BACKGROUND Patients with benign prostatic disease often experience detrusor morphological changes and dysfunction.In severe cases,it leads to bladder detrusor dysfunction,resulting in dysuria,frequent urination,urgent...BACKGROUND Patients with benign prostatic disease often experience detrusor morphological changes and dysfunction.In severe cases,it leads to bladder detrusor dysfunction,resulting in dysuria,frequent urination,urgent urination,incomplete urination,and other symptoms including renal function injury.An operation to restore normal urination function and to control postoperative complications,as far as possible,is the most common method for benign prostatic disease.AIM To observe the effect of precise nursing service mode on postoperative urinary incontinence prevention in patients with prostate disease.METHODS In total,130 patients diagnosed with benign prostatic disease,from January 2018 to June 2021,in our hospital,were selected and divided into observation and control groups according to their treatment options.Sixty-five cases in the control group were given routine nursing mode intervention and 65 cases in the observation group received precise nursing service mode intervention.The intervention with the observation group included psychological counseling about negative emotions,pelvic floor exercises,and post-hospital discharge care.The complications of the two groups were counted,and the general postoperative conditions of the two groups were recorded.The urinary flow dynamics indexes of the two groups were detected,and differences in clinical international prostate system score(IPSS)and urinary incontinence quality of life questionnaire(I-QOL)scores were evaluated.RESULTS Postoperative exhaust time(18.65±3.23 h and 24.63±4.51 h),the time of indwelling catheter(4.85±1.08 d and 5.63±1.24 d),and hospitalization time(8.78±2.03 d and 10.23±2.28 d)in the observation group were lower than in the control group.The difference was statistically significant(P<0.05).After the operation,the maximum urinary flow rate(Qmax)increased(P<0.05),the residual urine volume(RUV)decreased(P<0.05),and the maximum closed urethral pressure(MUCP)was not statistically significant(P>0.05)compared to pre-operation.The Qmax of the observation group was higher than that of the control group,while the RUV was lower than that of the control group.There was no significant difference in MUCP between the observation and control groups(P>0.05).The I-QOL score of the two groups improved(P<0.05),and the IPSS decreased(P<0.05).After the operation,the I-QOL score of the observation group was higher than that of the control group,and the IPSS was lower than that of the control group(P<0.05).There were no significant differences in the incidence of urethral injury(1.54%and 3.08%),bladder spasm(0.00%and 1.54%),and secondary bleeding(1.54%and 4.62)between the observation and control groups(P>0.05).CONCLUSION The precise nursing service mode can reduce the incidence of postoperative urinary incontinence in patients with prostate disease,thus improving postoperative urodynamics and rehabilitation,and quality of life.展开更多
The dynamics of the confinement transition from L mode to H mode（LH） is investigated in detail theoretically via the extended three-wave coupling model describing the interaction of turbulence and zonal flow（ZF） f...The dynamics of the confinement transition from L mode to H mode（LH） is investigated in detail theoretically via the extended three-wave coupling model describing the interaction of turbulence and zonal flow（ZF） for the first time.Thereinto, turbulence is divided into a positive-frequency（PF） wave and a negative-frequency（NF） one, and the gradient of pressure is added as the auxiliary energy for the system. The LH confinement transition is observed for a sufficiently high input energy. Moreover, it is found that the rotation direction of the limit cycle oscillation（LCO） of PF wave and pressure gradient is reversed during the transition. The mechanism is illustrated by exploring the wave phases. The results presented here provide a new insight into the analysis of the LH transition, which is helpful for the experiments on the fusion devices.展开更多
Human endometrium undergoes dynamic shedding,regeneration,and differentiation,with remarkable changes in gene expression across the menstrual cycle.The development of a receptive endometrium within a particular time f...Human endometrium undergoes dynamic shedding,regeneration,and differentiation,with remarkable changes in gene expression across the menstrual cycle.The development of a receptive endometrium within a particular time frame(window of implantation)is critical for successful embryo implantation.To understand the role of the endometrium in human fertility and regenerative biology,transcriptomic characterization of the endometrium has traditionally been pursued at the tissue bulk level using microarray and next-generation sequencing.Owing to the rapid development of single-cell RNA sequencing technology,researchers have uncovered heterogeneous molecular activities in individual cells masked by bulk analysis.In this review,we opted to mainly focus on single-cell analysis in endometrial research and introduce basic knowledge of single-cell RNA sequencing and the isolation of single cells from endometrial cells.We also discussed how single-cell approaches are used to understand the transformation and regeneration of the endometrium physiologically and uncover endometrial factors that contribute to uterine pathology.展开更多
基金Supported by Nursing Scientific Research Project Fund of Nursing Society of Guangdong Province,No.gdhlxueh2019zx218Shenzhen Bao’an District Science and Technology Plan,No.20200515053525001.
文摘BACKGROUND Patients with benign prostatic disease often experience detrusor morphological changes and dysfunction.In severe cases,it leads to bladder detrusor dysfunction,resulting in dysuria,frequent urination,urgent urination,incomplete urination,and other symptoms including renal function injury.An operation to restore normal urination function and to control postoperative complications,as far as possible,is the most common method for benign prostatic disease.AIM To observe the effect of precise nursing service mode on postoperative urinary incontinence prevention in patients with prostate disease.METHODS In total,130 patients diagnosed with benign prostatic disease,from January 2018 to June 2021,in our hospital,were selected and divided into observation and control groups according to their treatment options.Sixty-five cases in the control group were given routine nursing mode intervention and 65 cases in the observation group received precise nursing service mode intervention.The intervention with the observation group included psychological counseling about negative emotions,pelvic floor exercises,and post-hospital discharge care.The complications of the two groups were counted,and the general postoperative conditions of the two groups were recorded.The urinary flow dynamics indexes of the two groups were detected,and differences in clinical international prostate system score(IPSS)and urinary incontinence quality of life questionnaire(I-QOL)scores were evaluated.RESULTS Postoperative exhaust time(18.65±3.23 h and 24.63±4.51 h),the time of indwelling catheter(4.85±1.08 d and 5.63±1.24 d),and hospitalization time(8.78±2.03 d and 10.23±2.28 d)in the observation group were lower than in the control group.The difference was statistically significant(P<0.05).After the operation,the maximum urinary flow rate(Qmax)increased(P<0.05),the residual urine volume(RUV)decreased(P<0.05),and the maximum closed urethral pressure(MUCP)was not statistically significant(P>0.05)compared to pre-operation.The Qmax of the observation group was higher than that of the control group,while the RUV was lower than that of the control group.There was no significant difference in MUCP between the observation and control groups(P>0.05).The I-QOL score of the two groups improved(P<0.05),and the IPSS decreased(P<0.05).After the operation,the I-QOL score of the observation group was higher than that of the control group,and the IPSS was lower than that of the control group(P<0.05).There were no significant differences in the incidence of urethral injury(1.54%and 3.08%),bladder spasm(0.00%and 1.54%),and secondary bleeding(1.54%and 4.62)between the observation and control groups(P>0.05).CONCLUSION The precise nursing service mode can reduce the incidence of postoperative urinary incontinence in patients with prostate disease,thus improving postoperative urodynamics and rehabilitation,and quality of life.
基金supported by the National Natural Science Foundation of China(Grant Nos.11305010 and 11475026)the Joint Foundation of the National Natural Science FoundationChina Academy of Engineering Physics(Grant No.U1530153)
文摘The dynamics of the confinement transition from L mode to H mode（LH） is investigated in detail theoretically via the extended three-wave coupling model describing the interaction of turbulence and zonal flow（ZF） for the first time.Thereinto, turbulence is divided into a positive-frequency（PF） wave and a negative-frequency（NF） one, and the gradient of pressure is added as the auxiliary energy for the system. The LH confinement transition is observed for a sufficiently high input energy. Moreover, it is found that the rotation direction of the limit cycle oscillation（LCO） of PF wave and pressure gradient is reversed during the transition. The mechanism is illustrated by exploring the wave phases. The results presented here provide a new insight into the analysis of the LH transition, which is helpful for the experiments on the fusion devices.
基金Shenzhen Knowledge Innovation Programme of the Shenzhen Science and Technology Innovation Commission(JCYJ20180508153031952)The University of Hong Kong-Shenzhen Hospital Scientific Research Training Plan(HKUSZH20192003)
文摘Human endometrium undergoes dynamic shedding,regeneration,and differentiation,with remarkable changes in gene expression across the menstrual cycle.The development of a receptive endometrium within a particular time frame(window of implantation)is critical for successful embryo implantation.To understand the role of the endometrium in human fertility and regenerative biology,transcriptomic characterization of the endometrium has traditionally been pursued at the tissue bulk level using microarray and next-generation sequencing.Owing to the rapid development of single-cell RNA sequencing technology,researchers have uncovered heterogeneous molecular activities in individual cells masked by bulk analysis.In this review,we opted to mainly focus on single-cell analysis in endometrial research and introduce basic knowledge of single-cell RNA sequencing and the isolation of single cells from endometrial cells.We also discussed how single-cell approaches are used to understand the transformation and regeneration of the endometrium physiologically and uncover endometrial factors that contribute to uterine pathology.
