Background Weaning causes redox dyshomeostasis in piglets,which leads to hepatic oxidative damage.Microbederived antioxidants(MA)have great potential for anti-oxidat ion.This study aimed to investigate changes in hepa...Background Weaning causes redox dyshomeostasis in piglets,which leads to hepatic oxidative damage.Microbederived antioxidants(MA)have great potential for anti-oxidat ion.This study aimed to investigate changes in hepatic redox system,mitochondrial function and apoptosis after weaning,and effects of MA on growth performance and liver health in weaning piglets.Methods This study consisted of 2 experimets.In the both experiments,piglets were weaned at 21 days of age.In Exp.1,at 21(W0),22(W1),25(W4),28(W7),and 35(W14)days of age,6 piglets were slaughtered at each timepoint.In Exp.2,piglets were divided into 2 groups:one received MA gavage(MA)and the other received saline gavage(CON).At 25 days of age,6 piglets from each group were sacrificed.Results In Exp.1,weaning caused growth inhibition and liver developmental retardation from W0 to W4.The mRNA sequencing between W0 and W4 revealed that pathways related to"regulation of apoptotic process"and"reactive oxygen species metabolic process"were enriched.Further study showed that weaning led to higher hepatic content of reactive oxygen species(ROS),H_(2)O_(2) and O_(2)~-.Weaning enhanced mitochondrial fission and suppressed their fusion,activated mitophagy,thus triggering cell apoptosis.In Exp.2,MA improved growth performance of piglets with higher average daily gain(ADG)and average daily feed intake(ADFI).The hepatic ROS,as well as products of oxidative damage malonaldehyde(MDA)and 8-hydroxy-2'-deoxyguanosine(8-OHdG)in the MA group decreased significantly than that of the CON group.The MA elevated mitochondrial membrane potential,increased activity of mitochondrial respiratory chain complexes(MRC)ⅠandⅣ,enhanced mitochondrial fusion and reduced mitophagy thus decreasing cell apoptosis.Conclusions The present study showed that MA improved the growth performance of weaning piglets and reversed weaning-induced oxidative damage,mitochondrial dysfunction,and apoptosis.Our results suggested that MA had promising prospects for maintaining liver health in weaning piglets and provided a reference for studies of liver diseases in humans.展开更多
As a promising graphene analogue,two-dimensional(2D)polymer nanosheets with unique 2D features,diversified topological structures and as well as tunable electronic properties,have received extensive attention in recen...As a promising graphene analogue,two-dimensional(2D)polymer nanosheets with unique 2D features,diversified topological structures and as well as tunable electronic properties,have received extensive attention in recent years.Here in this review,we summarized the recent research progress in the preparation methods of 2D polymer nanosheets,mainly including interfacial polymerization and solution polymerization.We also discussed the recent research advancements of 2D polymer nanosheets in the fields of energy storage and conversion applications,such as batteries,supercapacitors,electrocatalysis and photocatalysis.Finally,on the basis of their current development,we put forward the existing challenges and some personal perspectives.展开更多
The development of solid-state electrolytes(SSEs)with high ionic conductivity,outstanding electrochemical window,and promising mechanical strength is a key factor in realizing the commercialization of high energy dens...The development of solid-state electrolytes(SSEs)with high ionic conductivity,outstanding electrochemical window,and promising mechanical strength is a key factor in realizing the commercialization of high energy density solid-state lithium metal batteries(LMBs).Covalent organic frameworks(COFs)are a functional crystalline material with highly customizable molecular networks and one-dimensional channel structures,thus showing great potential applications in SSEs.Herein,we design flexible COF-poly(vinyl ethylene carbonate)(PVEC)(abbreviated as COF-PVEC)composite electrolyte films with excellent ionic conductivity and high mechanical strength,enabling dendrite-free and long-term running solid-state LMBs.Owing to the lithiumphilic triazine and carbon–carbon double bonds groups in the COF skeleton,the obtained flexible COF-PVEC shows high ionic conductivity up to 1.11×10^(−4)S·cm^(−1)at 40℃,and enlarged electrochemical window up to 4.6 V(vs.Li^(+)/Li)compared with pure PVEC electrolyte.At the same time,the lithium dendrites are efficiently inhibited after discharge–charging cycles,due to the improved Young’s modulus(150 MPa)and ordered channels of COF.Using the various features of COF-PVEC,we assembled a solid-state full battery with LiFePO4 cathode,which showed superior rate capacity(151.8,146.2,139.2,128.1,113.7,and 100.8 mAh·g^(−1)at 0.1,0.2,0.5,1,1.5,and 2 C,respectively)and excellent long-term cycling stability(over 400 cycles at 1 C).We believe that the COF-based composite electrolyte can become one of the most promising high-performance SSEs for solid-state LMBs.展开更多
Expanding the structural diversity of crystalline two-dimensional polymers(2DPs) is highly desired but remains a considerable challenge. Herein we report the first synthesis of novel crystalline secondary amine-linked...Expanding the structural diversity of crystalline two-dimensional polymers(2DPs) is highly desired but remains a considerable challenge. Herein we report the first synthesis of novel crystalline secondary amine-linked triazine-based 2DPs(SAT-2DPs) by using benzidine or 4, 4′′-diamino-p-terphenyl and cyanuric chloride under solvothermal conditions. We find the structures of diamine-based monomers play a crucial role in deciding whether the synthesized material is crystalline 2DPs nanosheets or amorphous nanoparticles, which is unexpected and provides an important understanding of the 2D polymerization mechanism.The obtained SAT-2DPs not only show a lateral size of micrometers and an ultrathin thickness of a few nanometers, but also demonstrate high crystallinity with a unique ABC stacking configuration, excellent solvent dispersibility and superior thermal stability. In addition, the resultant SAT-2DPs are used to guide uniform lithium-ion deposition due to their abundant nitrogen atoms and ordered open channels. The assembled asymmetric coin cells(Li|Cu) with SAT-2DPs realize the average coulombic efficient up to 99.3% during discharge-charge cycles. This work provides valuable insights into the synthesis of new 2DPs for various applications.展开更多
基金supported by the National Natural Science Foundation of China(Gant no.32272903)。
文摘Background Weaning causes redox dyshomeostasis in piglets,which leads to hepatic oxidative damage.Microbederived antioxidants(MA)have great potential for anti-oxidat ion.This study aimed to investigate changes in hepatic redox system,mitochondrial function and apoptosis after weaning,and effects of MA on growth performance and liver health in weaning piglets.Methods This study consisted of 2 experimets.In the both experiments,piglets were weaned at 21 days of age.In Exp.1,at 21(W0),22(W1),25(W4),28(W7),and 35(W14)days of age,6 piglets were slaughtered at each timepoint.In Exp.2,piglets were divided into 2 groups:one received MA gavage(MA)and the other received saline gavage(CON).At 25 days of age,6 piglets from each group were sacrificed.Results In Exp.1,weaning caused growth inhibition and liver developmental retardation from W0 to W4.The mRNA sequencing between W0 and W4 revealed that pathways related to"regulation of apoptotic process"and"reactive oxygen species metabolic process"were enriched.Further study showed that weaning led to higher hepatic content of reactive oxygen species(ROS),H_(2)O_(2) and O_(2)~-.Weaning enhanced mitochondrial fission and suppressed their fusion,activated mitophagy,thus triggering cell apoptosis.In Exp.2,MA improved growth performance of piglets with higher average daily gain(ADG)and average daily feed intake(ADFI).The hepatic ROS,as well as products of oxidative damage malonaldehyde(MDA)and 8-hydroxy-2'-deoxyguanosine(8-OHdG)in the MA group decreased significantly than that of the CON group.The MA elevated mitochondrial membrane potential,increased activity of mitochondrial respiratory chain complexes(MRC)ⅠandⅣ,enhanced mitochondrial fusion and reduced mitophagy thus decreasing cell apoptosis.Conclusions The present study showed that MA improved the growth performance of weaning piglets and reversed weaning-induced oxidative damage,mitochondrial dysfunction,and apoptosis.Our results suggested that MA had promising prospects for maintaining liver health in weaning piglets and provided a reference for studies of liver diseases in humans.
基金the National Natural Science Foundation of China(Nos.51873039 and 51673042)the Young Elite Scientist Sponsorship Program by CAST(No.2017QNRC001)the fund for post-doctoral program of Henan University to Z.H.C.(No.FJ3050A0670001).
文摘As a promising graphene analogue,two-dimensional(2D)polymer nanosheets with unique 2D features,diversified topological structures and as well as tunable electronic properties,have received extensive attention in recent years.Here in this review,we summarized the recent research progress in the preparation methods of 2D polymer nanosheets,mainly including interfacial polymerization and solution polymerization.We also discussed the recent research advancements of 2D polymer nanosheets in the fields of energy storage and conversion applications,such as batteries,supercapacitors,electrocatalysis and photocatalysis.Finally,on the basis of their current development,we put forward the existing challenges and some personal perspectives.
基金the National Natural Science Foundation of China(Nos.22022510,51873039,and 21374106)the National Key Research and Development Program of China(No.2018YFD0400700).
文摘The development of solid-state electrolytes(SSEs)with high ionic conductivity,outstanding electrochemical window,and promising mechanical strength is a key factor in realizing the commercialization of high energy density solid-state lithium metal batteries(LMBs).Covalent organic frameworks(COFs)are a functional crystalline material with highly customizable molecular networks and one-dimensional channel structures,thus showing great potential applications in SSEs.Herein,we design flexible COF-poly(vinyl ethylene carbonate)(PVEC)(abbreviated as COF-PVEC)composite electrolyte films with excellent ionic conductivity and high mechanical strength,enabling dendrite-free and long-term running solid-state LMBs.Owing to the lithiumphilic triazine and carbon–carbon double bonds groups in the COF skeleton,the obtained flexible COF-PVEC shows high ionic conductivity up to 1.11×10^(−4)S·cm^(−1)at 40℃,and enlarged electrochemical window up to 4.6 V(vs.Li^(+)/Li)compared with pure PVEC electrolyte.At the same time,the lithium dendrites are efficiently inhibited after discharge–charging cycles,due to the improved Young’s modulus(150 MPa)and ordered channels of COF.Using the various features of COF-PVEC,we assembled a solid-state full battery with LiFePO4 cathode,which showed superior rate capacity(151.8,146.2,139.2,128.1,113.7,and 100.8 mAh·g^(−1)at 0.1,0.2,0.5,1,1.5,and 2 C,respectively)and excellent long-term cycling stability(over 400 cycles at 1 C).We believe that the COF-based composite electrolyte can become one of the most promising high-performance SSEs for solid-state LMBs.
基金support by the National Natural Science Foundation of China (51873039, 51673042)the Young Elite Scientist Sponsorship Program by CAST (2017QNRC001)。
文摘Expanding the structural diversity of crystalline two-dimensional polymers(2DPs) is highly desired but remains a considerable challenge. Herein we report the first synthesis of novel crystalline secondary amine-linked triazine-based 2DPs(SAT-2DPs) by using benzidine or 4, 4′′-diamino-p-terphenyl and cyanuric chloride under solvothermal conditions. We find the structures of diamine-based monomers play a crucial role in deciding whether the synthesized material is crystalline 2DPs nanosheets or amorphous nanoparticles, which is unexpected and provides an important understanding of the 2D polymerization mechanism.The obtained SAT-2DPs not only show a lateral size of micrometers and an ultrathin thickness of a few nanometers, but also demonstrate high crystallinity with a unique ABC stacking configuration, excellent solvent dispersibility and superior thermal stability. In addition, the resultant SAT-2DPs are used to guide uniform lithium-ion deposition due to their abundant nitrogen atoms and ordered open channels. The assembled asymmetric coin cells(Li|Cu) with SAT-2DPs realize the average coulombic efficient up to 99.3% during discharge-charge cycles. This work provides valuable insights into the synthesis of new 2DPs for various applications.
