BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung cancer.Even in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical man...BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung cancer.Even in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical manifestations.SCLC is most closely related to paraneoplastic syndrome,and some cases present as paraneoplastic peripheral neuropathy(PPN).PPN in SCLC appears early,lacks specificity,and often occurs before diagnosis of the primary tumor.It is easy to be misdiagnosed as a primary disease of the nervous system,leading to missed diagnosis and delayed diagnosis and treatment.CASE SUMMARY This paper reports two cases of SCLC with limb weakness as the first symptom.The first symptoms of one patient were rash,limb weakness,and abnormal electromyography.The patient was repeatedly referred to the hospital for limb weakness and rash for>1 year,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually aggravated.The patient was later diagnosed with SCLC,and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone therapy.The second case presented with limb numbness and weakness as the first symptom,but the patient did not pay attention to it.Later,the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the vein.However,he was diagnosed with extensive SCLC and died 1 year after diagnosis.CONCLUSION The two cases had PPN and abnormal electromyography,highlighting its correlation with early clinical indicators of SCLC.展开更多
Numerical simulation and experimental methods were used to investigate the effects of weld penetration on tensile properties of 2219 aluminum alloy tungsten inert gas(TIG)welded joints.The results show that when other...Numerical simulation and experimental methods were used to investigate the effects of weld penetration on tensile properties of 2219 aluminum alloy tungsten inert gas(TIG)welded joints.The results show that when other geometric parameters are consistent,within a certain range,the deeper the weld penetration of the capping weld is,the lower the tensile strength of the j oint is.The deeper weld penetration of the capping weld can cause the more concentrated stress at the weld toe and the joint is more likely to crack accordingly.Based on necessary assumptions,a model for analyzing the mathematical relation between the weld penetration of the capping weld and the tensile strength of the joint was proposed to validate the experimental results. The decrease of weld penetration of capping weld can be controlled by decreasing welding current,helium content or increasing welding voltage.展开更多
In as-welded state,each region of 2219 aluminum alloy TIG-welded joint shows diff erent microstructure and microhardness due to the diff erent welding heat cycles and the resulting evolution of second phases.After the...In as-welded state,each region of 2219 aluminum alloy TIG-welded joint shows diff erent microstructure and microhardness due to the diff erent welding heat cycles and the resulting evolution of second phases.After the post-weld heat treatment,both the amount and the size of the eutectic structure orθphases decreased.Correspondingly,both the Cu content inα-Al matrix and the microhardness increased to a similar level in each region of the joint,and the tensile strength of the entire joint was greatly improved.Post-weld heat treatment played the role of solid solution strengthening and aging strengthening.After the post-weld heat treatment,the weld performance became similar to other regions,but weld reinforcements lost their reinforcing eff ect on the weld and their existence was more of an adverse eff ect.The joint without weld reinforcements after the post-weld heat treatment had the optimal tensile properties,and the specimens randomly crack in the weld zone.展开更多
基金Supported by Science and Technology Plan Project of Jiaxing,No.2021AD30044Supporting Discipline of Neurology in Jiaxing,No.2023-ZC-006Affiliated Hospital of Jiaxing University,No.2020-QMX-16.
文摘BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung cancer.Even in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical manifestations.SCLC is most closely related to paraneoplastic syndrome,and some cases present as paraneoplastic peripheral neuropathy(PPN).PPN in SCLC appears early,lacks specificity,and often occurs before diagnosis of the primary tumor.It is easy to be misdiagnosed as a primary disease of the nervous system,leading to missed diagnosis and delayed diagnosis and treatment.CASE SUMMARY This paper reports two cases of SCLC with limb weakness as the first symptom.The first symptoms of one patient were rash,limb weakness,and abnormal electromyography.The patient was repeatedly referred to the hospital for limb weakness and rash for>1 year,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually aggravated.The patient was later diagnosed with SCLC,and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone therapy.The second case presented with limb numbness and weakness as the first symptom,but the patient did not pay attention to it.Later,the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the vein.However,he was diagnosed with extensive SCLC and died 1 year after diagnosis.CONCLUSION The two cases had PPN and abnormal electromyography,highlighting its correlation with early clinical indicators of SCLC.
基金Project(U1637601)supported by the Joint Funds of the National Natural Science Foundation of China
文摘Numerical simulation and experimental methods were used to investigate the effects of weld penetration on tensile properties of 2219 aluminum alloy tungsten inert gas(TIG)welded joints.The results show that when other geometric parameters are consistent,within a certain range,the deeper the weld penetration of the capping weld is,the lower the tensile strength of the j oint is.The deeper weld penetration of the capping weld can cause the more concentrated stress at the weld toe and the joint is more likely to crack accordingly.Based on necessary assumptions,a model for analyzing the mathematical relation between the weld penetration of the capping weld and the tensile strength of the joint was proposed to validate the experimental results. The decrease of weld penetration of capping weld can be controlled by decreasing welding current,helium content or increasing welding voltage.
基金supported by the Joint Funds of the National Natural Science Foundation of China (Grant No. U1637601)
文摘In as-welded state,each region of 2219 aluminum alloy TIG-welded joint shows diff erent microstructure and microhardness due to the diff erent welding heat cycles and the resulting evolution of second phases.After the post-weld heat treatment,both the amount and the size of the eutectic structure orθphases decreased.Correspondingly,both the Cu content inα-Al matrix and the microhardness increased to a similar level in each region of the joint,and the tensile strength of the entire joint was greatly improved.Post-weld heat treatment played the role of solid solution strengthening and aging strengthening.After the post-weld heat treatment,the weld performance became similar to other regions,but weld reinforcements lost their reinforcing eff ect on the weld and their existence was more of an adverse eff ect.The joint without weld reinforcements after the post-weld heat treatment had the optimal tensile properties,and the specimens randomly crack in the weld zone.
