Nanofibers based on cellulose are highly desired due to their remarkable biocompatibility and attractive physical and biochemical characteristics.The current research describes a simple electrospinning process and the...Nanofibers based on cellulose are highly desired due to their remarkable biocompatibility and attractive physical and biochemical characteristics.The current research describes a simple electrospinning process and the nano-materials therefrom,utilizing the classical cellulose-cuprammonium solution without the more exotic chemical solvent combinations.Furthermore,without the use of organic solvents,a binary polymer system with the addition of polyethylene oxide(PEO)is introduced to improve the robustness of the electrospinning and the properties of the final material.The impacts of the cellulose source,cellulose mass fraction and PEO formulation on spinnability,fiber morphology and mechanical properties are investigated.Nanofibers with diameters ranging from 130 nm to 382 nm are successfully fabricated.The presence of copper in the fabricated material is confirmed by using the X-ray photoelectron spectroscopy(XPS)analysis.The cuprammonium process significantly changes the original crystalline structure of cellulose I into celluloseⅢwithin the nanofiber morphology.The nanofibrous membranes also demonstrate notable antibacterial characteristics for Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).展开更多
Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the body.It alternates between inflammation and oxidative stress-mediated injury in various disease models.As part of its limiting func...Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the body.It alternates between inflammation and oxidative stress-mediated injury in various disease models.As part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular level.Taurine effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord injury.Although various therapies are available,effective management of these disorders remains a global challenge.Approximately 30 million people are affected worldwide.The design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders.The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review.This article is a good resource for understanding the general effects of taurine on various diseases.Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.展开更多
基金Foundation items:Key Project of State Key Laboratory of Bio-Fibers and Eco-Textiles of Qingdao University,China(No.RZ2000003348)High Level Talents Research Start-Up Fund,China(No.DC1900000746)+1 种基金China Postdoctoral Science Foundation(No.2024M751568)Shandong Province Postdoctoral Innovation Project,China(No.SDCX-ZG-202400294)。
文摘Nanofibers based on cellulose are highly desired due to their remarkable biocompatibility and attractive physical and biochemical characteristics.The current research describes a simple electrospinning process and the nano-materials therefrom,utilizing the classical cellulose-cuprammonium solution without the more exotic chemical solvent combinations.Furthermore,without the use of organic solvents,a binary polymer system with the addition of polyethylene oxide(PEO)is introduced to improve the robustness of the electrospinning and the properties of the final material.The impacts of the cellulose source,cellulose mass fraction and PEO formulation on spinnability,fiber morphology and mechanical properties are investigated.Nanofibers with diameters ranging from 130 nm to 382 nm are successfully fabricated.The presence of copper in the fabricated material is confirmed by using the X-ray photoelectron spectroscopy(XPS)analysis.The cuprammonium process significantly changes the original crystalline structure of cellulose I into celluloseⅢwithin the nanofiber morphology.The nanofibrous membranes also demonstrate notable antibacterial characteristics for Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).
文摘Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the body.It alternates between inflammation and oxidative stress-mediated injury in various disease models.As part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular level.Taurine effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord injury.Although various therapies are available,effective management of these disorders remains a global challenge.Approximately 30 million people are affected worldwide.The design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders.The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review.This article is a good resource for understanding the general effects of taurine on various diseases.Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.
