During the last decades the whispering gallery mode based sensors have become a prominent solution for label-free sensing of various physical and chemical parameters.At the same time,the widespread utilization of the ...During the last decades the whispering gallery mode based sensors have become a prominent solution for label-free sensing of various physical and chemical parameters.At the same time,the widespread utilization of the approach is hindered by the restricted applicability of the known configurations for ambient variations quantification outside the laboratory conditions and their low affordability,where necessity on the spectrally-resolved data collection is among the main limiting factors.In this paper we demonstrate the first realization of an affordable whispering gallery mode sensor powered by deep learning and multi-resonator imaging at a fixed frequency.It has been shown that the approach enables refractive index unit(RIU)prediction with an absolute error at 3×10^(-6) level for dynamic range of the RIU variations from 0 to 2×10^(-3) with temporal resolution of several milliseconds and instrument-driven detection limit of 3×10−5.High sensing accuracy together with instrumental affordability and production simplicity places the reported detector among the most cost-effective realizations of the whispering gallery mode approach.The proposed solution is expected to have a great impact on the shift of the whole sensing paradigm away from the model-based and to the flexible self-learning solutions.展开更多
The per-and polyfluoroalkyl substances(PFAS)are a group of organofluorine chemicals treated as the emerging pollutants that are currently of particularly acute concern.These compounds have been employed intensively as...The per-and polyfluoroalkyl substances(PFAS)are a group of organofluorine chemicals treated as the emerging pollutants that are currently of particularly acute concern.These compounds have been employed intensively as surfactants over multiple decades and are already to be found in surface and ground waters at amounts sufficient to have an effect on human health and ecosystems.Because of the carbon–fluorine bonds,the PFAS have an extreme environmental persistence and their negative impact accumulates with further production and penetration into the environment.In Germany alone,more than thousands of sites have been identified as contaminated with PFAS;thus,timely detection of PFAS residue is becoming a high priority.In this paper,we report on the high performance optical detection method based on whispering gallery mode(WGM)microcavities applied for the first time to detect PFAS contaminants in aqueous solutions.A self-sensing boosted 4D microcavity fabricated with two-photon polymerization is employed as an individual sensing unit.In an example of the multiplexed imaging sensor with multiple hundreds of simultaneously interrogated microcavities we demonstrate the possibility to detect the PFAS chemicals representatives at a level down to 1 ppb(parts per billion).展开更多
Water monitoring,environmental analysis,cell culture stability,and biomedical applications require precise pH control.Traditional methods,such as pH strips and meters,have limitations:pH strips lack precision,whereas ...Water monitoring,environmental analysis,cell culture stability,and biomedical applications require precise pH control.Traditional methods,such as pH strips and meters,have limitations:pH strips lack precision,whereas electrochemical meters,although more accurate,are fragile,prone to drift,and unsuitable for small volumes.In this paper,we propose a method for the optical detection of pH based on a multiplexed sensor with 4D microcavities fabricated via two-photon polymerization.This approach employs pH-triggered reversible variations in microresonator geometry and integrates hundreds of dual optically coupled 4D microcavities to achieve the detection limit of 0.003 pH units.The proposed solution is a clear example of the use-case-oriented application of two-photon polymerized structures of high optical quality.Owing to the benefits of the multiplexed imaging platform,the dual 4D microresonators can be integrated with other microresonator types for pH-corrected biochemical studies.展开更多
文摘During the last decades the whispering gallery mode based sensors have become a prominent solution for label-free sensing of various physical and chemical parameters.At the same time,the widespread utilization of the approach is hindered by the restricted applicability of the known configurations for ambient variations quantification outside the laboratory conditions and their low affordability,where necessity on the spectrally-resolved data collection is among the main limiting factors.In this paper we demonstrate the first realization of an affordable whispering gallery mode sensor powered by deep learning and multi-resonator imaging at a fixed frequency.It has been shown that the approach enables refractive index unit(RIU)prediction with an absolute error at 3×10^(-6) level for dynamic range of the RIU variations from 0 to 2×10^(-3) with temporal resolution of several milliseconds and instrument-driven detection limit of 3×10−5.High sensing accuracy together with instrumental affordability and production simplicity places the reported detector among the most cost-effective realizations of the whispering gallery mode approach.The proposed solution is expected to have a great impact on the shift of the whole sensing paradigm away from the model-based and to the flexible self-learning solutions.
基金Bundesministerium für Bildung und Forschung(03VP08220)。
文摘The per-and polyfluoroalkyl substances(PFAS)are a group of organofluorine chemicals treated as the emerging pollutants that are currently of particularly acute concern.These compounds have been employed intensively as surfactants over multiple decades and are already to be found in surface and ground waters at amounts sufficient to have an effect on human health and ecosystems.Because of the carbon–fluorine bonds,the PFAS have an extreme environmental persistence and their negative impact accumulates with further production and penetration into the environment.In Germany alone,more than thousands of sites have been identified as contaminated with PFAS;thus,timely detection of PFAS residue is becoming a high priority.In this paper,we report on the high performance optical detection method based on whispering gallery mode(WGM)microcavities applied for the first time to detect PFAS contaminants in aqueous solutions.A self-sensing boosted 4D microcavity fabricated with two-photon polymerization is employed as an individual sensing unit.In an example of the multiplexed imaging sensor with multiple hundreds of simultaneously interrogated microcavities we demonstrate the possibility to detect the PFAS chemicals representatives at a level down to 1 ppb(parts per billion).
基金the German Federal Ministry for Research and Education(BMBF)for partially funding this work under the VIP+-Programme in the project IntellOSS,03VP08220.
文摘Water monitoring,environmental analysis,cell culture stability,and biomedical applications require precise pH control.Traditional methods,such as pH strips and meters,have limitations:pH strips lack precision,whereas electrochemical meters,although more accurate,are fragile,prone to drift,and unsuitable for small volumes.In this paper,we propose a method for the optical detection of pH based on a multiplexed sensor with 4D microcavities fabricated via two-photon polymerization.This approach employs pH-triggered reversible variations in microresonator geometry and integrates hundreds of dual optically coupled 4D microcavities to achieve the detection limit of 0.003 pH units.The proposed solution is a clear example of the use-case-oriented application of two-photon polymerized structures of high optical quality.Owing to the benefits of the multiplexed imaging platform,the dual 4D microresonators can be integrated with other microresonator types for pH-corrected biochemical studies.
