To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hyp...To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hypotension and perioperative organ injury,[1]the results of prospective randomized trials with regard to tight blood pressure management and clinical outcomes were inconsistent.[2–4]Organ injury could be also provoked by surgery-induced stress.Dexmedetomidine has been validated to attenuate the over-expression of stress mediators;however,whether perioperative dexmedetomidine can improve clinical outcomes remains uncertain.[5,6]Therefore,this 2×2 factorial randomized trial was designed to investigate whether targeted blood pressure management with/without dexmedetomidine administration could minimize the occurrence of a composite of major organ injuries and complications within 30 days in moderateto-high risk patients after major non-cardiac surgery.展开更多
基金supported by grants from the National Key Research&Development Program of China(Nos.2023YFC2506900 and 2018YFC2001800)the National High Level Hospital Clinical Research Funding(Nos.2022CR74 and 2022CR78 of Peking University First Hos pital)Braun Anesthesia Scientific Research Fund(No.BBDF-2019-004).
文摘To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hypotension and perioperative organ injury,[1]the results of prospective randomized trials with regard to tight blood pressure management and clinical outcomes were inconsistent.[2–4]Organ injury could be also provoked by surgery-induced stress.Dexmedetomidine has been validated to attenuate the over-expression of stress mediators;however,whether perioperative dexmedetomidine can improve clinical outcomes remains uncertain.[5,6]Therefore,this 2×2 factorial randomized trial was designed to investigate whether targeted blood pressure management with/without dexmedetomidine administration could minimize the occurrence of a composite of major organ injuries and complications within 30 days in moderateto-high risk patients after major non-cardiac surgery.
