Enhancing the interconnection of devices and systems,the Internet of Things(IoT)is a paradigm-shifting technology.IoT security concerns are still a substantial concern despite its extraordinary advantages.This paper o...Enhancing the interconnection of devices and systems,the Internet of Things(IoT)is a paradigm-shifting technology.IoT security concerns are still a substantial concern despite its extraordinary advantages.This paper offers an extensive review of IoT security,emphasizing the technology’s architecture,important security elements,and common attacks.It highlights how important artificial intelligence(AI)is to bolstering IoT security,especially when it comes to addressing risks at different IoT architecture layers.We systematically examined current mitigation strategies and their effectiveness,highlighting contemporary challenges with practical solutions and case studies from a range of industries,such as healthcare,smart homes,and industrial IoT.Our results highlight the importance of AI methods that are lightweight and improve security without compromising the limited resources of devices and computational capability.IoT networks can ensure operational efficiency and resilience by proactively identifying and countering security risks by utilizing machine learning capabilities.This study provides a comprehensive guide for practitioners and researchers aiming to understand the intricate connection between IoT,security challenges,and AI-driven solutions.展开更多
Congenital unilateral lower lip palsy(CULLP),or congenital hypoplasia of the depressor anguli oris muscle,also known as asymmetric crying facies,is a rare condition that results in asymmetry of the lower lip during sm...Congenital unilateral lower lip palsy(CULLP),or congenital hypoplasia of the depressor anguli oris muscle,also known as asymmetric crying facies,is a rare condition that results in asymmetry of the lower lip during smiling,laughing,and crying.Although the etiology is unknown,weakness of the depressor labii inferioris(DLI)muscle is implicated as a contributing factor.Currently,no well-established treatment options are available.This case report describes an 18-year-old male patient diagnosed with CULLP.Physical examination revealed a symmetric face at rest,but asymmetry when smiling and opening the mouth.Following the administration of lidocaine into the affected DLI muscle,the patient’s smile and lower lip symmetry were immediately restored without any adverse effects.Subsequently,administration of botulinum toxin for neuromodulation of the DLI muscle led to a significant improvement in symmetry and oral function within 2 weeks,which was sustained at 1 month and 3 months post-treatment.No adverse effects were reported,and both patients and families expressed high satisfaction with the outcomes.This case highlights the potential use of neuromodulation as a minimally invasive and effective treatment for CULLP.展开更多
In the current work,inclined magnetic field,thermal radiation,and the Cattaneo-Christov heat flux are taken into account as we analyze the impact of chemical reaction on magneto-hydrodynamic Casson nanofluid flow on a...In the current work,inclined magnetic field,thermal radiation,and the Cattaneo-Christov heat flux are taken into account as we analyze the impact of chemical reaction on magneto-hydrodynamic Casson nanofluid flow on a stretching sheet.Modified Buongiorno’s nanofluid model has been used to model the flow governing equations.The stretching surface is embedded in a porousmedium.By using similarity transformations,the nonlinear partial differential equations are transformed into a set of dimensionless ordinary differential equations.The numerical solution of transformed dimensionless equations is achieved by applying the shooting procedure together with Rung-Kutta 4th-order method employing MATLAB.The impact of significant parameters on the velocity profile f(ζ),temperature distributionθ(ζ),concentration profileϕ(ζ),skin friction coefficient(Cf),Nusselt number(Nux)and Sherwood number(Shx)are analyzed and displayed in graphical and tabular formats.With an increase in Casson fluid 0.5<β<2,the motion of the Casson fluid decelerates whereas the temperature profile increases.As the thermal relation factor expands 0.1<γ1<0.4,the temperature reduces,and consequently thermal boundary layer shrinks.Additionally,by raising the level of thermal radiation 1<Rd<7,the temperature profile significantly improves,and an abrupt expansion has also been observed in the associated thermal boundary with raise thermal radiation strength.It was observed that higher permeability 0<K<4 hinders the acceleration of Casson fluid.Higher Brownian motion levels 0.2<Nb<0.6 correspond to lower levels of the Casson fluid concentration profile.Moreover,it is observed that chemical reaction 0.2<γ2<0.5 has an inverse relation with the concentration level of Casson fluid.The current model’s significant uses include heat energy enhancement,petroleum recovery,energy devices,food manufacturing processes,and cooling device adjustment,among others.Furthermore,present outcomes have been found in great agreementwith already publishedwork.展开更多
This study intends to evaluate the influence of temperature stratification on an unsteady fluid flow past an accelerated vertical plate in the existence of viscous dissipation.It is assumed that the medium under study...This study intends to evaluate the influence of temperature stratification on an unsteady fluid flow past an accelerated vertical plate in the existence of viscous dissipation.It is assumed that the medium under study is a grey,non-scattered fluid that both fascinates and transmits radiation.The leading equations are discretized using the finite differencemethod(FDM).UsingMATLABsoftware,the impacts of flowfactors on flowfields are revealed with particular examples in graphs and a table.In this regard,FDM results show that the velocity and temperature gradients increase with an increase of Eckert number.Furthermore,tables of the data indicate the influence of flow-contributing factors on the skin friction coefficients,and Nusselt numbers.When comparing constant and variable flow regimes,the constant flow regime has greater values for the nondimensional skin friction coefficient.This research is both innovative and fascinating since it has the potential to expand our understanding of fluid dynamics and to improve many different sectors.展开更多
Heat transfer improves significantly when the working fluid has high thermal conductivity.Heat transfer can be found in fields such as food processing,solar through collectors,and drug delivery.Considering this notabl...Heat transfer improves significantly when the working fluid has high thermal conductivity.Heat transfer can be found in fields such as food processing,solar through collectors,and drug delivery.Considering this notable fact,this work is focused on investigating the bio-convection-enhanced heat transfer in the existence of convective boundary conditions in the flow of hybrid nanofluid across a stretching surface.Buongiorno fluid model with hybrid nanoparticles has been employed along the swimming microorganisms to investigate the mixture base working fluid.The developed nonlinear flow governing equations have been tackled numerically with the help of the bvp4c.The effects of relevant parameters on the flowdynamic have been portrayed in a graphical representation.The velocity profile decreases by raising the levels of buoyancy ratio and mixed convection in the range of 0.1<λ≤0.3.It has been discovered thatwhen bioconvection levels rise,motile microbemigration abruptly slows,which results in a decrease in fluid acceleration.The concentration of fluid flow declined for the Lewis number,but the opposite trend has been observed for the elastic parameter,thermophoresis parameter,and buoyancy ratio.With rising values of Brownian motion and thermophoretic diffusion,the surface drag and Nusselt number decrease significantly.Whereas,the opposite trend has been observed when the values of the thermal Biot number,Prandtl number and buoyancy ratio are enhanced.Additionally,data from this study have been validated by comparison with those that have previously been published,and an appropriate rate of agreement has been observed.展开更多
Photonic nanojets(PNJs) have a wide range of applications in laser processing, nanolithography, optical highdensity storage, super-resolution microscopy, and other fields due to their processing capacity to overcome t...Photonic nanojets(PNJs) have a wide range of applications in laser processing, nanolithography, optical highdensity storage, super-resolution microscopy, and other fields due to their processing capacity to overcome the diffraction limit. Herein, we control static microsphere be developed into the motion state to fabricate vector graphics nano-grooves.The microspheres roll on the substrate while the laser is kept synchronously irradiated, and the overlapping PNJ ablated craters form patterned grooves on the indium-tin oxide(ITO) substrate. Thus, PNJ has been expanded from “point”processing to “line” processing. The fabricated nano grooves have high continuity and consistency. Whereas, the precise customization of critical groove dimension can be achieved via modulation in diameter and kinetics of dielectric microshperes. Furthermore, by etching vectographs on an ITO conductive glass substrate, we demonstrated the advantages and potential of the proposed method in nanopatterning. The proposed method effectively reduces the cost and complexity of photonic nanojets applied in nanopatterning. The proposed nanopatterning methodology will play a vital role in the fabrication of semiconductor materials, sensors, microfluidic devices, surface-enhanced Raman scattering(SERS), biomedicine, nanoscience and nanoengineering.展开更多
Extracellular RNAs(exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There...Extracellular RNAs(exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.展开更多
Power flow analysis is a numerical way of study of behavior of flow of electric power in an interconnected system. In order to meet the growing demands of electrical energy in an optimum way, there is a need to upgrad...Power flow analysis is a numerical way of study of behavior of flow of electric power in an interconnected system. In order to meet the growing demands of electrical energy in an optimum way, there is a need to upgrade existing systems or to install new systems. Therefore, planning of new installations and determination of best operating conditions of existing systems need power flow analysis. In this way, cost/benefit ratio for both suppliers and customers is maintained. This research involves the design and power flow analysis of IEEE-14 bus system. Newton Raphson method is applied for better efficiency and reduced computational time. Simulation analysis is conducted in ETAP software because of its excessive used in real life systems.展开更多
Obesity is one of the most prevalent health problems facing the United States today, with a recent JAMA articlepublished in 2014 estimating the prevalence of one third of all adults in the United States being obese. A...Obesity is one of the most prevalent health problems facing the United States today, with a recent JAMA articlepublished in 2014 estimating the prevalence of one third of all adults in the United States being obese. Also, due to technological advancements, the incidence of spine surgeries is growing. Considering these overall increases in both obesity and the performance of spinal surgeries, it can be inferred that more spinal surgery candidates will be obese. Due to this, certain factors must be taken into consideration when dealing with spine surgeries in the obese. Obesity is closely correlated with additional medical comorbidities, including hypertension, coronary artery disease, congestive heart failure, and diabetes mellitus. The pre-operative evaluation may be more difficult, as a more extensive medical evaluation may be needed. Also, adequate radiographic images can be difficult to obtain due to patient size and equipment limitations. Administering anesthesia becomes more difficult, as does proper patient positioning. Postoperatively, the obese patient is at greater risk for reintubation, difficulty with pain control, wound infection and deep vein thrombosis. However, despite these concerns, appropriate clinical outcomes can still be achieved in the obese spine surgical candidate. Obesity, therefore, is not a contraindication to spine surgery, and appropriate patient selection remains the key to obtaining favorable clinical outcomes.展开更多
Astrocytomas are tumors that arise from astrocytes—star-shaped cells that make up the “glue-like” or supportive tissue of the brain. Astrocytomas can appear in various parts of the brain and nervous system, includi...Astrocytomas are tumors that arise from astrocytes—star-shaped cells that make up the “glue-like” or supportive tissue of the brain. Astrocytomas can appear in various parts of the brain and nervous system, including the cerebellum, the cerebrum, the central areas of the brain, the brainstem and the spinal cord. The main objective of this study was to detect the sensitivity of the CT scan in diagnosis of the brain astrocytoma, in patients who were confirmed as brain gliomas using computerized tomography of the brain versus brain tissue biopsy after surgery. One hundred and one patients were included in this study. Bio-data collected for these patients (age, gender), radiographic appearance, contrast enhancement and the site of the tumor, were statistically analyzed. Out of the 101 patients with brain gliomas, 52 (51.5%) were male whose ages ranged between 1 and 80 years, and 64 (63.4%) cases were diagnosed as astrocytoma by CT. This study concluded that the CT brain was sensitive in the diagnosis of brain astrocytomas.展开更多
<strong>Background:</strong> SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is both a dermatological and a rheumatological entity, with the common denominator of an aseptic inflammato...<strong>Background:</strong> SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is both a dermatological and a rheumatological entity, with the common denominator of an aseptic inflammatory process, the bone manifestations of which are the essential element of the diagnosis. Despite its chronic and recurrent nature, SAPHO syndrome is very rarely the cause of major disability, even after several decades of evolution. <strong>Objective:</strong> We want to illustrate through three clinical cases, the importance of the anamnesis, the clinic, the diagnostic criteria in the diagnosis of SAPHO syndrome. <strong>Presentation of the cases:</strong> We studied the clinical file of three patients consulted in the Rheumatology Department of the CHU Aristide LeDantec in Dakar, Senegal, between January 2012 and December 2020, suffering from SAPHO syndrome of diagnosis established in accordance with the diagnostic criteria of SAPHO syndrome proposed by Khan et al. of 1994. <strong>Conclusion:</strong> SAPHO syndrome is a rare pathological entity, over a period of 8 years we report 3 cases.展开更多
Swarming and pairing behaviors are significant to population dispersal of termites.Tandem running is a key process in pairing behavior of dealates to find a mate.Succinylation can lead to significant changes in protei...Swarming and pairing behaviors are significant to population dispersal of termites.Tandem running is a key process in pairing behavior of dealates to find a mate.Succinylation can lead to significant changes in protein structure and function,which is widely involved in metabolism and behavior regulation in many organisms.However,whether succinylation modification regulates termites’tandem running is currently unknown.In this research,we performed quantitative modified proteomics of the subterranean termite Reticulitermes chinensis Snyder before and after alate swarming.The succinylation levels of accessory gland protein(ACP)were significantly altered after alate swarming.We found that ACP is enriched in male accessory gland and female oocytes of termites.The acetylation and succinylation sites of ACP affected tandem running of dealates.The transcriptome and metabolome analyses of alates injected with ACP and its mutant proteins showed thatβ-alanine metabolism pathway was the major downstream pathway of ACP.Silencing the significantly differentially expressed genes in theβ-alanine metabolic pathway(acyl-CoA dehydrogenase,enoyl-CoA hydratase,3-hydroxyisobutyrate dehydrogenase,methylmalonate-semialdehyde dehydrogenase)suppressed tandem running and altered oviposition of paired dealates.These findings demonstrate that protein translation modification is an important regulator of tandem running behavior of termites,which implies that the succinylation and acetylation modification sites of ACP could be potential targets for insecticide action.Our research offers a potential approach for developing novel dispersal inhibitors against social insect pests.展开更多
In the original version of this article,the order of qPCR bars between dsGFP-and dsIDH-injected termites in Figure 1E was incorrect.This error has been corrected in the following Figure 1 in this article.We apologize ...In the original version of this article,the order of qPCR bars between dsGFP-and dsIDH-injected termites in Figure 1E was incorrect.This error has been corrected in the following Figure 1 in this article.We apologize for any inconvenience that it may have caused.展开更多
文摘Enhancing the interconnection of devices and systems,the Internet of Things(IoT)is a paradigm-shifting technology.IoT security concerns are still a substantial concern despite its extraordinary advantages.This paper offers an extensive review of IoT security,emphasizing the technology’s architecture,important security elements,and common attacks.It highlights how important artificial intelligence(AI)is to bolstering IoT security,especially when it comes to addressing risks at different IoT architecture layers.We systematically examined current mitigation strategies and their effectiveness,highlighting contemporary challenges with practical solutions and case studies from a range of industries,such as healthcare,smart homes,and industrial IoT.Our results highlight the importance of AI methods that are lightweight and improve security without compromising the limited resources of devices and computational capability.IoT networks can ensure operational efficiency and resilience by proactively identifying and countering security risks by utilizing machine learning capabilities.This study provides a comprehensive guide for practitioners and researchers aiming to understand the intricate connection between IoT,security challenges,and AI-driven solutions.
文摘Congenital unilateral lower lip palsy(CULLP),or congenital hypoplasia of the depressor anguli oris muscle,also known as asymmetric crying facies,is a rare condition that results in asymmetry of the lower lip during smiling,laughing,and crying.Although the etiology is unknown,weakness of the depressor labii inferioris(DLI)muscle is implicated as a contributing factor.Currently,no well-established treatment options are available.This case report describes an 18-year-old male patient diagnosed with CULLP.Physical examination revealed a symmetric face at rest,but asymmetry when smiling and opening the mouth.Following the administration of lidocaine into the affected DLI muscle,the patient’s smile and lower lip symmetry were immediately restored without any adverse effects.Subsequently,administration of botulinum toxin for neuromodulation of the DLI muscle led to a significant improvement in symmetry and oral function within 2 weeks,which was sustained at 1 month and 3 months post-treatment.No adverse effects were reported,and both patients and families expressed high satisfaction with the outcomes.This case highlights the potential use of neuromodulation as a minimally invasive and effective treatment for CULLP.
文摘In the current work,inclined magnetic field,thermal radiation,and the Cattaneo-Christov heat flux are taken into account as we analyze the impact of chemical reaction on magneto-hydrodynamic Casson nanofluid flow on a stretching sheet.Modified Buongiorno’s nanofluid model has been used to model the flow governing equations.The stretching surface is embedded in a porousmedium.By using similarity transformations,the nonlinear partial differential equations are transformed into a set of dimensionless ordinary differential equations.The numerical solution of transformed dimensionless equations is achieved by applying the shooting procedure together with Rung-Kutta 4th-order method employing MATLAB.The impact of significant parameters on the velocity profile f(ζ),temperature distributionθ(ζ),concentration profileϕ(ζ),skin friction coefficient(Cf),Nusselt number(Nux)and Sherwood number(Shx)are analyzed and displayed in graphical and tabular formats.With an increase in Casson fluid 0.5<β<2,the motion of the Casson fluid decelerates whereas the temperature profile increases.As the thermal relation factor expands 0.1<γ1<0.4,the temperature reduces,and consequently thermal boundary layer shrinks.Additionally,by raising the level of thermal radiation 1<Rd<7,the temperature profile significantly improves,and an abrupt expansion has also been observed in the associated thermal boundary with raise thermal radiation strength.It was observed that higher permeability 0<K<4 hinders the acceleration of Casson fluid.Higher Brownian motion levels 0.2<Nb<0.6 correspond to lower levels of the Casson fluid concentration profile.Moreover,it is observed that chemical reaction 0.2<γ2<0.5 has an inverse relation with the concentration level of Casson fluid.The current model’s significant uses include heat energy enhancement,petroleum recovery,energy devices,food manufacturing processes,and cooling device adjustment,among others.Furthermore,present outcomes have been found in great agreementwith already publishedwork.
文摘This study intends to evaluate the influence of temperature stratification on an unsteady fluid flow past an accelerated vertical plate in the existence of viscous dissipation.It is assumed that the medium under study is a grey,non-scattered fluid that both fascinates and transmits radiation.The leading equations are discretized using the finite differencemethod(FDM).UsingMATLABsoftware,the impacts of flowfactors on flowfields are revealed with particular examples in graphs and a table.In this regard,FDM results show that the velocity and temperature gradients increase with an increase of Eckert number.Furthermore,tables of the data indicate the influence of flow-contributing factors on the skin friction coefficients,and Nusselt numbers.When comparing constant and variable flow regimes,the constant flow regime has greater values for the nondimensional skin friction coefficient.This research is both innovative and fascinating since it has the potential to expand our understanding of fluid dynamics and to improve many different sectors.
文摘Heat transfer improves significantly when the working fluid has high thermal conductivity.Heat transfer can be found in fields such as food processing,solar through collectors,and drug delivery.Considering this notable fact,this work is focused on investigating the bio-convection-enhanced heat transfer in the existence of convective boundary conditions in the flow of hybrid nanofluid across a stretching surface.Buongiorno fluid model with hybrid nanoparticles has been employed along the swimming microorganisms to investigate the mixture base working fluid.The developed nonlinear flow governing equations have been tackled numerically with the help of the bvp4c.The effects of relevant parameters on the flowdynamic have been portrayed in a graphical representation.The velocity profile decreases by raising the levels of buoyancy ratio and mixed convection in the range of 0.1<λ≤0.3.It has been discovered thatwhen bioconvection levels rise,motile microbemigration abruptly slows,which results in a decrease in fluid acceleration.The concentration of fluid flow declined for the Lewis number,but the opposite trend has been observed for the elastic parameter,thermophoresis parameter,and buoyancy ratio.With rising values of Brownian motion and thermophoretic diffusion,the surface drag and Nusselt number decrease significantly.Whereas,the opposite trend has been observed when the values of the thermal Biot number,Prandtl number and buoyancy ratio are enhanced.Additionally,data from this study have been validated by comparison with those that have previously been published,and an appropriate rate of agreement has been observed.
基金Projects(LZ20E050003, LD22E050001) supported by the Zhejiang Provincial Natural Science Foundation of China。
文摘Photonic nanojets(PNJs) have a wide range of applications in laser processing, nanolithography, optical highdensity storage, super-resolution microscopy, and other fields due to their processing capacity to overcome the diffraction limit. Herein, we control static microsphere be developed into the motion state to fabricate vector graphics nano-grooves.The microspheres roll on the substrate while the laser is kept synchronously irradiated, and the overlapping PNJ ablated craters form patterned grooves on the indium-tin oxide(ITO) substrate. Thus, PNJ has been expanded from “point”processing to “line” processing. The fabricated nano grooves have high continuity and consistency. Whereas, the precise customization of critical groove dimension can be achieved via modulation in diameter and kinetics of dielectric microshperes. Furthermore, by etching vectographs on an ITO conductive glass substrate, we demonstrated the advantages and potential of the proposed method in nanopatterning. The proposed method effectively reduces the cost and complexity of photonic nanojets applied in nanopatterning. The proposed nanopatterning methodology will play a vital role in the fabrication of semiconductor materials, sensors, microfluidic devices, surface-enhanced Raman scattering(SERS), biomedicine, nanoscience and nanoengineering.
文摘Extracellular RNAs(exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.
文摘Power flow analysis is a numerical way of study of behavior of flow of electric power in an interconnected system. In order to meet the growing demands of electrical energy in an optimum way, there is a need to upgrade existing systems or to install new systems. Therefore, planning of new installations and determination of best operating conditions of existing systems need power flow analysis. In this way, cost/benefit ratio for both suppliers and customers is maintained. This research involves the design and power flow analysis of IEEE-14 bus system. Newton Raphson method is applied for better efficiency and reduced computational time. Simulation analysis is conducted in ETAP software because of its excessive used in real life systems.
文摘Obesity is one of the most prevalent health problems facing the United States today, with a recent JAMA articlepublished in 2014 estimating the prevalence of one third of all adults in the United States being obese. Also, due to technological advancements, the incidence of spine surgeries is growing. Considering these overall increases in both obesity and the performance of spinal surgeries, it can be inferred that more spinal surgery candidates will be obese. Due to this, certain factors must be taken into consideration when dealing with spine surgeries in the obese. Obesity is closely correlated with additional medical comorbidities, including hypertension, coronary artery disease, congestive heart failure, and diabetes mellitus. The pre-operative evaluation may be more difficult, as a more extensive medical evaluation may be needed. Also, adequate radiographic images can be difficult to obtain due to patient size and equipment limitations. Administering anesthesia becomes more difficult, as does proper patient positioning. Postoperatively, the obese patient is at greater risk for reintubation, difficulty with pain control, wound infection and deep vein thrombosis. However, despite these concerns, appropriate clinical outcomes can still be achieved in the obese spine surgical candidate. Obesity, therefore, is not a contraindication to spine surgery, and appropriate patient selection remains the key to obtaining favorable clinical outcomes.
文摘Astrocytomas are tumors that arise from astrocytes—star-shaped cells that make up the “glue-like” or supportive tissue of the brain. Astrocytomas can appear in various parts of the brain and nervous system, including the cerebellum, the cerebrum, the central areas of the brain, the brainstem and the spinal cord. The main objective of this study was to detect the sensitivity of the CT scan in diagnosis of the brain astrocytoma, in patients who were confirmed as brain gliomas using computerized tomography of the brain versus brain tissue biopsy after surgery. One hundred and one patients were included in this study. Bio-data collected for these patients (age, gender), radiographic appearance, contrast enhancement and the site of the tumor, were statistically analyzed. Out of the 101 patients with brain gliomas, 52 (51.5%) were male whose ages ranged between 1 and 80 years, and 64 (63.4%) cases were diagnosed as astrocytoma by CT. This study concluded that the CT brain was sensitive in the diagnosis of brain astrocytomas.
文摘<strong>Background:</strong> SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is both a dermatological and a rheumatological entity, with the common denominator of an aseptic inflammatory process, the bone manifestations of which are the essential element of the diagnosis. Despite its chronic and recurrent nature, SAPHO syndrome is very rarely the cause of major disability, even after several decades of evolution. <strong>Objective:</strong> We want to illustrate through three clinical cases, the importance of the anamnesis, the clinic, the diagnostic criteria in the diagnosis of SAPHO syndrome. <strong>Presentation of the cases:</strong> We studied the clinical file of three patients consulted in the Rheumatology Department of the CHU Aristide LeDantec in Dakar, Senegal, between January 2012 and December 2020, suffering from SAPHO syndrome of diagnosis established in accordance with the diagnostic criteria of SAPHO syndrome proposed by Khan et al. of 1994. <strong>Conclusion:</strong> SAPHO syndrome is a rare pathological entity, over a period of 8 years we report 3 cases.
基金supported by the National Natural Science Foundation of China(31772516 and 32170500).
文摘Swarming and pairing behaviors are significant to population dispersal of termites.Tandem running is a key process in pairing behavior of dealates to find a mate.Succinylation can lead to significant changes in protein structure and function,which is widely involved in metabolism and behavior regulation in many organisms.However,whether succinylation modification regulates termites’tandem running is currently unknown.In this research,we performed quantitative modified proteomics of the subterranean termite Reticulitermes chinensis Snyder before and after alate swarming.The succinylation levels of accessory gland protein(ACP)were significantly altered after alate swarming.We found that ACP is enriched in male accessory gland and female oocytes of termites.The acetylation and succinylation sites of ACP affected tandem running of dealates.The transcriptome and metabolome analyses of alates injected with ACP and its mutant proteins showed thatβ-alanine metabolism pathway was the major downstream pathway of ACP.Silencing the significantly differentially expressed genes in theβ-alanine metabolic pathway(acyl-CoA dehydrogenase,enoyl-CoA hydratase,3-hydroxyisobutyrate dehydrogenase,methylmalonate-semialdehyde dehydrogenase)suppressed tandem running and altered oviposition of paired dealates.These findings demonstrate that protein translation modification is an important regulator of tandem running behavior of termites,which implies that the succinylation and acetylation modification sites of ACP could be potential targets for insecticide action.Our research offers a potential approach for developing novel dispersal inhibitors against social insect pests.
文摘In the original version of this article,the order of qPCR bars between dsGFP-and dsIDH-injected termites in Figure 1E was incorrect.This error has been corrected in the following Figure 1 in this article.We apologize for any inconvenience that it may have caused.
