Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis ...Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.展开更多
目的:评价0.05%丁酸氯倍他松乳膏(CB)治疗湿疹的临床疗效和安全性。方法:多中心、随机双盲、赋形剂(基质)对照临床研究。中重度湿疹患者随机纳入0.05%CB试验组或基质对照组,局部外用,每日2次,疗程2周。进入试验后受试者每日填写日记,并...目的:评价0.05%丁酸氯倍他松乳膏(CB)治疗湿疹的临床疗效和安全性。方法:多中心、随机双盲、赋形剂(基质)对照临床研究。中重度湿疹患者随机纳入0.05%CB试验组或基质对照组,局部外用,每日2次,疗程2周。进入试验后受试者每日填写日记,并于第7天和14天随访评价临床疗效和安全性。结果:8个试验中心共入组受试者240例,试验组及对照组各120例;治疗14d,试验组湿疹面积及严重程度指数(EASI)平均下降65.34%,对照组EASI平均下降38.84%,试验组明显优于对照组,差异有统计学意义(F=24.01,P<0.000 1)。治疗第7天及14天时,研究者总体评价(investigator's global assessment,IGA)评分和基于IGA的治疗成功率、直观模拟尺法(VAS)瘙痒症状自我评价等指标试验组均明显优于对照组,差异均有统计学意义(P<0.001)。安全性评价指标在试验组和对照组组间及组内治疗前后比较差别均无统计学意义(P>0.05)。结论:0.05%CB适用于治疗中重度湿疹,起效快,疗效和安全性良好。展开更多
文摘Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.
文摘目的:评价0.05%丁酸氯倍他松乳膏(CB)治疗湿疹的临床疗效和安全性。方法:多中心、随机双盲、赋形剂(基质)对照临床研究。中重度湿疹患者随机纳入0.05%CB试验组或基质对照组,局部外用,每日2次,疗程2周。进入试验后受试者每日填写日记,并于第7天和14天随访评价临床疗效和安全性。结果:8个试验中心共入组受试者240例,试验组及对照组各120例;治疗14d,试验组湿疹面积及严重程度指数(EASI)平均下降65.34%,对照组EASI平均下降38.84%,试验组明显优于对照组,差异有统计学意义(F=24.01,P<0.000 1)。治疗第7天及14天时,研究者总体评价(investigator's global assessment,IGA)评分和基于IGA的治疗成功率、直观模拟尺法(VAS)瘙痒症状自我评价等指标试验组均明显优于对照组,差异均有统计学意义(P<0.001)。安全性评价指标在试验组和对照组组间及组内治疗前后比较差别均无统计学意义(P>0.05)。结论:0.05%CB适用于治疗中重度湿疹,起效快,疗效和安全性良好。
