Dear editor, Following its entrance into the human body through inhalation, carbon monoxide （CO） forms carboxyhemoglobin （COHb） by binding to hemoglobin （Hb） within the blood. Massive ischemic tissue necrosis oc...Dear editor, Following its entrance into the human body through inhalation, carbon monoxide （CO） forms carboxyhemoglobin （COHb） by binding to hemoglobin （Hb） within the blood. Massive ischemic tissue necrosis occurs in 0.5%-1% of cases with CO poisoning. The affinity of CO to Hb is 200-250 times more when compared to the affinity of oxygen. As a result of CO binding to Hb, oxygen delivery to the tissues is reduced, and tissue hypoxia develops. This affects mostly the brain and heart, which are the organs with the highest demand for oxygen.展开更多
文摘Dear editor, Following its entrance into the human body through inhalation, carbon monoxide （CO） forms carboxyhemoglobin （COHb） by binding to hemoglobin （Hb） within the blood. Massive ischemic tissue necrosis occurs in 0.5%-1% of cases with CO poisoning. The affinity of CO to Hb is 200-250 times more when compared to the affinity of oxygen. As a result of CO binding to Hb, oxygen delivery to the tissues is reduced, and tissue hypoxia develops. This affects mostly the brain and heart, which are the organs with the highest demand for oxygen.
