Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years.The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high ...Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years.The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high level of clinical interest.However,there are very few explorations of in vivo measurements of orthodontic force,and existing studies are limited to a large number of couplings,which are inconvenient for clinical use.In this work,we developed a wireless flexible measurement system that allows quantitative measurement of the orthodontic force of an invisible aligner on a dental model.The system is wireless,tiny,flexible,fast responding,and has a range suitable for the range of orthodontic forces.We show the difference in the orthodontic force applied to different tooth positions and the difference in the orthodontic force applied to different positions of the same tooth.In addition,the system can evaluate the mechanical differences between aligners of different brands and materials as well as the deviation of fabrication results.This system provides a test tool and evaluation method for future real-time assessment of clinical orthodontic forces.展开更多
With the development and rising of antimicrobial resistance,rapid and effective killings of bacteria are urgently needed,especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be ...With the development and rising of antimicrobial resistance,rapid and effective killings of bacteria are urgently needed,especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be treated with conventional antibiotics.Here,a rapid and broad-spectrum antibacterial strategy is demonstrated through photothermal ablation with MXene and light.Ti3C2 MXenes,when combined with 808 nm light,show significant antibacterial effects in just 20 min.The antibacterial strategy is effective to 15 bacterial species tested,including methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Enterococci(VRE).In addition,the rapid antibacterial strategy works for MRSA biofilms,by damaging the structures as well as killing bacteria in biofilms.Furthermore,the investigation of the antibacterial mechanisms shows that Ti3C2 with light kills bacteria mainly physically through inserting/contact and photothermal effect.This work broadens the potential applications of MXene and provides a way to eradicate bacteria and biofilms physically,without the likelihood of resistance development.展开更多
基金Beijing Natural Science Foundation(L232109)National Natural Science Foundation of China(No.12202274 and No.52171234)+1 种基金Fundamental Research Funds for the Central Universities(YWF-22-K-101)National Key Research and Development Project(Nos.2021YFC2400703 and 2019YFE0101100).
文摘Invisible orthodontic treatment is an effective form of malocclusion treatment favored in recent years.The magnitude of its orthodontic force has a crucial impact on the outcome of the treatment and has gained a high level of clinical interest.However,there are very few explorations of in vivo measurements of orthodontic force,and existing studies are limited to a large number of couplings,which are inconvenient for clinical use.In this work,we developed a wireless flexible measurement system that allows quantitative measurement of the orthodontic force of an invisible aligner on a dental model.The system is wireless,tiny,flexible,fast responding,and has a range suitable for the range of orthodontic forces.We show the difference in the orthodontic force applied to different tooth positions and the difference in the orthodontic force applied to different positions of the same tooth.In addition,the system can evaluate the mechanical differences between aligners of different brands and materials as well as the deviation of fabrication results.This system provides a test tool and evaluation method for future real-time assessment of clinical orthodontic forces.
基金the National Natural Science Foundation of China(81901790 and 21803006)the Natural Science Foundation of Beijing(7204274)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Interdisciplinary Medicine Seed Fund of Peking University(BMU2017MX015)。
文摘With the development and rising of antimicrobial resistance,rapid and effective killings of bacteria are urgently needed,especially for antibiotic-resistant bacteria and bacterial biofilms that are usually hard to be treated with conventional antibiotics.Here,a rapid and broad-spectrum antibacterial strategy is demonstrated through photothermal ablation with MXene and light.Ti3C2 MXenes,when combined with 808 nm light,show significant antibacterial effects in just 20 min.The antibacterial strategy is effective to 15 bacterial species tested,including methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Enterococci(VRE).In addition,the rapid antibacterial strategy works for MRSA biofilms,by damaging the structures as well as killing bacteria in biofilms.Furthermore,the investigation of the antibacterial mechanisms shows that Ti3C2 with light kills bacteria mainly physically through inserting/contact and photothermal effect.This work broadens the potential applications of MXene and provides a way to eradicate bacteria and biofilms physically,without the likelihood of resistance development.
