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TGF-β信号缺陷是否是人类癌症中的致命弱点? 被引量:3
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作者 david a.foster Noga Gadir 《癌症》 SCIE CAS CSCD 北大核心 2008年第8期882-884,共3页
癌细胞中的存活信号可激活mTOR-哺乳动物雷帕霉素靶蛋白。mTOR可抑制TGF-β信号,后者可使细胞周期停滞于G1后期,因此,活化后的mTOR可防止细胞周期停滞于TGF-β介导的检验点。雷帕霉素可重新激活TGF-β信号,从而导致G1期细胞停滞。在人... 癌细胞中的存活信号可激活mTOR-哺乳动物雷帕霉素靶蛋白。mTOR可抑制TGF-β信号,后者可使细胞周期停滞于G1后期,因此,活化后的mTOR可防止细胞周期停滞于TGF-β介导的检验点。雷帕霉素可重新激活TGF-β信号,从而导致G1期细胞停滞。在人类癌症中,TGF-β信号通常发生缺陷,相反,在雷帕霉素作用下,TGF-β信号缺陷的癌细胞不发生G1期停滞,而发生凋亡。因此,在基于雷帕霉素的抗癌治疗策略中,TGF-β信号缺陷可能是癌细胞的致命弱点。 展开更多
关键词 TGF-Β MTOR 雷帕霉素 凋亡 存活信号 癌细胞
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Deformation correlations,stress field switches and evolution of an orogenic intersection:The Pan-African Kaoko-Damara orogenic junction,Namibia 被引量:1
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作者 Ben Goscombe david a.foster +3 位作者 david Gray Ben Wade Antonios Marsellos Jason Titus 《Geoscience Frontiers》 SCIE CAS CSCD 2017年第6期1187-1232,共46页
Age calibrated deformation histories established by detailed mapping and dating of key magmatic time markers are correlated across all tectono-metamorphic provinces in the Damara Orogenic System.Correlations across st... Age calibrated deformation histories established by detailed mapping and dating of key magmatic time markers are correlated across all tectono-metamorphic provinces in the Damara Orogenic System.Correlations across structural belts result in an internally consistent deformation framework with evidence of stress field rotations with similar timing,and switches between different deformation events.Horizontal principle compressive stress rotated clockwise ~180°in total during Kaoko Belt evolution,and^135° during Damara Belt evolution.At most stages,stress field variation is progressive and can be attributed to events within the Damara Orogenic System,caused by changes in relative trajectories of the interacting Rio De La Plata,Congo,and Kalahari Cratons.Kaokoan orogenesis occurred earliest and evolved from collision and obduction at ~590 Ma,involving E-W directed shortening,progressing through different transpressional states with ~45° rotation of the stress field to strike-slip shear under NW-SE shortening at ~550-530 Ma.Damaran orogenesis evolved from collision at ~555-550 Ma with NW-SE directed shortening in common with the Kaoko Belt,and subsequently evolved through ~90°rotation of the stress field to NE-SW shortening at ~512-508 Ma.Both Kaoko and Damara orogenic fronts were operating at the same time,with all three cratons being coaxially convergent during the 550-530 Ma period;Rio De La Plata directed SE against the Congo Craton margin,and both together over-riding the Kalahari Craton margin also towards the SE.Progressive stress field rotation was punctuated by rapid and significant switches at ~530-525 Ma,~508 Ma and ~505 Ma.These three events included:(1)Culmination of main phase orogenesis in the Damara Belt,coinciding with maximum burial and peak metamorphism at 530-525 Ma.This occurred at the same time as termination of transpression and initiation of transtensional reactivation of shear zones in the Kaoko Belt.Principle compressive stress switched from NW-SE to NNW-SSE shortening in both Kaoko and Damara Belts at this time.This marks the start of Congo-Kalahari stress field overwhelming the waning Rio De La Plata-Congo stress field,and from this time forward contraction across the Damara Belt generated the stress field governing subsequent low-strain events in the Kaoko Belt.(2)A sudden switch to E-W directed shortening at ~508 Ma is interpreted as a far-field effect imposed on the Damara Orogenic System,most plausibly from arc obduction along the orogenic margin of Gondwana(Ross-Delamerian Orogen).(3)This imposed stress field established a N-S extension direction exploited by decompression melts,switch to vertical shortening,and triggered gravitational collapse and extension of the thermally weakened hot orogen core at ~505 Ma,producing an extensional metamorphic core complex across the Central Zone. 展开更多
关键词 Damara OROGEN Stress fields OROGENY Assembly of GONDWANA Event geochronology DEFORMATION CORRELATIONS
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从河流到海沟:主动和被动陆缘沉积搬运的主控因素
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作者 曾乐田 王策 +3 位作者 david a.foster 苏明 崔贺旗 贾俊民 《中国科学:地球科学》 CSCD 北大核心 2024年第12期3916-3928,共13页
主动和被动陆缘沉积物的输送存在显著差异,然而定量研究这些特定沉积过程的机会相对较少.南海东北部既包含主动陆缘,也包含准被动陆缘,为区分这两类陆缘沉积物物源和搬运过程提供了独特的研究区域.本研究通过分析表层沉积物中的碎屑锆石... 主动和被动陆缘沉积物的输送存在显著差异,然而定量研究这些特定沉积过程的机会相对较少.南海东北部既包含主动陆缘,也包含准被动陆缘,为区分这两类陆缘沉积物物源和搬运过程提供了独特的研究区域.本研究通过分析表层沉积物中的碎屑锆石U-Pb年龄来示踪南海东北部不同区域沉积物的物源,揭示影响陆缘沉积物搬运的主要控制因素.研究结果显示,南海东北部从大陆架到马尼拉海沟的沉积物物源在空间上存在显著差异.陆架区沉积物主要来源于华南东部的九龙江和台湾岛西南部的高屏溪,沉积物搬运受被动陆缘地形和洋流的控制.相比之下,澎湖-高屏峡谷系统中的沉积物主要来自于台湾岛西部的高屏溪和浊水溪.定量分析结果表明,由于高屏峡谷与高屏溪直接相连,该峡谷为马尼拉海沟提供了~86.2%的陆源碎屑物质.基于物源分析结果,本研究提出了不同类型陆缘的沉积物搬运模式.在被动陆缘,入海水系带来的沉积物进入大陆架后受洋流的影响显著,而较高的地形会阻碍其搬运,导致沉积物难以进入海沟系统.相反,在主动陆缘,由于陆架较窄,海底峡谷可与河口直接相连,重力流能够将大量沉积物直接输送至海沟进行沉积.该研究有助于揭示南海东北部沉积物从河流到海沟的搬运过程,并探讨影响陆缘沉积物输送的主要控制因素. 展开更多
关键词 沉积物搬运过程 物源示踪 碎屑锆石 海底峡谷 陆缘 中国南海
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