Recently,immunotherapy has redefined cancer treatment by promoting the rapid killing of tumor cells through the immune system.Herbal medicines have been increasingly used as adjunct therapies to complement cancer trea...Recently,immunotherapy has redefined cancer treatment by promoting the rapid killing of tumor cells through the immune system.Herbal medicines have been increasingly used as adjunct therapies to complement cancer treatment along with chemotherapy and radiotherapy to delay tumor development,reduce pain,and prolong patient survival.However,the potential immunotherapeutic effects of these herbal derivatives are limited by their structural instability,poor membrane permeability,and low bioavailability.To address this issue,nanotechnology has been used to enhance the activity of active compounds.Therefore,this review focuses on the effectiveness of the active ingredients of herbal medicines in suppressing tumor progression by modulating both the innate and adaptive immune systems,challenges in their delivery,and the application of nanocarriers for the effective delivery of these herbal components.展开更多
基金the National Natural Science Foundation of China(82260695,82360781)the Jiangxi Provincial Natural Science Foundation(20232ACB206062)+4 种基金Jiangxi Provincial Department of Education(GJJ2400823)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202207)Young Jinggang Scholar of Jiangxi Province(Jing Zhang)and New Century Talents Project of Jiangxi Province(2017082,Xiang Li and 2020028,Jing Zhang)the Science and Technology Innovation Team of Jiangxi University of Chinese Medicine(CXTD22001 and CXTD22006)Jiangxi University of Traditional Chinese Medicine Special Zone Construction Project of Traditional Chinese Medicine(New Drug Creation Direction)(TQ-20).
文摘Recently,immunotherapy has redefined cancer treatment by promoting the rapid killing of tumor cells through the immune system.Herbal medicines have been increasingly used as adjunct therapies to complement cancer treatment along with chemotherapy and radiotherapy to delay tumor development,reduce pain,and prolong patient survival.However,the potential immunotherapeutic effects of these herbal derivatives are limited by their structural instability,poor membrane permeability,and low bioavailability.To address this issue,nanotechnology has been used to enhance the activity of active compounds.Therefore,this review focuses on the effectiveness of the active ingredients of herbal medicines in suppressing tumor progression by modulating both the innate and adaptive immune systems,challenges in their delivery,and the application of nanocarriers for the effective delivery of these herbal components.
