Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society.Neuroinflammation is one of the main factors leading to cognitive impairment.The infl...Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society.Neuroinflammation is one of the main factors leading to cognitive impairment.The inflammasomes are multi-protein complexes that respond to various microorganisms and endogenous danger signals,helping to initiate innate protective responses in inflammatory diseases.NLRP3 inflammasomes produce proinflammatory cytokines(interleukin IL-1βand IL-18)by activating caspase-1.In this review,we comprehensively describe the structure and functions of the NLRP3 inflammasome.We also explore the intrinsic relationship between the NLRP3 inflammasome and cognitive impairment,which involves immune cell activation,cell apoptosis,oxidative stress,mitochondrial autophagy,and neuroinflammation.Finally,we describe NLRP3 inflammasome antagonists as targeted therapies to improve cognitive impairment.展开更多
We examine whether management earnings forecasts(MEFs)help reduce the stock return seasonality associated with earnings seasonality around earnings announcements(EAs)in Chinese A-share markets.We find that firms in hi...We examine whether management earnings forecasts(MEFs)help reduce the stock return seasonality associated with earnings seasonality around earnings announcements(EAs)in Chinese A-share markets.We find that firms in historically low earnings seasons outperform firms in high earnings seasons by 2.1%around MEFs.Firms in low earnings seasons also have higher trading volume and return volatility than their counterparts around EAs and MEFs.MEFs significantly reduce the ability of historical seasonal earnings rankings to negatively predict announcement returns,volume and volatility around EAs.The reduction effects are stronger when MEFs are voluntary or made closer to EAs.The evidence suggests that MEFs facilitate the correction of investors’tendency to extrapolate earnings seasonality and its resulted stock mispricing.展开更多
基金supported by grants from the doctoral start-up fund of the Second Affiliated Hospital of Nanchang University(B3150)Jiangxi Provincial Natural Science Foundation(20232BAB216042).
文摘Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society.Neuroinflammation is one of the main factors leading to cognitive impairment.The inflammasomes are multi-protein complexes that respond to various microorganisms and endogenous danger signals,helping to initiate innate protective responses in inflammatory diseases.NLRP3 inflammasomes produce proinflammatory cytokines(interleukin IL-1βand IL-18)by activating caspase-1.In this review,we comprehensively describe the structure and functions of the NLRP3 inflammasome.We also explore the intrinsic relationship between the NLRP3 inflammasome and cognitive impairment,which involves immune cell activation,cell apoptosis,oxidative stress,mitochondrial autophagy,and neuroinflammation.Finally,we describe NLRP3 inflammasome antagonists as targeted therapies to improve cognitive impairment.
基金the financial support of the National Natural Science Foundation of China(NSFC)(Grant#91746109,#71773100 and#72073109)
文摘We examine whether management earnings forecasts(MEFs)help reduce the stock return seasonality associated with earnings seasonality around earnings announcements(EAs)in Chinese A-share markets.We find that firms in historically low earnings seasons outperform firms in high earnings seasons by 2.1%around MEFs.Firms in low earnings seasons also have higher trading volume and return volatility than their counterparts around EAs and MEFs.MEFs significantly reduce the ability of historical seasonal earnings rankings to negatively predict announcement returns,volume and volatility around EAs.The reduction effects are stronger when MEFs are voluntary or made closer to EAs.The evidence suggests that MEFs facilitate the correction of investors’tendency to extrapolate earnings seasonality and its resulted stock mispricing.
