Dear Editor,In this letter,an output tracking control problem of uncertain cyber-physical systems(CPSs)is considered in the perspective of high-order fully actuated(HOFA)system theory,where a lumped disturbance is use...Dear Editor,In this letter,an output tracking control problem of uncertain cyber-physical systems(CPSs)is considered in the perspective of high-order fully actuated(HOFA)system theory,where a lumped disturbance is used to denote the total uncertainties containing parameters perturbations and external disturbances.展开更多
A chitosan （CS）-based low-pH-sensitive intelligent corrosion inhibitor was prepared by loading a pH-sensitive hydrogel with benzotriazole （BTA）; the pH-sensitive hydrogel was synthetized by crosslinking CS with gl...A chitosan （CS）-based low-pH-sensitive intelligent corrosion inhibitor was prepared by loading a pH-sensitive hydrogel with benzotriazole （BTA）; the pH-sensitive hydrogel was synthetized by crosslinking CS with glutaraldehyde （GTA）. Analysis by Fou- tier-transform inflared （FT-IR） spectroscopy showed that Schiff reactions occurred between amino and aldehyde groups. The swelling abil- ity of the hydrogel was investigated using a mass method, and it was observed to swell more in an acidic environment than in an alkaline en- vironment. The hydrogel＇s loading capacity of BTA was approximately 0.377 g·g ^-1, and its release speed was faster in an acidic environment than in an alkaline environment because of its swelling behavior. The corrosion inhibition ability of the intelligent inhibitor was tested by immersion and electrochemical methods. The results showed that after 4 h of immersion, the polarization resistance （Rp） value of copper with the intelligent inhibitor was approximately twice of that of copper with BTA, indicating that the intelligent inhibitor could effectively prevent copper from corroding.展开更多
Atherosclerotic cardiovascular disease is the main cause of mortality and morbidity in the world. Plasma levels of low density lipoprotein cholesterol （LDL-C） are positively correlated with the risk of atheroscleros...Atherosclerotic cardiovascular disease is the main cause of mortality and morbidity in the world. Plasma levels of low density lipoprotein cholesterol （LDL-C） are positively correlated with the risk of atherosclerosis. High plasma LDL concentrations in patients with hypercholesterolemia lead to build-up of LDL in the inner walls of the arteries, which becomes oxidized and promotes the formation of foam cells, consequently initiating atherosclerosis. Plasma LDL is mainly cleared through the LDL receptor （LDLR） pathway. Mutations in the LDLR cause familiar hyperch- olesterolemia and increase the risk of premature coronary heart disease. The expression of LDLR is regulated at the transcriptional level via the sterol regulatory element binding protein 2 （SREBP-2） and at the posttranslational levels mainly through proprotein convertase subtilisin/kexin-type 9 （PCSK9） and inducible degrader of the LDLR （IDOL）. In this review, we summarize the latest advances in the studies of PCSK9.展开更多
Flexure-based mechanisms are widely utilized in nano manipulations. The closed-form statics and dynamics modeling is difficult due to the complex topologies, the inevitable compliance of levers, the Hertzian contact i...Flexure-based mechanisms are widely utilized in nano manipulations. The closed-form statics and dynamics modeling is difficult due to the complex topologies, the inevitable compliance of levers, the Hertzian contact interface, etc. This paper presents the closed-form modeling of an XY nano-manipulator consisting of statically indeterminate symmetric(SIS) structures using leaf and circular flexure hinges. Theoretical analysis reveals that the lever’s compliance, the contact stiffness, and the load mass have significant influence on the static and dynamic performances of the system.Experiments are conducted to verify the effectiveness of the established models. If no piezoelectric actuator(PEA) is installed, the influence of the contact stiffness can be eliminated. Experimental results show that the estimation error on the output stiffness and first natural frequency can reach 2% and 1.7%, respectively. If PEAs are installed, the contact stiffness shows up in the models. As no effective method is currently available to measure or estimate the contact stiffness, it is impossible to precisely estimate the performance of the overall system. In this case, the established closed-form models can be utilized to calculate the bounds of the performance. The established closed-form models are widely applicable in the design and optimization of planar flexure-based mechanisms.展开更多
Flash flood hazard mapping is a supporting component of non-structural measures for flash flood prevention. Pilot case studies are necessary to develop more practicable methods for the technical support systems of fla...Flash flood hazard mapping is a supporting component of non-structural measures for flash flood prevention. Pilot case studies are necessary to develop more practicable methods for the technical support systems of flash flood hazard mapping. In this study, the headwater catchment of the Xiapu River Basin in central China was selected as a pilot study area for flash flood hazard mapping. A conceptual distributed hydrological model was developed for flood calculation based on the framework of the Xinanjiang model, which is widely used in humid and semi-humid regions in China. The developed model employs the geomorphological unit hydrograph method, which is extremely valuable when simulating the overland flow process in ungauged catchments, as compared with the original Xinanjiang model. The model was tested in the pilot study area, and the results agree with the measured data on the whole. After calibration and validation, the model is shown to be a useful tool for flash flood calculation. A practicable method for flash flood hazard mapping using the calculated peak discharge and digital elevation model data was presented, and three levels of flood hazards were classified. The resulting flash flood hazard maps indicate that the method successfully predicts the spatial distribution of flash flood hazards, and it can meet the current requirements in China.展开更多
BACKGROUND Serum protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) is a promising biomarker for hepatocellular carcinoma(HCC) surveillance.AIM To identify the contributing factors related to the abnormal...BACKGROUND Serum protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) is a promising biomarker for hepatocellular carcinoma(HCC) surveillance.AIM To identify the contributing factors related to the abnormal elevation of PIVKA-Ⅱ level and assess their potential influence on the performance of PIVKA-Ⅱ in detecting HCC.METHODS This study retrospectively enrolled in 784 chronic liver disease(CLD) patients and 267 HCC patients in Mengchao Hepatobiliary Hospital of Fujian Medical University from April 2016 to December 2019. Logistic regression and the area under the receiver operating characteristic curve(AUC) were used to evaluate the influencing factors and diagnostic performance of PIVKA-Ⅱ for HCC, respectively.RESULTS Elevated PIVKA-Ⅱ levels were independently positively associated with alcohol-related liver disease, serum alkaline phosphatase(ALP), and total bilirubin(TBIL) for CLD patients and aspartate aminotransferase(AST) and tumor size for HCC patients(all P < 0.05). Serum PIVKA-Ⅱ were significantly lower in patients with viral etiology, ALP ≤ 1 × upper limit of normal(ULN), TBIL ≤ 1 × ULN, and AST ≤ 1 × ULN than in those with nonviral disease and abnormal ALP, TBIL, or AST(all P < 0.05), but the differences disappeared in patients with early-stage HCC. For patients with TBIL ≤ 1 × ULN, the AUC of PIVKA-Ⅱ was significantly higher compared to that in patients with TBIL > 1 × ULN(0.817 vs 0.669, P = 0.015), while the difference between ALP ≤ 1 × ULN and ALP > 1 × ULN was not statistically significant(0.783 vs 0.729, P = 0.398). These trends were then more prominently perceived in subgroups of patients with viral etiology and HBV alone.CONCLUSION Serum PIVKA-Ⅱ has better performance in detecting HCC at an early stage for CLD patients with normal serum TBIL.展开更多
In this work the surface of LiNi0.5Mn1.5O4(LMN)particles is modified by Mn3O4 coating through a simple wet grinding method,the electronic conductivity is significantly improved from 1.53×10^-7 S/cm to 3.15×1...In this work the surface of LiNi0.5Mn1.5O4(LMN)particles is modified by Mn3O4 coating through a simple wet grinding method,the electronic conductivity is significantly improved from 1.53×10^-7 S/cm to 3.15×10^-5 S/cm after 2.6 wt%Mn3O4 coating.The electrochemical test results indicate that Mn3O4 coating dramatically enhances both rate performance and cycling capability(at 55℃)of LNM.Among the samples,2.6 wt%Mn3O4-coated LNM not only exhibits excellent rate capability(a large capacity of 108 m Ah/g at 10 C rate)but also shows 78%capacity retention at 55 ℃ and 1 C rate after 100 cycles.展开更多
The short-term corrosion behavior of API X100 steel in an acidic simulated soil was investigated by electrochemical measurements and soaking experiments,followed by corrosion morphology observations and X-ray photoele...The short-term corrosion behavior of API X100 steel in an acidic simulated soil was investigated by electrochemical measurements and soaking experiments,followed by corrosion morphology observations and X-ray photoelectron spectroscopy analyses.The results show that X100 steel exhibits an obvious pitting susceptibility in an acidic soil environment.Pits nucleate after approximately 10 h of immersion.Along with the nucleation and growth of the pits,the charge-transfer resistance and open-circuit potential first increase sharply,then decrease slowly,and eventually reach a steady state.The maxima of the charge-transfer resistance and open-circuit potential are attained at approximately 10 h.The evolution of the electrochemical process is confirmed by the analysis of the product film.The product film exhibits a porous and loose structure and could not protect the substrate well.The product film is primarily composed of ferrous carbonate and ferrous hydroxide（Fe（OH）2）.The concentration of Fe（OH）2 in the product film increases from the inside to the outside layer.展开更多
An ultra-broadband perfect absorber consisting of cascaded nanodisk arrays is demonstrated by placing insulatormetal-insulator-metal nanodisks on insulator-metal film stacks.The absorber shows over 90% absorption in a...An ultra-broadband perfect absorber consisting of cascaded nanodisk arrays is demonstrated by placing insulatormetal-insulator-metal nanodisks on insulator-metal film stacks.The absorber shows over 90% absorption in a wavelength range between 600 nm and 4000 nm under transverse magnetic(TM) polarization,with an average absorptivity of 91.5%and a relative absorption bandwidth of 147.8%.The analysis of the electric field and magnetic field show that the synergy of localized surface plasmons,propagating surface plasmons,and plasmonic resonant cavity modes leads to the ultrabroadband perfect absorption,which accords well with the results of impedance-matched analysis.The influences of structural parameters and different metal materials on absorption performance are discussed.Furthermore,the absorber is polarization-independent,and the absorption remains more than 90% at a wide incident angle up to 400 under TE polarization and TM polarization.The designed ultra-broadband absorber has promising prospects in photoelectric detection and imaging.展开更多
AIM: To investigate whether non-canonical autophagy transport receptor cell cycle progression 1(CCPG1) is involved in the corneal antifungal immune response.METHODS: Human corneal epithelial cells(HCECs) and human mye...AIM: To investigate whether non-canonical autophagy transport receptor cell cycle progression 1(CCPG1) is involved in the corneal antifungal immune response.METHODS: Human corneal epithelial cells(HCECs) and human myeloid leukemia mononuclear cells(THP-1) macrophages stimulated by Aspergil us fumigatus(A. fumigatus) were used as cell models. The expression of CCPG1 m RNA was detected by q RT-PCR. Western blot was used to determine the protein expression of CCPG1 and interleukin-1β(IL-1β). The dectin-1 neutralizing antibody was used to detect the association between dectin-1 and CCPG1. Immunofluorescence was used to observe the colocalization of CCPG1 and C-type lectin-like receptor-1(CLEC-1) in THP-1 macrophages.RESULTS: The expression of CCPG1 started to increase at 4 h after infection and increased in a time-dependent manner in HCECs and THP-1 macrophages. With dectin-1 neutralizing antibody pretreatment, the expression of IL-1β was down-regulated. CCPG1 up-regulation in response to A. fumigatus infection was independent of dectin-1. Immunofluorescence showed the colocalization of CCPG1 and CLEC-1 in THP-1 macrophages.CONCLUSION: As a specific autophagy protein of noncanonical autophagy pathway, CCPG1 is involved in corneal infection with A. fumigatus.展开更多
For many years,unprotected left main stenosis(ULMS)has been remained as the forbidden fruit of interventional cardiology.However,with the remarkable improvement in medical device technology,procedural techniques and a...For many years,unprotected left main stenosis(ULMS)has been remained as the forbidden fruit of interventional cardiology.However,with the remarkable improvement in medical device technology,procedural techniques and antithrombotic agents during the last decades,percutaneous coronary intervention(PCI)with stenting for ULMS has become technically feasible and has exhibited favorable clinical outcomes.展开更多
We theoretically investigate several parameters for the nuclear magnetic resonance gyroscope based on ^（133）C_（s–）^（129）Xe/^（131）Xe. For a cell containing a mixture of ^（133）Cs at saturated pressure, we inv...We theoretically investigate several parameters for the nuclear magnetic resonance gyroscope based on ^（133）C_（s–）^（129）Xe/^（131）Xe. For a cell containing a mixture of ^（133）Cs at saturated pressure, we investigate the optimal quenching gas（N_2） pressure and the corresponding pump laser intensity to achieve 30% ^（133）Cs polarization at the center of the cell when the static magnetic field B0 is 5 μT with different ^（129）Xe/^（131）Xe pressure. The effective field produced by spin-exchange polarized ^（129）Xe or ^（131）Xe sensed by ^（133）Cs can also be discussed in different^（129）Xe/^（131）Xe pressure conditions. Furthermore,the relationship between the detected signal and the probe laser frequency is researched. We obtain the optimum probe laser detuning from the D2（6~2S_（1/2）→ 6~2P_（3/2）） resonance with different ^（129）Xe/^（131）Xe pressure owing to the pressure broadening.展开更多
BACKGROUND Complications of vascular closure devices mainly include bleeding,vascular injury,and trapped device that cannot be removed percutaneously.However,arterial stenosis or occlusion induced by vascular injury i...BACKGROUND Complications of vascular closure devices mainly include bleeding,vascular injury,and trapped device that cannot be removed percutaneously.However,arterial stenosis or occlusion induced by vascular injury is rare.This article introduces a rare case with severe acute limb ischemia after using the vascular closure device(StarClose).CASE SUMMARY A 54-year-old man was admitted because of necrosis of the second toe of the left foot for 2 mo.Ultrasound showed left femoral artery stenosis,and occlusion of the left popliteal,posterior tibial,peroneal,anterior tibial and dorsalis pedis arteries,suggesting arteriosclerosis obliterans of low extremities,gangrene and type 2 diabetes.He underwent an interventional procedure of drug-eluting balloon in the left lower limb via antegrade puncture of the left common femoral artery.He developed acute limb ischemia after 1 h,and severe pain,numbness,pale skin,low skin temperature and weakened sensation in the left foot.Injury of the common femoral artery intima was considered.Exploratory surgery showed occlusion at the puncture point accompanied with bulged vascular lumen and flipped vascular intima caused by StarClose.The flipped intima was removed.The limb blood supply was restored and the limb was saved post-surgery.He recovered well at final follow-up.CONCLUSION Incorrect use of the vascular closure device was the main cause of severe acute limb ischemia in this case.展开更多
The addition of nanoparticles serves as an effective reinforcement strategy for polymeric coatings,utilizing their unique characteristics as well as extraordinary mechanical,thermal,and electrical properties.The excep...The addition of nanoparticles serves as an effective reinforcement strategy for polymeric coatings,utilizing their unique characteristics as well as extraordinary mechanical,thermal,and electrical properties.The exceptionally high surface-to-volume ratio of nanoparticles imparts remarkable reinforcing potentials,yet it simultaneously gives rise to a prevalent tendency for nanoparticles to agglomerate into clusters within nanocomposites.The agglomeration behavior of the nanoparticles is predominantly influenced by their distinct microstructures and varied weight concentrations.This study investigated the synergistic effects of nanoparticle geometric shape and weight concentration on the dispersion characteristics of nanoparticles and the physical-mechanical performances of nano-reinforced epoxy coatings.Three carbon-based nanoparticles,nanodiamonds(NDs),carbon nanotubes(CNTs),and graphenes(GNPs),were incorporated into epoxy coatings at three weight concentrations(0.5%,1.0%,and 2.0%).The experimental findings reveal that epoxy coatings reinforced with NDs demonstrated the most homogenous dispersion characteristics,lowest viscosity,and reduced porosity among all the nanoparticles,which could be attributed to the spherical geometry shape.Due to the superior physical properties,ND-reinforced nanocomposites displayed the highest abrasion resistance and tensile properties.Specifically,the 1.0wt%ND-reinforced nanocomposites exhibited 60%,52%,and 97%improvements in mass lost,tensile strength,and failure strain,respectively,compared to pure epoxy.Furthermore,the representative volume element(RVE)modeling was employed to validate the experimental results,while highlighting the critical role of nanoparticle agglomeration,orientation,and the presence of voids on the mechanical properties of the nanocomposites.Nano-reinforced epoxy coatings with enhanced mechanical properties are well-suited for application in protective coatings for pipelines,industrial equipment,and automotive parts,where high wear resistance is essential.展开更多
With the development of artificial intelligence,neural network provides unique opportunities for holography,such as high fidelity and dynamic calculation.How to obtain real 3D scene and generate high fidelity hologram...With the development of artificial intelligence,neural network provides unique opportunities for holography,such as high fidelity and dynamic calculation.How to obtain real 3D scene and generate high fidelity hologram in real time is an urgent problem.Here,we propose a liquid lens based holographic camera for real 3D scene hologram acquisition using an end-to-end physical model-driven network(EEPMD-Net).As the core component of the liquid camera,the first 10 mm large aperture electrowetting-based liquid lens is proposed by using specially fabricated solution.The design of the liquid camera ensures that the multi-layers of the real 3D scene can be obtained quickly and with great imaging performance.The EEPMD-Net takes the information of real 3D scene as the input,and uses two new structures of encoder and decoder networks to realize low-noise phase generation.By comparing the intensity information between the reconstructed image after depth fusion and the target scene,the composite loss function is constructed for phase optimization,and the high-fidelity training of hologram with true depth of the 3D scene is realized for the first time.The holographic camera achieves the high-fidelity and fast generation of the hologram of the real 3D scene,and the reconstructed experiment proves that the holographic image has the advantage of low noise.The proposed holographic camera is unique and can be used in 3D display,measurement,encryption and other fields.展开更多
The balance between intestinal cholesterol absorption and cholesterol synthesis in the liver has remained a puzzling phenomenon for a long time because no study has been able to explain how the consumption of a choles...The balance between intestinal cholesterol absorption and cholesterol synthesis in the liver has remained a puzzling phenomenon for a long time because no study has been able to explain how the consumption of a cholesterol-rich diet impairs cholesterol synthesis in the liver.Recently,a group of researchers uncovered a hormone produced in the intestine without any known function,which they named cholesin,that suppresses sterol regulatory element-binding protein 2(SREBP-2),the master regulator of cholesterol synthesis in the liver.展开更多
Mitochondria are dynamic organelles with multiple functions.They participate in necrotic cell death and programmed apoptotic,and are crucial for cell metabolism and survival.Mitophagy serves as a cytoprotective mechan...Mitochondria are dynamic organelles with multiple functions.They participate in necrotic cell death and programmed apoptotic,and are crucial for cell metabolism and survival.Mitophagy serves as a cytoprotective mechanism to remove superfluous or dysfunctional mitochondria and maintain mitochondrial fine-tuning numbers to balance intracellular homeostasis.Growing evidences show that mitophagy,as an acute tissue stress response,plays an important role in maintaining the health of the mitochondrial network.Since the timely removal of abnormal mitochondria is essential for cell survival,cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments.A better understanding of the mechanism of mitophagy in various diseases is crucial for the treatment of diseases and therapeutic target design.In this review,we summarize the molecular mechanisms of mitophagy-mediated mitochondrial elimination,how mitophagy maintains mitochondrial homeostasis at the system levels and organ,and what alterations in mitophagy are related to the development of diseases,including neurological,cardiovascular,pulmonary,hepatic,renal disease,etc.,in recent advances.Finally,we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials.Research advances in signaling transduction of mitophagy will have an important role in developing new therapeutic strategies for precision medicine.展开更多
Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiologi...Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19.展开更多
A new strategy of thermally activated delayed fluorescence(TADF)material-sensitized circularly polarized luminescence(CPL)has been proposed for improving the efficiencies of fluorescent circularly polarized organic li...A new strategy of thermally activated delayed fluorescence(TADF)material-sensitized circularly polarized luminescence(CPL)has been proposed for improving the efficiencies of fluorescent circularly polarized organic lightemitting diodes(OLEDs)(CP-OLEDs).Consequently,a pair of helicene enantiomers,(P)-HAI and(M)-HAI,were synthesized.The helicene enantiomers with the rigid helicalπ-skeleton had highly thermal and enantiomeric stabilities,and they also showed excellent photophysical properties,especially,intense mirror-image CPL activities with large luminescence dissymmetry factor(|g_(lum)|)values of about 6×10^(-3).Notably,the CP-OLEDs with the helicene enantiomers as emitters and a TADF molecule as sensitizer not only displayed better performance of lower turn-on voltage(V_(T))of 2.6 V,four-fold maxmium-external quantum efficiency(EQE_(max))of 5.3%,and lower efficiencies roll-off of 1.9%at 1000 cd m^(-2),than those of the devices without TADF sensitizer,but also exhibited intense circularly polarized electroluminescence(CPEL)with the electroluminescence dissymmetry factor(g_(EL))values of-2.3×10^(-3)and+3.0×10^(-3).Meanwhile,this study also represents the first thermally activated sensitized fluorescent CP-OLEDs with markedly enhanced efficiencies and intense CPEL.展开更多
Background：The pro-inflammatory cytokine,interleukin-6 （IL-6）,stimulates the metastasis of several neoplasms.An association of its serum level and the single nucleotide polymorphism （SNP） rs1800795 with neuroblas...Background：The pro-inflammatory cytokine,interleukin-6 （IL-6）,stimulates the metastasis of several neoplasms.An association of its serum level and the single nucleotide polymorphism （SNP） rs1800795 with neuroblastoma （NB） has been reported in American and Italian cohorts.This study was to clarify whether the same association exists in Chinese children.Methods：A total of 130 NB patients,with 77 boys （59％）,53 girls （41％）,mean age 41 ± 5 months,were assigned to two groups：high risk （HR） versus intermediate-low risk （non-HR）,and 50 healthy children were randomly selected as the age-and gender-matched controls.Peripheral blood samples were analyzed to determine serum IL-6 level using enzyme linked immunosorbent assay and rs1800795 SNPs phenotype using polymerase chain reaction and gene sequencing.Results：There were 87 NB patients in the HR group and 43 NB patients in the non-HR group.A comparison of allele and genotype frequencies of the rs1800795 polymorphism between patients and controls found no association with NB risk （P ＞ 0.05）.The frequency of GG＋GC genotype was higher in HR-NB patients than in non-HR-NB patients （64.4％ vs.48.8％,P =0.02）,and serum IL-6 level was much higher in HR-NB patients with GG＋GC genotype than in HR-NB patients with CC genotype （4.36 ± 1.1 pg/ml vs.1.83 ± 0.5 pg/ml;P =0.02）,but not in Non-HR-NB patients.Conclusions：The polymorphism rs1800795 is associated with serum IL-6 level and level of NB risk.GG genotype might indicate that the tumor is highly malignant （prone to metastasis） and associated with poor prognosis.展开更多
基金supported in part by the National Natural Science Foundation of China(621732556218,8101)the Shenzhen Key Laboratory of Control Theory and Intelligent Systems(ZDSYS20220330161800001)。
文摘Dear Editor,In this letter,an output tracking control problem of uncertain cyber-physical systems(CPSs)is considered in the perspective of high-order fully actuated(HOFA)system theory,where a lumped disturbance is used to denote the total uncertainties containing parameters perturbations and external disturbances.
基金supported by the National Natural Science Foundation of China (No. 51222106)the Fundamental Research Funds for the Central Universities of China (No. FRF-TP-14-011C1)
文摘A chitosan （CS）-based low-pH-sensitive intelligent corrosion inhibitor was prepared by loading a pH-sensitive hydrogel with benzotriazole （BTA）; the pH-sensitive hydrogel was synthetized by crosslinking CS with glutaraldehyde （GTA）. Analysis by Fou- tier-transform inflared （FT-IR） spectroscopy showed that Schiff reactions occurred between amino and aldehyde groups. The swelling abil- ity of the hydrogel was investigated using a mass method, and it was observed to swell more in an acidic environment than in an alkaline en- vironment. The hydrogel＇s loading capacity of BTA was approximately 0.377 g·g ^-1, and its release speed was faster in an acidic environment than in an alkaline environment because of its swelling behavior. The corrosion inhibition ability of the intelligent inhibitor was tested by immersion and electrochemical methods. The results showed that after 4 h of immersion, the polarization resistance （Rp） value of copper with the intelligent inhibitor was approximately twice of that of copper with BTA, indicating that the intelligent inhibitor could effectively prevent copper from corroding.
基金D.W.Z.is a Scholar of the Alberta Heritage Foundation for Medical Research and is supported in part by a Canadian Institutes of Health Research New Investigator AwardZhang laboratory is supported by Canadian Foundation for Innovation,grants from a Grant-in-Aidfor Heart and Stroke Foundation of CanadaPfizer Canada, the Canadian Institutes of Health Research(MOP 93794), and Mazankowski Alberta Heart Institute
文摘Atherosclerotic cardiovascular disease is the main cause of mortality and morbidity in the world. Plasma levels of low density lipoprotein cholesterol （LDL-C） are positively correlated with the risk of atherosclerosis. High plasma LDL concentrations in patients with hypercholesterolemia lead to build-up of LDL in the inner walls of the arteries, which becomes oxidized and promotes the formation of foam cells, consequently initiating atherosclerosis. Plasma LDL is mainly cleared through the LDL receptor （LDLR） pathway. Mutations in the LDLR cause familiar hyperch- olesterolemia and increase the risk of premature coronary heart disease. The expression of LDLR is regulated at the transcriptional level via the sterol regulatory element binding protein 2 （SREBP-2） and at the posttranslational levels mainly through proprotein convertase subtilisin/kexin-type 9 （PCSK9） and inducible degrader of the LDLR （IDOL）. In this review, we summarize the latest advances in the studies of PCSK9.
基金Supported by National Natural Science Foundation of China(Grant Nos.61403214,61327802,U1613220)Tianjin Provincial Natural Science Foundation of China(Grant Nos.14JCZDJC31800,14JCQNJC04700)
文摘Flexure-based mechanisms are widely utilized in nano manipulations. The closed-form statics and dynamics modeling is difficult due to the complex topologies, the inevitable compliance of levers, the Hertzian contact interface, etc. This paper presents the closed-form modeling of an XY nano-manipulator consisting of statically indeterminate symmetric(SIS) structures using leaf and circular flexure hinges. Theoretical analysis reveals that the lever’s compliance, the contact stiffness, and the load mass have significant influence on the static and dynamic performances of the system.Experiments are conducted to verify the effectiveness of the established models. If no piezoelectric actuator(PEA) is installed, the influence of the contact stiffness can be eliminated. Experimental results show that the estimation error on the output stiffness and first natural frequency can reach 2% and 1.7%, respectively. If PEAs are installed, the contact stiffness shows up in the models. As no effective method is currently available to measure or estimate the contact stiffness, it is impossible to precisely estimate the performance of the overall system. In this case, the established closed-form models can be utilized to calculate the bounds of the performance. The established closed-form models are widely applicable in the design and optimization of planar flexure-based mechanisms.
基金supported by the Key Project in the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period(Grant No.2012BAK10B04)the Specific Research Fund of the China Institute of Water Resources and Hydropower Research(Grant No.JZ0145B032014)
文摘Flash flood hazard mapping is a supporting component of non-structural measures for flash flood prevention. Pilot case studies are necessary to develop more practicable methods for the technical support systems of flash flood hazard mapping. In this study, the headwater catchment of the Xiapu River Basin in central China was selected as a pilot study area for flash flood hazard mapping. A conceptual distributed hydrological model was developed for flood calculation based on the framework of the Xinanjiang model, which is widely used in humid and semi-humid regions in China. The developed model employs the geomorphological unit hydrograph method, which is extremely valuable when simulating the overland flow process in ungauged catchments, as compared with the original Xinanjiang model. The model was tested in the pilot study area, and the results agree with the measured data on the whole. After calibration and validation, the model is shown to be a useful tool for flash flood calculation. A practicable method for flash flood hazard mapping using the calculated peak discharge and digital elevation model data was presented, and three levels of flood hazards were classified. The resulting flash flood hazard maps indicate that the method successfully predicts the spatial distribution of flash flood hazards, and it can meet the current requirements in China.
基金Supported by the National Key Clinical Discipline,Fuzhou “14th Five-Year Plan” Clinical Key Specialty (laboratory medicine)the National Science Foundation of China,No. 82002587
文摘BACKGROUND Serum protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) is a promising biomarker for hepatocellular carcinoma(HCC) surveillance.AIM To identify the contributing factors related to the abnormal elevation of PIVKA-Ⅱ level and assess their potential influence on the performance of PIVKA-Ⅱ in detecting HCC.METHODS This study retrospectively enrolled in 784 chronic liver disease(CLD) patients and 267 HCC patients in Mengchao Hepatobiliary Hospital of Fujian Medical University from April 2016 to December 2019. Logistic regression and the area under the receiver operating characteristic curve(AUC) were used to evaluate the influencing factors and diagnostic performance of PIVKA-Ⅱ for HCC, respectively.RESULTS Elevated PIVKA-Ⅱ levels were independently positively associated with alcohol-related liver disease, serum alkaline phosphatase(ALP), and total bilirubin(TBIL) for CLD patients and aspartate aminotransferase(AST) and tumor size for HCC patients(all P < 0.05). Serum PIVKA-Ⅱ were significantly lower in patients with viral etiology, ALP ≤ 1 × upper limit of normal(ULN), TBIL ≤ 1 × ULN, and AST ≤ 1 × ULN than in those with nonviral disease and abnormal ALP, TBIL, or AST(all P < 0.05), but the differences disappeared in patients with early-stage HCC. For patients with TBIL ≤ 1 × ULN, the AUC of PIVKA-Ⅱ was significantly higher compared to that in patients with TBIL > 1 × ULN(0.817 vs 0.669, P = 0.015), while the difference between ALP ≤ 1 × ULN and ALP > 1 × ULN was not statistically significant(0.783 vs 0.729, P = 0.398). These trends were then more prominently perceived in subgroups of patients with viral etiology and HBV alone.CONCLUSION Serum PIVKA-Ⅱ has better performance in detecting HCC at an early stage for CLD patients with normal serum TBIL.
基金the National Key R&D Program of China(No.2018YFB0905400)the Fundamental Research Funds for the Central Universities(No.JZ2019HGBZ0140)+2 种基金the National Natural Science Foundation of China(No.U1630106No.51577175)China Postdoctoral Science Foundation(No.172731)。
文摘In this work the surface of LiNi0.5Mn1.5O4(LMN)particles is modified by Mn3O4 coating through a simple wet grinding method,the electronic conductivity is significantly improved from 1.53×10^-7 S/cm to 3.15×10^-5 S/cm after 2.6 wt%Mn3O4 coating.The electrochemical test results indicate that Mn3O4 coating dramatically enhances both rate performance and cycling capability(at 55℃)of LNM.Among the samples,2.6 wt%Mn3O4-coated LNM not only exhibits excellent rate capability(a large capacity of 108 m Ah/g at 10 C rate)but also shows 78%capacity retention at 55 ℃ and 1 C rate after 100 cycles.
基金financially supported by the National High-Tech Research and Development Program of China (No.2012AA040105)the National Nature Science Foundation of China (Nos. 51131001 and 51741034)the Beijing Higher Education Young Elite Teacher Project
文摘The short-term corrosion behavior of API X100 steel in an acidic simulated soil was investigated by electrochemical measurements and soaking experiments,followed by corrosion morphology observations and X-ray photoelectron spectroscopy analyses.The results show that X100 steel exhibits an obvious pitting susceptibility in an acidic soil environment.Pits nucleate after approximately 10 h of immersion.Along with the nucleation and growth of the pits,the charge-transfer resistance and open-circuit potential first increase sharply,then decrease slowly,and eventually reach a steady state.The maxima of the charge-transfer resistance and open-circuit potential are attained at approximately 10 h.The evolution of the electrochemical process is confirmed by the analysis of the product film.The product film exhibits a porous and loose structure and could not protect the substrate well.The product film is primarily composed of ferrous carbonate and ferrous hydroxide（Fe（OH）2）.The concentration of Fe（OH）2 in the product film increases from the inside to the outside layer.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61775140 and 62005165)。
文摘An ultra-broadband perfect absorber consisting of cascaded nanodisk arrays is demonstrated by placing insulatormetal-insulator-metal nanodisks on insulator-metal film stacks.The absorber shows over 90% absorption in a wavelength range between 600 nm and 4000 nm under transverse magnetic(TM) polarization,with an average absorptivity of 91.5%and a relative absorption bandwidth of 147.8%.The analysis of the electric field and magnetic field show that the synergy of localized surface plasmons,propagating surface plasmons,and plasmonic resonant cavity modes leads to the ultrabroadband perfect absorption,which accords well with the results of impedance-matched analysis.The influences of structural parameters and different metal materials on absorption performance are discussed.Furthermore,the absorber is polarization-independent,and the absorption remains more than 90% at a wide incident angle up to 400 under TE polarization and TM polarization.The designed ultra-broadband absorber has promising prospects in photoelectric detection and imaging.
基金Supported by the National Natural Science Foundation of China(No.82171019)the Natural Science Foundation of Shandong Province(No.ZR2021MH368)+1 种基金Traditional Chinese Medicine Research Project of Qingdao(No.2020-zyy055)Shandong Qingdao Outstanding Health Professional Development Fund。
文摘AIM: To investigate whether non-canonical autophagy transport receptor cell cycle progression 1(CCPG1) is involved in the corneal antifungal immune response.METHODS: Human corneal epithelial cells(HCECs) and human myeloid leukemia mononuclear cells(THP-1) macrophages stimulated by Aspergil us fumigatus(A. fumigatus) were used as cell models. The expression of CCPG1 m RNA was detected by q RT-PCR. Western blot was used to determine the protein expression of CCPG1 and interleukin-1β(IL-1β). The dectin-1 neutralizing antibody was used to detect the association between dectin-1 and CCPG1. Immunofluorescence was used to observe the colocalization of CCPG1 and C-type lectin-like receptor-1(CLEC-1) in THP-1 macrophages.RESULTS: The expression of CCPG1 started to increase at 4 h after infection and increased in a time-dependent manner in HCECs and THP-1 macrophages. With dectin-1 neutralizing antibody pretreatment, the expression of IL-1β was down-regulated. CCPG1 up-regulation in response to A. fumigatus infection was independent of dectin-1. Immunofluorescence showed the colocalization of CCPG1 and CLEC-1 in THP-1 macrophages.CONCLUSION: As a specific autophagy protein of noncanonical autophagy pathway, CCPG1 is involved in corneal infection with A. fumigatus.
基金the Key Medical Professional Development Plan of Beijing Municipal Hospital Administration (ZYLX201817)。
文摘For many years,unprotected left main stenosis(ULMS)has been remained as the forbidden fruit of interventional cardiology.However,with the remarkable improvement in medical device technology,procedural techniques and antithrombotic agents during the last decades,percutaneous coronary intervention(PCI)with stenting for ULMS has become technically feasible and has exhibited favorable clinical outcomes.
基金Project supported by the National High Technology Research and Development Program of China(Grant No.2014AA123401)the National Key BasResearch and Development Program of China(Grant Nos.2016YFA0302103 and 2012CB821302)+1 种基金the National Natural Science Foundation of China(Gra11134003)Shanghai Excellent Academic Leaders Program of China(Grant No.12XD1402400)
文摘We theoretically investigate several parameters for the nuclear magnetic resonance gyroscope based on ^（133）C_（s–）^（129）Xe/^（131）Xe. For a cell containing a mixture of ^（133）Cs at saturated pressure, we investigate the optimal quenching gas（N_2） pressure and the corresponding pump laser intensity to achieve 30% ^（133）Cs polarization at the center of the cell when the static magnetic field B0 is 5 μT with different ^（129）Xe/^（131）Xe pressure. The effective field produced by spin-exchange polarized ^（129）Xe or ^（131）Xe sensed by ^（133）Cs can also be discussed in different^（129）Xe/^（131）Xe pressure conditions. Furthermore,the relationship between the detected signal and the probe laser frequency is researched. We obtain the optimum probe laser detuning from the D2（6~2S_（1/2）→ 6~2P_（3/2）） resonance with different ^（129）Xe/^（131）Xe pressure owing to the pressure broadening.
基金Supported by the Traditional Chinese Medicine Science,No.2017-057,2017-058 and 2019-0969Technology Development Project of Shandong Province,No.2019-0971
文摘BACKGROUND Complications of vascular closure devices mainly include bleeding,vascular injury,and trapped device that cannot be removed percutaneously.However,arterial stenosis or occlusion induced by vascular injury is rare.This article introduces a rare case with severe acute limb ischemia after using the vascular closure device(StarClose).CASE SUMMARY A 54-year-old man was admitted because of necrosis of the second toe of the left foot for 2 mo.Ultrasound showed left femoral artery stenosis,and occlusion of the left popliteal,posterior tibial,peroneal,anterior tibial and dorsalis pedis arteries,suggesting arteriosclerosis obliterans of low extremities,gangrene and type 2 diabetes.He underwent an interventional procedure of drug-eluting balloon in the left lower limb via antegrade puncture of the left common femoral artery.He developed acute limb ischemia after 1 h,and severe pain,numbness,pale skin,low skin temperature and weakened sensation in the left foot.Injury of the common femoral artery intima was considered.Exploratory surgery showed occlusion at the puncture point accompanied with bulged vascular lumen and flipped vascular intima caused by StarClose.The flipped intima was removed.The limb blood supply was restored and the limb was saved post-surgery.He recovered well at final follow-up.CONCLUSION Incorrect use of the vascular closure device was the main cause of severe acute limb ischemia in this case.
基金supported by the National Science Foundation(NSF)(No.CMMI-1750316)Pipeline and Hazardous Materials Safety Administration(PHMSA)of U.S.Department of Transportation(No.693JK31950008CAAP).
文摘The addition of nanoparticles serves as an effective reinforcement strategy for polymeric coatings,utilizing their unique characteristics as well as extraordinary mechanical,thermal,and electrical properties.The exceptionally high surface-to-volume ratio of nanoparticles imparts remarkable reinforcing potentials,yet it simultaneously gives rise to a prevalent tendency for nanoparticles to agglomerate into clusters within nanocomposites.The agglomeration behavior of the nanoparticles is predominantly influenced by their distinct microstructures and varied weight concentrations.This study investigated the synergistic effects of nanoparticle geometric shape and weight concentration on the dispersion characteristics of nanoparticles and the physical-mechanical performances of nano-reinforced epoxy coatings.Three carbon-based nanoparticles,nanodiamonds(NDs),carbon nanotubes(CNTs),and graphenes(GNPs),were incorporated into epoxy coatings at three weight concentrations(0.5%,1.0%,and 2.0%).The experimental findings reveal that epoxy coatings reinforced with NDs demonstrated the most homogenous dispersion characteristics,lowest viscosity,and reduced porosity among all the nanoparticles,which could be attributed to the spherical geometry shape.Due to the superior physical properties,ND-reinforced nanocomposites displayed the highest abrasion resistance and tensile properties.Specifically,the 1.0wt%ND-reinforced nanocomposites exhibited 60%,52%,and 97%improvements in mass lost,tensile strength,and failure strain,respectively,compared to pure epoxy.Furthermore,the representative volume element(RVE)modeling was employed to validate the experimental results,while highlighting the critical role of nanoparticle agglomeration,orientation,and the presence of voids on the mechanical properties of the nanocomposites.Nano-reinforced epoxy coatings with enhanced mechanical properties are well-suited for application in protective coatings for pipelines,industrial equipment,and automotive parts,where high wear resistance is essential.
基金supported by the National Key Research and Development Program of China(2021YFB2802100)the National Natural Science Foundation of China(62020106010,62275009,U22A2079,and U21B2034).
文摘With the development of artificial intelligence,neural network provides unique opportunities for holography,such as high fidelity and dynamic calculation.How to obtain real 3D scene and generate high fidelity hologram in real time is an urgent problem.Here,we propose a liquid lens based holographic camera for real 3D scene hologram acquisition using an end-to-end physical model-driven network(EEPMD-Net).As the core component of the liquid camera,the first 10 mm large aperture electrowetting-based liquid lens is proposed by using specially fabricated solution.The design of the liquid camera ensures that the multi-layers of the real 3D scene can be obtained quickly and with great imaging performance.The EEPMD-Net takes the information of real 3D scene as the input,and uses two new structures of encoder and decoder networks to realize low-noise phase generation.By comparing the intensity information between the reconstructed image after depth fusion and the target scene,the composite loss function is constructed for phase optimization,and the high-fidelity training of hologram with true depth of the 3D scene is realized for the first time.The holographic camera achieves the high-fidelity and fast generation of the hologram of the real 3D scene,and the reconstructed experiment proves that the holographic image has the advantage of low noise.The proposed holographic camera is unique and can be used in 3D display,measurement,encryption and other fields.
基金supported by a grant from the Natural Sciences and Engineering Research Council of Canada(RGPIN-2024-06088)and China Institute at the University of Alberta.
文摘The balance between intestinal cholesterol absorption and cholesterol synthesis in the liver has remained a puzzling phenomenon for a long time because no study has been able to explain how the consumption of a cholesterol-rich diet impairs cholesterol synthesis in the liver.Recently,a group of researchers uncovered a hormone produced in the intestine without any known function,which they named cholesin,that suppresses sterol regulatory element-binding protein 2(SREBP-2),the master regulator of cholesterol synthesis in the liver.
基金The current work was supported by the National Natural Science Foundation of China(Project nos.81870337)the Guangdong Natural Science Research Grant(No.2021A1515010717).The Figs.2,4,5 and 6 were partly generated using Servier Medical Art,provided by Servier,licensed under a Creative Commons Attribution 3.0 unported license.We also thank Illustrator of biological sequences(IBS)software for the Fig.3 preparation.
文摘Mitochondria are dynamic organelles with multiple functions.They participate in necrotic cell death and programmed apoptotic,and are crucial for cell metabolism and survival.Mitophagy serves as a cytoprotective mechanism to remove superfluous or dysfunctional mitochondria and maintain mitochondrial fine-tuning numbers to balance intracellular homeostasis.Growing evidences show that mitophagy,as an acute tissue stress response,plays an important role in maintaining the health of the mitochondrial network.Since the timely removal of abnormal mitochondria is essential for cell survival,cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments.A better understanding of the mechanism of mitophagy in various diseases is crucial for the treatment of diseases and therapeutic target design.In this review,we summarize the molecular mechanisms of mitophagy-mediated mitochondrial elimination,how mitophagy maintains mitochondrial homeostasis at the system levels and organ,and what alterations in mitophagy are related to the development of diseases,including neurological,cardiovascular,pulmonary,hepatic,renal disease,etc.,in recent advances.Finally,we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials.Research advances in signaling transduction of mitophagy will have an important role in developing new therapeutic strategies for precision medicine.
基金This study was partly supported by National Natural Science Foundation of China(82041022 to:G Cao)Science and Technology Commission Shanghai Municipality(20JC1410200,20431900404 to:G Cao)Ministry of Science and Technology of the People’s Republic of China(2018ZX10101003-001-003 to:G Cao).
文摘Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19.
基金the National Natural Science Foundation of China(21871272,91956119 and 21521002)the Youth Innovation Promotion Association CAS(2019034)Qingdao University of Science and Technology(QUSTHX201929)。
文摘A new strategy of thermally activated delayed fluorescence(TADF)material-sensitized circularly polarized luminescence(CPL)has been proposed for improving the efficiencies of fluorescent circularly polarized organic lightemitting diodes(OLEDs)(CP-OLEDs).Consequently,a pair of helicene enantiomers,(P)-HAI and(M)-HAI,were synthesized.The helicene enantiomers with the rigid helicalπ-skeleton had highly thermal and enantiomeric stabilities,and they also showed excellent photophysical properties,especially,intense mirror-image CPL activities with large luminescence dissymmetry factor(|g_(lum)|)values of about 6×10^(-3).Notably,the CP-OLEDs with the helicene enantiomers as emitters and a TADF molecule as sensitizer not only displayed better performance of lower turn-on voltage(V_(T))of 2.6 V,four-fold maxmium-external quantum efficiency(EQE_(max))of 5.3%,and lower efficiencies roll-off of 1.9%at 1000 cd m^(-2),than those of the devices without TADF sensitizer,but also exhibited intense circularly polarized electroluminescence(CPEL)with the electroluminescence dissymmetry factor(g_(EL))values of-2.3×10^(-3)and+3.0×10^(-3).Meanwhile,this study also represents the first thermally activated sensitized fluorescent CP-OLEDs with markedly enhanced efficiencies and intense CPEL.
文摘Background：The pro-inflammatory cytokine,interleukin-6 （IL-6）,stimulates the metastasis of several neoplasms.An association of its serum level and the single nucleotide polymorphism （SNP） rs1800795 with neuroblastoma （NB） has been reported in American and Italian cohorts.This study was to clarify whether the same association exists in Chinese children.Methods：A total of 130 NB patients,with 77 boys （59％）,53 girls （41％）,mean age 41 ± 5 months,were assigned to two groups：high risk （HR） versus intermediate-low risk （non-HR）,and 50 healthy children were randomly selected as the age-and gender-matched controls.Peripheral blood samples were analyzed to determine serum IL-6 level using enzyme linked immunosorbent assay and rs1800795 SNPs phenotype using polymerase chain reaction and gene sequencing.Results：There were 87 NB patients in the HR group and 43 NB patients in the non-HR group.A comparison of allele and genotype frequencies of the rs1800795 polymorphism between patients and controls found no association with NB risk （P ＞ 0.05）.The frequency of GG＋GC genotype was higher in HR-NB patients than in non-HR-NB patients （64.4％ vs.48.8％,P =0.02）,and serum IL-6 level was much higher in HR-NB patients with GG＋GC genotype than in HR-NB patients with CC genotype （4.36 ± 1.1 pg/ml vs.1.83 ± 0.5 pg/ml;P =0.02）,but not in Non-HR-NB patients.Conclusions：The polymorphism rs1800795 is associated with serum IL-6 level and level of NB risk.GG genotype might indicate that the tumor is highly malignant （prone to metastasis） and associated with poor prognosis.
