目的:探究叶酸受体(Folate receptor alpha, FR-α)蛋白联合消除速率常数K (the modeled CA125 ELIMination rate constant K, KELIM)在预测晚期卵巢高级别浆液性腺癌(ovarian high-grade serous adenocarcinoma, HGCS)铂类药物化疗后...目的:探究叶酸受体(Folate receptor alpha, FR-α)蛋白联合消除速率常数K (the modeled CA125 ELIMination rate constant K, KELIM)在预测晚期卵巢高级别浆液性腺癌(ovarian high-grade serous adenocarcinoma, HGCS)铂类药物化疗后铂耐药复发中的应用。方法:收集行满意肿瘤细胞减灭术,以术后联合铂类为基础,规范化疗的40例患者,根据患者停止化疗后6个月复发情况,分为铂敏感复发组和铂耐药复发组(各20例),分析总结HGCS铂耐药的因素。结果:FR-α在HGCS中高表达,阳性率为75%;两组患者年龄、BMI、术前CA125等一般资料比较差异无统计学意义(P > 0.05),KELIM评分、FR-α、ROMA比较差异具有统计学意义(P α是晚期卵巢高级别浆液性腺癌铂耐药复发独立的预后因素(OR:0.181,95%CI:0.033~0.982,P = 0.048;OR:0.030,95%CI:0.002~0.475,P = 0.013);将Logistic多因素分析有意义的指标,绘制ROC曲线,结果:FR-α联合KELIM评分曲线下面积为0.818 (95%CI:0.683~0.952,P = 0.001),灵敏度为0.80%。结论:FR-α在HGCS中高表达,FR-α、KELIM值是HGCS铂耐药复发独立的预后因素,二者联合检测对HGCS铂类耐复发具有一定预测价值。Objective: To explore the application of folate receptor alpha (FR-α) protein combined with the modeled CA125 ELIMination rate constant K (KELIM) in predicting platinum-resistant recurrence after platinum-based chemotherapy in advanced ovarian high-grade serous adenocarcinoma (HGCS). Methods: Forty patients who underwent satisfactory tumor cytoreductive surgery and postoperative platinum-based chemotherapy were collected. According to the recurrence of patients 6 months after chemotherapy, they were divided into platinum-sensitive recurrence group and platinum-resistant recurrence group (20 cases each). The factors of platinum resistance in HGCS were analyzed and summarized. Results: FR-α was highly expressed in HGCS, with a positive rate of 75%. There was no significant difference in age, BMI, preoperative CA125 and other general data between the two groups (P > 0.05). There were significant differences in KELIM score, FR-α and ROMA between the two groups (P α were independent prognostic factors for platinum-resistant recurrence of advanced ovarian high-grade serous adenocarcinoma (OR: 0.181, 95%CI: 0.033~0.982, P = 0.048;OR: 0.030, 95%CI: 0.002~0.475, P = 0.013);logistic multivariate analysis was used to analyze the meaningful indicators, and the ROC curve was drawn. Results: The area under the curve of FR-α combined with KELIM score was 0.818 (95%CI: 0.683~0.952, P = 0.001), and the sensitivity was 0.80%. Conclusion: FR-α is highly expressed in HGCS. FR-α and KELIM values are independent prognostic factors for platinum-resistant recurrence of HGCS. The combined detection of the two has a certain predictive value for platinum-resistant recurrence of HGCS.展开更多
文摘目的:探究叶酸受体(Folate receptor alpha, FR-α)蛋白联合消除速率常数K (the modeled CA125 ELIMination rate constant K, KELIM)在预测晚期卵巢高级别浆液性腺癌(ovarian high-grade serous adenocarcinoma, HGCS)铂类药物化疗后铂耐药复发中的应用。方法:收集行满意肿瘤细胞减灭术,以术后联合铂类为基础,规范化疗的40例患者,根据患者停止化疗后6个月复发情况,分为铂敏感复发组和铂耐药复发组(各20例),分析总结HGCS铂耐药的因素。结果:FR-α在HGCS中高表达,阳性率为75%;两组患者年龄、BMI、术前CA125等一般资料比较差异无统计学意义(P > 0.05),KELIM评分、FR-α、ROMA比较差异具有统计学意义(P α是晚期卵巢高级别浆液性腺癌铂耐药复发独立的预后因素(OR:0.181,95%CI:0.033~0.982,P = 0.048;OR:0.030,95%CI:0.002~0.475,P = 0.013);将Logistic多因素分析有意义的指标,绘制ROC曲线,结果:FR-α联合KELIM评分曲线下面积为0.818 (95%CI:0.683~0.952,P = 0.001),灵敏度为0.80%。结论:FR-α在HGCS中高表达,FR-α、KELIM值是HGCS铂耐药复发独立的预后因素,二者联合检测对HGCS铂类耐复发具有一定预测价值。Objective: To explore the application of folate receptor alpha (FR-α) protein combined with the modeled CA125 ELIMination rate constant K (KELIM) in predicting platinum-resistant recurrence after platinum-based chemotherapy in advanced ovarian high-grade serous adenocarcinoma (HGCS). Methods: Forty patients who underwent satisfactory tumor cytoreductive surgery and postoperative platinum-based chemotherapy were collected. According to the recurrence of patients 6 months after chemotherapy, they were divided into platinum-sensitive recurrence group and platinum-resistant recurrence group (20 cases each). The factors of platinum resistance in HGCS were analyzed and summarized. Results: FR-α was highly expressed in HGCS, with a positive rate of 75%. There was no significant difference in age, BMI, preoperative CA125 and other general data between the two groups (P > 0.05). There were significant differences in KELIM score, FR-α and ROMA between the two groups (P α were independent prognostic factors for platinum-resistant recurrence of advanced ovarian high-grade serous adenocarcinoma (OR: 0.181, 95%CI: 0.033~0.982, P = 0.048;OR: 0.030, 95%CI: 0.002~0.475, P = 0.013);logistic multivariate analysis was used to analyze the meaningful indicators, and the ROC curve was drawn. Results: The area under the curve of FR-α combined with KELIM score was 0.818 (95%CI: 0.683~0.952, P = 0.001), and the sensitivity was 0.80%. Conclusion: FR-α is highly expressed in HGCS. FR-α and KELIM values are independent prognostic factors for platinum-resistant recurrence of HGCS. The combined detection of the two has a certain predictive value for platinum-resistant recurrence of HGCS.
