Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UES)following robot-assisted radical cystectomy(RARC)and urinary diversion.Methods:Retrospective review of our R...Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UES)following robot-assisted radical cystectomy(RARC)and urinary diversion.Methods:Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was performed.Patients who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation(RUER)were identified.KaplaneMeier method was used to compute the cumulative incidence recurrence rate of UES after RUER.A multivariable regression model was used to identify variables associated with UES recurrence.Results:A total of 123(15%)out of 808 RARC patients developed UES,of whom 52 underwent reimplantation(45 patients underwent RUER[n=55 cases]and seven patients underwent open ureteroenteric reimplantation).The median time from RARC to UES was 4.4(interquartile range 3.0e7.0)months,and the median time between UES and RUER was 5.2(interquartile range 3.2e8.9)months.The 3-year recurrence rate after RUER is about 29%.On multivariable analysis,longer hospital stay(hazard ratio 1.37,95%confidence interval 1.16e1.61,p<0.01)was associated with recurrent UES after RUER.Conclusion:RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.展开更多
Peyronie’s disease(PD)is an acquired connective tissue disorder of the tunica albuginea of the corpus cavernosum,characterized by excessive fibrosis and plaque formation.PD can result in significant physical and psyc...Peyronie’s disease(PD)is an acquired connective tissue disorder of the tunica albuginea of the corpus cavernosum,characterized by excessive fibrosis and plaque formation.PD can result in significant physical and psychological morbidity;as it may prevent intercourse and cause adverse impacts on partner relationships.The exact etiology and pathophysiology remain unclear,and many misconceptions about the disease associations,course and treatment exist.The disease has two distinct stages.The acute stage is characterized by pain,and disease may progress during this stage.Non-surgical managements at this stage aim to alleviate pain and stabilize the disease.Results for non-surgical treatment are often conflicting.The chronic stage occurs 6e12 months later,where pain disappears and the deformity stabilizes.Surgical treatment is reserved for significant deformity or with inability to penetrative intercourse.The choice of the surgical technique depends on the length of the penis,degree of deformity,erectile function,patients’expectations and surgeon’s preference.展开更多
Besides（-）-epicatechin,epicatechin-（4β-8 ）-epicatechin（procyanidin B2）,epicatechin-（4β-6 ）-epicatechin （procyanidin B5）,epicatechin-（4β-8,2β-O-7）-epicatechin（proanthocyanidin A2） and epicatechin- （4...Besides（-）-epicatechin,epicatechin-（4β-8 ）-epicatechin（procyanidin B2）,epicatechin-（4β-6 ）-epicatechin （procyanidin B5）,epicatechin-（4β-8,2β-O-7）-epicatechin（proanthocyanidin A2） and epicatechin- （4β-8）-epicatechin-（4β-8）-epicatechin（procyanidin C1）,which were isolated before from Adansonia digitata, in this work an A-type proanthocyanidin trimer,i.e.epicatechin-（4β-8）-epicatechin-（4β-8,2β-0-7）- epicatechin,tetrameric procyanidin D1,i.e.epicatechin-（4β-8）-epicatechin-（4β-8）-epicatechin-（4β-8）- epicatechin and a polymeric compound were isolated from the pericarp（fruit wall） of the fruits for the first time from this plant.The antioxidant activity of different fractions and pure compounds was experimentally evaluated in the DPPH<sup>-</sup> assay.The ethyl acetate fraction,and most of the isolated compounds displayed a high activity(IC<sub>50</sub> 2.40-9.60μg/ml) compared with the reference antioxidant Trolox(IC<sub>50</sub> 12.18μg/ml) as a standard.展开更多
文摘Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UES)following robot-assisted radical cystectomy(RARC)and urinary diversion.Methods:Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was performed.Patients who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation(RUER)were identified.KaplaneMeier method was used to compute the cumulative incidence recurrence rate of UES after RUER.A multivariable regression model was used to identify variables associated with UES recurrence.Results:A total of 123(15%)out of 808 RARC patients developed UES,of whom 52 underwent reimplantation(45 patients underwent RUER[n=55 cases]and seven patients underwent open ureteroenteric reimplantation).The median time from RARC to UES was 4.4(interquartile range 3.0e7.0)months,and the median time between UES and RUER was 5.2(interquartile range 3.2e8.9)months.The 3-year recurrence rate after RUER is about 29%.On multivariable analysis,longer hospital stay(hazard ratio 1.37,95%confidence interval 1.16e1.61,p<0.01)was associated with recurrent UES after RUER.Conclusion:RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.
文摘Peyronie’s disease(PD)is an acquired connective tissue disorder of the tunica albuginea of the corpus cavernosum,characterized by excessive fibrosis and plaque formation.PD can result in significant physical and psychological morbidity;as it may prevent intercourse and cause adverse impacts on partner relationships.The exact etiology and pathophysiology remain unclear,and many misconceptions about the disease associations,course and treatment exist.The disease has two distinct stages.The acute stage is characterized by pain,and disease may progress during this stage.Non-surgical managements at this stage aim to alleviate pain and stabilize the disease.Results for non-surgical treatment are often conflicting.The chronic stage occurs 6e12 months later,where pain disappears and the deformity stabilizes.Surgical treatment is reserved for significant deformity or with inability to penetrative intercourse.The choice of the surgical technique depends on the length of the penis,degree of deformity,erectile function,patients’expectations and surgeon’s preference.
文摘Besides（-）-epicatechin,epicatechin-（4β-8 ）-epicatechin（procyanidin B2）,epicatechin-（4β-6 ）-epicatechin （procyanidin B5）,epicatechin-（4β-8,2β-O-7）-epicatechin（proanthocyanidin A2） and epicatechin- （4β-8）-epicatechin-（4β-8）-epicatechin（procyanidin C1）,which were isolated before from Adansonia digitata, in this work an A-type proanthocyanidin trimer,i.e.epicatechin-（4β-8）-epicatechin-（4β-8,2β-0-7）- epicatechin,tetrameric procyanidin D1,i.e.epicatechin-（4β-8）-epicatechin-（4β-8）-epicatechin-（4β-8）- epicatechin and a polymeric compound were isolated from the pericarp（fruit wall） of the fruits for the first time from this plant.The antioxidant activity of different fractions and pure compounds was experimentally evaluated in the DPPH<sup>-</sup> assay.The ethyl acetate fraction,and most of the isolated compounds displayed a high activity(IC<sub>50</sub> 2.40-9.60μg/ml) compared with the reference antioxidant Trolox(IC<sub>50</sub> 12.18μg/ml) as a standard.
