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.62305006,and 61701261)the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20230287,BK20230286,and BK20160417)Nantong Social Livelihood Science and Technology Planning Project(Grant Nos.MS12022003,and MS2023071)。
文摘Optical whispering-gallery-mode microcavities have attracted significant attention for their potential in ultrasensitive ultrasound sensing,despite always relying on expensive tunable lasers in applications.In this study,we integrated an electrothermal tuning function inside the microcavity,enabling fast scanning of modes by applying voltages,which helps provide real-time searching and tracking of the optimal mode.Our device demonstrated a quality factor exceeding 10^(6)with a broad tuning range over 33 GHz.This structure achieved high sensitivity in ultrasound detection,with a noise equivalent pressure(NEP)of 3.35 m Pa/Hz^(1/2)at 20 MHz.We further reported the advantages of the mode thermal broadening effect for ultrasound detection,with successfully obtaining high-contrast photoacoustic images.Our research introduces an innovative approach for cost-effective,high-stability ultrasound detection with microcavity,showing great value for application in photoacoustic imaging.
基金supported by the National Science Foundation of China(Grant No.92050113,No.12274295,No.11304201)National key research and development program(Grant No.2016YFA0302500,2017YFA0303700)Shanghai MEC Scientific Innovation Program(Grant No.E00075).
文摘Transparency and perfect absorption are two contradictory terms;a perfect absorber never permits waves to transmit through.However,this statement only remains true in the linear regime,where the nonlinearity has been omitted and the physical system like the perfect absorber is not affected by the incoming waves.Here we experimentally demonstrate an intriguing self-induced transparency effect in a perfectly absorbing optical microcavity,which perfectly absorbs any incoming waves at the low power level,but allows a portion of waves to be transmitted at the higher power due to the nonlinear coupling between the fundamental and its second harmonic modes.Moreover,the asymmetric scattering nature of the microcavity enables a chiral and unidirectional reflection in one of the input ports,this leads to asymmetric and chiral coherent control of the perfect absorption states through phase varying.More importantly,such chiral behaviors also empower the chiral emission of second-harmonic generation with a high distinct ratio in the transparency state.These results pave the way for controllable transparency in a wide range of fields in optics,microwaves,acoustics,mechanics,and matter waves.
基金funded by the Youth Science Foundation of Guangxi Medical University(GXMUYSF201810)the National Natural Science Foundation of China(81901538,81670750,81770759)+3 种基金the Sigrid Juse’lius Foundation and the Recruitment Fund of Hehai Universitythe National Key Research and Development Program of China(2017YFC0908000)the Major Project of Guangxi Innovation Driven(AA18118016)the Guangxi Key Laboratory for Genomic and Personalized Medicine(16-380-54,17-259-45,19-050-22,19-185-33,and 20-065-33)。
文摘Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the prostate.However,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic tissues.Here,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular compositions.We identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune function.In addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and aging.These results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development.
