Objective: To investigate the effect of mucosolvan combined with fiberoptic bronchoscopy on respiratory function, inflammatory response and stress state in patients with severe pneumonia. Methods: From January 2017 to...Objective: To investigate the effect of mucosolvan combined with fiberoptic bronchoscopy on respiratory function, inflammatory response and stress state in patients with severe pneumonia. Methods: From January 2017 to June 2018, 82 patients with severe pneumonia were randomly divided into observation group and control group (all 41 cases). Patients in the control group received conventional anti-infective treatment, and the observation group was treated with fiberoptic bronchoscopy combined with mucosolvan on the basis of the control group. Respiratory function, inflammatory response and stress status were compared between the two groups. Results: Before treatment, there was no significant difference in Cdyn, WOB and PaO2/FiO2 between the two groups. After treatment, Cdyn and PaO2/FiO2 in the observation group were (36.28±4.28) mL/cmH2O and (376.23±24.21) mmHg respectively, while those in the control group were (26.89±3.76) mL/cmH2O and (322.12±23.16) mmHg, respectively. The levels of Cdyn and PaO2/FiO2 in the observation group were higher than those in the control group. After treatment, the WOB in the observation group was (7.81±0.72) J/L, and the WOB in the control group was (8.33±1.23) J/L. WOB of both groups was lower than that before treatment, and in observation group WOB was lower than that of control group, the difference was statistically significant. In CRP, PCT and sTREM-1 levels, there was no significant difference between the two groups before treatment. After treatment, CRP, PCT and sTREM-1 in the observation group were (39.10±6.03) mg/L, (14.57±2.05) ng/L, (15.02±3.02) ng/L respectively, while those in the control group were (59.72±8.81) mg/L, (20.03±3.09) ng/L, (34.21±5.28) ng/L, respectively. CRP, PCT, sTREM-1 in both groups were lower than those before treatment, and CRP, PCT, sTREM-1 in observation group were lower than those in control group. Before treatment, there was no significant difference with Cor, Ang-I and Ang-II in two groups. After treatment, the levels of Cor, Ang-I and Ang-II in the observation group were (114.76±15.85) ng/mL, (6.72±0.64) ng/mL, (27.28±3.43) ng/mL respectively, while those in the control group were (193.15±22.64) ng/mL, (12.10±1.68) ng/mL, (43.02±5.57) ng/mL, respectively. In the observation group, the levels of Cor, Ang-I and Ang-II were lower than those in the control group. Conclusion: Mucosolvan combined with fiberoptic bronchoscopy can effectively improve the respiratory function of patients with severe pneumonia, and reduce inflammation and stress state of the body.展开更多
Objective:To explore the effects of intensive insulin therapy on immune function, inflammatory markers, matrix metalloproteinase and stress response in patients with severe pneumonia.Methods: From January 2016 to Dece...Objective:To explore the effects of intensive insulin therapy on immune function, inflammatory markers, matrix metalloproteinase and stress response in patients with severe pneumonia.Methods: From January 2016 to December 2017, 80 cases of severe pneumonia in ICU of our hospital were selected as the subjects of this study, according to the principle of randomization, they were divided into control group (40 cases) and observation group (40 cases). The control group was given routine insulin + routine treatment, and the observation group was given insulin intensification + routine treatment. The changes of immune function, inflammation index, matrix metalloproteinase and stress level were compared between the two groups before and after treatment.Results: After treatment, the levels of IgA, IgG and IgM in the two groups were significantly higher than those before treatment, and the levels of IgA, IgG and IgM in the observation group were significantly higher than those in the control group;the levels of TNF-α, sTREM1 and CRP in the two groups were significantly lower than those before treatment, and the levels of TNF-α, sTREM1 and CRP in the observation group were significantly lower than those in the control group;the levels of TIMP-1, MMP-9 and MMP-9/TIMP-1 in the two groups were significantly lower than those before treatment, and the levels of TIMP-1, MMP-9 and MMP-9/TIMP-1 in the observation group were significantly lower than those in the control group;the levels of SF and LPO in the two groups were significantly lower than those before treatment, while the levels of SOD in the observation group were significantly higher than those before treatment, and the levels of SF and LPO in the observation group were significantly lower than those in the control group, while the levels of SOD in the observation group were significantly higher than those in the control group. Conclusions:Intensive insulin therapy can effectively improve the immune function of severe pneumonia patients, reduce their inflammatory reaction, matrix metalloproteinase levels and oxidative stress injury.展开更多
文摘Objective: To investigate the effect of mucosolvan combined with fiberoptic bronchoscopy on respiratory function, inflammatory response and stress state in patients with severe pneumonia. Methods: From January 2017 to June 2018, 82 patients with severe pneumonia were randomly divided into observation group and control group (all 41 cases). Patients in the control group received conventional anti-infective treatment, and the observation group was treated with fiberoptic bronchoscopy combined with mucosolvan on the basis of the control group. Respiratory function, inflammatory response and stress status were compared between the two groups. Results: Before treatment, there was no significant difference in Cdyn, WOB and PaO2/FiO2 between the two groups. After treatment, Cdyn and PaO2/FiO2 in the observation group were (36.28±4.28) mL/cmH2O and (376.23±24.21) mmHg respectively, while those in the control group were (26.89±3.76) mL/cmH2O and (322.12±23.16) mmHg, respectively. The levels of Cdyn and PaO2/FiO2 in the observation group were higher than those in the control group. After treatment, the WOB in the observation group was (7.81±0.72) J/L, and the WOB in the control group was (8.33±1.23) J/L. WOB of both groups was lower than that before treatment, and in observation group WOB was lower than that of control group, the difference was statistically significant. In CRP, PCT and sTREM-1 levels, there was no significant difference between the two groups before treatment. After treatment, CRP, PCT and sTREM-1 in the observation group were (39.10±6.03) mg/L, (14.57±2.05) ng/L, (15.02±3.02) ng/L respectively, while those in the control group were (59.72±8.81) mg/L, (20.03±3.09) ng/L, (34.21±5.28) ng/L, respectively. CRP, PCT, sTREM-1 in both groups were lower than those before treatment, and CRP, PCT, sTREM-1 in observation group were lower than those in control group. Before treatment, there was no significant difference with Cor, Ang-I and Ang-II in two groups. After treatment, the levels of Cor, Ang-I and Ang-II in the observation group were (114.76±15.85) ng/mL, (6.72±0.64) ng/mL, (27.28±3.43) ng/mL respectively, while those in the control group were (193.15±22.64) ng/mL, (12.10±1.68) ng/mL, (43.02±5.57) ng/mL, respectively. In the observation group, the levels of Cor, Ang-I and Ang-II were lower than those in the control group. Conclusion: Mucosolvan combined with fiberoptic bronchoscopy can effectively improve the respiratory function of patients with severe pneumonia, and reduce inflammation and stress state of the body.
文摘Objective:To explore the effects of intensive insulin therapy on immune function, inflammatory markers, matrix metalloproteinase and stress response in patients with severe pneumonia.Methods: From January 2016 to December 2017, 80 cases of severe pneumonia in ICU of our hospital were selected as the subjects of this study, according to the principle of randomization, they were divided into control group (40 cases) and observation group (40 cases). The control group was given routine insulin + routine treatment, and the observation group was given insulin intensification + routine treatment. The changes of immune function, inflammation index, matrix metalloproteinase and stress level were compared between the two groups before and after treatment.Results: After treatment, the levels of IgA, IgG and IgM in the two groups were significantly higher than those before treatment, and the levels of IgA, IgG and IgM in the observation group were significantly higher than those in the control group;the levels of TNF-α, sTREM1 and CRP in the two groups were significantly lower than those before treatment, and the levels of TNF-α, sTREM1 and CRP in the observation group were significantly lower than those in the control group;the levels of TIMP-1, MMP-9 and MMP-9/TIMP-1 in the two groups were significantly lower than those before treatment, and the levels of TIMP-1, MMP-9 and MMP-9/TIMP-1 in the observation group were significantly lower than those in the control group;the levels of SF and LPO in the two groups were significantly lower than those before treatment, while the levels of SOD in the observation group were significantly higher than those before treatment, and the levels of SF and LPO in the observation group were significantly lower than those in the control group, while the levels of SOD in the observation group were significantly higher than those in the control group. Conclusions:Intensive insulin therapy can effectively improve the immune function of severe pneumonia patients, reduce their inflammatory reaction, matrix metalloproteinase levels and oxidative stress injury.
