Magnetically responsive scaffolds are extensively utilized in tissue engineering for their ability to simulate dynamic three-dimensional(3D)cell microenvironment in a rapid,reversible,and contactless manner.However,ex...Magnetically responsive scaffolds are extensively utilized in tissue engineering for their ability to simulate dynamic three-dimensional(3D)cell microenvironment in a rapid,reversible,and contactless manner.However,existing magnetic scaffolds struggle to provide tunable dynamic compression comparable to natural tissues due to the weak magnetism of magnetic nanoparticles and the mechanical brittleness of hydrogels.Here,we propose a biomimetic 3D magnetic scaffold offering tunable and stable magnetically induced compression for dynamic 3D cell culture.By employing hard magnetic particles NdFeB@SiO_(2) and a mechanically stable elastomer,Ecoflex,the scaffold achieves 15%compression in the magnetic field(240 mT).Moreover,this magnetic scaffold demonstrates remarkable deformation and mechanical stability during 4000 compression cycles.The magnetic scaffold exhibits stiffness(0.78 kPa)and viscoelasticity(relaxation time of 17 s)similar to adipose tissue.Notably,it is verified that human adipose-derived stem cells(hADSCs)are successfully cultured in this magnetic scaffold and the proliferation of hADSCs can be modulated by magnetically induced dynamic compression.This magnetic scaffold for dynamic 3D cell culture can be potentially utilized in cell biology and tissue engineering.展开更多
Introducing the top partner is a common way to cancel the largest quadratically divergent contribution to the Higgs mass induced by the top quark. In this work, we study single top partner production in the tZ channel...Introducing the top partner is a common way to cancel the largest quadratically divergent contribution to the Higgs mass induced by the top quark. In this work, we study single top partner production in the tZ channel at eγ collision in the littlest Higgs model with T-parity(LHT). Since it is well known that polarized beams can enhance the cross section, we analyze the signal via polarized electron beams,and photon beams. we have selected two decay modes for comparison, based on the leptonic or the hadronic decays of the W and Z from the top partner. We then construct a detailed detector simulation, and choose a set of cuts to enhance signal significance. For mode A(B), the capacity for exclusion in this process at s1/2=3TeV is comparable to the current experimental limits with L=1000(500) fb-1. If the integrated luminosity can be increased to 3000 fb-1, the top partner mass+mTcan be excluded up to 1350(1440) GeV at 2σ level. We also considered the initial state radiation effect, and find that this effect reduces the excluding ability of the eγ collision on the the top partner mass by approximately 10 GeV. Moreover, the ability to exclude the LHT parameter space at eγ collision complements the existing research.展开更多
In this paper, we give interior gradient and Hessian estimates for systems of semi-linear degenerate elliptic partial differential equations on bounded domains, using both tools of backward stochastic differential equ...In this paper, we give interior gradient and Hessian estimates for systems of semi-linear degenerate elliptic partial differential equations on bounded domains, using both tools of backward stochastic differential equations and quasi-derivatives.展开更多
Liver fibrosis is typically caused by chronic viral hepatitis and,more recently,fatty liver disease associated with obesity.There are currently no approved drugs for liver cirrhosis,and liver transplantation is limite...Liver fibrosis is typically caused by chronic viral hepatitis and,more recently,fatty liver disease associated with obesity.There are currently no approved drugs for liver cirrhosis,and liver transplantation is limited by donor scarcity,thus driving the investigation of novel therapeutic strategies.The development of liver fibrosis presents with stage-and zone-dependent characteristics that manifest as distinct dynamic changes during vascularization and extracellular matrix(ECM)deposition.However,current cellular therapies do not consider the spatiotem-poral variations of liver fibrosis without identifying the precise location and stage to administer the intervention to achieve optimal therapeutic effects.Herein,we focus on endothelial cell(EC)and macrophage therapy for liver fibrosis because of their important roles in regulating the spatiotemporal changes of vascularization and ECM deposition during liver fibrosis progression.Overall,this review summarizes the stage-dependent EC and macrophage therapy for liver fibrosis,elucidates their respective mechanisms,and exemplifies potential strategies to realize precise cell therapy by targeting specific liver zones.展开更多
基金supported by the CAMS Innovation Fund for Medical Sciences (2021-I2M-1-052)。
文摘Magnetically responsive scaffolds are extensively utilized in tissue engineering for their ability to simulate dynamic three-dimensional(3D)cell microenvironment in a rapid,reversible,and contactless manner.However,existing magnetic scaffolds struggle to provide tunable dynamic compression comparable to natural tissues due to the weak magnetism of magnetic nanoparticles and the mechanical brittleness of hydrogels.Here,we propose a biomimetic 3D magnetic scaffold offering tunable and stable magnetically induced compression for dynamic 3D cell culture.By employing hard magnetic particles NdFeB@SiO_(2) and a mechanically stable elastomer,Ecoflex,the scaffold achieves 15%compression in the magnetic field(240 mT).Moreover,this magnetic scaffold demonstrates remarkable deformation and mechanical stability during 4000 compression cycles.The magnetic scaffold exhibits stiffness(0.78 kPa)and viscoelasticity(relaxation time of 17 s)similar to adipose tissue.Notably,it is verified that human adipose-derived stem cells(hADSCs)are successfully cultured in this magnetic scaffold and the proliferation of hADSCs can be modulated by magnetically induced dynamic compression.This magnetic scaffold for dynamic 3D cell culture can be potentially utilized in cell biology and tissue engineering.
基金supported by the National Natural Science Foundation of China(NNSFC)under grant No.11405047。
文摘Introducing the top partner is a common way to cancel the largest quadratically divergent contribution to the Higgs mass induced by the top quark. In this work, we study single top partner production in the tZ channel at eγ collision in the littlest Higgs model with T-parity(LHT). Since it is well known that polarized beams can enhance the cross section, we analyze the signal via polarized electron beams,and photon beams. we have selected two decay modes for comparison, based on the leptonic or the hadronic decays of the W and Z from the top partner. We then construct a detailed detector simulation, and choose a set of cuts to enhance signal significance. For mode A(B), the capacity for exclusion in this process at s1/2=3TeV is comparable to the current experimental limits with L=1000(500) fb-1. If the integrated luminosity can be increased to 3000 fb-1, the top partner mass+mTcan be excluded up to 1350(1440) GeV at 2σ level. We also considered the initial state radiation effect, and find that this effect reduces the excluding ability of the eγ collision on the the top partner mass by approximately 10 GeV. Moreover, the ability to exclude the LHT parameter space at eγ collision complements the existing research.
基金supported by National Natural Science Foundation of China(Grant No.11631004)Science and Technology Commission of Shanghai Municipality(Grant No.14XD1400400)
文摘In this paper, we give interior gradient and Hessian estimates for systems of semi-linear degenerate elliptic partial differential equations on bounded domains, using both tools of backward stochastic differential equations and quasi-derivatives.
文摘Liver fibrosis is typically caused by chronic viral hepatitis and,more recently,fatty liver disease associated with obesity.There are currently no approved drugs for liver cirrhosis,and liver transplantation is limited by donor scarcity,thus driving the investigation of novel therapeutic strategies.The development of liver fibrosis presents with stage-and zone-dependent characteristics that manifest as distinct dynamic changes during vascularization and extracellular matrix(ECM)deposition.However,current cellular therapies do not consider the spatiotem-poral variations of liver fibrosis without identifying the precise location and stage to administer the intervention to achieve optimal therapeutic effects.Herein,we focus on endothelial cell(EC)and macrophage therapy for liver fibrosis because of their important roles in regulating the spatiotemporal changes of vascularization and ECM deposition during liver fibrosis progression.Overall,this review summarizes the stage-dependent EC and macrophage therapy for liver fibrosis,elucidates their respective mechanisms,and exemplifies potential strategies to realize precise cell therapy by targeting specific liver zones.
