Medicinal plants represent a huge reservoir of secondary metabolites(SMs),substances with significant pharmaceutical and industrial potential.However,obtaining secondary metabolites remains a challenge due to their lo...Medicinal plants represent a huge reservoir of secondary metabolites(SMs),substances with significant pharmaceutical and industrial potential.However,obtaining secondary metabolites remains a challenge due to their low-yield accumulation in medicinal plants;moreover,these secondary metabolites are produced through tightly coordinated pathways involving many spatiotemporally and environmentally regulated steps.The first regulatory layer involves a complex network of transcription factors;a second,more recently discovered layer of complexity in the regulation of SMs is epigenetic modification,such as DNA methylation,histone modification and small RNA-based mechanisms,which can jointly or separately influence secondary metabolites by regulating gene expression.Here,we summarize the findings in the fields of genetic and epigenetic regulation with a special emphasis on SMs in medicinal plants,providing a new perspective on the multiple layers of regulation of gene expression.展开更多
Natural product biosynthesis in medicinal plants has always been a research focus in biology.Terpenoids,phenolics,and alkaloids,all of which have medicinal value for humans,are the three most prominent natural product...Natural product biosynthesis in medicinal plants has always been a research focus in biology.Terpenoids,phenolics,and alkaloids,all of which have medicinal value for humans,are the three most prominent natural products found in medicinal plants(Cravens et al.2019;Li et al.2023;Zhao et al.2023).Many medicinal plants produce natural products that have special biological functions,such as regulating plant growth and resisting stress.展开更多
基金Open access funding provided by Shanghai Jiao Tong Universitysupported by the National Natural Science Foundation of China(No.81960691 to Y.Z.,81760694 to Y.Z.,31971543 to Y.L.,32260095 to G.L.)+2 种基金Yunnan Characteristic Plant Extraction Laboratory(2022YKZY001 to S.Y.)the Major Special Science and Technology Project of Yunnan Province(No.202102AA310031 to Y.L.)Yunnan Province Youth Talent Support Program(No.YNWR-QNBJ-2018-324 to L.Y.,XDYCQNRC-2022-0219 to Y.Z.).
文摘Medicinal plants represent a huge reservoir of secondary metabolites(SMs),substances with significant pharmaceutical and industrial potential.However,obtaining secondary metabolites remains a challenge due to their low-yield accumulation in medicinal plants;moreover,these secondary metabolites are produced through tightly coordinated pathways involving many spatiotemporally and environmentally regulated steps.The first regulatory layer involves a complex network of transcription factors;a second,more recently discovered layer of complexity in the regulation of SMs is epigenetic modification,such as DNA methylation,histone modification and small RNA-based mechanisms,which can jointly or separately influence secondary metabolites by regulating gene expression.Here,we summarize the findings in the fields of genetic and epigenetic regulation with a special emphasis on SMs in medicinal plants,providing a new perspective on the multiple layers of regulation of gene expression.
基金supported by the National Natural Science Foundation of China(No.81960691 to Y.Z.81760694 to Y.Z.)+1 种基金Yunnan Characteristic Plant Extraction Laboratory(2022YKZY001 to S.Y.)Yunnan Province Youth Talent Support Program(XDYC-QNRC-2022-0219 to Y.Z.).
文摘Natural product biosynthesis in medicinal plants has always been a research focus in biology.Terpenoids,phenolics,and alkaloids,all of which have medicinal value for humans,are the three most prominent natural products found in medicinal plants(Cravens et al.2019;Li et al.2023;Zhao et al.2023).Many medicinal plants produce natural products that have special biological functions,such as regulating plant growth and resisting stress.
