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人工真皮联合富血小板纤维蛋白修复小面积深度创面的临床疗效
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作者 狄海萍 郑军杰 +8 位作者 刘磊 郭海娜 邢培朋 曹大勇 马超 黄万新 张博 夏成德 周超 《中华损伤与修复杂志(电子版)》 CAS 2024年第4期288-293,共6页
目的:探讨人工真皮联合富血小板纤维蛋白(PRF)修复小面积深度创面的临床疗效。方法:采用前瞻性随机对照研究方法。2018年1月至2021年12月,郑州市第一人民医院烧伤科收治40例符合入选标准的小面积深度创面患者,按区组随机化法将患者分为2... 目的:探讨人工真皮联合富血小板纤维蛋白(PRF)修复小面积深度创面的临床疗效。方法:采用前瞻性随机对照研究方法。2018年1月至2021年12月,郑州市第一人民医院烧伤科收治40例符合入选标准的小面积深度创面患者,按区组随机化法将患者分为2组,每组20例。人工真皮组中男11例,女9例,年龄(43.10±4.54)岁,创面面积(35.85±5.64)cm^(2);联合组中男13例,女7例,年龄(43.55±4.71)岁,创面面积(37.65±6.21)cm^(2)。患者创面彻底清创后,人工真皮组外用人工真皮覆盖创面,联合组抽取患者静脉全血制备PRF填塞创面后,外用人工真皮覆盖创面,而后行规律换药。待肉芽组织生长覆盖创面后,对两组患者行Ⅱ期自体皮片移植术修复创面。记录患者换药次数、创面愈合时间。自体皮片移植术后第7天,计算皮片成活率。观察人工真皮下是否出现血肿及创面感染等不良反应。创面愈合后6个月,随访观察患者植皮区是否出现破溃,采用温哥华瘢痕量表(VSS)评价创面瘢痕生长情况。对数据行独立样本t检验、Mann-Whitney U检验和χ^(2)检验。结果:联合组患者换药次数为(8.65±2.54)次,明显少于人工真皮组的(10.75±3.16)次(t=2.316,P<0.05);联合组患者创面愈合时间为(29.95±4.71)d,明显短于人工真皮组的(35.55±5.34)d(t=3.520,P<0.05)。自体皮片移植术后第7天,联合组患者皮片成活率为(92.9±6.9)%,人工真皮组为(91.3±8.7)%,2组比较差异无统计学意义(t=0.645,P>0.05)。两组患者人工真皮下均未出现血肿,未发生感染等不良反应。创面愈合后6个月,两组患者植皮区均未出现破溃;联合组患者创面VSS评分[5.00(4.00,6.00)分]低于人工真皮组[6.00(5.00,6.00)分],差异有统计学意义(Z=2.422,P<0.05)。结论:人工真皮联合PRF修复小面积深度创面的临床效果明显,可减少换药次数,缩短创面愈合时间,改善创面瘢痕增生情况。 展开更多
关键词 创面修复 富血小板纤维蛋白 人工真皮
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Corrosion damage behaviors of rubber O-rings under simulated acid fracturing conditions 被引量:1
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作者 Dezhi Zeng Yang Zhong +3 位作者 dayong cao Peng Zhao Tuanhui Fu Yadong Qi 《Petroleum》 EI CSCD 2023年第2期248-254,共7页
To explore the damage behavior of O-ring in acid environment,a high-temperature and high-pressure(HTHP)autoclave was used to simulate the service environment of O-ring,and then 168h corrosion test of hydrogenated nitr... To explore the damage behavior of O-ring in acid environment,a high-temperature and high-pressure(HTHP)autoclave was used to simulate the service environment of O-ring,and then 168h corrosion test of hydrogenated nitrile butadiene rubber(HNBR)and fluororubber(FM)O-rings were carried out.The corrosion damage behaviors of two kinds of rubber O-rings in the acidizing fluid were studied through determining their tensile strength,elongation at break,hardness,permanent compressive deformation,tensile fracture morphology and sealing property.The results showed that the crosssectional area and the compression permanent deformation increased,the tensile strength and hardness decreased when the HNBR and FM O-rings under the free state were subjected to acid corrosion.The elongation at break of HNBR decreased,and that of FM rubber increased greatly.Similar with free state,the HNBR and FM O-rings under sealed state also presented the same variation trend.The decrease in the reliability of the O-rings under the sealed state was less significant than that in the free state.In the test,tensile fractures were mostly brittle fractures,HNBR and FM O-rings had obvious corrosion damages such as deformation and swelling.The results could provide a technical basis for the selection of sealing materials,tool optimization design,and construction work in oil and gas fields. 展开更多
关键词 Acid fracturing condition HNBR FM O-RING Damage behavior
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