For infrared focal plane graded during signal acquisition array sensors, imagery is departicularly nonuniformity. In this paper, an adaptive nonuniformity correction technique is proposed which simultaneously estimate...For infrared focal plane graded during signal acquisition array sensors, imagery is departicularly nonuniformity. In this paper, an adaptive nonuniformity correction technique is proposed which simultaneously estimates detector-level and readout- channel-level correction parameters using neural network approaches. Firstly, an improved neural network framework is designed to compute the desired output. Secondly, an adaptive learning rate rule is used in the gain and offset parameter estimation process. Experimental results show the proposed algorithm can achieve a faster convergence speed and better stability, remove nonuniformity and track parameters drift effectively, and present a good adaptability to scene changes and nonuniformity conditions.展开更多
Background When resuscitating patients with septic shock,cerebrovascular reactivity parameters are calculated by monitoring regional cerebral oxygen saturation(rSO_(2))using near-infrared spectroscopy to determine the...Background When resuscitating patients with septic shock,cerebrovascular reactivity parameters are calculated by monitoring regional cerebral oxygen saturation(rSO_(2))using near-infrared spectroscopy to determine the optimal blood pressure.Here,we aimed to analyze the impact of cerebral autoregulation-directed optimal blood pressure management on the incidence of delirium and the prognosis of patients with septic shock.Methods This prospective randomized controlled clinical study was conducted in the Xiangya Hospital of Central South University,China.Fifty-one patients with septic shock(December 2020–May 2022)were enrolled and randomly allocated to the experimental(n=26)or control group(n=25).Using the ICM+software,we monitored the dynamic changes in rSO_(2) and mean arterial pressure(MAP)and calculated the cerebrovascular reactivity parameter tissue oxygen reactivity index to determine the optimal blood pressure to maintain normal cerebral autoregulation function during resuscitation in the experimental group.The control group was treated according to the Surviving Sepsis Campaign Guidelines.Differences in the incidence of delirium and 28-day mortality between the two groups were compared,and the risk factors were analyzed.Results The 51 patients,including 39 male and 12 female,had a mean age of(57.0±14.9)years.The incidence of delirium was 40.1%(23/51),and the 28-day mortality rate was 29.4%(15/51).The mean MAP during the first 24 h of intensive care unit(ICU)admission was higher([84.5±12.2]mmHg vs.[77.4±11.8]mmHg,P=0.040),and the incidence of delirium was lower(30.8%vs.60.0%,P=0.036)in the experimental group than in the control group.The use of cerebral autoregulation-directed optimal blood pressure(odds ratio[OR]=0.090,95%confidence interval[CI]:0.009 to 0.923,P=0.043)and length of ICU stay(OR=1.473,95%CI:1.093 to 1.985,P=0.011)were risk factors for delirium during septic shock.Vasoactive drug dose(OR=8.445,95%CI:1.26 to 56.576,P=0.028)and partial pressure of oxygen(PaO_(2))(OR=0.958,95%CI:0.921 to 0.996,P=0.032)were the risk factors for 28-day mortality.Conclusions The use of cerebral autoregulation-directed optimal blood pressure management during shock resuscitation reduces the incidence of delirium in patients with septic shock.展开更多
Photonic nanojets(PNJs)are subwavelength jet-like propagating waves generated by illuminating a dielectric microstructure with an electromagnetic wave,conventionally a linearly polarized plane wave.Here,we study the d...Photonic nanojets(PNJs)are subwavelength jet-like propagating waves generated by illuminating a dielectric microstructure with an electromagnetic wave,conventionally a linearly polarized plane wave.Here,we study the donut-like PNJ produced when a circularly polarized vortex beam is used instead.This novel PNJ also has a reverse energy flow at the donut-like focal plane depending on both the optical vortex topological charge and microsphere size.Our tunable PNJ,which we investigate numerically and analytically,can find applications in optical micromanipulation and trapping.展开更多
Background:The coronavirus disease 2019(COVID-19)pandemic is currently threatening the health of individuals worldwide.We compared the clinical characteristics between younger patients(aged<60 years)and older patie...Background:The coronavirus disease 2019(COVID-19)pandemic is currently threatening the health of individuals worldwide.We compared the clinical characteristics between younger patients(aged<60 years)and older patients(aged≥60 years)with COVID-19,detected the risk factors associated with a prolonged hospital stay,and examined the treatments commonly used with a particular focus on antiviral therapies.Methods:This retrospective study was conducted at the West Campus,Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology(Wuhan,China).The sample consisted of 123 patients admitted to the hospital between 9th February,2020,and 3rd March,2020.The data related to the demographics,laboratory findings,and treatment were analyzed to identify discrepancies between younger and older patients and those with and without primary diseases.The risk factors that contribute to a prolonged hospital stay were subsequently identified.Results:Patients aged≥60 years required longer hospital stay than younger patients(P=0.001).The percentage of lymphocytes was significantly lower in older patients and those with primary diseases(P=0.016 and P=0.042,respectively).The findings revealed that the risk factors that contributed to the length of hospital stay were age,the number of days of illness before hospitalization,white blood cell(WBC)count and albumin levels at admission,a neutrophil fraction at discharge,and antibiotic treatment.Analysis using a model that consisted of the above five risk factors for predicting prolonged hospital stay(>14 days)yielded an area under the ROC(AuROC)curve of 0.716.Antiviral and antibiotic treatments were administered to 97.6%and 39.0%of patients,respectively.The antiviral drugs most commonly administered were traditional Chinese medicine(83.7%)and arbidol(75.6%).Conclusions:In this study,older patients and those with primary diseases were at a higher risk of worse clinical manifestations.The physicians who treat the patients should pay close attention to the risk factors that contribute to the length of hospital stay,which could be used for predicting prolonged hospital stay.Traditional Chinese medicine and arbidol were the most frequently used antiviral drugs.Nevertheless,the extent to which these medications can effectively treat COVID-19 warrants further investigation.展开更多
基金supported by the National Natural Science Foundation of China (61101199)the Natural Science Foundation of Jiangsu Province (K2011699)the Colleges and Universities Innovation Projects (CX08B 045Z)
文摘For infrared focal plane graded during signal acquisition array sensors, imagery is departicularly nonuniformity. In this paper, an adaptive nonuniformity correction technique is proposed which simultaneously estimates detector-level and readout- channel-level correction parameters using neural network approaches. Firstly, an improved neural network framework is designed to compute the desired output. Secondly, an adaptive learning rate rule is used in the gain and offset parameter estimation process. Experimental results show the proposed algorithm can achieve a faster convergence speed and better stability, remove nonuniformity and track parameters drift effectively, and present a good adaptability to scene changes and nonuniformity conditions.
基金supported by the National Natural Science Foundation of China(82372199)National Natural Science Foundation of China(81901264,81974285)Clinical Medical Technology Innovation Guidance Project of Hunan Science and Technology Department(2021SK53803).
文摘Background When resuscitating patients with septic shock,cerebrovascular reactivity parameters are calculated by monitoring regional cerebral oxygen saturation(rSO_(2))using near-infrared spectroscopy to determine the optimal blood pressure.Here,we aimed to analyze the impact of cerebral autoregulation-directed optimal blood pressure management on the incidence of delirium and the prognosis of patients with septic shock.Methods This prospective randomized controlled clinical study was conducted in the Xiangya Hospital of Central South University,China.Fifty-one patients with septic shock(December 2020–May 2022)were enrolled and randomly allocated to the experimental(n=26)or control group(n=25).Using the ICM+software,we monitored the dynamic changes in rSO_(2) and mean arterial pressure(MAP)and calculated the cerebrovascular reactivity parameter tissue oxygen reactivity index to determine the optimal blood pressure to maintain normal cerebral autoregulation function during resuscitation in the experimental group.The control group was treated according to the Surviving Sepsis Campaign Guidelines.Differences in the incidence of delirium and 28-day mortality between the two groups were compared,and the risk factors were analyzed.Results The 51 patients,including 39 male and 12 female,had a mean age of(57.0±14.9)years.The incidence of delirium was 40.1%(23/51),and the 28-day mortality rate was 29.4%(15/51).The mean MAP during the first 24 h of intensive care unit(ICU)admission was higher([84.5±12.2]mmHg vs.[77.4±11.8]mmHg,P=0.040),and the incidence of delirium was lower(30.8%vs.60.0%,P=0.036)in the experimental group than in the control group.The use of cerebral autoregulation-directed optimal blood pressure(odds ratio[OR]=0.090,95%confidence interval[CI]:0.009 to 0.923,P=0.043)and length of ICU stay(OR=1.473,95%CI:1.093 to 1.985,P=0.011)were risk factors for delirium during septic shock.Vasoactive drug dose(OR=8.445,95%CI:1.26 to 56.576,P=0.028)and partial pressure of oxygen(PaO_(2))(OR=0.958,95%CI:0.921 to 0.996,P=0.032)were the risk factors for 28-day mortality.Conclusions The use of cerebral autoregulation-directed optimal blood pressure management during shock resuscitation reduces the incidence of delirium in patients with septic shock.
基金supported by the National Key R&D Program of China(Nos.2018YFA0306200 and 2017YFA0303700)the National Natural Science Foundation of China(NSFC)(Nos.91750202,61805119,61604073,and 11404170)+1 种基金the Natural Science Foundation of Jiangsu Province of China(Nos.BK20160839 and BK20180469)the Scientific Research Project of Nanjing University of Posts and Telecommunications(No.NY219045)。
文摘Photonic nanojets(PNJs)are subwavelength jet-like propagating waves generated by illuminating a dielectric microstructure with an electromagnetic wave,conventionally a linearly polarized plane wave.Here,we study the donut-like PNJ produced when a circularly polarized vortex beam is used instead.This novel PNJ also has a reverse energy flow at the donut-like focal plane depending on both the optical vortex topological charge and microsphere size.Our tunable PNJ,which we investigate numerically and analytically,can find applications in optical micromanipulation and trapping.
基金supported by the Natural Science Founda-tion of Hunan Province(Grant Number:2020JJ5918 awarded to Qian-Yi Peng)the National Natural Science Foundation of China(Grant Number:81974285 awarded to Qian-Yi Peng)the National Natural Science Foundation of China(Grant Num-ber:81873956 awarded to Li-Na Zhang).
文摘Background:The coronavirus disease 2019(COVID-19)pandemic is currently threatening the health of individuals worldwide.We compared the clinical characteristics between younger patients(aged<60 years)and older patients(aged≥60 years)with COVID-19,detected the risk factors associated with a prolonged hospital stay,and examined the treatments commonly used with a particular focus on antiviral therapies.Methods:This retrospective study was conducted at the West Campus,Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology(Wuhan,China).The sample consisted of 123 patients admitted to the hospital between 9th February,2020,and 3rd March,2020.The data related to the demographics,laboratory findings,and treatment were analyzed to identify discrepancies between younger and older patients and those with and without primary diseases.The risk factors that contribute to a prolonged hospital stay were subsequently identified.Results:Patients aged≥60 years required longer hospital stay than younger patients(P=0.001).The percentage of lymphocytes was significantly lower in older patients and those with primary diseases(P=0.016 and P=0.042,respectively).The findings revealed that the risk factors that contributed to the length of hospital stay were age,the number of days of illness before hospitalization,white blood cell(WBC)count and albumin levels at admission,a neutrophil fraction at discharge,and antibiotic treatment.Analysis using a model that consisted of the above five risk factors for predicting prolonged hospital stay(>14 days)yielded an area under the ROC(AuROC)curve of 0.716.Antiviral and antibiotic treatments were administered to 97.6%and 39.0%of patients,respectively.The antiviral drugs most commonly administered were traditional Chinese medicine(83.7%)and arbidol(75.6%).Conclusions:In this study,older patients and those with primary diseases were at a higher risk of worse clinical manifestations.The physicians who treat the patients should pay close attention to the risk factors that contribute to the length of hospital stay,which could be used for predicting prolonged hospital stay.Traditional Chinese medicine and arbidol were the most frequently used antiviral drugs.Nevertheless,the extent to which these medications can effectively treat COVID-19 warrants further investigation.
